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    Chemistry

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    Also known as: Esomeprazole sodium, Esomeprazole (sodium), H199/18 sodium, Esomeprazole (as sodium), Esomeprazole sodium [usan], 161796-78-7
    Molecular Formula
    C17H18N3NaO3S
    Molecular Weight
    367.4  g/mol
    InChI Key
    RYXPMWYHEBGTRV-JIDHJSLPSA-N
    FDA UNII
    L2C9GWQ43H
    Esomeprazole Sodium
    The S-isomer of omeprazole.
    1 2D Structure

    Esomeprazole Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
    2.1.2 InChI
    InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3;/q-1;+1/t24-;/m0./s1
    2.1.3 InChI Key
    RYXPMWYHEBGTRV-JIDHJSLPSA-N
    2.1.4 Canonical SMILES
    CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
    2.1.5 Isomeric SMILES
    CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    L2C9GWQ43H
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Esomeprazole

    2. Esomeprazole Magnesium

    3. Esomeprazole Potassium

    4. Esomeprazole Sodium

    5. Esomeprazole Strontium

    6. Esomeprazole Strontium Anhydrous

    7. Nexium

    8. Strontium, Esomeprazole

    2.3.2 Depositor-Supplied Synonyms

    1. Esomeprazole Sodium

    2. Esomeprazole (sodium)

    3. H199/18 Sodium

    4. Esomeprazole (as Sodium)

    5. Esomeprazole Sodium [usan]

    6. 161796-78-7

    7. Esomeprazole Sodium (usan)

    8. (s)-omeprazole Sodium Salt

    9. L2c9gwq43h

    10. Sodium;5-methoxy-2-[(s)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

    11. Nexium Iv (tn)

    12. 1h-benzimidazole, 5-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt

    13. 5-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)-1h-benzimidazole, Sodium Salt

    14. Chembl1200470

    15. Esomeprazole Sodium [vandf]

    16. Esomeprazole Sodium [mart.]

    17. Esomeprazole Sodium [who-dd]

    18. S2233

    19. Ccg-268253

    20. Esomeprazole Sodium [orange Book]

    21. Esomeprazole Sodium [ep Monograph]

    22. Hy-17023

    23. O0560

    24. 1h-benzimidazole, 6-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt (1:1)

    25. D04056

    26. Q-100194

    27. Q27282619

    28. 5-methoxy-2-[(s)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1h-benzimidazole Sodium Salt

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 367.4 g/mol
    Molecular Formula C17H18N3NaO3S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass367.09665690 g/mol
    Monoisotopic Mass367.09665690 g/mol
    Topological Polar Surface Area81.5 Ų
    Heavy Atom Count25
    Formal Charge0
    Complexity459
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameEsomeprazole sodium
    Drug LabelThe active ingredient in esomeprazole sodium for injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H-benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isome...
    Active IngredientEsomeprazole sodium
    Dosage FormInjectable
    RouteIntravenous
    Strengtheq 20mg base/vial; eq 40mg base/vial
    Market StatusPrescription
    CompanySun Pharma Global

    2 of 2  
    Drug NameEsomeprazole sodium
    Drug LabelThe active ingredient in esomeprazole sodium for injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H-benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isome...
    Active IngredientEsomeprazole sodium
    Dosage FormInjectable
    RouteIntravenous
    Strengtheq 20mg base/vial; eq 40mg base/vial
    Market StatusPrescription
    CompanySun Pharma Global

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    Proton Pump Inhibitors

    Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]

    API Reference Price

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AESS24004 M.MAY-2024 E.APR-2027)","address":"M-134, 2ND FLOOR","city":"NEW DELHI","supplier":"RAJASTHAN ANTIBIOTICS","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO THE ORDER OF","customerCountry":"BANGLADESH","quantity":"12.00","actualQuantity":"12","unit":"KGS","unitRateFc":"300","totalValueFC":"3412.9","currency":"USD","unitRateINR":23833.75,"date":"25-Sep-2024","totalValueINR":"286005","totalValueInUsd":"3412.9","indian_port":"Delhi Air","hs_no":"29420090","bill_no":"4313139","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Sterile","supplierPort":"Delhi Air","supplierAddress":"M-134, 2ND FLOOR, NEW DELHI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727202600,"product":"ESOMEPRAZOLE SODIUM STERILE (34% TO 38%W\/W) (B.NO. AESS24004 MFG: 05\/24, EXP: 04\/27)","address":"M-134, 2ND FLOOR","city":"NEW DELHI","supplier":"RAJASTHAN ANTIBIOTICS","supplierCountry":"INDIA","foreign_port":"MOSCOW DOMODEDOVO","customer":"TO THE ORDER OF.","customerCountry":"RUSSIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"62250","totalValueFC":"694.5","currency":"INR","unitRateINR":58195.949999999997,"date":"25-Sep-2024","totalValueINR":"58195.95","totalValueInUsd":"694.5","indian_port":"Delhi Air","hs_no":"29420090","bill_no":"4313317","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Sterile","supplierPort":"Delhi Air","supplierAddress":"M-134, 2ND FLOOR, NEW DELHI","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626287400,"product":"ESOMEPRAZOLE SODIUM (QTY: 1 X 2GMS, VALUE: USD 79.59)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S. PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.002","unit":"KGS","unitRateFc":"39795","totalValueFC":"83","currency":"USD","unitRateINR":"3092735","date":"15-Jul-2021","totalValueINR":"6185.47","totalValueInUsd":"83","indian_port":"HYDERABAD AIR","hs_no":"29333990","bill_no":"4692522","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1652034600,"product":"ESOMEPRAZOLE SODIUM, BATCH NO. PCEPZNF003 (RE-IMPORT VIDE S.B.NO. 1636348 DT 07-05-2021)","address":"SPARC TANDALJA","city":"VADODARA","supplier":"YANGTZE RIVER IMPORT & EXPORT CO.LTD,","supplierCountry":"INDIA","foreign_port":"NA","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"3000","totalValueFC":"18147","currency":"USD","unitRateINR":"233750.4","date":"09-May-2022","totalValueINR":"1402502.63","totalValueInUsd":"18147","indian_port":"DELHI AIR","hs_no":"29332990","bill_no":"8597298","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"SPARC TANDALJA"}]
    13-Jan-2021
    25-Sep-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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