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ACTIVE PHARMA INGREDIENTS

67 API Suppliers, 21 USDMF, 13 CEP/COS, 1 JDMF, 5 EU WC, 19 KDMF, 21 NDC API, 48 Listed Suppliers, $ API Reference Price

67 API Suppliers
21 USDMF
13 CEP/COS
1 JDMF
5 EU WC
19 KDMF
21 NDC API
48 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

14 Drugs in Development

14 Drugs in Development

INTERMEDIATES

5 Intermediates Suppliers

5 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

348 FDF Dossiers, 88 FDA Orange Book, 34 Europe, 62 Canada, 70 South Africa, 94 Listed Dossiers

348 FDF Dossiers
88 FDA Orange Book
34 Europe
62 Canada
70 South Africa
94 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INTRAVENOUS - 0.5MG/5ML (0.1MG/ML), SOLUTION;INTRAVENOUS - 100MG/10ML (10MG/ML), SOLUTION;INTRAVENOUS - 10MG/ML (10MG/ML), SOLUTION;INTRAVENOUS - 1MG/10ML (0.1MG/ML), SOLUTION;INTRAVENOUS - 50MG/5ML (10MG/ML), SOLUTION;INTRAVENOUS - 100MG/10ML (10MG/ML), SOLUTION;INTRAVENOUS - 10MG/ML (10MG/ML), SOLUTION;INTRAVENOUS - 50MG/5ML (10MG/ML), SOLUTION/DROPS;OPHTHALMIC - 10%, SOLUTION/DROPS;OPHTHALMIC - 2.5%, TABLET;ORAL - 4MG;200MG;10MG, TABLET;ORAL - 200MG;10MG, SYRUP;ORAL - 5MG/5ML;6.25MG/5ML

drugProductComposition
SOLUTION;INTRAVENOUS - 0.5MG/5ML (0.1MG/ML)
SOLUTION;INTRAVENOUS - 100MG/10ML (10MG/ML)
SOLUTION;INTRAVENOUS - 10MG/ML (10MG/ML)
SOLUTION;INTRAVENOUS - 1MG/10ML (0.1MG/ML)
SOLUTION;INTRAVENOUS - 50MG/5ML (10MG/ML)
SOLUTION;INTRAVENOUS - 100MG/10ML (10MG/ML)
SOLUTION;INTRAVENOUS - 10MG/ML (10MG/ML)
SOLUTION;INTRAVENOUS - 50MG/5ML (10MG/ML)
SOLUTION/DROPS;OPHTHALMIC - 10%
SOLUTION/DROPS;OPHTHALMIC - 2.5%
TABLET;ORAL - 4MG;200MG;10MG
TABLET;ORAL - 200MG;10MG
SYRUP;ORAL - 5MG/5ML;6.25MG/5ML

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Evonik, 15 Rochem International Inc, 23 SPI Pharma, 2 Seqens, 35 DKSH, 2 Jai Radhe Sales, 3 Pharm-RX Chemical, 10 Faran Shimi Pharmaceutical, 13 Boai NKY Pharmaceuticals Ltd, 16 Gangwal Healthcare, 2 Kewpie Corporation, 20 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 24 Actylis, 4 Aeon Procare, 3 Alcedo Pharmachem, 9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 50 BASF, 8 Beneo, 2 Bioplus Life Sciences, 4 Clariant, 13 Corel Pharma Chem, 7 DFE Pharma, 6 Finar, 16 Gangwal Chemicals, 1 Huzhou Sunflower Pharmaceutical, 7 Ideal Cures Pvt Ltd, 5 Ingredion Pharma Solutions, 39 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 2 Lubrizol Life Science Health, 26 Microlex e.U, 2 Nanjing Bold Chemical, 2 Nippon Fine Chemical, 2 Nomisma Healthcare, 5 Novo Excipients, 4 Pharmatrans-Sanaq, 12 Pluviaendo, 4 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 50 Roquette, 20 Seppic, 2 Shandong Focus Biotechnology Co., Ltd, 8 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 3 Shijiazhuang Huaxu Pharmaceutical, 12 Sigachi Industries, 3 The Dow Chemical Company, 3 Ulanqab Kema New Material, 1 Valens Pharmachem, 5 Vasa Pharmachem, 4 Zhejiang Huakang Pharmaceutical

relatedExcipients
1 Minakem
1 Evonik
15 Rochem International Inc
23 SPI Pharma
2 Seqens
35 DKSH
2 Jai Radhe Sales
3 Pharm-RX Chemical
10 Faran Shimi Pharmaceutical
13 Boai NKY Pharmaceuticals Ltd
16 Gangwal Healthcare
2 Kewpie Corporation
20 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
24 Actylis
4 Aeon Procare
3 Alcedo Pharmachem
9 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
50 BASF
8 Beneo
2 Bioplus Life Sciences
4 Clariant
13 Corel Pharma Chem
7 DFE Pharma
6 Finar
16 Gangwal Chemicals
1 Huzhou Sunflower Pharmaceutical
7 Ideal Cures Pvt Ltd
5 Ingredion Pharma Solutions
39 Kerry
4 Kima Chemical
6 Lonza Capsugel
2 Lubrizol Life Science Health
26 Microlex e.U
2 Nanjing Bold Chemical
2 Nippon Fine Chemical
2 Nomisma Healthcare
5 Novo Excipients
4 Pharmatrans-Sanaq
12 Pluviaendo
4 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
50 Roquette
20 Seppic
2 Shandong Focus Biotechnology Co., Ltd
8 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
3 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
3 Ulanqab Kema New Material
1 Valens Pharmachem
5 Vasa Pharmachem
4 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

143 Fillers, Diluents & Binders, 71 Topical, 69 Thickeners and Stabilizers, 68 Coating Systems & Additives, 59 Direct Compression, 57 Solubilizers, 52 Taste Masking, 48 Parenteral, 44 Disintegrants & Superdisintegrants, 40 Controlled & Modified Release, 36 Lubricants & Glidants, 36 Granulation, 35 Film Formers & Plasticizers, 27 Emulsifying Agents, 25 Chewable & Orodispersible Aids, 24 Co-Processed Excipients, 18 Rheology Modifiers, 15 Surfactant & Foaming Agents, 14 API Stability Enhancers, 9 Empty Capsules, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 95 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
95 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

16 Finished Drug Prices

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16 Finished Drug Prices

MARKET PLACE

34 APIs, 4 FDF Dossiers

marketPlace
34 APIs
4 FDF Dossiers

PATENTS & EXCLUSIVITIES

15 US Patents

patents
15 US Patents

REF. STANDARDS & IMPURITIES

3 EDQM , 6 USP , 16 Others

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3 EDQM
6 USP
16 Others

Phenylephrine Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 158

MARKET PLACE

API

FDF

5INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

348

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

14DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

531 RELATED EXCIPIENT COMPANIES

900EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 61-76-7, Phenylephrine hcl, Biomydrin, Nostril, (r)-phenylephrine hydrochloride, L-phenylephrine hydrochloride

Molecular Formula

C₉H₁₄ClNO₂

Molecular Weight

203.66 g/mol

InChI Key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

FDA UNII

04JA59TNSJ

An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.

1 2D Structure

Phenylephrine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride

2.1.2 InChI

InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

2.1.3 InChI Key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

2.1.4 Canonical SMILES

CNCC(C1=CC(=CC=C1)O)O.Cl

2.1.5 Isomeric SMILES

CNC[C@@H](C1=CC(=CC=C1)O)O.Cl

2.2 Other Identifiers

2.2.1 UNII

04JA59TNSJ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (r)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol

2. Metaoxedrin

3. Metasympatol

4. Mezaton

5. Neo Synephrine

6. Neo-synephrine

7. Neosynephrine

8. Phenylephrine

9. Phenylephrine Tannate

10. Tannate, Phenylephrine

2.3.2 Depositor-Supplied Synonyms

1. 61-76-7

2. Phenylephrine Hcl

3. Biomydrin

4. Nostril

5. (r)-phenylephrine Hydrochloride

6. L-phenylephrine Hydrochloride

7. (r)-(-)-phenylephrine Hydrochloride

8. Phenylephrine.hcl

9. Mydfrin

10. Metaoxedrine Chloride

11. Vazculep

12. Neo-synephrine

13. Adrianol

14. Neophryn

15. Prefrin

16. Rhinall

17. Alcon Efrin

18. (-)-phenylephrine Hydrochloride

19. Nci-c55641

20. Efricel

21. Isopto Frin

22. Prefrin Liquifilm

23. (r)-3-(1-hydroxy-2-(methylamino)ethyl)phenol Hydrochloride

24. 3-[(1r)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride

25. Afrin 4 Hour Nasal Spray

26. Nsc-757273

27. 04ja59tnsj

28. Phenylephrine (hydrochloride)

29. Mls000069696

30. Ncgc00024257-04

31. Neosympatol

32. Synethenate

33. Almefrin

34. Consdrin

35. Emagrin

36. Fenilfar

37. Histabid

38. Idrianol

39. Lexatol

40. Oftalfrine

41. Phenistan

42. Pyristan

43. Smr000058497

44. Stanephrin

45. Sucraphen

46. Synasal

47. Fenox

48. Meta-sympatol

49. Alcon-efrin

50. (r)-(-)-1-(3-hydroxyphenyl)-2-methylaminoethanol Hydrochloride

51. [(2r)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-methylazanium;chloride

52. Dsstox_cid_1142

53. Op-isophrin

54. Dsstox_rid_75972

55. Neo-synesin 1

56. Dsstox_gsid_21142

57. Neooxedrine Chloride

58. 3-[(1r)-1-hydroxy-2-(methylamino)ethyl]phenol Hydrochloride

59. Consdrin Hydrochloride

60. Isophrin Hydrochloride

61. Vasosulf

62. Relief

63. Metaoxedrine Hydrochloride

64. Neosynephrine Hydrochloride

65. Sudafed Pe

66. Chebi:8094

67. Op-isophrin-z

68. Cas-61-76-7

69. Meta-synephrine Hydrochloride

70. Ccris 219

71. Levophenylephrine Hydrochloride

72. Phenylephrine Hydrochloride, L-

73. R-(-)-m-synephrine Hydrochloride

74. D-(-)-phenylephrine Hydrochloride

75. Einecs 200-517-3

76. Unii-04ja59tnsj

77. M-methylaminoethanolphenol Hydrochloride

78. Benzedrex Nasal Spray, Regular

79. Sr-01000075286

80. Mfcd00012605

81. Phenylephrine Hydrochloride [usp:jan]

82. Vicks Sinex Vapospray

83. Neo-synephrine (tn)

84. L-1-(m-hydroxyphenyl)-2-methyl-aminoethanol Hydrochloride

85. Vicks Sinex Nasal Spray

86. 1-m-hydroxy-alpha-(methylaminomethyl)benzyl Alcohol Hydrochloride

87. Opera_id_1786

88. (-)-m-hydroxy-alpha-((methylamino)methyl)benzyl Alcohol Hydrochloride

89. (r)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol Hydrochloride

90. (-)-alpha-hydroxy-beta-(methylamino)ethyl-alpha-(3-hydroxybenzene) Hydrochloride

91. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride, (-)-

92. Ec 200-517-3

93. Schembl24654

94. Mls006012005

95. Spectrum1500483

96. Phenylephrine Hydrochloride,(s)

97. Chembl1200339

98. Dtxsid3021142

99. L(-)-phenylephrine Hydrochloride

100. Hms1920h08

101. Pharmakon1600-01500483

102. Bcp23410

103. Hy-b0471

104. Tox21_110897

105. Tox21_201261

106. Tox21_302846

107. Tox21_500920

108. Ccg-39113

109. Nsc757273

110. S2569

111. Akos022190146

112. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride (r)-

113. Benzyl Alcohol, M-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride, (-)-

114. Tox21_110897_1

115. Lp00920

116. Nsc 757273

117. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride, (alphar)-

118. Phenylephrine Hydrochloride (jp17/usp)

119. Phenylephrine Hydrochloride [mi]

120. Ncgc00024257-08

121. Ncgc00094231-01

122. Ncgc00256496-01

123. Ncgc00258813-01

124. Ncgc00261605-01

125. Phenylephrine Hydrochloride [jan]

126. Bp166231

127. Bcp0726000237

128. Phenylephrine Hydrochloride [mart.]

129. Phenylephrine Hydrochloride [vandf]

130. Phenylephrine Hydrochloride [usp-rs]

131. Phenylephrine Hydrochloride [who-dd]

132. (r)-(-)-phenylephrine Hydrochloride, Powder

133. Eu-0100920

134. P0398

135. Sw219446-1

136. Vu0239753-6

137. D00511

138. D70603

139. P 6126

140. Phenylephrine Hydrochloride [orange Book]

141. A833410

142. Phenylephrine Hydrochloride [ep Monograph]

143. Phenylephrine Hydrochloride [usp Monograph]

144. Omidria Component Phenylephrine Hydrochloride

145. Q-201561

146. Sr-01000075286-1

147. Phenylephrine Hydrochloride Component Of Omidria

148. Prefrin-a Component Phenylephrine Hydrochloride

149. Q27107758

150. (r)-(-)-phenylephrine Hydrochloride, Analytical Standard

151. Cyclomydril Component Phenylephrine Hydrochloride

152. Phenergan Vc Component Phenylephrine Hydrochloride

153. Phenylephrine Hydrochloride Component Of Prefrin-a

154. Pherazine Vc Component Phenylephrine Hydrochloride

155. Phenylephrine Hydrochloride Component Of Cyclomydril

156. Phenylephrine Hydrochloride Component Of Phenergan Vc

157. Phenylephrine Hydrochloride Component Of Pherazine Vc

158. Promethazine Vc Component Phenylephrine Hydrochloride

159. Phenylephrine Hydrochloride Component Of Promethazine Vc

160. (r)-(-)-phenylephrine Hydrochloride, Tested According To Ph.eur.

161. Advil Congestion Relief Component Phenylephrine Hydrochloride

162. Benzenemethanol, 3-hydroxy-a-[(methylamino)methyl]-, Hydrochloride,(ar)-

163. Phenylephrine Hydrochloride Component Of Advil Congestion Relief

164. Phenylephrine Hydrochloride, British Pharmacopoeia (bp) Reference Standard

165. Phenylephrine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

166. (-)-m-hydroxy-.alpha.-((methylamino)methyl)benzyl Alcohol Hydrochloride

167. Benzenemethanol, 3-hydroxy-.alpha.-((methylamino)methyl)-, Hydrochloride (r)-

168. Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, Hydrochloride (1:1), (alphar)-

169. Phenylephrine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

170. Phenylephrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

171. Phenylephrine Hydrochloride For Peak Identification, European Pharmacopoeia (ep) Reference Standard

172. R-(-)-phenylephrine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₉H₁₄ClNO₂
Molecular Weight	203.66 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	203.0713064 g/mol
Monoisotopic Mass	203.0713064 g/mol
Topological Polar Surface Area	52.5 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	130
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Phenylephrine hydrochloride
Drug Label	NEO-SYNEPHRINE hydrochloride, brand of phenylephrine hydrochloride injectino, is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine. NEO-SYNEPHRINE hydrochloride is a synthetic sympathomimetic agent in sterile form f...
Active Ingredient	Phenylephrine hydrochloride
Dosage Form	Solution/drops; Solution
Route	Ophthalmic; Iv (infusion)
Strength	10mg/ml (10mg/ml); 10%; 2.5%
Market Status	Prescription
Company	West Ward Pharm; Paragon Bioteck

2 of 2
Drug Name	Phenylephrine hydrochloride
Drug Label	NEO-SYNEPHRINE hydrochloride, brand of phenylephrine hydrochloride injectino, is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine. NEO-SYNEPHRINE hydrochloride is a synthetic sympathomimetic agent in sterile form f...
Active Ingredient	Phenylephrine hydrochloride
Dosage Form	Solution/drops; Solution
Route	Ophthalmic; Iv (infusion)
Strength	10mg/ml (10mg/ml); 10%; 2.5%
Market Status	Prescription
Company	West Ward Pharm; Paragon Bioteck

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Mydriatics

Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

Nasal Decongestants

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

Adrenergic alpha-1 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)

Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

alpha-1 Adrenergic Agonist [EPC]; Adrenergic alpha1-Agonists [MoA]

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - SOLUTION;INTRAVENOUS - 0.5MG/5ML (0....DOSAGE - SOLUTION;INTRAVENOUS - 0.5MG/5ML (0.1MG/ML)