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    Chemistry

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    Also known as: Ranitidine hydrochloride, 66357-59-3, 71130-06-8, Fendibina, Gastridina, Gastrolav
    Molecular Formula
    C13H23ClN4O3S
    Molecular Weight
    350.87  g/mol
    InChI Key
    GGWBHVILAJZWKJ-KJEVSKRMSA-N
    Ranitidine Hydrochloride
    A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
    1 2D Structure

    Ranitidine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride
    2.1.2 InChI
    InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+;
    2.1.3 InChI Key
    GGWBHVILAJZWKJ-KJEVSKRMSA-N
    2.1.4 Canonical SMILES
    CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl
    2.1.5 Isomeric SMILES
    CN/C(=C\[N+](=O)[O-])/NCCSCC1=CC=C(O1)CN(C)C.Cl
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Ah 19065

    2. Ah-19065

    3. Ah19065

    4. Biotidin

    5. Hydrochloride, Ranitidine

    6. N (2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-1,1-ethenediamine

    7. Ranisen

    8. Ranitidin

    9. Ranitidine

    10. Ranitidine Hydrochloride

    11. Sostril

    12. Zantac

    13. Zantic

    2.2.2 Depositor-Supplied Synonyms

    1. Ranitidine Hydrochloride

    2. 66357-59-3

    3. 71130-06-8

    4. Fendibina

    5. Gastridina

    6. Gastrolav

    7. Kuracid

    8. Raniberl

    9. Ranibloc

    10. Alquen

    11. Rani-nerton

    12. Zantac

    13. Nu-ranit

    14. Rani-q

    15. Ranitidine (hydrochloride)

    16. Santanol

    17. Tanidina

    18. Toriol

    19. Coralen

    20. Quantor

    21. Radin

    22. Chebi:8777

    23. Gastrial

    24. Raniben

    25. Ranibeta

    26. Azantac

    27. Zantac (tn)

    28. (e)-1-n'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-n-methyl-2-nitroethene-1,1-diamine;hydrochloride

    29. Mfcd00941509

    30. {2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}[(z)-1-(methylamino)-2-nitroethenyl]amine Hydrochloride

    31. Smr000653467

    32. (e)-n-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-n-methyl-2-nitroethene-1,1-diamine

    33. N-(2-((5-((dimethylamino)methyl)furfuryl)thio)ethyl)-n'-methyl-2-nitrovinylidenediamine Monohydrochloride

    34. C13h22n4o3s.hcl

    35. Zantic

    36. Zantac;noctone

    37. Sr-01000075288

    38. Ah19065

    39. Ah-19065

    40. Prestwick_635

    41. Einecs 275-207-4

    42. Ranitidine (zantac)

    43. Ranitidine Hydrochloride 100 Microg/ml In Acetonitrile

    44. Epitope Id:127516

    45. Mls001146938

    46. Mls002548856

    47. Chembl1092473

    48. Hy-b0281a

    49. Hms1568j03

    50. Amy24712

    51. Bcp28420

    52. N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-n'-methyl-2-nitro-1,1-ethenediamine Hydrochloride

    53. N-[2-[5-[(dimethylamino)methyl]furfurylthio]ethyl]-n'-methyl-2-nitro-1,1-ethenediamine Hydrochloride

    54. Tox21_501073

    55. S1801

    56. Ranitidine Hydrochloride (jp17/usp)

    57. Akos015895250

    58. Ccg-212946

    59. Lp01073

    60. Nc00479

    61. Ranitidine For Impurity A Identification

    62. Ncgc00094351-01

    63. Ncgc00261758-01

    64. Ac-12743

    65. N-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-n'-methyl-2-nitroethene-1,1-diamine Hydrochloride

    66. Eu-0101073

    67. R-101

    68. R0073

    69. Sw196800-3

    70. Bim-0051043.0001

    71. D00673

    72. 357n593

    73. A835435

    74. Sr-01000075288-2

    75. W-104534

    76. (e)-n-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-n'-methyl-2-nitroethene-1,1-diamine Hydrochloride

    77. (e)-n1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-n1-methyl-2-nitroethene-1,1-diamine Hydrochloride

    78. (e)-n1'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-n1-methyl-2-nitro-ethene-1,1-diamine Hydrochloride

    79. 1,1-ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-n'-methyl-2-nitro-, Hydrochloride

    80. N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-n'-methyl-2-nitroethene-1,1-diamine Hydrochloride

    81. N-(2-(((5-((dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-n-methyl-2-nitroethene-1,1-diaminehydrochloride

    82. N-(2-((5-(dimethylaminomethyl)furan-2-yl)methylsulfanyl)ethyl)-n'-methyl-2-nitroethene-1,1-diamine Hcl

    83. N-[2-[[[5-[(dimethylamino)methyl]-2 -furanyl]methyl]thio]ethyl]-n'-methyl-2-nitro-1,1-e Thanediamine Hydrochloride

    2.3 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 350.87 g/mol
    Molecular Formula C13H23ClN4O3S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count9
    Exact Mass350.1179395 g/mol
    Monoisotopic Mass350.1179395 g/mol
    Topological Polar Surface Area112 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity347
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 10  
    Drug NameRanitidine hydrochloride
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet; Syrup; Capsule; Injectable
    RouteInjection; Oral
    Strengtheq 150mg base; eq 15mg base/ml; eq 75mg base; 25mg/ml; eq 300mg base; eq 25mg base/ml
    Market StatusOver the Counter; Prescription
    CompanyVintage Pharms; Amneal Pharms; Wockhardt; Silarx; Breckenridge Pharm; Teva; Pharm Assoc; Apotex; Torpharm; Shasun Chems; Taro; Sandoz; Par Pharm; Perrigo R And D; Svads Holdings Sa; Glenmark Generics; Amneal Pharms Ny; Ivax Sub Teva Pharms; Hi Tech Pharma

    2 of 10  
    Drug NameZantac
    PubMed HealthRanitidine (Injection)
    Drug ClassesAntiulcer, Gastric Acid Secretion Inhibitor
    Drug LabelThe active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
    Active IngredientRanitidine hydrochloride
    Dosage FormSyrup; Injectable
    RouteInjection; Oral
    Strengtheq 15mg base/ml; eq 25mg base/ml
    Market StatusPrescription
    CompanyCovis Injectables; Glaxo Grp

    3 of 10  
    Drug NameZantac 150
    PubMed HealthRanitidine
    Drug ClassesAntiulcer, Gastric Acid Secretion Inhibitor
    Drug LabelThe active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 150mg base
    Market StatusOver the Counter; Prescription
    CompanyBoehringer Ingelheim; Glaxo Grp

    4 of 10  
    Drug NameZantac 300
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 300mg base
    Market StatusPrescription
    CompanyGlaxo Grp

    5 of 10  
    Drug NameZantac 75
    Drug LabelThe active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 75mg base
    Market StatusOver the Counter
    CompanyBoehringer Ingelheim

    6 of 10  
    Drug NameRanitidine hydrochloride
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet; Syrup; Capsule; Injectable
    RouteInjection; Oral
    Strengtheq 150mg base; eq 15mg base/ml; eq 75mg base; 25mg/ml; eq 300mg base; eq 25mg base/ml
    Market StatusOver the Counter; Prescription
    CompanyVintage Pharms; Amneal Pharms; Wockhardt; Silarx; Breckenridge Pharm; Teva; Pharm Assoc; Apotex; Torpharm; Shasun Chems; Taro; Sandoz; Par Pharm; Perrigo R And D; Svads Holdings Sa; Glenmark Generics; Amneal Pharms Ny; Ivax Sub Teva Pharms; Hi Tech Pharma

    7 of 10  
    Drug NameZantac
    PubMed HealthRanitidine (Injection)
    Drug ClassesAntiulcer, Gastric Acid Secretion Inhibitor
    Drug LabelThe active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
    Active IngredientRanitidine hydrochloride
    Dosage FormSyrup; Injectable
    RouteInjection; Oral
    Strengtheq 15mg base/ml; eq 25mg base/ml
    Market StatusPrescription
    CompanyCovis Injectables; Glaxo Grp

    8 of 10  
    Drug NameZantac 150
    PubMed HealthRanitidine
    Drug ClassesAntiulcer, Gastric Acid Secretion Inhibitor
    Drug LabelThe active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 150mg base
    Market StatusOver the Counter; Prescription
    CompanyBoehringer Ingelheim; Glaxo Grp

    9 of 10  
    Drug NameZantac 300
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 300mg base
    Market StatusPrescription
    CompanyGlaxo Grp

    10 of 10  
    Drug NameZantac 75
    Drug LabelThe active ingredient in ZANTAC 150 Tablets, ZANTAC 300 Tablets, and ZANTAC Syrup is ranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2...
    Active IngredientRanitidine hydrochloride
    Dosage FormTablet
    RouteOral
    Strengtheq 75mg base
    Market StatusOver the Counter
    CompanyBoehringer Ingelheim

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Histamine H2 Antagonists

    Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Histamine-2 Receptor Antagonist [EPC]; Histamine H2 Receptor Antagonists [MoA]

    API Reference Price

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    02-Jan-2021
    29-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    DOSAGE - TABLET;ORAL - EQ 150MG BASE **Federa...DOSAGE - TABLET;ORAL - EQ 150MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 18703

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    DOSAGE - TABLET;ORAL - EQ 300MG BASE **Federa...DOSAGE - TABLET;ORAL - EQ 300MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    DOSAGE - INJECTABLE;INJECTION - EQ 25MG BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 25MG BASE/ML

    USFDA APPLICATION NUMBER - 19090

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    DOSAGE - TABLET;ORAL - EQ 75MG BASE

    USFDA APPLICATION NUMBER - 20520

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    DOSAGE - TABLET;ORAL - EQ 150MG BASE

    USFDA APPLICATION NUMBER - 21698

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