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Firocoxib

Rochem Firocoxib

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Fishfa Biogenics: Renowned Manufacturer, & Exporter of Tacrolimus & Mupirocin API.

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xyz-pharma-m-2024-10-07

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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Transo-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

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xyz-pharma-m-2024-10-07

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5 API Suppliers, 6 NDC API, 6 VMF, 5 Listed Suppliers, $ API Reference Price

5 API Suppliers
6 NDC API
6 VMF
5 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 Canada

3 FDF Dossiers
3 Canada

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 Clariant

relatedExcipients
1 Nanjing Well Pharmaceutical
1 Clariant

EXCIPIENTS BY APPLICATIONS

2 Topical, 1 Parenteral, 1 Film Formers & Plasticizers, 1 Rheology Modifiers, 1 Coating Systems & Additives, 1 Surfactant & Foaming Agents, 1 Fillers, Diluents & Binders, 1 Thickeners and Stabilizers

excipientsByApplications
2 Topical
1 Parenteral
1 Film Formers & Plasticizers
1 Rheology Modifiers
1 Coating Systems & Additives
1 Surfactant & Foaming Agents
1 Fillers, Diluents & Binders
1 Thickeners and Stabilizers

MARKET PLACE

1 APIs

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1 APIs

PATENTS & EXCLUSIVITIES

4 Health Canada Patents

patents
4 Health Canada Patents

Rochem Firocoxib

Synopsis

ACTIVE PHARMA INGREDIENTS

5

API Suppliers

0

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

0

EU WC

0

KDMF

6

NDC API

6

VMF

5

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 1,614

MARKET PLACE

1

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

3

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

3

Canada

0

Australia

0

South Africa

0

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DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

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USP

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JP

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US Patents

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4

Health Canada Patents

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GLOBAL SALES INFORMATION

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NA

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2 RELATED EXCIPIENT COMPANIES

9EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 189954-96-9, Equioxx, Previcox, Librens, Ml 1785713, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one

Molecular Formula

C₁₇H₂₀O₅S

Molecular Weight

336.4 g/mol

InChI Key

FULAPETWGIGNMT-UHFFFAOYSA-N

FDA UNII

Y6V2W4S4WT

Firocoxib

Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.

1 2D Structure

Firocoxib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one

2.1.2 InChI

InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3

2.1.3 InChI Key

FULAPETWGIGNMT-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)S(=O)(=O)C)C

2.2 Other Identifiers

2.2.1 UNII

Y6V2W4S4WT

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

2. Equioxx

3. Ml 1,785,713

4. Ml 1785713

5. Ml-1,785,713

6. Ml-1785713

7. Ml1,785,713

8. Ml1785713

2.3.2 Depositor-Supplied Synonyms

1. 189954-96-9

2. Equioxx

3. Previcox

4. Librens

5. Ml 1785713

6. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one

7. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one

8. Ml-1,785,713

9. Nsc-758895

10. Y6v2w4s4wt

11. Chembl69998

12. Chebi:76136

13. Firocoxib (ema Epar: Veterinary)

14. Equixx

15. Ml-1785713

16. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

17. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-

18. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-

19. 3-(cyclopropylmethoxy)-4-(4-methanesulfonylphenyl)-5,5-dimethyl-2,5-dihydrofuran-2-one

20. Firocoxib [usan:inn]

21. Unii-y6v2w4s4wt

22. Firocoxibum

23. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5h)-furanone

24. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5h)-one

25. Firocoxib [inn]

26. Firocoxib [mi]

27. Firocoxib (usan/inn)

28. Firocoxib [usan]

29. Firocoxib [mart.]

30. Equioxx (tn) [veterinary]

31. Firocoxib [green Book]

32. Amy378

33. Schembl1383179

34. Dtxsid40870188

35. Hms3264g15

36. Pharmakon1600-01504526

37. Bcp07253

38. Zinc3623447

39. Bdbm50080082

40. Nsc758895

41. Ccg-213396

42. Cs-3419

43. Db09217

44. Nsc 758895

45. Ncgc00389572-01

46. Ncgc00389572-02

47. Ac-33540

48. As-73802

49. Hy-14670

50. Sbi-0206717.p001

51. Ft-0668544

52. Firocoxib, Vetranal(tm), Analytical Standard

53. C18363

54. C73637

55. D03712

56. Ab01563063_01

57. 954f969

58. A918990

59. Sr-01000872758

60. J-012265

61. Q2034390

62. Sr-01000872758-1

63. 3-(cyclopropylmethoxy)-4-(4-methylsulfonyl)phenyl)-5,5-dimethylfuranone

64. 3-(cyclopropylmethoxy)-4-[4-(methanesulfonyl)phenyl]-5,5-dimethylfuran-2(5h)-one

65. 3-cyclopropylmethoxy-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5h-furan-2-one

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₀O₅S
Molecular Weight	336.4 g/mol
XLogP3	2.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	336.10314491 g/mol
Monoisotopic Mass	336.10314491 g/mol
Topological Polar Surface Area	78 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	614
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Used for the treatment of pain inflammation and fever in horses and dogs.

* Tablets:

For the relief of pain and inflammation associated with osteoarthritis in dogs.

For the relief of postoperative pain and inflammation associated with soft-tissue, orthopaedic and dental surgery in dogs.

* Oral paste:

Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.

Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.

5 Pharmacology and Biochemistry

5.1 ATC Code

QM01AH90

QM01AH90

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API Reference Price

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NO. 377\/1B, BS. UDHYAN BUNGLO","city":"AHMEDABAD,GUJARAT","supplier":"LASHPLUS CORPORATION LIMITED","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"XYLOPIA LABS PRIVATE ","customerCountry":"INDIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"1250","totalValueFC":"7562.1","currency":"USD","unitRateINR":"104750","date":"02-Jan-2024","totalValueINR":"628500","totalValueInUsd":"7562.1","indian_port":"Bombay Air","hs_no":"29322090","bill_no":"9496486","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"ROOM 1450, 14\/F, ETON TOWER, 8 HYSAN AVENUE, CAUSEWAY BAY, HONG KONGSDNF Hong Kong","customerAddress":"SUR. NO. 377\/1B, BS. UDHYAN BUNGLO"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706812200,"product":"FIROCOXIB","address":"213, LAXMI PLAZA, LAXMI INDL.","city":"MUMBAI, MAHARASHTRA","supplier":"SICHUAN QINGMU PHARMACEUTICAL ","supplierCountry":"CHINA","foreign_port":"CHENGDU","customer":"ASHISH LIFE SCIENCE PVT LIMITED","customerCountry":"INDIA","quantity":"18.00","actualQuantity":"18","unit":"KGS","unitRateFc":"900","totalValueFC":"16390.6","currency":"USD","unitRateINR":"75555","date":"02-Feb-2024","totalValueINR":"1359990","totalValueInUsd":"16390.6","indian_port":"Bombay Air","hs_no":"29322090","bill_no":"9948629","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHENGDU","supplierAddress":"LTD NO. 55 SOUTH SHUNJIANG AVENUE,EAST ECONOMIC DEVELOPMENT ZONE, MEISHAN CITY SICHUAN 612100 CHINA","customerAddress":"213, LAXMI PLAZA, LAXMI INDL."},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707503400,"product":"FIROCOXIB","address":"ZYDUS CORPORATE PARK, SCHEME NO. 63, SURVEY NO. 536","city":"AHMEDABAD","supplier":"LASHPLUS CORPORATION LIMITED","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"27.00","actualQuantity":"27","unit":"KGS","unitRateFc":"1172.9","totalValueFC":"32098.3","currency":"USD","unitRateINR":"98641.3","date":"10-Feb-2024","totalValueINR":"2663314","totalValueInUsd":"32098.3","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29322090","bill_no":"1000544","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"ROOM 1450, 14\/F, ETON TOWER, 8 HYSAN AVENUE, CAUSEWAY BAY, HONG KONGSDNF Hong Kong Hong Kong","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO. 63, SURVEY NO. 536"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720549800,"product":"FIROCOXIB","address":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA","city":"NASIK,MAHARASHTRA","supplier":"TAIZHOU CRENE BIOTECHNOLOGY ","supplierCountry":"CHINA","foreign_port":"HANGCHOW (HANGZHOU)","customer":"REYAANSH HEALTHCARE","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"1575","totalValueFC":"6364.7","currency":"USD","unitRateINR":"133008.8","date":"10-Jul-2024","totalValueINR":"532035","totalValueInUsd":"6364.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"4427374","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGCHOW (HANGZHOU)","supplierAddress":"ECONOMIC DEVELOPED ZONE OF TAIZHOUZHEJIANG CHINA Guangzhou, , CHINASDNF CHINA","customerAddress":"F 43 DEOLALI PLAZA, LAM ROAD,DEOLA"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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