menu
    • menu

    Find Triethanolamine Salicylate manufacturers, exporters & distributors on PharmaCompass

    Mission CDMO team brings reliability, resourcefulness, & responsiveness in executing your development project.

    Virtual Booth

    Contact Supplier

    Bora Pharmaceuticals- Making success more certain.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Athena Pharmaceutiques is a Partner of Choice for Drug Delivery & Life Cycle Management.

    Virtual Booth

    Contact Supplier

    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    MARKET PLACE

    PharmaCompass

    Synopsis

    Product SearchProduct Search

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    0

    API Suppliers

    API Suppliers

    0

    USDMF

    US DMFs Filed

    0

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    0

    Listed Suppliers

    Other Suppliers

    API REF. PRICE (USD/KG)

    $
    $ 0

    MARKET PLACE

    2

    API

    0

    FDF

    0INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    13

    FDF Dossiers

    FDF Dossiers

    0

    FDA Orange Book

    FDA (Orange Book)

    0

    Europe

    Europe

    13

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    0

    Listed Dossiers

    Listed Dossiers

    1DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    0

    USP

    0

    JP

    0

    Others

    PATENTS & EXCLUSIVITIES

    0

    US Patents

    0

    US Exclusivities

    0

    Health Canada Patents

    DIGITAL CONTENT

    0

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    0

    News #PharmaBuzz

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Finished Drug Prices

    NA

    150 RELATED EXCIPIENT COMPANIES

    270EXCIPIENTS BY APPLICATIONS

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: Triethanolamine salicylate, 2174-16-5, Tea-salicylate, Neo heliopan ts, Tea salicylate, Neotan w
    Molecular Formula
    C13H21NO6
    Molecular Weight
    287.31  g/mol
    InChI Key
    UEVAMYPIMMOEFW-UHFFFAOYSA-N
    FDA UNII
    H8O4040BHD
    Triethanolamine Salicylate
    Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability. It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties. As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains.
    1 2D Structure

    Triethanolamine Salicylate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic acid
    2.1.2 InChI
    InChI=1S/C7H6O3.C6H15NO3/c8-6-4-2-1-3-5(6)7(9)10;8-4-1-7(2-5-9)3-6-10/h1-4,8H,(H,9,10);8-10H,1-6H2
    2.1.3 InChI Key
    UEVAMYPIMMOEFW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C(=C1)C(=O)O)O.C(CO)N(CCO)CCO
    2.2 Other Identifiers
    2.2.1 UNII
    H8O4040BHD
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Myoflex

    2. Triethanolamine Salicylate

    2.3.2 Depositor-Supplied Synonyms

    1. Triethanolamine Salicylate

    2. 2174-16-5

    3. Tea-salicylate

    4. Neo Heliopan Ts

    5. Tea Salicylate

    6. Neotan W

    7. Salicylic Acid Trolamine

    8. H8o4040bhd

    9. 2-hydroxybenzoic Acid, Compd. With 2,2',2''-nitrilotris(ethanol) (1:1)

    10. Trolamine Salicylate (usp)

    11. Trolamine Salicylate [usp]

    12. Benzoic Acid, 2-hydroxy-, Compd. With 2,2',2''-nitrilotris(ethanol) (1:1)

    13. Arthricream

    14. Myoflex

    15. Sunarome W

    16. Benzoic Acid, 2-hydroxy-, Compd. With 2,2',2''-nitrilotris[ethanol] (1:1)

    17. Arthricream (tn)

    18. Dsstox_cid_27945

    19. Dsstox_rid_82697

    20. Unii-h8o4040bhd

    21. Dsstox_gsid_47969

    22. Schembl15847

    23. Salicylic Acid Triethanolamine

    24. Tea-salicylate [inci]

    25. Chembl2107288

    26. Dtxsid4047969

    27. 2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic Acid

    28. Triethanolamine, Salicylate

    29. Salicylic Acid Triethanolamine Salt

    30. Einecs 218-531-3

    31. Tox21_201084

    32. Trolamine Salicylate [mart.]

    33. Trolamine Salicylate [who-dd]

    34. Db11079

    35. Triethanolamine Salicylate [mi]

    36. Ncgc00248985-01

    37. Ncgc00258636-01

    38. Triethanolamine Salicylate [vandf]

    39. Cas-2174-16-5

    40. Trolamine Salicylate [usp Impurity]

    41. Trolamine Salicylate [usp Monograph]

    42. Ft-0708839

    43. 2,2',2''-nitrilotriethanol 2-hydroxybenzoate

    44. D08501

    45. Q7845153

    46. Salicylic Acid, Compound With 2,2',2''-nitrilotriethanol (1:1)

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 287.31 g/mol
    Molecular Formula C13H21NO6
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count7
    Exact Mass287.13688739 g/mol
    Monoisotopic Mass287.13688739 g/mol
    Topological Polar Surface Area122 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity189
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Indicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Trolamine salicylate is a salicylate that inhibits cyclo-oxygenase (COX) enzymes responsible for generating pro-inflammatory factors such as to induce pain and inflammation. It is thought to mediate its analgesic effect through inhibition of COX-2 enzyme, which is an induced enzyme responsible for inflammatory responses and pain in muscle and joint disorders. By inhibiting fatty acid COX enzyme, trolamine salicylate inhibits the production of prostaglandins and thromboxanes in inflammatory cells involved in generating pain and inflammation. It thereby works to temporarily reduce mild to moderate pain. In subjects with muscle soreness from exercise, administration of topical trolamine salicylate was associated with reduced duration and severity of muscule soreness compared to placebo. In subjects with osteoarthritis in hands, trolamine salicylate cream was shown to be effective in achieving temporary relief of minor pain and stiffness.

    5.2 Absorption, Distribution and Excretion

    Absorption

    Following topical administration of 10% trolamine salicylate in healthy volunteers, salicylic acid could not be detected in serum indicating low systemic absorption.

    Route of Elimination

    Following topical administration of 10% trolamine salicylate in healthy volunteers, urinary recovery of total salicylate during the first 24 hours was 6.9 mg (p < 0.05), which is 1.4% of total dose.

    Volume of Distribution

    Topical administration of 1 gram of 10% trolamine salicylate in abdominal rat skin resulted in an approximate extravascular volume of distribution (V/F) of 24.0 mL.

    5.3 Mechanism of Action

    Inflammation and tissue damage in different conditions including arthritis, bursitis, joint disorder, bruises, and strains or sprains of muscle origin, induce mild to moderate pain and are associated with increase prostaglandin synthesis. This is thought to be a result of COX-2 enzyme induction. COX-2 is induced in inflammatory cells in case of cell injury, infection or activation from inflammatory cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-. Upon activation, COX-2 produces prostanoid mediators of inflammation such as prostaglandins and thromboxanes. Trolamine salicylate mediates its analgesic effect by inhibiting the production of inflammatory mediators that sensitize nociceptive nerve endings and generate pain.

    Related Excipient Companies

    Upload your portfolio for free, ask us

    Excipients by Applications

    Click here to find the perfect excipient manufacturers by their capabilities

    Coating Systems & Additives

    read-more
    read-more

    Topical

    read-more
    read-more

    Solubilizers

    read-more
    read-more

    Film Formers & Plasticizers

    read-more
    read-more

    Controlled & Modified Release

    read-more
    read-more

    Parenteral

    read-more
    read-more

    Thickeners and Stabilizers

    read-more
    read-more

    Emulsifying Agents

    read-more
    read-more

    Fillers, Diluents & Binders

    read-more
    read-more

    Surfactant & Foaming Agents

    read-more
    read-more

    Co-Processed Excipients

    read-more
    read-more

    Direct Compression

    read-more
    read-more

    Lubricants & Glidants

    read-more
    read-more

    Taste Masking

    read-more
    read-more

    Rheology Modifiers

    read-more
    read-more

    Empty Capsules

    read-more
    read-more

    API Stability Enhancers

    read-more
    read-more

    Vegetarian Capsules

    read-more
    read-more

    Granulation

    read-more
    read-more

    Chewable & Orodispersible Aids

    read-more
    read-more

    Coloring Agents

    read-more
    read-more

    Soft Gelatin

    read-more
    read-more

    Disintegrants & Superdisintegrants

    read-more
    read-more

    Market Place

    Do you need sourcing support? Ask us

    ABOUT THIS PAGE

    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search