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29 API Suppliers, 19 USDMF, 8 EU WC, 11 KDMF, 8 NDC API, 15 Listed Suppliers, $ API Reference Price

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8 EU WC
11 KDMF
8 NDC API
15 Listed Suppliers
$ API Reference Price

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64 FDF Dossiers, 34 FDA Orange Book, 10 Europe, 4 Canada, 1 South Africa, 15 Listed Dossiers

64 FDF Dossiers
34 FDA Orange Book
10 Europe
4 Canada
1 South Africa
15 Listed Dossiers

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1 Minakem, 3 Rochem International Inc, 14 SPI Pharma, 13 DKSH, 1 Jai Radhe Sales, 2 Pharm-RX Chemical, 2 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 8 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 3 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 BASF, 1 Bioplus Life Sciences, 10 Corel Pharma Chem, 2 DFE Pharma, 1 Finar, 9 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 19 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 1 NEWEDGE Overseas, 3 Novo Excipients, 3 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 14 Roquette, 7 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 The Dow Chemical Company, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 1 Vasa Pharmachem

relatedExcipients
1 Minakem
3 Rochem International Inc
14 SPI Pharma
13 DKSH
1 Jai Radhe Sales
2 Pharm-RX Chemical
2 Faran Shimi Pharmaceutical
4 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
8 Gangwal Healthcare
3 Nanjing Well Pharmaceutical
1 Pfanstiehl
1 ACG Worldwide
3 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
10 BASF
1 Bioplus Life Sciences
10 Corel Pharma Chem
2 DFE Pharma
1 Finar
9 Gangwal Chemicals
7 Ideal Cures Pvt Ltd
1 Ingredion Pharma Solutions
19 Kerry
3 Kima Chemical
6 Lonza Capsugel
8 Microlex e.U
1 NEWEDGE Overseas
3 Novo Excipients
3 Pharmatrans-Sanaq
2 Pluviaendo
2 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
14 Roquette
7 Seppic
3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
9 Sigachi Industries
2 The Dow Chemical Company
1 Ulanqab Kema New Material
1 Valens Pharmachem
1 Vasa Pharmachem

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DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 20 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
20 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 2 Annual Reports

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2 US Medicaid Prescriptions
2 Annual Reports

MARKET PLACE

12 APIs, 4 FDF Dossiers

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12 APIs
4 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 US Patents, 3 Health Canada Patents

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3 US Patents
3 Health Canada Patents

Synopsis

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2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

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USP

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PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

372,965,336

Annual Reports (USD Million)

627

Finished Drug Prices

194 RELATED EXCIPIENT COMPANIES

339EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 845273-93-0, 2-propen-1-amine polymer with (chloromethyl)oxirane carbonate, Carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine, Sevelamercarbonate, Gt-335-012, Chembl1201799

Molecular Formula

C₇H₁₄ClNO₄

Molecular Weight

211.64 g/mol

InChI Key

PADGNZFOVSZIKZ-UHFFFAOYSA-N

A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.

1 2D Structure

Sevelamer Carbonate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

2.1.2 InChI

InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)

2.1.3 InChI Key

PADGNZFOVSZIKZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C=CCN.C1C(O1)CCl.C(=O)(O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Carbonate, Sevelamer

2. Gt335 012

3. Gt335-012

4. Gt335012

5. Hydrochloride, Sevelamer

6. Renagel

7. Sevelamer

8. Sevelamer Hydrochloride

2.2.2 Depositor-Supplied Synonyms

1. 845273-93-0

2. 2-propen-1-amine Polymer With (chloromethyl)oxirane Carbonate

3. Carbonic Acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

4. Sevelamercarbonate

5. Gt-335-012

6. Chembl1201799

7. Bcp13411

8. Ex-a4743

9. Akos037515475

10. Hs-0081

11. Gt335-012

12. Gt335 012;gt335-012;gt335012;carbonate, Sevelamer

2.3 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₇H₁₄ClNO₄
Molecular Weight	211.64 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	211.0611356 g/mol
Monoisotopic Mass	211.0611356 g/mol
Topological Polar Surface Area	96.1 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	81.4
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Indication

Renvela is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Renvela is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus 1. 78 mmol/l.

Renvela should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy vitamin D3 or one of its analogues to control the development of renal bone disease.

Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Sevelamer carbonate Winthrop is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus > 1. 78 mmol/L.

Sevelamer carbonate Winthrop should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]

5.3 ATC Code

V03AE02

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API Reference Price

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