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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 2 USDMF, 1 CEP/COS, 1 JDMF, 1 KDMF, 4 NDC API, 3 Listed Suppliers, $ API Reference Price

5 API Suppliers
2 USDMF
1 CEP/COS
1 JDMF
1 KDMF
4 NDC API
3 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

38 FDF Dossiers, 3 FDA Orange Book, 11 Europe, 10 Canada, 5 South Africa, 9 Listed Dossiers

38 FDF Dossiers
3 FDA Orange Book
11 Europe
10 Canada
5 South Africa
9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 1 DKSH, 1 Jai Radhe Sales, 1 Faran Shimi Pharmaceutical, 1 Nanjing Well Pharmaceutical, 7 Actylis, 1 BASF, 2 Finar, 3 Gangwal Chemicals, 1 Kerry, 2 Microlex e.U, 1 Nanjing Bold Chemical, 2 Pluviaendo, 1 Roquette, 6 Seppic

relatedExcipients
1 SPI Pharma
1 DKSH
1 Jai Radhe Sales
1 Faran Shimi Pharmaceutical
1 Nanjing Well Pharmaceutical
7 Actylis
1 BASF
2 Finar
3 Gangwal Chemicals
1 Kerry
2 Microlex e.U
1 Nanjing Bold Chemical
2 Pluviaendo
1 Roquette
6 Seppic

EXCIPIENTS BY APPLICATIONS

12 Solubilizers, 12 Parenteral, 4 Topical, 3 Emulsifying Agents, 2 API Stability Enhancers, 2 Thickeners and Stabilizers, 2 Film Formers & Plasticizers, 2 Co-Processed Excipients, 2 Fillers, Diluents & Binders, 2 Surfactant & Foaming Agents, 1 Taste Masking, 1 Controlled & Modified Release, 1 Direct Compression, 1 Rheology Modifiers

excipientsByApplications
12 Solubilizers
12 Parenteral
4 Topical
3 Emulsifying Agents
2 API Stability Enhancers
2 Thickeners and Stabilizers
2 Film Formers & Plasticizers
2 Co-Processed Excipients
2 Fillers, Diluents & Binders
2 Surfactant & Foaming Agents
1 Taste Masking
1 Controlled & Modified Release
1 Direct Compression
1 Rheology Modifiers

DIGITAL CONTENT

4 NEWS #PharmaBuzz

media
4 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

7 Finished Drug Prices

globalSalesInformation
7 Finished Drug Prices

MARKET PLACE

14 APIs, 3 FDF Dossiers

marketPlace
14 APIs
3 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 6 Others

otherSolutions
1 USP
6 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 290,200

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

31 RELATED EXCIPIENT COMPANIES

47EXCIPIENTS BY APPLICATIONS

Chemistry

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Click the button for full data set

Also known as: 522-48-5, Tetrahydrozoline hcl, Tetryzoline hydrochloride, Tyzine, Visine, Murine plus

Molecular Formula

C₁₃H₁₇ClN₂

Molecular Weight

236.74 g/mol

InChI Key

BJORNXNYWNIWEY-UHFFFAOYSA-N

FDA UNII

0YZT43HS7D

Tetrahydrozoline Hydrochloride is the hydrochloride salt form of tetrahydrozoline, an imidazole derivative with sympathomimetic property. Applied locally to the eye or nose, tetrahydrozoline binds to and activates alpha-adrenergic receptors, resulting in vasoconstriction and decreased nasal and ophthalmic congestion.

1 2D Structure

Tetrahydrozoline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride

2.1.2 InChI

InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

2.1.3 InChI Key

BJORNXNYWNIWEY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC(C2=CC=CC=C2C1)C3=NCCN3.Cl

2.2 Other Identifiers

2.2.1 UNII

0YZT43HS7D

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline

2. Berberil N

3. Caltheon

4. Collyrium Fresh

5. Diabenyl T

6. Eye-sine

7. Eye-zine

8. Murine Plus

9. Murine Sore Eyes

10. Ophtalmin

11. Optazine Fresh

12. Optigene

13. Rhinopront

14. Tetra-ide

15. Tetraclear

16. Tetrahydrozoline

17. Tetrahydrozoline Monohydrochloride

18. Tetrahydrozoline, (+-)-isomer

19. Tetrahydrozoline, (-)-isomer

20. Tetrilin

21. Tetryzoline

22. Tyzine

23. Vasopos

24. Visine

25. Vispring

26. Yxin

2.3.2 Depositor-Supplied Synonyms

1. 522-48-5

2. Tetrahydrozoline Hcl

3. Tetryzoline Hydrochloride

4. Tyzine

5. Visine

6. Murine Plus

7. Vasopos

8. Tyzanol Hydrochloride

9. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazole Hydrochloride

10. Tetrahydrozoline (hydrochloride)

11. Nsc-757339

12. 0yzt43hs7d

13. Mls000069739

14. 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline Hydrochloride

15. 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline Monohydrochloride

16. 1h-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, Monohydrochloride

17. 2-tetralin-1-yl-4,5-dihydro-1h-imidazole Hydrochloride

18. 522-48-5 (hcl)

19. Smr000058219

20. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazole;hydrochloride

21. 1h-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, Hydrochloride (1:1)

22. Dsstox_cid_25316

23. Dsstox_rid_80797

24. Dsstox_gsid_45316

25. Rhinopront

26. Yxin

27. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazole Hcl

28. Sr-01000000161

29. Einecs 208-329-3

30. Unii-0yzt43hs7d

31. Ai3-50165

32. Tetryzoline Hcl

33. Tetrahydrozoline Monohydrochloride

34. Tetrahydrozoline Hydrochloride [usp]

35. Mfcd00058029

36. Prestwick_1025

37. Tyzine (tn)

38. Opera_id_1724

39. Ncgc00016485-01

40. Cas-522-48-5

41. Schembl25702

42. Mls000079025

43. Mls001146954

44. Mls002222291

45. Mls002548902

46. Spectrum1500567

47. Chebi:9492

48. Chembl1200413

49. Dtxsid7045316

50. Hy-b0556a

51. Hms1570k17

52. Hms1921c21

53. Pharmakon1600-01500567

54. Bcp15857

55. Tox21_110450

56. Tox21_501137

57. Ccg-39268

58. Nsc757339

59. 2-imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)-, Hydrochloride

60. Akos015899540

61. Tox21_110450_1

62. Ac-1110

63. Lp01137

64. Nc00484

65. Nsc 757339

66. Tetrahydrozoline Hydrochloride, >=98%

67. Ncgc00016018-10

68. Ncgc00094403-01

69. Ncgc00094403-02

70. Ncgc00094403-03

71. Ncgc00094403-04

72. Ncgc00094403-05

73. Ncgc00261822-01

74. Tetryzoline Hydrochloride [mart.]

75. As-15973

76. Tetrahydrozoline Hydrochloride (jan/usp)

77. Tetryzoline Hydrochloride [who-dd]

78. Tetrahydrozoline Hydrochloride [mi]

79. Tetrahydrozoline Hydrochloride [jan]

80. Eu-0101137

81. Ft-0675067

82. S4043

83. Sw197098-3

84. T3148

85. Tetrahydrozoline Hydrochloride [vandf]

86. Vu0239726-5

87. D01023

88. T 4264

89. Tetrahydrozoline Hydrochloride [usp-rs]

90. Tetryzoline Hydrochloride [ep Monograph]

91. 522t485

92. A851840

93. Q-201816

94. Sr-01000000161-2

95. Sr-01000000161-8

96. Tetrahydrozoline Hydrochloride [orange Book]

97. Q27237368

98. Tetrahydrozoline Hydrochloride [usp Monograph]

99. Z1695906783

100. 1h-imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-,monohydrochloride

101. 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1h-imidazolehydrochloride

102. 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazole Hydrochloride

103. 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazole Monohydrochloride

104. Tetrahydrozoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

105. Tetrahydrozoline Hydrochloride, United States Pharmacopeia (usp) Reference Standard

106. Tetrahydrozoline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₇ClN₂
Molecular Weight	236.74 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	236.1080262 g/mol
Monoisotopic Mass	236.1080262 g/mol
Topological Polar Surface Area	24.4 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	259
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Tyzine
Drug Label	Tyzine Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant. The chemical structure is:Nasal Solution is available for topical nasal application as 0.1%...
Active Ingredient	Tetrahydrozoline hydrochloride
Dosage Form	Spray; Solution
Route	Nasal
Strength	0.05%; 0.1%
Market Status	Prescription
Company	Fougera Pharms

2 of 2
Drug Name	Tyzine
Drug Label	Tyzine Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant. The chemical structure is:Nasal Solution is available for topical nasal application as 0.1%...
Active Ingredient	Tetrahydrozoline hydrochloride
Dosage Form	Spray; Solution
Route	Nasal
Strength	0.05%; 0.1%
Market Status	Prescription
Company	Fougera Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Ophthalmic Solutions

Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS. (See all compounds classified as Ophthalmic Solutions.)

Nasal Decongestants

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993) (See all compounds classified as Nasal Decongestants.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

API SUPPLIERS

01

Seqens

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma Manufacturing 2024

Not Confirmed

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

Contact Supplier

France

Virtual Booth

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USDMF CEP/COS

JDMF EU-WC NDC

KDMF

VMF ASMF

AUDIT

02

SIMS Srl

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma Manufacturing 2024

Not Confirmed

03

Zentiva

Czech Republic

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma Manufacturing 2024

Not Confirmed

04

Conscientia Industrial

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma Manufacturing 2024

Not Confirmed

05

Albemarle Corporation

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma Manufacturing 2024

Not Confirmed

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USDMF

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CEP/COS

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JDMF

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1679077800,"product":"TETRAHYDROZOLINE RELATED COMPOUND E(QTY:1 X .1 GMS, VALUE:USD71.29)(FOC)","address":"P.NO. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1691692200,"product":"TETRAHYDROZOLINE HYDROCHLORIDE QTY:1 X 200 MG, VALUE: USD 265 FOC","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,TURKAPALLY-V SHAMIRPET","city":"HYDERABAD","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"ITALY","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.01","unit":"KGS","unitRateFc":"1325000","totalValueFC":"275.5","currency":"USD","unitRateINR":"2259208.9","date":"11-Aug-2023","totalValueINR":"22820.292","totalValueInUsd":"275.5","indian_port":"HYDERABAD AIR","hs_no":"29332990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. 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