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Fenoprofen Calcium

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41 FDF Dossiers, 40 FDA Orange Book, 1 Listed Dossiers

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CAPSULE;ORAL - EQ 200MG BASE, CAPSULE;ORAL - EQ 400MG BASE

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CAPSULE;ORAL - EQ 400MG BASE

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 7 DKSH, 2 Jai Radhe Sales, 4 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 10 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 4 ACG Worldwide, 5 Actylis, 1 Aeon Procare, 1 Alcedo Pharmachem, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 20 BASF, 10 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 11 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 16 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 9 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 4 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 16 Roquette, 13 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 1 Ulanqab Kema New Material, 3 Vasa Pharmachem

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Synopsis

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Chemistry

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Also known as: Fenoprofen calcium, 34597-40-5, Calcium fenoprofen, Fenoprofen calcium anhydrous, Fenprofen calcium, 56367-29-4

Molecular Formula

C₃₀H₂₆CaO₆

Molecular Weight

522.6 g/mol

InChI Key

VHUXSAWXWSTUOD-UHFFFAOYSA-L

FDA UNII

8R95A3O51K

A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.

1 2D Structure

Fenoprofen Calcium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;2-(3-phenoxyphenyl)propanoate

2.1.2 InChI

InChI=1S/2C15H14O3.Ca/c2*1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13;/h2*2-11H,1H3,(H,16,17);/q;;+2/p-2

2.1.3 InChI Key

VHUXSAWXWSTUOD-UHFFFAOYSA-L

2.1.4 Canonical SMILES

CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)[O-].CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)[O-].[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

8R95A3O51K

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Fenoprofen

2. Fenoprofen Calcium

3. Fenoprofen Dihydrate, Calcium Salt

4. Fenoprofen, Anhydrous, Calcium Salt

5. Nalfon

6. Nalgesic

2.3.2 Depositor-Supplied Synonyms

1. Fenoprofen Calcium

2. 34597-40-5

3. Calcium Fenoprofen

4. Fenoprofen Calcium Anhydrous

5. Fenprofen Calcium

6. 56367-29-4

7. Calcium;2-(3-phenoxyphenyl)propanoate

8. Fenoprofencalcium

9. 2-(3-phenoxyphenyl)propionic Acid Calcium Salt

10. 8r95a3o51k

11. Fenoprofen Calcium Salt

12. 71720-56-4

13. Fenoprofen Calcium (anhydrous)

14. Einecs 252-107-9

15. Nalfon 200

16. Calcium Bis[2-(3-phenoxyphenyl)propanoate]

17. Anhydrous Fenoprofen Calcium

18. Calcium (1)-bis(2-(3-phenoxyphenyl)propionate)

19. Dl-2-(3-phenoxyphenyl)propionic Acid Calcium Salt

20. Unii-8r95a3o51k

21. Chebi:5010

22. Schembl7408071

23. (+-)-alpha-methyl-3-phenoxybenzeneacetic Acid Calcium Salt

24. Dtxsid80904653

25. Hms3651o19

26. Calcium Fenoprofen Anhydrous

27. Einecs 260-133-7

28. Benzeneacetic Acid, Alpha-methyl-3-phenoxy-, Calcium Salt, (+-)-

29. Mfcd00079289

30. S1823

31. Calcium 2-(m-phenoxyphenyl)propionate

32. Akos015960717

33. Ac-4549

34. Ccg-269871

35. Calcium Alpha-(m-phenoxyphenyl)propionate

36. Calcium Alpha-methyl-3-phenoxybenzeneacetate

37. Calcium (+-)-2-(3-phenoxyphenyl)propionate

38. F0372

39. Ft-0668500

40. Sw196529-2

41. C02539

42. Q27106621

43. Bis[(s)-alpha-methyl-3-phenoxybenzeneacetic Acid]calcium Salt

44. Benzeneacetic Acid, ,alpha.-methyl-3-phenoxy-, Calcium Salt (2:1)

45. Benzeneacetic Acid, .alpha.-methyl-3-phenoxy-, Calcium Salt

46. Benzeneacetic Acid, .alpha.-methyl-3-phenoxy-, Calcium Salt (2:1)

47. Benzeneacetic Acid, .alpha.-methyl-3-phenoxy-, Calcium Salt, (+/-)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₃₀H₂₆CaO₆
Molecular Weight	522.6 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	522.1355294 g/mol
Monoisotopic Mass	522.1355294 g/mol
Topological Polar Surface Area	98.7 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	265
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Fenoprofen calcium
PubMed Health	Fenoprofen (By mouth)
Drug Classes	Analgesic, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Drug Label	Nalfon (fenoprofen calcium capsules, USP) is a nonsteroidal, anti-inflammatory, antiarthritic drug. Nalfon capsules contain fenoprofen calcium as the dihydrate in an amount equivalent to 200 mg (0.826 mmol) or 400 mg (1.65 mmol) of fenoprofen. The...
Active Ingredient	Fenoprofen calcium
Dosage Form	Tablet
Route	Oral
Strength	eq 600mg base
Market Status	Prescription
Company	Mylan Pharms

2 of 4
Drug Name	Nalfon
Drug Label	Nalfon (fenoprofen calcium capsules, USP) is a nonsteroidal, anti-inflammatory, antiarthritic drug. Nalfon capsules contain fenoprofen calcium as the dihydrate in an amount equivalent to 200 mg (0.826 mmol) or 400 mg (1.65 mmol) of fenoprofen. The...
Active Ingredient	Fenoprofen calcium
Dosage Form	Capsule
Route	Oral
Strength	eq 200mg base; eq 400mg base
Market Status	Prescription
Company	Xspire

3 of 4
Drug Name	Fenoprofen calcium
PubMed Health	Fenoprofen (By mouth)
Drug Classes	Analgesic, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent
Drug Label	Nalfon (fenoprofen calcium capsules, USP) is a nonsteroidal, anti-inflammatory, antiarthritic drug. Nalfon capsules contain fenoprofen calcium as the dihydrate in an amount equivalent to 200 mg (0.826 mmol) or 400 mg (1.65 mmol) of fenoprofen. The...
Active Ingredient	Fenoprofen calcium
Dosage Form	Tablet
Route	Oral
Strength	eq 600mg base
Market Status	Prescription
Company	Mylan Pharms

4 of 4
Drug Name	Nalfon
Drug Label	Nalfon (fenoprofen calcium capsules, USP) is a nonsteroidal, anti-inflammatory, antiarthritic drug. Nalfon capsules contain fenoprofen calcium as the dihydrate in an amount equivalent to 200 mg (0.826 mmol) or 400 mg (1.65 mmol) of fenoprofen. The...
Active Ingredient	Fenoprofen calcium
Dosage Form	Capsule
Route	Oral
Strength	eq 200mg base; eq 400mg base
Market Status	Prescription
Company	Xspire

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cyclooxygenase Inhibitors [MoA]; Nonsteroidal Anti-inflammatory Drug [EPC]; Anti-Inflammatory Agents, Non-Steroidal [CS]

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API Reference Price

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DOSAGE - CAPSULE;ORAL - EQ 200MG BASE

USFDA APPLICATION NUMBER - 17604

DOSAGE - CAPSULE;ORAL - EQ 400MG BASE

USFDA APPLICATION NUMBER - 17604

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ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

9 API Suppliers

8 USDMF

2 EU WC

4 NDC API

2 Listed Suppliers

$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

41 FDF Dossiers

40 FDA Orange Book

1 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - EQ 200MG BASE

CAPSULE;ORAL - EQ 400MG BASE

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

2 Seqens

7 DKSH

2 Jai Radhe Sales

4 Faran Shimi Pharmaceutical

4 Boai NKY Pharmaceuticals Ltd

10 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

4 ACG Worldwide

5 Actylis

1 Aeon Procare

1 Alcedo Pharmachem

8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

20 BASF

10 Corel Pharma Chem

3 DFE Pharma

1 Finar

11 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

16 Kerry

3 Kima Chemical

6 Lonza Capsugel

9 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

2 Novo Excipients

2 Pharmatrans-Sanaq

4 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

16 Roquette

13 Seppic

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

2 The Dow Chemical Company

1 Ulanqab Kema New Material

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

46 Coating Systems & Additives

45 Fillers, Diluents & Binders

30 Disintegrants & Superdisintegrants

30 Direct Compression

26 Controlled & Modified Release

26 Thickeners and Stabilizers

19 Granulation

18 Solubilizers

15 Lubricants & Glidants

13 Co-Processed Excipients

11 Topical

10 Film Formers & Plasticizers

9 Chewable & Orodispersible Aids

9 Empty Capsules

9 Taste Masking

7 Parenteral

7 Emulsifying Agents