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    Also known as: 132-20-7, Inhiston, Trimetose, Daneral, Naphcon a, Pheniramine hydrogen maleate
    Molecular Formula
    C20H24N2O4
    Molecular Weight
    356.4  g/mol
    InChI Key
    SSOXZAQUVINQSA-BTJKTKAUSA-N
    FDA UNII
    NYW905655B
    Pheniramine Maleate
    One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
    1 2D Structure

    Pheniramine Maleate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    SSOXZAQUVINQSA-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    NYW905655B
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Avil

    2. Bimaleate, Pheniramine

    3. Daneral

    4. Histapyridamine

    5. Maleate, Pheniramine

    6. Pheniramine

    7. Pheniramine Bimaleate

    8. Propheniramine

    9. Prophenpyridamine

    2.3.2 Depositor-Supplied Synonyms

    1. 132-20-7

    2. Inhiston

    3. Trimetose

    4. Daneral

    5. Naphcon A

    6. Pheniramine Hydrogen Maleate

    7. Pheniramine Maleate Salt

    8. Prophenpyridamine Maleate

    9. Antolozine

    10. Fervex

    11. Pheniramine (maleate)

    12. 1-phenyl-1-(2-pyridyl)-3-dimethylaminopropane Maleate

    13. Nsc-757270

    14. Chebi:31990

    15. Nyw905655b

    16. Pm-241

    17. Avil-retard

    18. N,n-dimethyl-3-phenyl-3-(2-pyridyl)propylamine Hydrogen Maleate

    19. 2-pyridinepropanamine, N,n-dimethyl-gamma-phenyl-, (2z)-2-butenedioate (1:1)

    20. Pheniramine Maleate [usan]

    21. Ccris 6265

    22. Sr-01000075263

    23. Einecs 205-051-4

    24. Ho 11513

    25. N,n-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine Maleate

    26. Unii-nyw905655b

    27. Pheniramine Maleate [usan:usp]

    28. Prestwick_769

    29. Mfcd00079250

    30. 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine, Maleate

    31. 2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine, Bimaleate

    32. Phenyl(2-pyridyl)(beta-n,n-dimethylaminomethyl) Methane Maleate

    33. 1-(n,n-dimethylamino)-3-(phenyl-3-alpha-pyridyl)propane Maleate

    34. 2-pyridinepropanamine, N,n-dimethyl-gamma-phenyl-, (z)-2-butenedioate (1:1)

    35. Chembl1653

    36. Schembl25318

    37. Mls001148181

    38. Spectrum1500478

    39. Pheniramine Maleate (jan/usp)

    40. 2-(alpha-(2-dimethylaminoethyl)benzyl)pyridine Bimaleate

    41. Pheniramine Maleate [mi]

    42. Hms500l17

    43. Pheniramine Maleate [jan]

    44. (z)-but-2-enedioic Acid;n,n-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine

    45. Hms1568k19

    46. Hms1920f22

    47. Hms2091p04

    48. Hms2095k19

    49. Hms2232i20

    50. Hms3263e03

    51. Hms3712k19

    52. Hms3885m20

    53. Pharmakon1600-01500478

    54. Pheniramine Maleate [vandf]

    55. Hy-b0971

    56. Pheniramine Maleate [mart.]

    57. Tox21_500981

    58. Ccg-39109

    59. Nsc757270

    60. Pheniramine Maleate [usp-rs]

    61. Pheniramine Maleate [who-dd]

    62. Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

    63. (2z)-but-2-enedioic Acid; Dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine

    64. Akos026749878

    65. Cs-4460

    66. Lp00981

    67. Nsc 757270

    68. 2-pyridinepropanamine, N,n-dimethyl-.gamma.-phenyl-, (2z)-2-butenedioate (1:1)

    69. 2-pyridinepropanamine, N,n-dimethyl-.gamma.-phenyl-, (z)-2-butenedioate (1:1)

    70. Ncgc00094281-01

    71. Ncgc00094281-02

    72. Ncgc00094281-03

    73. Ncgc00094281-04

    74. Ncgc00094281-05

    75. Ncgc00261666-01

    76. Pheniramine Maleate [ep Impurity]

    77. Pheniramine Maleate [orange Book]

    78. Ac-15941

    79. As-12971

    80. Bp166247

    81. Pheniramine Maleate [ep Monograph]

    82. Smr000653458

    83. Pheniramine Maleate [usp Monograph]

    84. Eu-0100981

    85. P2271

    86. S4045

    87. Sw196908-3

    88. Visine-a Component Pheniramine Maleate

    89. Naphcon-a Component Pheniramine Maleate

    90. D01174

    91. P 6902

    92. Pheniramine Maleate Component Of Opcon-a

    93. Pheniramine Maleate Component Of Visine-a

    94. Pheniramine Maleate Component Of Naphcon-a

    95. J-006144

    96. Sr-01000075263-1

    97. Sr-01000075263-4

    98. Sr-01000075263-7

    99. Q27114744

    100. Benzenepropanoic Acid, 4-(1-methylethyl)-.alpha.-oxo-

    101. 1-phenyl-1-(2-pyridyl)-3-dimethaminopropane Maleinate

    102. 2-(.alpha.-(2-dimethylaminoethyl)benzyl)pyridine Bimaleate

    103. Pheniramine Maleate, European Pharmacopoeia (ep) Reference Standard

    104. 2-(.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine Bimaleate

    105. Pheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

    106. Pyridine, 2-(.alpha.-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

    107. 155683-11-7

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 356.4 g/mol
    Molecular Formula C20H24N2O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass356.17360725 g/mol
    Monoisotopic Mass356.17360725 g/mol
    Topological Polar Surface Area90.7 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity340
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    API Reference Price

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    06-Jan-2022
    30-Jun-2025
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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.02675%...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.02675%;0.315%

    USFDA APPLICATION NUMBER - 20065

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    DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.025%;0...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.025%;0.3%

    USFDA APPLICATION NUMBER - 20485

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    ABOUT THIS PAGE

    Looking for 155683-11-7 / Pheniramine Maleate API manufacturers, exporters & distributors?

    Pheniramine Maleate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Pheniramine Maleate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pheniramine Maleate manufacturer or Pheniramine Maleate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pheniramine Maleate manufacturer or Pheniramine Maleate supplier.

    PharmaCompass also assists you with knowing the Pheniramine Maleate API Price utilized in the formulation of products. Pheniramine Maleate API Price is not always fixed or binding as the Pheniramine Maleate Price is obtained through a variety of data sources. The Pheniramine Maleate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Pheniramine Maleate

    Synonyms

    132-20-7, Inhiston, Trimetose, Daneral, Naphcon a, Pheniramine hydrogen maleate

    Cas Number

    155683-11-7

    Unique Ingredient Identifier (UNII)

    NYW905655B

    About Pheniramine Maleate

    One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.

    Fervex Manufacturers

    A Fervex manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fervex, including repackagers and relabelers. The FDA regulates Fervex manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fervex API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Fervex manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Fervex Suppliers

    A Fervex supplier is an individual or a company that provides Fervex active pharmaceutical ingredient (API) or Fervex finished formulations upon request. The Fervex suppliers may include Fervex API manufacturers, exporters, distributors and traders.

    click here to find a list of Fervex suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Fervex USDMF

    A Fervex DMF (Drug Master File) is a document detailing the whole manufacturing process of Fervex active pharmaceutical ingredient (API) in detail. Different forms of Fervex DMFs exist exist since differing nations have different regulations, such as Fervex USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Fervex DMF submitted to regulatory agencies in the US is known as a USDMF. Fervex USDMF includes data on Fervex's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fervex USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Fervex suppliers with USDMF on PharmaCompass.

    Fervex CEP

    A Fervex CEP of the European Pharmacopoeia monograph is often referred to as a Fervex Certificate of Suitability (COS). The purpose of a Fervex CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Fervex EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Fervex to their clients by showing that a Fervex CEP has been issued for it. The manufacturer submits a Fervex CEP (COS) as part of the market authorization procedure, and it takes on the role of a Fervex CEP holder for the record. Additionally, the data presented in the Fervex CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Fervex DMF.

    A Fervex CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Fervex CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Fervex suppliers with CEP (COS) on PharmaCompass.

    Fervex WC

    A Fervex written confirmation (Fervex WC) is an official document issued by a regulatory agency to a Fervex manufacturer, verifying that the manufacturing facility of a Fervex active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Fervex APIs or Fervex finished pharmaceutical products to another nation, regulatory agencies frequently require a Fervex WC (written confirmation) as part of the regulatory process.

    click here to find a list of Fervex suppliers with Written Confirmation (WC) on PharmaCompass.

    Fervex NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Fervex as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Fervex API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Fervex as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Fervex and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Fervex NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Fervex suppliers with NDC on PharmaCompass.

    Fervex GMP

    Fervex Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Fervex GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fervex GMP manufacturer or Fervex GMP API supplier for your needs.

    Fervex CoA

    A Fervex CoA (Certificate of Analysis) is a formal document that attests to Fervex's compliance with Fervex specifications and serves as a tool for batch-level quality control.

    Fervex CoA mostly includes findings from lab analyses of a specific batch. For each Fervex CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Fervex may be tested according to a variety of international standards, such as European Pharmacopoeia (Fervex EP), Fervex JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fervex USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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