BLOG
MARKET INTEL by PharmaCompass
CONTENT by Suppliers
- Interview #SpeakPharma
- Video #SupplierSpotlight
- Vlog #PharmaReel
- Company Bio #AboutSupplier
- Service Bio #AboutCapabilities
News
Create content with us, ask us
- AEROSOL
- BIOLOGIC DRUGS
- CAPSULE
- CREAM / LOTION / OINTMENT
- ELIXIR
- EMULSION
- FILM
- GEL
- GRANULE / PELLET
- DIETARY SUPPLEMENT (NUTRACEUTICAL)
- INJECTABLE / PARENTERAL
- LIPOSOME / MICROSPHERE / NANOPARTICLE
- LIQUID
- MEDICAL DEVICE
- PASTE
- PATCH
- PESSARY
- POWDER
- SOFTGEL CAPSULE
- SOLUTION
- SPRAY
- SUPPOSITORY
- SUSPENSION
- SYRUP
- TABLET
- VETERINARY
- NASAL
- TROCHE & LOZENGE
- LYOPHILIZATION
- DENTAL
- RAW MATERIALS
- TECHNOLOGIES
- EQUIPMENT
- COMPOUNDING
01 Oral
02 Oral
03 Overview
04 Overview
05 Overview
06 Overview
07 Overview
08 Overview
09 Overview
01 Accuwell Medics
02 Athens Life Science
03 Bahrain Pharma
04 Basic Pharma
05 Biological E
06 Bliss Gvs Pharma Ltd
07 Bora Pharmaceuticals
08 Curtis Health Caps
09 DPT Laboratories, Ltd
10 Delpharm Group
11 Famar
12 Flagship Biotech International Pvt. Ltd
13 Fulton Medicinali S.p.A
14 Gracure Pharmaceuticals Limited
15 Grunenthal
16 Humanis
17 JGL d.d
18 Jubilant HollisterStier
19 LGM Pharma
20 Lecifarma
21 Legacy Pharmaceuticals Switzerland
22 Madras Pharmaceuticals
23 ORIT LABS LLC
24 Omni Protech Drugs
25 One Pharma
26 PENMIX LTD.
27 Pierre Fabre
28 Priyans Drugs
29 Renejix
30 Saneca Pharmaceuticals
31 Servier
32 Sofarimex
33 Softigel Procaps
34 Specpharm
35 Temad Co
36 US Pharma
01 Bahrain
02 Colombia
03 Croatia
04 France
05 Germany
06 Greece
07 Greece
08 India
09 Iran
10 Italy
11 Netherlands
12 Poland
13 Portugal
14 Singapore
15 Slovakia
16 South Africa
17 South Korea
18 Switzerland
19 Taiwan
20 Turkey
21 U.S.A
22 U.S.A
23 U.S.A
- Analytical > Analytical Method Development
- Analytical > Analytical Testing Services > Inhalation Products
- Analytical > BioAnalytical Services
- API & Drug Product Development > API Development
- API & Drug Product Development > API Development > Antibody Drug Conjugate
- API & Drug Product Development > API Development > Fine Chemical / Intermediate
- API & Drug Product Development > API Development > High Potency APIs (HPAPIs)
- API & Drug Product Development > API Development > Impurity / Reference Standard
- API & Drug Product Development > API Development > Oligosaccharides & Polysaccharides
- API & Drug Product Development > API Development > Overview
- API & Drug Product Development > API Development > Process Development & Optimization
- API & Drug Product Development > API Development > Protein / Peptide
- API & Drug Product Development > API Development > Separation & Purification
- API & Drug Product Development > API Development > Small Molecules
- API & Drug Product Development > API Development > Spray Drying
- API & Drug Product Development > Formulation Development
- API & Drug Product Development > Formulation Development > Buccal / Orodispersible
- API & Drug Product Development > Formulation Development > Capsule
- API & Drug Product Development > Formulation Development > Chewable / Suckable
- API & Drug Product Development > Formulation Development > Clinical Supply
- API & Drug Product Development > Formulation Development > Compounding
- API & Drug Product Development > Formulation Development > Controlled / Immediate / Modified Release
- API & Drug Product Development > Formulation Development > Controlled Substance
- API & Drug Product Development > Formulation Development > Granule / Pellets
- API & Drug Product Development > Formulation Development > Inhalation / Nasal
- API & Drug Product Development > Formulation Development > Injectable / Parenteral
- API & Drug Product Development > Formulation Development > Liquid Formulation
- API & Drug Product Development > Formulation Development > Lyophilization
- API & Drug Product Development > Formulation Development > Ophthalmic
- API & Drug Product Development > Formulation Development > Pediatric Formulation
- API & Drug Product Development > Formulation Development > Scale-Up Capabilities
- API & Drug Product Development > Formulation Development > Sterile Liquid Formulation
- API & Drug Product Development > Formulation Development > Suspension
- API & Drug Product Development > Formulation Development > Tablet
- API & Drug Product Development > Formulation Development > Topical
- API & Drug Product Development > Preformulation & Material Science > Particle Size Reduction & Micronization
- API & Drug Product Development > Preformulation & Material Science > Polymorph & Crystal Screening
- API & Drug Product Development > Preformulation & Material Science > Solubility Assessment & Enhancement
- API & Drug Product Development > Preformulation & Material Science > Taste Masking
- API Manufacturing > Antibiotic
- API Manufacturing > Antibody Drug Conjugate
- API Manufacturing > Biologics, Bioprocess & Fermentation
- API Manufacturing > Chiral Synthesis
- API Manufacturing > Clinical Supply
- API Manufacturing > Continuous Flow Process
- API Manufacturing > Contract Manufacturing
- API Manufacturing > Controlled Substance
- API Manufacturing > Custom Synthesis & Manufacturing
- API Manufacturing > Cytotoxic Compound
- API Manufacturing > Drying > Spray Drying
- API Manufacturing > Fine Chemical / Intermediate
- API Manufacturing > GMP Manufacturing
- API Manufacturing > Hazardous Chemistry
- API Manufacturing > High Potency APIs (HPAPIs)
- API Manufacturing > Micronization
- API Manufacturing > Oligosaccharides & Polysaccharides
- API Manufacturing > Organometallic Chemistry
- API Manufacturing > Organometallic Chemistry > Cyanation
- API Manufacturing > Organometallic Chemistry > Metal Hydride Reduction
- API Manufacturing > Ozonolysis
- API Manufacturing > Process Development & Optimization
- API Manufacturing > Protein / Peptide > Synthesis
- API Manufacturing > Reference Standard
- API Manufacturing > Scale Up
- API Manufacturing > Separation & Purification
- API Manufacturing > Small Molecules
- Clinical Trials > Packaging & Logistics
- Clinical Trials > Medical Writing & Language Translation
- Clinical Trials > Patient / Investigator Recruitment
- Clinical Trials > Technology / Data / Analytics
- Drug Product Manufacturing > Biologic Drugs
- Drug Product Manufacturing > Capsule
- Drug Product Manufacturing > Capsule > Steroid / Hormone
- Drug Product Manufacturing > Compounding
- Drug Product Manufacturing > Cream / Lotion / Ointment
- Drug Product Manufacturing > Emulsion > Overview
- Drug Product Manufacturing > Gel > Overview
- Drug Product Manufacturing > Granule / Pellet
- Drug Product Manufacturing > Injectable / Parenteral
- Drug Product Manufacturing > Injectable / Parenteral > Overview
- Drug Product Manufacturing > Injectable / Parenteral > Pre-Filled Syringe
- Drug Product Manufacturing > Liquid
- Drug Product Manufacturing > Lyophilization
- Drug Product Manufacturing > Nasal
- Drug Product Manufacturing > Softgel Capsule
- Drug Product Manufacturing > Solution > Overview
- Drug Product Manufacturing > Spray
- Drug Product Manufacturing > Suppository
- Drug Product Manufacturing > Suspension > Overview
- Drug Product Manufacturing > Syrup
- Drug Product Manufacturing > Tablet
- Drug Product Manufacturing > Technologies
- Drug Product Manufacturing > Technologies > Orally Disintegrating Tablets (ODTs)
- Drug Product Manufacturing > Technologies > Taste Masking
- Packaging > Clinical Services
- Packaging > Contract Services
- Packaging > Contract Services > Serialization Compliance
- Packaging > Logistic Services
- Empty Capsules
- Empty Capsules > Clinical Supply
- Empty Capsules > HardGel
- Empty Capsules > Inhalation
- Emulsifying Agents
- Soft Gelatin
- Solubilizers
Looking for syrup drug products? Find a CMO offering oral liquids, such as syrup, oral suspension & other pharmaceutical formulations on PharmaCompass.
Q1. What are syrups and what are the different types?
Syrup is a concentrated or nearly saturated solution of sucrose or sugar substitute in water with or without flavoring agents and medicinal substances. The concentration of sugar in syrup is 66.7 % w/w. Syrup, also includes any other liquid dosage form prepared in a sweet and viscid vehicle, including oral suspensions. Syrups may be medicated or non-medicated (flavoured syrups). The non-medicated syrup is intended as a vehicle or flavor in pharmaceutical preparations.
For providing temporary relief to patients in case of sneezing, coughs, runny noses which are commonly caused by cold, high fever, or allergies, cough syrups are used from ancient times. Moreover, the rising geriatric population, which is more susceptible to such ailments, is providing a thrust to market growth. Some of the leading syrups manufacturers or syrups contract manufacturers offering pharmaceutical contract manufacturing services for dry and liquid syrups and other liquid orals for commercial purposes are explored ahead.
There are various types of syrups which are noted below:
Simple Syrup - When purified water alone is used in making the solution of sucrose, the preparation is known as syrup, or simple syrup. Hence, these are sugar-based syrup, which are concentrated solutions of sucrose.
Artificial Syrup: These syrups are formulated with artificial sweetening agents and viscosity builders. These are also called flavored syrups. These syrups contain pleasantly flavored substances but not medicinal substances, hence called non-medicated syrups or flavored syrups e.g. cherry, acacia, and raspberry syrup. It is intended as a vehicle or flavor for preparations.
Medicated Syrup - Pharmaceutical syrups contain an active pharmaceutical ingredient (API) known as medicated syrup, e.g. cough syrup. In these syrups, there are always therapeutic compounds added (e.g. guaifenesin syrup).
There are two types of medicinal syrup. One is made from extractive drugs where fluid extract of the respective medicines is mixed with the syrup and the other is made up of chemicals which can be either a simple solution or a chemical reaction used to modify the taste of medicinal agents.
Classification of pharmaceutical syrups based on their basic formula:
Sugar-Based Syrups – Although there are many different sugars, but sucrose and dextrose are widely used in the preparation of syrup.
Sugar-Free Syrups - These syrups contain artificial sweeteners. These are intended as a substitute for sugar-based syrups and are intended to be administered to persons who must regulate their sugar and calorie intake.
Q2. What are the benefits of pharmaceutical syrups over other dosage forms?
There are various benefits of pharmaceutical syrups over other dosage forms which are mentioned below:
- Pharmaceutical syrups are appropriate for any patient, whatever the age is.
- Syrups are better for patients who have trouble swallowing.
- No nursing is required for the administration of pharmaceutical syrups, which means the patient can take it with no help.
- They are attractive in appearance and give beneficial psychological effects.
- Syrup dosage form is preferred for certain types of products like cough medicines.
- Drugs with bitter and unpleasant taste can be given in sweetened, coloured and flavored vehicles.
- It is the best choice for geriatric and pediatric patients.
- Syrup retards oxidation because it partly hydrolyzes into dextrose and levulose (reducing sugary). Hence it prevents decomposition of many substances and no preservative is needed against the growth of micro-organisms such as bacteria, molds, fungi, etc.
- Syrups come in tamper-proof packaging to prevent spillage and damage during transit.
Pharmaceutical contract manufacturers that may have experience and expertise in oral pharmaceutical formulation development and manufacturing may offer pharmaceutical syrup contract manufacturing services along with services for liquid orals such as solution, oral suspension, elixirs, etc. from development to commercialization.
Q3. What are the key ingredients of pharmaceutical syrup formulations and what are the different steps involved in the manufacturing of syrups?
When developing and manufacturing pharmaceutical syrups, consideration is first given to the characteristics of the active pharmaceutical ingredient. Most pharmaceutical syrups contain the following components in addition to purified water and active pharmaceutical ingredient(s).
Sugar - Usually sucrose and other substitutes are added for sweetness and viscosity. There are various sugar-free alternatives available such as sorbitol, saccharine, aspartame, etc. Sucrose is one of the purest commercially available substances and is the preferred carbohydrate in the manufacturing of pharmaceutical syrup because of purity, degree of sweetness, lack of color and ease of handling.
Antimicrobial Preservatives - Syrup, USP is protected from bacterial contamination by virtue of its high solute concentration. But more dilute syrups are good media for microbial growth and hence require the addition of preservatives. Among the anti-microbial preservatives the most commonly used in syrups with the usually effective concentrations are benzoic acid 0.1-0.2%, sodium benzoate 0.1-0.2% and various combinations of methylparabens, propylparabens and butyl parabens, etc.
Flavors and Colorants - Flavours used in the syrup formulation must be non-toxic, soluble and compatible with the preparation.
Miscellaneous Agents - Syrups may also contain special solvents (including alcohol) solubilizing agents, thickening agents and stabilizers. A thickening agent or thickener is a substance which can increase the viscosity of the diluted syrups without substantially changing its other properties.Tween 20 emerges as solubilizer of choice for certain syrups.
There are various methods for the formulation of pharmaceutical syrups. Based on the physical and chemical properties of the active pharmaceutical ingredients (APIs), the choice of the method is selected.
Pharmaceutical syrups are produced by mixing purified water, sweeteners, active pharmaceutical
ingredients (API), aromas, flavours and other ingredients (thickeners, solubilizers). Traditional
cough syrups are formulated around a pharmaceutical syrup at 60-75% concentration which is made from sucrose, maltodextrin, glucose, invert syrup, etc.
The manufacturing process of syrups must achieve several functions:
- Dissolving of the sugars (sucrose, glucose, maltodextrin,sorbitol) in the appropriate solvent.
- Hydration of the powdered ingredients.
- Blending ingredients of widely different viscosity. Preparations should be heated before finishing the addition of components.
- Solid products are added by means of solid-liquid blenders or vacuum systems.
- Dissolving active pharmaceutical ingredients (APIs) with the help of solubilizing agents and solvents. A high shear mixer is used for mixing.
- When the process is finished, the end product is filtered (if required) and sent to the storage tanks. The end product must be smooth, agglomerate-free and homogeneous.
- The product is transferred from the storage tanks to the filling machines by pumps and finally packed into the bottles. All the manufacturing equipment should comply with the GMP standards.
There are a number of syrup pharmaceutical manufacturers which can offer contract manufacturing services for medicated and flavoured syrups. These liquid oral dosage forms can be outsourced from CDMOs offering pharmaceutical contract manufacturing services for oral solids and oral liquids such as oral suspension, syrup, solutions, elixirs, etc.
Q4. Which are the leading companies offering pharmaceutical syrup contract manufacturing services?
Various pharmaceutical organizations, such as a contract development and manufacturing organization (CDMO) and contract manufacturing organization (CMOs), pharmaceutical contract manufacturers can offer end-to-end pharmaceutical formulation development and manufacturing services for oral liquids, including syrup, suspension, solutions, elixirs, etc.
Some of the top syrups contract manufacturers offering dry and liquid syrups for clinical and commercial purposes are mentioned below.
Polpharma- Pharmaceutical Syrup Contract Manufacturing Services
Polpharma offers customized contract manufacturing of various liquid dosage forms such as oral liquids, syrups, suspensions and solutions. Its pharmaceutical plant at SANTO has a complete modern production cycle of oral solid dosage forms (capsules, granules, sachets), oral liquids (syrups), solutions for internal and external use, etc.
Temad Co- Third Party Contract Manufacturing for Pharmaceutical Syrups
Temad deals in the production of finished dosage products including various kinds of syrups, tablets and capsules. It is one of the top syrup pharmaceutical manufacturers and with a production line for oral solutions (syrup) which is licensed to produce methadone syrups, opium and guaicodin in its product line.
Madras Pharmaceuticals -Pharmaceutical Contract Manufacturing Services
Madras Pharma offers pharmaceutical contract manufacturing for syrups and has capabilities to offer liquid orals, including oral suspension, solution and micro-emulsion, external semi-solids (cream, gel, ointment, lotions), medicated dusting powders and lyophilised injections, etc. It is one of the leading syrups contract manufacturers with seven state-of-the-art world-class manufacturing facilities equipped with ultramodern plants and machineries for manufacturing of a wide variety of formulations.
Grunenthal- Pharmaceutical Third Party Manufacturing Services
Grunenthal is one of the leading syrups manufacturers that offers pharmaceutical third party manufacturing services for semi-solid and liquid pharmaceutical forms, including, creams, ointments, gels, lotions, sterile ampoules, syrups, suspensions, etc. It is one of the leading pharmaceutical contract manufacturers and their Latin American site is the primary manufacturing site for supply of solid, semi-solid and liquid products.
Pierre Fabre- Third Party Contract Manufacturing for Pharmaceutical Syrups
Pierre Fabre CDMO is among the leading syrup pharmaceutical manufacturers that offers complete services, from pharmaceutical formulation to commercial manufacturing for non-sterile liquids (syrups and sprays) and paste forms (creams, ointments, gels), etc. The Pierre Fabre group offers pharmaceutical and non-pharmaceutical subcontracting activities (CDMO) which combine a high level of quality, skill and performance.
Fareva- Third Party Contract Manufacturing
Fareva offers pharmaceutical third party manufacturing services for syrups, injectables, creams, ointments, granules, capsules, gels, suppositories, etc. It is one of the leading syrups manufacturers which offers various other pharmaceutical forms, including suspensions, emulsions, powders, lyophilised products, syringes (PFS), etc.
01
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
02
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
03
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
04
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
05
Pharma Service : Drug Product Manufacturing
06
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
07
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
08
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
09
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
10
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
11
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
12
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
13
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
14
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
15
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
16
Pharma Service : Drug Product Manufacturing
17
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
18
Pharma Service : Drug Product Manufacturing
19
Pharma Service : Drug Product Manufacturing
20
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
21
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
22
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
23
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
24
Pharma Service : Drug Product Manufacturing
25
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
26
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
27
Pharma Service : Drug Product Manufacturing
28
Pharma Service : Drug Product Manufacturing
29
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
30
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
31
Pharma Service : Drug Product Manufacturing
32
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
33
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
34
Pharma Service : Drug Product Manufacturing
35
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
36
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
37
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
38
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
39
Pharma Service : Drug Product Manufacturing
Pharma Service : Drug Product Manufacturing
- Privacy policy
- Terms and conditions
- Disclaimers
-
LOOKING FOR A SUPPLIER?
Latest Content by PharmaCompass
Our BLOG!