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Chemistry

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Also known as: 15078-28-1, Pentacyanidonitrosylferrate(2-), Iron(4+);nitroxyl anion;pentacyanide, Pentacyano(nitroso)iron(2-), Chebi:7596, Pentacyanidonitrosylferrate(iii)
Molecular Formula
C5FeN6O-2
Molecular Weight
215.94  g/mol
InChI Key
PAORBFBZBNPTCL-UHFFFAOYSA-N

Sodium Nitroprusside
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
1 2D Structure

Sodium Nitroprusside

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
iron(4+);nitroxyl anion;pentacyanide
2.1.2 InChI
InChI=1S/5CN.Fe.NO/c5*1-2;;1-2/q5*-1;+4;-1
2.1.3 InChI Key
PAORBFBZBNPTCL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.[N-]=O.[Fe+4]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Cyanonitrosylferrate

2. Disodium Salt Nitroprusside

3. Ketostix

4. Naniprus

5. Nipride

6. Nipruton

7. Nitriate

8. Nitropress

9. Nitroprussiat Fides

10. Nitroprusside

11. Nitroprusside, Disodium Salt

12. Nitroprusside, Disodium Salt, Dihydrate

13. Nitroprusside, Sodium

14. Sodium Nitroprusside

2.2.2 Depositor-Supplied Synonyms

1. 15078-28-1

2. Pentacyanidonitrosylferrate(2-)

3. Iron(4+);nitroxyl Anion;pentacyanide

4. Pentacyano(nitroso)iron(2-)

5. Chebi:7596

6. Pentacyanidonitrosylferrate(iii)

7. [fe(cn)5(no)](2-)

8. Bdbm50377921

9. Db00325

10. Ncgc00166055-01

11. Ncgc00166055-04

12. Sbi-0206675.p002

13. C07269

14. Ab00920709_03

15. Ferrate(2-), Pentakis(cyano-.kappa.c)-nitrosyl

2.2.3 Other Synonyms

1. Nitroprusside Sodium

2. Nitroprusside Sodium Dihydrate

2.3 Create Date
2006-12-13
3 Chemical and Physical Properties
Molecular Weight 215.94 g/mol
Molecular Formula C5FeN6O-2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count12
Rotatable Bond Count0
Exact Mass215.948294 g/mol
Monoisotopic Mass215.948294 g/mol
Topological Polar Surface Area137 Ų
Heavy Atom Count13
Formal Charge-2
Complexity119
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count7
4 Drug and Medication Information
4.1 Drug Indication

For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure


5 Pharmacology and Biochemistry
5.1 Pharmacology

Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins. Other smooth muscle (e.g., uterus, duodenum) is not affected. Sodium nitroprusside is more active on veins than on arteries.


5.2 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Indicators and Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)


Nitric Oxide Donors

A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


5.3 Absorption, Distribution and Excretion

Route of Elimination

One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN ions, thiosulfate reacts with cyanide to produce thiocyanate, thiocyanate is eliminated in the urine.


5.4 Metabolism/Metabolites

Metabolized by reaction with hemoglobin to produce cyanmethemoglobin and cynide ions


5.5 Biological Half-Life

Approximately 2 minutes


5.6 Mechanism of Action

One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN- ions; methemoglobin, obtained from hemoglobin, can sequester cyanide as cyanmethemoglobin; thiosulfate reacts with cyanide to produce thiocyanate; thiocyanate is eliminated in the urine; cyanide not otherwise removed binds to cytochromes. Cyanide ion is normally found in serum; it is derived from dietary substrates and from tobacco smoke. Cyanide binds avidly (but reversibly) to ferric ion (Fe+++), most body stores of which are found in erythrocyte methemoglobin (metHgb) and in mitochondrial cytochromes. When CN is infused or generated within the bloodstream, essentially all of it is bound to methemoglobin until intraerythrocytic methemoglobin has been saturated. Sodium nitroprusside is further broken down in the circulation to release nitric oxide (NO), which activates guanylate cyclase in the vascular smooth muscle. This leads to increased production of intracellular cGMP, which stimulates calcium ion movement from the cytoplasm to the endoplasmic reticulum, reducing the level of available calcium ions that can bind to calmodulin. This ultimately results in vascular smooth muscle relaxation and vessel dilation.


API Reference Price

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Looking for 15078-28-1 / Sodium Nitroprusside API manufacturers, exporters & distributors?

Sodium Nitroprusside manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sodium Nitroprusside API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Nitroprusside manufacturer or Sodium Nitroprusside supplier for your needs.

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PharmaCompass also assists you with knowing the Sodium Nitroprusside API Price utilized in the formulation of products. Sodium Nitroprusside API Price is not always fixed or binding as the Sodium Nitroprusside Price is obtained through a variety of data sources. The Sodium Nitroprusside Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sodium Nitroprusside

Synonyms

15078-28-1, Pentacyanidonitrosylferrate(2-), Iron(4+);nitroxyl anion;pentacyanide, Pentacyano(nitroso)iron(2-), Chebi:7596, Pentacyanidonitrosylferrate(iii)

Cas Number

15078-28-1

About Sodium Nitroprusside

A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.

Nipruss Manufacturers

A Nipruss manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Nipruss, including repackagers and relabelers. The FDA regulates Nipruss manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Nipruss API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Nipruss manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Nipruss Suppliers

A Nipruss supplier is an individual or a company that provides Nipruss active pharmaceutical ingredient (API) or Nipruss finished formulations upon request. The Nipruss suppliers may include Nipruss API manufacturers, exporters, distributors and traders.

click here to find a list of Nipruss suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Nipruss USDMF

A Nipruss DMF (Drug Master File) is a document detailing the whole manufacturing process of Nipruss active pharmaceutical ingredient (API) in detail. Different forms of Nipruss DMFs exist exist since differing nations have different regulations, such as Nipruss USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Nipruss DMF submitted to regulatory agencies in the US is known as a USDMF. Nipruss USDMF includes data on Nipruss's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Nipruss USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Nipruss suppliers with USDMF on PharmaCompass.

Nipruss CEP

A Nipruss CEP of the European Pharmacopoeia monograph is often referred to as a Nipruss Certificate of Suitability (COS). The purpose of a Nipruss CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Nipruss EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Nipruss to their clients by showing that a Nipruss CEP has been issued for it. The manufacturer submits a Nipruss CEP (COS) as part of the market authorization procedure, and it takes on the role of a Nipruss CEP holder for the record. Additionally, the data presented in the Nipruss CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Nipruss DMF.

A Nipruss CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Nipruss CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Nipruss suppliers with CEP (COS) on PharmaCompass.

Nipruss WC

A Nipruss written confirmation (Nipruss WC) is an official document issued by a regulatory agency to a Nipruss manufacturer, verifying that the manufacturing facility of a Nipruss active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Nipruss APIs or Nipruss finished pharmaceutical products to another nation, regulatory agencies frequently require a Nipruss WC (written confirmation) as part of the regulatory process.

click here to find a list of Nipruss suppliers with Written Confirmation (WC) on PharmaCompass.

Nipruss NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Nipruss as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Nipruss API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Nipruss as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Nipruss and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Nipruss NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Nipruss suppliers with NDC on PharmaCompass.

Nipruss GMP

Nipruss Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Nipruss GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Nipruss GMP manufacturer or Nipruss GMP API supplier for your needs.

Nipruss CoA

A Nipruss CoA (Certificate of Analysis) is a formal document that attests to Nipruss's compliance with Nipruss specifications and serves as a tool for batch-level quality control.

Nipruss CoA mostly includes findings from lab analyses of a specific batch. For each Nipruss CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Nipruss may be tested according to a variety of international standards, such as European Pharmacopoeia (Nipruss EP), Nipruss JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Nipruss USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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