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Chemistry

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Also known as: Noscapine hydrochloride, 912-60-7, Narcotine hydrochloride, Ttn62ith9i, Teletux, Tucotine
Molecular Formula
C22H24ClNO7
Molecular Weight
449.9  g/mol
InChI Key
MFLVZFXCSKVCSH-URBRKQAFSA-N

Noscapine Hydrochloride
A naturally occurring opium alkaloid that is a centrally acting antitussive agent.
1 2D Structure

Noscapine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-3H-2-benzofuran-1-one;chloride
2.1.2 InChI
InChI=1S/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18+;/m1./s1
2.1.3 InChI Key
MFLVZFXCSKVCSH-URBRKQAFSA-N
2.1.4 Canonical SMILES
C[NH+]1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.[Cl-]
2.1.5 Isomeric SMILES
C[NH+]1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.[Cl-]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Capval

2. Capval Tropfen

3. Embonate, Noscapine Hydrogen

4. Hydrochloride, Noscapine

5. Hydrogen Embonate, Noscapine

6. Librochin Prikkelhoest

7. Narcotine

8. Noscapect

9. Noscapine

10. Noscapine Hydrochloride

11. Noscapine Hydrogen Embonate

12. Prikkelhoest, Librochin

13. Tropfen, Capval

14. Tuscalman

2.2.2 Depositor-Supplied Synonyms

1. Noscapine Hydrochloride

2. 912-60-7

3. Narcotine Hydrochloride

4. Ttn62ith9i

5. Teletux

6. Tucotine

7. Stilco

8. Lyobex Retard

9. Difmetus Kapseln

10. Tussicure P

11. Germose Noscapine

12. Opian Hydrochloride

13. Vadebex Hydrochloride

14. Coscopin Hydrochloride

15. Nectadon Hydrochloride

16. Opianine Hydrochloride

17. Terbenol Hydrochloride

18. Coscotabs Hydrochloride

19. Narcosine Hydrochloride

20. Narcompren Hydrochloride

21. Narcotine, Hydrochloride

22. Unii-ttn62ith9i

23. Nsc 5366 Hydrochloride

24. Key-tusscapine Hydrochloride

25. Methoxyhydrastine Hydrochloride

26. Ccris 8985

27. 1-alpha-narcotine Hydrochloride

28. Noscapine Hydrochloride [jan:nf]

29. 1(3h)-isobenzofuranone, 6,7-dimethoxy-3-((5r)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, Hydrochloride, (3s)-

30. Einecs 213-014-9

31. Noscapinehydrochloride

32. 1(3h)isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, Hydrochloride, (s-(r*,s*))-

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 449.9 g/mol
Molecular Formula C22H24ClNO7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass449.1241298 g/mol
Monoisotopic Mass449.1241298 g/mol
Topological Polar Surface Area76.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity647
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)


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17-Jan-2022
24-Apr-2025
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ABOUT THIS PAGE

Looking for 219533-73-0 / Noscapine Hydrochloride API manufacturers, exporters & distributors?

Noscapine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Noscapine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Noscapine Hydrochloride manufacturer or Noscapine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Noscapine Hydrochloride manufacturer or Noscapine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Noscapine Hydrochloride API Price utilized in the formulation of products. Noscapine Hydrochloride API Price is not always fixed or binding as the Noscapine Hydrochloride Price is obtained through a variety of data sources. The Noscapine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Noscapine Hydrochloride

Synonyms

912-60-7, Narcotine hydrochloride, Ttn62ith9i, Teletux, Tucotine, Stilco

Cas Number

219533-73-0

About Noscapine Hydrochloride

A naturally occurring opium alkaloid that is a centrally acting antitussive agent.

Noscapine HCl Manufacturers

A Noscapine HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Noscapine HCl, including repackagers and relabelers. The FDA regulates Noscapine HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Noscapine HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Noscapine HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Noscapine HCl Suppliers

A Noscapine HCl supplier is an individual or a company that provides Noscapine HCl active pharmaceutical ingredient (API) or Noscapine HCl finished formulations upon request. The Noscapine HCl suppliers may include Noscapine HCl API manufacturers, exporters, distributors and traders.

click here to find a list of Noscapine HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Noscapine HCl JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Noscapine HCl Drug Master File in Japan (Noscapine HCl JDMF) empowers Noscapine HCl API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Noscapine HCl JDMF during the approval evaluation for pharmaceutical products. At the time of Noscapine HCl JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Noscapine HCl suppliers with JDMF on PharmaCompass.

Noscapine HCl CEP

A Noscapine HCl CEP of the European Pharmacopoeia monograph is often referred to as a Noscapine HCl Certificate of Suitability (COS). The purpose of a Noscapine HCl CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Noscapine HCl EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Noscapine HCl to their clients by showing that a Noscapine HCl CEP has been issued for it. The manufacturer submits a Noscapine HCl CEP (COS) as part of the market authorization procedure, and it takes on the role of a Noscapine HCl CEP holder for the record. Additionally, the data presented in the Noscapine HCl CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Noscapine HCl DMF.

A Noscapine HCl CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Noscapine HCl CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Noscapine HCl suppliers with CEP (COS) on PharmaCompass.

Noscapine HCl WC

A Noscapine HCl written confirmation (Noscapine HCl WC) is an official document issued by a regulatory agency to a Noscapine HCl manufacturer, verifying that the manufacturing facility of a Noscapine HCl active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Noscapine HCl APIs or Noscapine HCl finished pharmaceutical products to another nation, regulatory agencies frequently require a Noscapine HCl WC (written confirmation) as part of the regulatory process.

click here to find a list of Noscapine HCl suppliers with Written Confirmation (WC) on PharmaCompass.

Noscapine HCl GMP

Noscapine HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Noscapine HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Noscapine HCl GMP manufacturer or Noscapine HCl GMP API supplier for your needs.

Noscapine HCl CoA

A Noscapine HCl CoA (Certificate of Analysis) is a formal document that attests to Noscapine HCl's compliance with Noscapine HCl specifications and serves as a tool for batch-level quality control.

Noscapine HCl CoA mostly includes findings from lab analyses of a specific batch. For each Noscapine HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Noscapine HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Noscapine HCl EP), Noscapine HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Noscapine HCl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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