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Looking for a contract manufacturer for capsule manufacturing services? Find CDMO, CMO offering hardgel, softgel, veg capsule, etc. on PharmaCompass

Q1. Capsules, what are they and what are the advantages?

In the pharmaceutical industry, capsules refer to solid dosage forms in which the drug is enclosed in a hard or soft soluble container. Capsules are usually administered orally, but occasionally may be administered rectally or vaginally. 

Orally administered medications are hands down, the world’s preferred way to take medicines. For developers, oral solid dosage or OSD forms like tablets and capsules remain the preferred administration route due to their cost-effectiveness, relative ease of manufacturing and the wide availability of patient-friendly dosing options.

Capsules are generally made from special film-forming materials (such as gelatin, cellulose, polysaccharides, and pure natural plant starch, etc.), which are used to enclose ingredients in a relatively stable shell, allowing them to be taken orally.

Capsules may also be filled with a range of formulation types including dry powders, semisolids, nonaqueous liquids, and other dosage forms such as beads, mini-tablets, and even mini capsules.

Therefore, various types of capsules, with shells and inner fills made of different materials, are available in the market. Traditional capsules are principally made from gelatin, which is a common ingredient in medicines and food products. 

 

Some Advantages of Capsules

- Capsules are tasteless, odorless, and can be administered easily. Drugs with unpleasant tastes and odors may also be enclosed in tasteless shells to make them more attractive to consumers.

- If properly stored the shells contain 12-15% of moisture which give flexibility and consequently very considerable resistance to mechanical stresses.

- Capsules can accommodate combinations of powders, and physicians may change the dose and combination of a capsule drug according to patient requirements.

- Presentation of a drug in a capsule rather than in tablets, allows quicker submission of a new drug for clinical trials because fewer development problems are involved.

- Other advantages of the capsule include the ability of an effective oxygen barrier and excellent chemical stability, which could improve product stability. For example, components that are unstable, sensitive to temperature, light and heat can be made into capsule forms.

Q2. What are the different types of capsules and what are their components?

Capsules are the dosage forms in which a drug formulation usually in a powder, semisolid, or liquid form is enclosed in a shell. This capsule shell is generally made from gelatin but can be made from other polymers such as hydroxypropyl methylcellulose (vegan capsules), polyvinyl alcohol (PVA), seaweed, or starch.

While there are a wide variety of capsules available in the pharmaceutical industry, hard capsules and soft capsules are the two most prolific capsule types in the market. Softgel capsules and hard gel capsules as well as their corresponding components are explored in detail below. 

 

Softgel Capsules

Soft gelatin capsules, also known as softgels or soft elastic capsules, are hermetically sealed one-piece capsules containing a liquid or a semisolid fill without an air or gas bubble. Softgels consist of two parts: solid capsule (outer shell) and a liquid or semi-solid center (inner fill). There are various softgel contract manufacturers that offer softgel capsule contract manufacturing services.

Softgel capsules offer several advantages such as delivering a liquid matrix designed to solubilize and improve the oral bioavailability of a poorly soluble compound, delivering low and ultra-low doses of a compound, delivering a low melting compound, and minimizing potential generation of dust during manufacturing, etc.

- Some Soft Capsule Outer Shell Ingredients

- Gelatin (e.g. bovine, porcine, piscine)

- Plasticizer (e.g. glycerin, sorbitol)

- Solvent (e.g. water)

- Flavoring agents (e.g. essential oils, sucrose)

- Colorants (e.g. dye, lakes)

- Preservatives (e.g. antioxidant agents, antimicrobial agents)

- Other additives

- Some Soft Capsule Inner Fill Materials

- Oily Mixtures

- Solutions

- Suspensions

 

Hard Gelatin Capsules

Hard capsules are rigid, cylindrical shells typically made of two parts - the body and the cap - which are filled with dry or liquid ingredients and then specially sealed to prevent leakages. These are one of the oldest forms of the pharmaceutical capsule.

Hard capsules also offer several advantages: they are less expensive, easy to fill, able to meet different demands, have a longer shelf life, are easily digestible, have better bioavailability compared to tablets and allow a better degree of flexibility, amongst several other benefits.

- Some Hard Capsule Outer Shell Ingredients

- Gelatin (e.g. Type A and Type B)

- Colorants (e.g. dye, lakes, mineral colors)

- Opacifiers (e.g. Tio2)

- Plasticizer (e.g. sorbitol, glycerin)

- Preservatives (e.g. propyl and methyl parabens)

- Some Hard Capsule Inner Fill Materials

- Dry powders

- Granules

- Pellets

 

Some Other Types of Capsules

- Veg Capsule or Vegan Capsule 

HPMC capsules or veg capsules are two-piece capsules that serve as vegetarian alternatives to hard gelatin capsules and satisfy certain dietary and cultural needs. HPMC used in veg capsules or vegan capsules is considered safe for normal human consumption.

- Chewable Capsule

Chewable capsules are capsules designed to be chewed to release the active and/or inert ingredients. Chewable capsules are a versatile dosage form offering several advantages including oral drug delivery without the need for water, ease of swallowing, the stability advantages of solid dosage forms, and patient-centric drug delivery.

Q3. What are the different steps involved in manufacturing capsules?

Capsule manufacturing starts with the dispense of raw materials, which then undergoes the process of granulation where sieving is done and various binders are added. This is followed by drying, sizing and blending of the materials. 

This material then undergoes capsule filling techniques after which it goes for capsule polishing. After all that the capsules go for primary packaging (e.g. blister packaging) and then secondary packaging. 

 

Manufacturing Capsules - Hard Gelatin Capsules

Hard gelatin capsules are fabricated and supplied empty to the pharmaceutical industry by empty shell suppliers, and are then filled in a separate operation. Manufacturing capsules involves a step by step process that requires strict quality control in the manufacture of hard gelatin capsules.

- Hard Gel Capsule Manufacturing Steps

Step 1: Preparation of gelatin solution (dipping solution)

Step 2: Dip-coating the gelatin solution on to metal pins (moulds)

Step 3: Rotation of the dip-coated pins

Step 4: Drying of the gelatin-coated pins

Step 5: Stripping and trimming

Step 6: Joining of the trimmed capsule shell

Step 7: Printing

Step 8: Developing and preparing the inner fill formulation

Step 9: Capsule filling using manual, semi automatic or automatic filling devices

Step 10: Sealing the filled hard capsules

Step 11: Cleaning and polishing the dry filled capsules

 

Manufacturing Capsules - Softgels

Soft gelatin capsules are made from a more flexible, plasticized gelatin film than hard gelatin capsules. A softgel consists of a gelatin-based shell surrounding a liquid fill. The shells are a combination of gelatin, water, opacifier, and a plasticizer, such as glycerin or sorbitol. In the encapsulation process, two flat ribbons are manufactured and brought together on a twin set of rotating dies.

- Softgel Capsule Manufacturing Steps 

Step 1: Raw material storage and selection

Step 2: Weighing softgel capsule ingredients for inner and outer fills

Step 3: Preparation of inner fill materials 

Step 4: Softgel encapsulation (Softgel capsule filling services)

Step 5: Drying

Step 6: Softgel dosage form inspection

Step 7: Soft shell capsule packaging

Step 8: Finished product storage and distribution

Q4. Which are the leading pharma contract manufacturers offering capsules?

Some leading pharma contract manufacturers or capsule contract manufacturers that offer custom formulation and product development services for capsules, capsule filling techniques, (e.g. softgel capsule filling services), softgel capsule contract manufacturing and hard capsule contract manufacturing are noted below.

 

AbbVie Contract Manufacturing - Capsule Contract Manufacturing

AbbVie Contract Manufacturing, a leading pharma contract manufacturer and developer, offers contract manufacturing of various oral solid dosage forms such as capsules, over-encapsulation, bi-layer tablets, mini and micro tablets, liquids, pellets, granules, etc.

AbbVie Contract Manufacturing manufactures and packages finished drug products, with specific expertise in producing tablets, capsules, liquid-filled capsules, granules, prefilled syringes and oral liquids. Their manufacturing expertise includes tablet coating, spray coating, drying granulation, etc.

Skyepharma - Capsule Filling and Packaging

Skyepharma’s capsule manufacturing capabilities include capsules filled with tablets, granules, pellets, or powders. They offer blister packaging in PVC, PVDC, Aclar, Triplex, etc. and blister packaging services including serialization and aggregation. They also offer custom formulation and product development services for capsules and other dosage forms.

Pfizer CentreOne - Capsule Filling and Packaging

Pfizer CentreOne offers flexible oral solid dose manufacturing with various delivery technologies of capsules such as immediate-release capsules, modified-release capsules, powder-filled capsules, pellet-filled capsules, etc. It also offers other capsule filling and packaging services such as coating, blending, etc.

Polpharma - Hard Capsule Manufacturing

Polpharma is a leading capsule contract manufacturer offering contract manufacturing for various oral solid dosage forms such as hard gelatin capsules (filled with powders, pellets, granules) using various capsule filling techniques, soft gelatin capsules (i.e. softgel capsule contract manufacturing along with softgel capsule filling services), tablets, multilayer tablets, film and sugar coated tablets.

Its site in New Doba, Poland specializes in contract manufacturing dry oral formulations, including producing and packing tablets, coated tablets and hard gelatin capsules, in blisters (blister packaging) and polyethylene containers.

Recipharm AB - Hard Capsule Manufacturing

Recipharm has the capabilities to deliver your project from development through to the manufacture of large commercial batch sizes of tablets, capsules, hard gelatin capsules and powders. It is a leading capsule contract manufacturer offering custom formulation and product development services for capsules and various other dosage forms.

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Douglas CDMO

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Virtual BoothEnd-to-end drug development, specializing in high-potency softgels and liquids, providing global partners with a competitive advantage.

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CAPSULE CONTRACT MANUFACTURING

Douglas CDMO manufactures various dosage forms, including solid oral doses & hard gelatin capsules with or without containment. It offers high/low shear granulation, drying, blending, hardgel & suppository encapsulation, compression & coating processes.

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Virtual BoothSkyepharma, an Expert and Innovative CDMO Partner for tailor-made solutions in complex oral solids and bioproduction.

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HIGHLY POTENT CAPSULE MANUFACTURING

Skyepharma excels in developing and manufacturing classic and complex oral dosage forms, including highly potent (OEB4+) capsules, modified release and coated capsules, and capsules filled with tablets, granules or pellets.

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AbbVie Contract Manufacturing

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CONTRACT MANUFACTURING FOR CAPSULES

AbbVie is a leading pharmaceutical developer and manufacturer that offers manufacturing of various oral solid dosage forms, such as granule-filled, liquid-filled (hard gelatin) and mini-tab-filled capsules.

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Biophore India Pharmaceuticals Pvt Ltd

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Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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CAPSULE CONTRACT MANUFACTURING

Biophore offers contract manufacturing for oral solid dosage forms, such as capsules and tablets.

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LGM Pharma

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CAPSULE CONTRACT MANUFACTURING

LGM Pharma, with an annual production capacity of 275 million solid doses, is an established CDMO partner for orally ingested therapeutics. It offers the manufacturing of different types of oral solids like capsules, tablets, beads, powders & granules.

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Athena Pharmaceutiques

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CONTRACT MANUFACTURING FOR CAPSULES

For over 12 years, Athena has been the partner of choice in the manufacturing of various dosage forms, such as capsules, pellets in capsules, enteric coated capsules, modified and immediate release capsules.

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Bora Pharmaceuticals

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CAPSULE CONTRACT MANUFACTURING

Bora provides customized cGMP manufacturing and packaging services for a broad range of OSD capsules and tablets, from routine to high-potency and complex OSDs in various scales, while maintaining the highest product quality.

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Fermion Oy

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CYTOTOXIC CAPSULE MANUFACTURING SERVICES

Fermion, through its mother company Orion, offers contract manufacturing services for capsules and tablets with expertise in highly potent, high-quality cytotoxics manufacturing.

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Temad Co

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CAPSULE MANUFACTURING

Temad offers the production of finished dosage products including various kinds of capsules & tablets from 2017 to achieve the most narcotics & non-narcotics market share in order to supply to domestic pharmaceutical companies and to the Middle East.

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Famar

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Virtual BoothFAMAR CDMO- From early development to commercial manufacturing.

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HARD GELATIN CAPSULE MANUFACTURING

Famar has expertise with hard gelatin capsules and the technology to cover all capsule sizes based on its customers' needs, with capabilities for extrusion or spheronization, powder, granules, pellets and micro-tab filling.

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