Synopsis
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USP
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JP
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1. Ncgc00167966-01
2. Dsstox_cid_26750
3. Dsstox_rid_81875
4. Dsstox_gsid_46750
5. Chembl1874250
6. Dtxsid20858848
7. Tox21_112595
8. Akos015960603
9. Ac-11740
10. Ac-31947
11. Cas-9004-61-9
12. (4xi)-alpha-d-xylo-hexopyranuronosyl-(1->3)-(3xi)-2-(acetylamino)-2-deoxy-beta-d-ribo-hexopyranosyl-(1->4)-(5xi)-beta-d-xylo-hexopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-d-glucopyranose
1. Hyaluronan
Molecular Weight | 776.6 g/mol |
---|---|
Molecular Formula | C28H44N2O23 |
XLogP3 | -7.4 |
Hydrogen Bond Donor Count | 14 |
Hydrogen Bond Acceptor Count | 23 |
Rotatable Bond Count | 12 |
Exact Mass | 776.23348565 g/mol |
Monoisotopic Mass | 776.23348565 g/mol |
Topological Polar Surface Area | 400 Ų |
Heavy Atom Count | 53 |
Formal Charge | 0 |
Complexity | 1300 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 16 |
Undefined Atom Stereocenter Count | 4 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 15901
Submission : 2002-03-15
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 15408
Submission : 2001-04-24
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 11593
Submission : 1995-07-20
Status : Inactive
Type : II
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API Imports and Exports
Importing Country | Total Quantity (KGS) |
Average Price (USD/KGS) |
Number of Transactions |
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Details:
Skinvive™ by Juvéderm® is a smooth, injectable HA gel that contains a small amount of local anesthetic (lidocaine). It improves skin quality in the cheeks by smoothing the skin and increasing hydration.
Lead Product(s): Hyaluronic Acid
Therapeutic Area: Dermatology Brand Name: Skinvive
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable May 15, 2023
Lead Product(s) : Hyaluronic Acid
Therapeutic Area : Dermatology
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
SKINVIVE™ by JUVÉDERM® Receives U.S. FDA Approval
Details : Skinvive™ by Juvéderm® is a smooth, injectable HA gel that contains a small amount of local anesthetic (lidocaine). It improves skin quality in the cheeks by smoothing the skin and increasing hydration.
Product Name : Skinvive
Product Type : Small molecule
Upfront Cash : Not Applicable
May 15, 2023
Details:
Juvederm Voluma™ XC (hyaluronic acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in the mid-face in adults over the age of 21.
Lead Product(s): Hyaluronic Acid
Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable January 18, 2023
Lead Product(s) : Hyaluronic Acid
Therapeutic Area : Dermatology
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
JUVÉDERM® VOLUX™ XC For Improvement Of Jawline Definition Now Available Nationwide
Details : Juvederm Voluma™ XC (hyaluronic acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in the mid-face in adults over the age of 21.
Product Name : Juvederm Volux XC
Product Type : Small molecule
Upfront Cash : Not Applicable
January 18, 2023
Details:
Allergan Aesthetics looks to further develop the Hybrid Injectables category by introducing its first dual-effect product, which combines the two active ingredients - hyaluronic acid, a well-known ingredient found in facial fillers and calcium hydroxyapatite in one injection.
Lead Product(s): Hyaluronic Acid,HYDROXYPROPYLMETHYLCELLULOSE
Therapeutic Area: Dermatology Brand Name: HArmonyCa
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 29, 2022
Lead Product(s) : Hyaluronic Acid,HYDROXYPROPYLMETHYLCELLULOSE
Therapeutic Area : Dermatology
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Allergan Aesthetics looks to further develop the Hybrid Injectables category by introducing its first dual-effect product, which combines the two active ingredients - hyaluronic acid, a well-known ingredient found in facial fillers and calcium hydroxyapa...
Product Name : HArmonyCa
Product Type : Small molecule
Upfront Cash : Not Applicable
March 29, 2022
Details:
JUVÉDERM® VOLBELLA® XC was first FDA–approved in 2016 for use in the lips and perioral rhytids.2 As the category leader, the JUVÉDERM® Collection of Fillers offers the broadest portfolio, and this latest approval marks the sixth approved indication in the U.S.
Lead Product(s): Hyaluronic Acid,Lidocaine
Therapeutic Area: Dermatology Brand Name: Juvéderm Volbella XC
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable February 08, 2022
Lead Product(s) : Hyaluronic Acid,Lidocaine
Therapeutic Area : Dermatology
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
FDA Approves JUVÉDERM® VOLBELLA® XC For Undereye Hollows
Details : JUVÉDERM® VOLBELLA® XC was first FDA–approved in 2016 for use in the lips and perioral rhytids.2 As the category leader, the JUVÉDERM® Collection of Fillers offers the broadest portfolio, and this latest approval marks the sixth approved indicatio...
Product Name : Juvéderm Volbella XC
Product Type : Small molecule
Upfront Cash : Not Applicable
February 08, 2022
Details:
JUVÉDERM (Hyaluronic Acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in mid-face and for augmentation of chin region to improve chin profile in adults over age of 21.
Lead Product(s): Hyaluronic Acid
Therapeutic Area: Dermatology Brand Name: Juvederm Volux XC
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 15, 2020
Lead Product(s) : Hyaluronic Acid
Therapeutic Area : Dermatology
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
FDA Approves JUVÉDERM® VOLUMA™ XC for Enhancement of the Chin Region
Details : JUVÉDERM (Hyaluronic Acid) is indicated for deep (subcutaneous and/or supraperiosteal) injection for cheek augmentation to correct age-related volume deficit in mid-face and for augmentation of chin region to improve chin profile in adults over age of 2...
Product Name : Juvederm Volux XC
Product Type : Small molecule
Upfront Cash : Not Applicable
June 15, 2020
Details:
New pre-clinical study showed that Dermial® hyaluronic acid matrix ingredient increased type I collagen production by almost half – an observation not seen with standard hyaluronic acid from fermentation or extraction origin.
Lead Product(s): Hyaluronic Acid,Dermatan Sulfate,Collagen
Therapeutic Area: Dermatology Brand Name: Dermial
Study Phase: PreclinicalProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable May 25, 2022
Lead Product(s) : Hyaluronic Acid,Dermatan Sulfate,Collagen
Therapeutic Area : Dermatology
Highest Development Status : Preclinical
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
New Study Reveals Bioiberica's Dermial® Delivers Superior Benefits for Skin Health
Details : New pre-clinical study showed that Dermial® hyaluronic acid matrix ingredient increased type I collagen production by almost half – an observation not seen with standard hyaluronic acid from fermentation or extraction origin.
Product Name : Dermial
Product Type : Small molecule
Upfront Cash : Not Applicable
May 25, 2022
Details:
Apsen’s Motilex HA combines two leading ingredients, b-2Cool native type II collagen and Mobilee, patented ingredient that synergistically combines a high concentration of hyaluronic acid with polysaccharides and collagen, to effectively maintain joint function.
Lead Product(s): Hyaluronic Acid,Type II Collagen
Therapeutic Area: Musculoskeletal Brand Name: Motilex HA
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Apsen
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Partnership April 26, 2021
Lead Product(s) : Hyaluronic Acid,Type II Collagen
Therapeutic Area : Musculoskeletal
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Apsen
Deal Size : Undisclosed
Deal Type : Partnership
Bioiberica and Apsen Reinforce Partnership with New Holistic Mobility Product–Motilex HA
Details : Apsen’s Motilex HA combines two leading ingredients, b-2Cool native type II collagen and Mobilee, patented ingredient that synergistically combines a high concentration of hyaluronic acid with polysaccharides and collagen, to effectively maintain joint...
Product Name : Motilex HA
Product Type : Small molecule
Upfront Cash : Undisclosed
April 26, 2021
Details:
The study, conducted in a rabbit model of osteoarthritis, set out to evaluate the effects of b-2Cool native type II collagen in combination with CS b-Bioactive chondroitin sulphate, glucosamine hydrochloride and Mobilee® which is a rooster comb extract rich in hyaluronic acid.
Lead Product(s): Undenatured Type II Collagen,Chondroitin Sulfate Sodium,Hyaluronic Acid
Therapeutic Area: Musculoskeletal Brand Name: Mobilee
Study Phase: ApprovedProduct Type: Large molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 07, 2020
Lead Product(s) : Undenatured Type II Collagen,Chondroitin Sulfate Sodium,Hyaluronic Acid
Therapeutic Area : Musculoskeletal
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
New Study Further Validates Bioiberica’s B-2cool® Native Type II Collagen as Trusted Source for...
Details : The study, conducted in a rabbit model of osteoarthritis, set out to evaluate the effects of b-2Cool native type II collagen in combination with CS b-Bioactive chondroitin sulphate, glucosamine hydrochloride and Mobilee® which is a rooster comb extract ...
Product Name : Mobilee
Product Type : Large molecule
Upfront Cash : Not Applicable
September 07, 2020
Details:
B-2Cool (Bioiberica’s native type II collagen) is an innovative ingredient, has been shown in four scientific studies to help maintain good joint health at a very low daily dose.
Lead Product(s): Undenatured Type II Collagen,Harpagophytum Procumbens Extract,Hyaluronic Acid
Therapeutic Area: Musculoskeletal Brand Name: Colnatur Forte
Study Phase: ApprovedProduct Type: Large molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable July 15, 2020
Lead Product(s) : Undenatured Type II Collagen,Harpagophytum Procumbens Extract,Hyaluronic Acid
Therapeutic Area : Musculoskeletal
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Laboratorios Ordesa Incorporates B-2cool®, Bioiberica’s Native Type II Collagen, in Its New Col...
Details : B-2Cool (Bioiberica’s native type II collagen) is an innovative ingredient, has been shown in four scientific studies to help maintain good joint health at a very low daily dose.
Product Name : Colnatur Forte
Product Type : Large molecule
Upfront Cash : Not Applicable
July 15, 2020
Details:
Bloomsurfact EncapCare (hyaluronic acid) is an emulsion solution for effective anti-aging skin rejuvenation & ensures high bioavailability & low irritation making it more friendly for sensitive skin.
Lead Product(s): Hyaluronic Acid
Therapeutic Area: Dermatology Brand Name: Bloomsurfact EncapCare
Study Phase: ApprovedProduct Type: Small molecule
Sponsor: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 12, 2023
Lead Product(s) : Hyaluronic Acid
Therapeutic Area : Dermatology
Highest Development Status : Approved
Partner/Sponsor/Collaborator : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
SCC77: Bloomage Bloomsurfact EncapCare RP Ensures 99% Dispersion of Anti-aging Ingredient
Details : Bloomsurfact EncapCare (hyaluronic acid) is an emulsion solution for effective anti-aging skin rejuvenation & ensures high bioavailability & low irritation making it more friendly for sensitive skin.
Product Name : Bloomsurfact EncapCare
Product Type : Small molecule
Upfront Cash : Not Applicable
December 12, 2023
Related Excipient Companies
Dosage Form : Solution
Grade : Oral, Topical
Application : Solubilizers
Excipient Details : Hydrosol 50 is used as a solubilizer and emulsifying agent in oral and topical liquid and semi-solid dosage forms.
Pharmacopoeia Ref : USP/NF
Technical Specs : N/A
Ingredient(s) : Polyoxyl 40 Hydrogenated Castor Oil
Excipients by Applications
Dosage Form : Tablet
Grade : Topical, Oral
Category : Fillers, Diluents & Binders, Lubricants & Glidants
Application : Fillers, Diluents & Binders, Lubricants & Glidants
Pharmacopoeia Ref : Monograph- Ph.Eur, USP/NF, JP/...
Technical Specs : Not Available
Ingredient(s) : Stearic Acid
Dosage Form : Tablet
Grade : Topical, Oral
Category : Fillers, Diluents & Binders, Lubricants & Glidants
Application : Fillers, Diluents & Binders, Lubricants & Glidants
Excipient Details : Stearic acid is a saturated, wax-like, fatty acid commonly used in the production of pharmaceutical tablets and capsules.
Pharmacopoeia Ref : Monograph- Ph.Eur, USP/NF, JP/...
Technical Specs : Not Available
Ingredient(s) : Stearic Acid
Grade : Not Available
Category : Co-Processed Excipients, Fillers, Diluents & Binders
Application : Co-Processed Excipients, Fillers, Diluents & Binders
Excipient Details : It is a Co-Processed Lactose starch for filler/binder having strong disintegrant properties.
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PharmaCompass offers a list of Hyaluronic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Hyaluronic Acid manufacturer or Hyaluronic Acid supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hyaluronic Acid manufacturer or Hyaluronic Acid supplier.
PharmaCompass also assists you with knowing the Hyaluronic Acid API Price utilized in the formulation of products. Hyaluronic Acid API Price is not always fixed or binding as the Hyaluronic Acid Price is obtained through a variety of data sources. The Hyaluronic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Hyaluronic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hyaluronic Acid, including repackagers and relabelers. The FDA regulates Hyaluronic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hyaluronic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Hyaluronic Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Hyaluronic Acid supplier is an individual or a company that provides Hyaluronic Acid active pharmaceutical ingredient (API) or Hyaluronic Acid finished formulations upon request. The Hyaluronic Acid suppliers may include Hyaluronic Acid API manufacturers, exporters, distributors and traders.
click here to find a list of Hyaluronic Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Hyaluronic Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Hyaluronic Acid active pharmaceutical ingredient (API) in detail. Different forms of Hyaluronic Acid DMFs exist exist since differing nations have different regulations, such as Hyaluronic Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Hyaluronic Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Hyaluronic Acid USDMF includes data on Hyaluronic Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hyaluronic Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Hyaluronic Acid suppliers with USDMF on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Hyaluronic Acid Drug Master File in Japan (Hyaluronic Acid JDMF) empowers Hyaluronic Acid API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Hyaluronic Acid JDMF during the approval evaluation for pharmaceutical products. At the time of Hyaluronic Acid JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Hyaluronic Acid suppliers with JDMF on PharmaCompass.
Hyaluronic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Hyaluronic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hyaluronic Acid GMP manufacturer or Hyaluronic Acid GMP API supplier for your needs.
A Hyaluronic Acid CoA (Certificate of Analysis) is a formal document that attests to Hyaluronic Acid's compliance with Hyaluronic Acid specifications and serves as a tool for batch-level quality control.
Hyaluronic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Hyaluronic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Hyaluronic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Hyaluronic Acid EP), Hyaluronic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hyaluronic Acid USP).