Overview of drug solubilizer excipients, emulsifiers & lipid based vehicles, like vitamin E TPGS, used in topical & oral pharmaceutical formulations.
Q1. What are pharmaceutical solubilizing agents?
Solubilizer agents, such as surfactants, are solubilizer excipients added to pharmaceutical formulations in order to increase the solubility of poorly soluble drugs, thereby increasing the bioavailability of the corresponding active pharmaceutical ingredient (API). Solubility is defined as the extent to which a given solute can dissolve in a pharmaceutical solvent, to form a saturated, homogeneous solution at a fixed temperature.
The solubility of poorly water-soluble drugs is way below the desired threshold, which lowers their absorption in the gastrointestinal tract. Furthermore, poorly water soluble drugs have reduced drug efficiencies as compared to pharmaceutical formulations with appropriate solubility profiles and may cause undesirable side effects upon administration.
Drug formulators are trying to better understand the mechanism of action of poorly soluble drugs, both before and after the active pharmaceutical ingredient (API) is released from the dosage form to cope with these issues. However, studying the transformation of such formulations in a complex gastrointestinal environment is riddled with challenges.
The method to increase the solubility of poorly water soluble drugs in pharmaceutical solvents is known as solubilization. Solubilization is the process that enables solubility enhancement of poorly soluble drugs by preparing isotropic, thermodynamically stable solutions via the addition of solubilizer excipients (also called solubilizing agents) to solutions. Solubilization progresses in the following step:
Step 1: Breaking interionic or intermolecular bonds of solutes. Step 2: Separation of pharmaceutical solvents into freed up spaces to accommodate solutes. Step 3: Interactions between pharmaceutical solvents and solutes (ions or molecules).
Methods of solubility enhancement employed in the pharmaceutical industry include:
- Addition of co-solvents
- pH/temperature modifications
- Particle size reduction
- Addition of surfactants
- Complexation
- Solid dispersion techniques
- Solid state manipulations
- Pharmaceutical solvent deposition
- And various other processes.
Commonly used solubilizer agents for oral dosage forms and paediatric pharmaceutical formulations are listed below:
- Alcohols such as ethanol
- Sugars such as sorbitol
- Polyethylene glycols such as PEG-400
- Propylene glycol
- Cyclodextrins
- Sodium Lauryl Sulphates
- And copious other solubilizer agents.
Q2. What is the role of solubilizers in pharmaceutical drug delivery?
Oral ingestion is the most convenient route of drug delivery and oral dosage forms are the most commonly employed pharmaceutical formulations due to ease of administration, high patient compliance, flexibility in the design of dosage forms, and cost effectiveness. However, the major challenge with the design of oral dosage forms lies within their poor bioavailability.
Oral bioavailability depends on several factors including aqueous solubility, drug permeability, dissolution rate, presystemic metabolism, and susceptibility to efflux mechanisms. The low solubility and dissolution rate of poorly water soluble drugs in aqueous gastrointestinal fluids often result in insufficient bioavailability of the corresponding APIs.
An insufficient solubility profile is one of the key factors responsible for reduced API (active pharmaceutical ingredient) bioavailability. Solubilizers or solubilizing agents enhance the bioavailability of oral dosage forms by increasing the solubility of poorly soluble drugs. These surface-active properties of solubilizing agents triggered the interest of drug formulation developers before it ultimately became a fixture in the toolbox of pharmaceutical drug delivery innovators.
Some commonly used solubilizer agents for pharmaceutical dosage forms are ethanol, sorbitol, polyethylene glycols, cyclodextrins, sodium lauryl sulphates, polysorbates , propylene glycol, etc. Furthermore, solubilizer excipients and co-solvents play a major role for the bioavailability enhancement of other dosage forms like parenteral formulations.
Solubilizing agents may also act as emulsifiers or emulsifying agents in the formulation of emulsion and self emulsifying drug delivery systems (SEEDS). Emulsifiers are used in pharmaceutical formulations to get stable emulsions to achieve the physico-chemical characteristics required for optimal delivery of API and absorption enhancement. Solubilizers such as polysorbates are used to solubilize oils in water and can be used in various topical formulations such as sprays, emulsion, creams, lotions, etc.
Q3. How are solubilizing agents classified?
Solubilizer excipients or solubilizing agents used in oral formulations are classified into the following types, explored below.
1. Water Soluble Organic Lipids
- E.g. Propylene glycol, glycerin, ethanol, etc.
Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly soluble drugs. Lipids act as vehicles for drug delivery and are combined with one or more surfactants and hydrophilic co-solvents to achieve solubility enhancement.
2. Non-ionic Surfactants
- E.g. Sorbitan monooleate, vitamin E TPGS (tocophersolan), etc.
Non-ionic surfactants are very useful as absorption enhancers as they improve the dissolution rate and permeability of drugs. Surfactants reduce surface tension and form colloidal aggregates called micelles; solubility increases as concentration of micelles (CMC) increases.
3. Water-insoluble Lipids
- E.g. Olive oil, peppermint oil, castor oil, etc.
Water insoluble lipids are insoluble in polar pharmaceutical solvents like water but highly soluble in the non-polar or weakly polar organic solvents, including ether, chloroform, benzene, and acetone. Water insoluble lipids, thus increase absorption and achieve solubility enhancement in non-polar pharmaceutical solvents also known as fat solvents.
4. Organic Liquids/Semi-solids
- E.g. Beeswax, d-alpha-tocopherol, etc.
Organic liquids and semi-solids are solubilizing agents or vehicles used to enhance the solubility of solids in the gastrointestinal tract. These lipid based drug delivery vehicles are employed in solid dispersion and solid state manipulation techniques of solubility enhancement.
5. Cyclodextrins
- E.g. alpha-cyclodextrin, beta-cyclodextrin, etc.
Cyclodextrins are used as solubilizing agents or complexing agents to increase the solubility, and consequently the stability, of poorly soluble drugs in aqueous solutions. They further reduce side effects and irritation in gastrointestinal systems, achieve odor and taste-masking, prevent drug drug or drug additive interactions, etc.
6. Phospholipids
- E.g. Hydrogenated soy phosphatidylcholine, l-alpha-dimyristoyl phosphatidylglycerol, etc.
Phospholipids are solubilizer agents/vehicles that are used in complexation techniques of solubilization. Drug-phospholipid complexes are considered ideal for oral delivery as they are biodegradable and non-toxic, which enable them to be employed as solubilizer excipients, emulsifying agents, and as matrix forming pharmaceutical excipients that increase the permeability and solubility of poorly water soluble drugs.
Q4. How do solubilizer excipients facilitate solubility enhancement and emulsion formulation?
Solubilization enhancement is used in pharmaceutical drug delivery to increase the solubility, defined as the maximum concentration of solute that can be dissolved in a given amount of solvent, of formulations. It is achieved by manipulating factors that affect solubilization such as temperature, pressure, and particle size or by using solubilizer excipients (solubilizer agents).
- Temperature: Generally an increase in temperature results in an increase in the solubility of oral formulations. However, the opposite can also be true in case of gaseous formulations.
- Endothermic Processes: Solubility increases as temperature increases.
- Exothermic Processes: Solubility increases as temperature decreases (for gaseous pharmaceutical formulations)
- Pressure: While changes in pressure have minimal or no effect on the solubility of solids and liquids, an increase in the pressure of gaseous solutes can facilitate solubility enhancement.
- Particle Size: Solubility increases as particle size decreases which leads to an increase in surface energy, however, there has to be a substantial reduction in size (<1 micrometer) for solubility enhancement to occur. Particle size reduction is usually achieved via micronization and nanoization technologies.
Poorly water soluble drug formulations are a major issue for the pharmaceutical industry. For solubility enhancement, there are various solubilizer excipients such as surfactants, lipids, cyclodextrins, etc. which can increase the bioavailability of active pharmaceutical ingredients (APIs) by increasing their solubility. Advanced solubility enhancing pharmaceutical excipients can accelerate the time it takes to bring pharmaceutical formulations to market. In aqueous-based solutions, solubilizers are used to modify the polarity of water to allow an increase in the solubility of a nonpolar drug.
In addition to solubility enhancement, some solubilizer excipients (for e.g. vitamin E TPGS/Tocophersolan) may also function as emulsifiers by enabling the formation of emulsion formulations. Emulsifying agents are soluble in both oil and water as one end of the molecule is attracted to water (hydrophilic) and the other end is attracted to fats/oils (lipophilic).
When a solubilizer is added to an oil and water product, one end of the molecule dissolves in water and the other dissolves in oil to form emulsion formulations, forcing these molecules to be near each other without separating, thereby acting as an emulsifier or an emulsifying agent . This push and pull of emulsifiers in oil and water keeps different substances suspended in a solution.
Surface active agents or emulsifying agents are added to emulsions to stabilize the dispersed and continuous phase by increasing the electrostatic repulsion or steric repulsion between them. Emulsifiers thus act on the interface and increase the kinetic stability of emulsions so that the size of the droplets do not change significantly with time.
Emulsion formulation is an essential process and is applied in the food industry to make butter, margarine, mayonnaise, etc. Many cosmetic and pharmaceutical dosage forms come in emulsion preparations, and chemical synthesis of glues, paints, and other polymer dispersions also utilizes emulsion formulation.
Q5. What are the different types of pharmaceutical solubilizers available in the market?
Poorly soluble drugs are a major issue for the pharmaceutical industry. By using solubility enhancement excipients pharmaceutical formulators can increase the bioavailability of active pharmaceutical ingredients (API). Advanced solubility enhancement excipients can help companies bring products to market faster.
There are various pharmaceutical companies that offer solubilizer excipients, including, but not limited to:
- PMC Isochem
(E.g. Vitamin E TPGS)
PMC Isochem offers Vitamin E TPGS or Tocophersolan, a water soluble derivative of natural Vitamin E, which is a multirole pharmaceutical excipient that functions as a solubilizer, plasticizer, vehicle for lipid based pharmaceutical formulations, binder, and as an emulsifier. Tocophersolan (Vitamin E-TPGS) has been approved by the FDA as a safe adjuvant and subsequently has been widely used in drug delivery systems.
- Gattefossé
(E.g. CapryolTM 90, Gelucire® 44/14, Labrasol® ALF, Labrasol®, etc.)
Gattefossé is a leading provider of lipid excipients and formulation solutions to healthcare industries worldwide. Their functional solubilizer excipients are designed to meet the most pressing formulation challenges in drug development; Poor solubility, permeability, and bioavailability, with lipid-based drug delivery systems consisting of single or multiple excipients.
- BASF North America
(E.g. Kolliphor EL, Kollidon VA 64, Soluplus, Kolliphor RH40, Kolliphor ELP, Kollisolv P 124, etc.)
Solubilization is an essential process that ideally results in crystal clear systems. The major challenge it poses is matching the lipophilic substance and the medium with the solubilizer. BASF’s comprehensive solubilizer portfolio allows customers to solubilize a wide range of lipophilic substances in different media, including water, alcohol and surfactant systems.
- ABITEC
(E.g. Captex 350 Glycerol Tricaprylate/Caprate/Laurate, Captex 200P, Caprol Polyglycerol Esters, etc.)
ABITEC develops and manufactures lipid-based excipients to enhance the bioavailability of poorly water-soluble and poorly permeable Active Pharmaceutical Ingredients (APIs) for the pharmaceutical industry.
- Roquette Pharma
(E.g. CRYSMEB, Glucono-Delta-Lactone, KLEPTOSE® 10, CLEARGUM® CO A1, etc.)
For several decades, formulators have trusted Roquette to help them overcome the challenge of API insolubility. Roquette offers versatile solubility enhancers that adapt to the demands of a formulations’ characteristics. Engineered to deliver functional reliability, their solutions deliver repeatable dissolution profiles batch after batch. No matter the drug characteristics or process strategy, they provide a range of products suited to enhance API solubility in oral dosage forms.
- SPI pharma
(E.g. Advantose 100)
SPI Pharma produces Advantose 100 solubilizer excipients. Advantose® 100 is a spray-dried maltose powder that provides excellent flow, solubility, & tableting properties for oral dosage formulations. Maltose is well known for its safety & mouthfeel qualities, especially in chewable tablets & lozenges. It is often used to achieve taste masking for tablets with undesirable taste profiles.
All Suppliers
01
PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.
Dosage Form : Capsule, Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution, Nasal Solution, Tablet
Grade : Oral, Parenteral, Nasal, Ophthalmic, Topical
Brand Name : ISODEL® Vitamin E TPGS (To...
Application : Solubilizers
Excipient Details : Vitamin E TPGS (Tocophersolan) is used as a solubilizer, emulsifying agent, plasticizer, stabilizer, and vehicle for lipid-based formulations.
Pharmacopoeia Ref : USP 40 – NF 35
Technical Specs : Specific Gravity: 1.06 at 50°C to 1.03 at 90°C; Solubility In Water: -20% at 20°C; Viscosity: 390cP at 50°C; Available in mol. wt. of 1500 g/mol, 200 g/mol, 2000 g/mol, 300 g/mol, 400 g/mol, 4000 g/mol.
Ingredient(s) : Tocophersolan
Dosage Form : Capsule, Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution, Nasal Solution, Tablet
Grade : Oral, Parenteral, Nasal, Ophthalmic, Topical
PMC Isochem is your partner for smart CDMOs of Intermediates, APIs, & excipients & a catalog of Intermediates & Generic APIs.
Ingredient(s) : Tocophersolan
Dosage Form : Capsule, Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution, Nasal Solution, Tablet
Category : Solubilizers
Brand : ISODEL® VITAMIN E TPGS (TOCOPHERSOLAN)
Pharmacopoeia Ref : USP 40 – NF 35
Technical Specs : Specific Gravity: 1.06 at 50°C to 1.03 at 90°C; Solubility In Water: -20% at 20°C; Viscosity: 390cP at 50°C; Available in mol. wt. of 1500 g/mol, 200 g/mol, 2000 g/mol, 300 g/mol, 400 g/mol, 4000 g/mol.
Grade : Oral, Parenteral, Nasal, Ophthalmic, Topical
02
Gangwal Healthcare is powered by innovation, driving health, wellness & healing.
Dosage Form : Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution, Tablet
Grade : Oral, Parenteral, Topical, Ophthalmic
Application : Solubilizers
Excipient Details : Complexol-HP (HP-beta-CD) is a water-soluble derivative of beta cyclodextrin, used as a solubilizer & complexing agent in pharmaceutical formulations.
Pharmacopoeia Ref : USP-NF, BP, IP, EP, DMF, EXCiP...
Technical Specs : NA
Ingredient(s) : Hydroxypropyl Betacyclodextrin
Dosage Form : Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution, Tablet
Grade : Oral, Parenteral, Topical, Ophthalmic
Gangwal Healthcare is powered by innovation, driving health, wellness & healing.
Ingredient(s) : Hydroxypropyl Betacyclodextrin
Dosage Form : Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution, Tablet
Category : Solubilizers
Brand : COMPLEXOL-HP®
Pharmacopoeia Ref : USP-NF, BP, IP, EP, DMF, EXCiPAT, KOSHER, HALAL, WHO-GMP
Technical Specs : NA
Grade : Oral, Parenteral, Topical, Ophthalmic
03
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Application : Solubilizers
Excipient Details : EUDRAGIT® L 100 (powder), a delayed release polymer is used to increase solubility of poorly soluble products such as tablets, capsules, ODTs, etc.
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : METHACRYLIC ACID COPOLYMER TYPE A
Category : Solubilizers
Brand : EUDRAGIT® L 100
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
04
SPI Pharma has been solving formulation challenges using superior functional materials.
Dosage Form : Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : Advantose® 100 is a spray-dried maltose powder used for direct compression, excellent solubility & tableting properties in chewables & lozenges.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Maltose Sugar
Dosage Form : Tablet
Grade : Oral
SPI Pharma has been solving formulation challenges using superior functional materials.
Brand : ADVANTOSE 100
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
05
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Solution
Grade : Oral
Brand Name : CAVAMAX® W7 PHARMA
Application : Solubilizers
Excipient Details : Cavamax W7 Pharma is used as a solubilizer in pharmaceutical liquid dosage forms such as solutions.
Pharmacopoeia Ref : GRAS certificate, GMP
Technical Specs : N/A
Ingredient(s) : Beta Cyclodextrin
Dosage Form : Solution
Grade : Oral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Brand : CAVAMAX® W7 PHARMA
Applications : Cavamax W7 Pharma is used as a solubilizer in pharmaceutical liquid dosage forms such as solutions.
Pharmacopoeia Ref : GRAS certificate, GMP
Technical Specs : N/A
Grade : Oral
06
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Solution
Grade : Oral
Brand Name : CAVAMAX® W8 PHARMA
Application : Solubilizers
Excipient Details : Cavamax W8 Pharma is used as a solubilizer in pharmaceutical liquid dosage forms such as solutions.
Pharmacopoeia Ref : GRAS certificate, GMP
Technical Specs : N/A
Ingredient(s) : Gamma Cyclodextrin Excipient
Dosage Form : Solution
Grade : Oral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Brand : CAVAMAX® W8 PHARMA
Applications : Cavamax W8 Pharma is used as a solubilizer in pharmaceutical liquid dosage forms such as solutions.
Pharmacopoeia Ref : GRAS certificate, GMP
Technical Specs : N/A
Grade : Oral
07
Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Application : Solubilizers
Excipient Details : NKY®-2P is used as a solubilizer in injectable liquid products and as high-concentration antibiotic solutions for veterinary parenteral formulations.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : 2-Pyrrolidone
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.
Brand : NKY®-2P
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Parenteral
08
ICE Pharma offers a unique range of bile acid products and best-in-class services for the pharmaceutical industry.
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Application : Solubilizers
Excipient Details : Glycocholic acid is the glycine conjugate of cholic acid and is used as an emulsifying agent and solubilizer in parenteral formulations.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Glycocholic Acid Excipient
Dosage Form : Injectable / Parenteral
Grade : Parenteral
ICE Pharma offers a unique range of bile acid products and best-in-class services for the pharmaceutical industry.
Ingredient(s) : Glycocholic Acid Excipient
Dosage Form : Injectable / Parenteral
Category : Solubilizers
Brand : GLYCOCHOLIC ACID
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Parenteral
09
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Parenteral, Oral, Topical
Application : Solubilizers
Excipient Details : Benzyl alcohol is used as a bacteriostatic & preservative in parenteral & ophthalmic products. It is widely used in oral & topical formulations.
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Ingredient(s) : Benzyl Alcohol
Dosage Form : Tablet
Grade : Parenteral, Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : BENZYL ALCOHOL
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Grade : Parenteral, Oral, Topical
10
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet
Grade : Parenteral, Oral, Topical
Application : Solubilizers
Excipient Details : Polysorbate 80 is used as a plasticizer, solubilizer, emulsifier, surfactant, and suspension stabilizer. It is also used in parenteral products.
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Ingredient(s) : Polysorbate 80
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet
Grade : Parenteral, Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Polysorbate 80
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet
Category : Solubilizers
Brand : POLYSORBATE 80
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Grade : Parenteral, Oral, Topical
11
Capital Farma, a leading European pharmaceutical company focusing on the development & distribution of niche APIs & Pharma Services.
Dosage Form : Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : Tartaric acid (Natural) is used to enhance the solubility of drugs with poor solubility, particularly in oral dosage forms.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Tartaric Acid
Dosage Form : Tablet
Grade : Oral
Capital Farma, a leading European pharmaceutical company focusing on the development & distribution of niche APIs & Pharma Services.
Brand : TARTARIC ACID
Applications : Tartaric acid (Natural) is used to enhance the solubility of drugs with poor solubility, particularly in oral dosage forms.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
12
SPI Pharma has been solving formulation challenges using superior functional materials.
Dosage Form : Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : Mannogem (mannitol powder) is an excellent excipient for use in wet granulation, lyophilization & improves solubility of poorly soluble APIs.
SPI Pharma has been solving formulation challenges using superior functional materials.
Brand : MANNOGEM POWDER
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
13
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Grade : Parenteral
Application : Solubilizers
Excipient Details : Dextran 40 is used as a solubilizer in parenteral formulations such as ophthalmic solutions and injections.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Ingredient(s) : Dextran 40 Excipient
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Grade : Parenteral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Ingredient(s) : Dextran 40 Excipient
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Category : Solubilizers
Brand : DEXTRAN 40
Applications : Dextran 40 is used as a solubilizer in parenteral formulations such as ophthalmic solutions and injections.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Grade : Parenteral
14
Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.
Dosage Form : Capsule, Suspension, Tablet
Grade : Oral (Pharma Grade)
Application : Solubilizers
Excipient Details : KoVidone® K12 is used as a solubilizer & anti-crystallization agent in liquid products & matrix for amorphous solid dispersion via hot melt extrusion.
Pharmacopoeia Ref : USP/NF, EP, JP, KP, IP, BP
Technical Specs : NA
Ingredient(s) : Polyvinylpyrrolidone K12
Dosage Form : Capsule, Suspension, Tablet
Grade : Oral (Pharma Grade)
Boai NKY Pharmaceuticals Ltd. is one of the largest global PVP suppliers.
Ingredient(s) : Polyvinylpyrrolidone K12
Dosage Form : Capsule, Suspension, Tablet
Category : Solubilizers
Brand : KOVIDONE® K12
Pharmacopoeia Ref : USP/NF, EP, JP, KP, IP, BP
Technical Specs : NA
Grade : Oral (Pharma Grade)
15
ICE Pharma offers a unique range of bile acid products and best-in-class services for the pharmaceutical industry.
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Brand Name : Sodium Deoxycholate
Application : Solubilizers
Excipient Details : Sodium Deoxycholate is used as a surfactant and emulsifier in emulsion and other dosage forms and is used to improve bioavailability.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Sodium Deoxycholate Excipient
Dosage Form : Injectable / Parenteral
Grade : Parenteral
ICE Pharma offers a unique range of bile acid products and best-in-class services for the pharmaceutical industry.
Ingredient(s) : Sodium Deoxycholate Excipient
Dosage Form : Injectable / Parenteral
Category : Solubilizers
Brand : SODIUM DEOXYCHOLATE
Applications : Sodium Deoxycholate is used as a surfactant and emulsifier in emulsion and other dosage forms and is used to improve bioavailability.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Parenteral
16
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Brand Name : Egg Yolk Lecithin
Application : Solubilizers
Excipient Details : Egg yolk lecithin is used as an emulsifier, solubilizer & liposome membrane material in fat emulsions, lipid microspheres, mixed micelles & liposomes.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Egg Yolk Lecithin
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : EGG YOLK LECITHIN
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Parenteral
17
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Granule / Pellet, Tablet
Grade : Oral
Brand Name : EUDRAGIT® L 100-55
Application : Solubilizers
Excipient Details : EUDRAGIT® L 100-55 (powder) is used in delayed release coatings to enhance solubility of poorly soluble drugs such as tablets, capsules & granules.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Methacrylic Acid - Ethyl Acrylate Copolymer
Dosage Form : Granule / Pellet, Tablet
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : Methacrylic Acid - Ethyl Acrylate Copolymer
Dosage Form : Granule / Pellet, Tablet
Category : Solubilizers
Brand : EUDRAGIT® L 100-55
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
18
SPI Pharma has been solving formulation challenges using superior functional materials.
Dosage Form : Capsule, Granule / Pellet, Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : TAP® pellets are spherical cores made of tartaric acid used for solubility enhancement of drugs exhibiting poor solubility in alkali environments.
Pharmacopoeia Ref : NA
Technical Specs : Bulk density: 0.8-1.1 g/ml
Ingredient(s) : Tartaric Acid
Dosage Form : Capsule, Granule / Pellet, Tablet
Grade : Oral
SPI Pharma has been solving formulation challenges using superior functional materials.
Ingredient(s) : Tartaric Acid
Dosage Form : Capsule, Granule / Pellet, Tablet
Category : Solubilizers
Brand : TAP®
Pharmacopoeia Ref : NA
Technical Specs : Bulk density: 0.8-1.1 g/ml
Grade : Oral
19
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Oral, Topical
Brand Name : Laurel Sorbitan (Span 20)
Application : Solubilizers
Excipient Details : Laurel sorbitan (Span 20) is used as stabilizer, emulsifier & solubilizer in oral & topical formulations such as tablets, creams, lotions, gels, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Laurel Sorbitan
Dosage Form : Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : LAUREL SORBITAN (SPAN 20)
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Oral, Topical
20
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Grade : Parenteral
Application : Solubilizers
Excipient Details : Dextran 5 is used as a solubilizer in parenteral formulations such as ophthalmic solutions and injections.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Ingredient(s) : Dextran 5 Excipient
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Grade : Parenteral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Ingredient(s) : Dextran 5 Excipient
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Category : Solubilizers
Brand : DEXTRAN 5
Applications : Dextran 5 is used as a solubilizer in parenteral formulations such as ophthalmic solutions and injections.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Grade : Parenteral
21
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Solution, Tablet
Grade : Parenteral, Oral, Topical
Application : Solubilizers
Excipient Details : Poloxamer 188 is used as a solubilizer, emulsifier, stabilizer in parenteral, OSDs & topical formulations such as creams, gels & lotions.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : Oxyethylene unit: 75%-85%, Oxypropylene unit: 25%-30%
Ingredient(s) : Poloxamer 188
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Solution, Tablet
Grade : Parenteral, Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Poloxamer 188
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Solution, Tablet
Category : Solubilizers
Brand : POLOXAMER 188
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : Oxyethylene unit: 75%-85%, Oxypropylene unit: 25%-30%
Grade : Parenteral, Oral, Topical
22
Gangwal Healthcare is powered by innovation, driving health, wellness & healing.
Application : Solubilizers
Excipient Details : Complexol-B (Beta Cyclodextrin) is used as a solubilizer, stabilizer and taste masking agent in tablets, syrups, capsules and lozenges.
Pharmacopoeia Ref : USP-NF, BP, IP, EP, DMF, EXCiP...
Technical Specs : NA
Ingredient(s) : Beta-Cyclodextrin
Gangwal Healthcare is powered by innovation, driving health, wellness & healing.
Brand : COMPLEXOL-B®
Applications : Complexol-B (Beta Cyclodextrin) is used as a solubilizer, stabilizer and taste masking agent in tablets, syrups, capsules and lozenges.
Pharmacopoeia Ref : USP-NF, BP, IP, EP, DMF, EXCiPAT, KOSHER, HALAL, WHO-GMP
Technical Specs : NA
Grade : Oral
23
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : EUDRAGIT® RL 100 (granules) is an excipient used as a solubilizer in combination with Eudragit® RS for creating sustained release drugs.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Ammonia Methacrylate Copolymer Type A
Dosage Form : Tablet
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Brand : EUDRAGIT® RL 100
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
24
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Injectable / Parenteral
Grade : Parenteral, Topical
Application : Solubilizers
Excipient Details : Sodium oleate is used as a solubilizer in parenteral dosage forms. It is also used as an emulsifier & as a plasticizer in softgel capsules.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Sodium Oleate
Dosage Form : Injectable / Parenteral
Grade : Parenteral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : SODIUM OLEATE
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Parenteral, Topical
25
Gangwal Healthcare is powered by innovation, driving health, wellness & healing.
Dosage Form : Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution
Grade : Oral, Ophthalmic, Injectable, Topical
Application : Solubilizers
Excipient Details : Tyloxapol is used as a solubilizing, emulsifying and stabilizing agent in nebulizers, eye drops, injectables, oral syrups and topical dosage forms.
Pharmacopoeia Ref : USP-NF, DMF, EXCiPAT, KOSHER, ...
Technical Specs : NA
Ingredient(s) : Tyloxapol
Dosage Form : Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution
Grade : Oral, Ophthalmic, Injectable, Topical
Gangwal Healthcare is powered by innovation, driving health, wellness & healing.
Ingredient(s) : Tyloxapol
Dosage Form : Cream / Lotion / Ointment, Injectable / Parenteral, Ophthalmic Solution
Category : Solubilizers
Brand : TYLOXAPOL
Pharmacopoeia Ref : USP-NF, DMF, EXCiPAT, KOSHER, HALAL, WHO-GMP
Technical Specs : NA
Grade : Oral, Ophthalmic, Injectable, Topical
26
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Application : Solubilizers
Excipient Details : EUDRAGIT® RS, a functional sustained release polymer, used in combination with EUDRAGIT® RL for customized release profiles in tablets, capsules, etc.
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : Ammonio Methacrylate Copolymer Type B
Category : Solubilizers
Brand : EUDRAGIT® RS 100
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
27
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Grade : Parenteral
Application : Solubilizers
Excipient Details : Dextran 70 is used as a solubilizer in parenteral formulations such as ophthalmic solutions and injections.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Ingredient(s) : Dextran 70 Excipient
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Grade : Parenteral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Ingredient(s) : Dextran 70 Excipient
Dosage Form : Injectable / Parenteral, Ophthalmic Solution
Category : Solubilizers
Brand : DEXTRAN 70
Applications : Dextran 70 is used as a solubilizer in parenteral formulations such as ophthalmic solutions and injections.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Grade : Parenteral
28
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Oral, Topical
Brand Name : Sorbitan Oleate (Span 80)
Application : Solubilizers
Excipient Details : Sorbitan oleate (Span 80) is used as a solubilizer, emulsifier & stabilizer in tablets, emulsions, creams, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : sorbitan oleate
Dosage Form : Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : SORBITAN OLEATE (SPAN 80)
Applications : Sorbitan oleate (Span 80) is used as a solubilizer, emulsifier & stabilizer in tablets, emulsions, creams, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Oral, Topical
29
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Application : Solubilizers
Excipient Details : Soya lecithin is used as solubilizer & emulsifier in parenteral dosage forms such as fat emulsion injections, mixed micelle preparations & emulsions.
Pharmacopoeia Ref : ChP/EP
Technical Specs : NA
Ingredient(s) : Soya Lecithin
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : SOYBEAN LECITHIN
Pharmacopoeia Ref : ChP/EP
Technical Specs : NA
Grade : Parenteral
30
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Capsule
Grade : Oral
Application : Solubilizers
Excipient Details : L-Lysine acetate is used as a solubilizer in capsules along with other oral solid dosage forms.
Pharmacopoeia Ref : NA
Technical Specs : Molecular weight: 206.24 g/mol
Ingredient(s) : L-Lysine Acetate
Dosage Form : Capsule
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Brand : L-LYSINE ACETATE
Applications : L-Lysine acetate is used as a solubilizer in capsules along with other oral solid dosage forms.
Pharmacopoeia Ref : NA
Technical Specs : Molecular weight: 206.24 g/mol
Grade : Oral
31
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Capsule, Granule / Pellet, Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : HPC-SSL SFP is used as a binder and solubilizer in solid dosage forms including tablets, capsules, granules, and pellets.
Pharmacopoeia Ref : EP, JP, USP/NF, CEP, GMP, Hala...
Technical Specs : N/A
Ingredient(s) : Hydroxypropyl Cellulose
Dosage Form : Capsule, Granule / Pellet, Tablet
Grade : Oral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Ingredient(s) : Hydroxypropyl Cellulose
Dosage Form : Capsule, Granule / Pellet, Tablet
Category : Solubilizers
Brand : HPC-SSL SFP
Applications : HPC-SSL SFP is used as a binder and solubilizer in solid dosage forms including tablets, capsules, granules, and pellets.
Pharmacopoeia Ref : EP, JP, USP/NF, CEP, GMP, Halal, Kosher, Non-GMO
Technical Specs : N/A
Grade : Oral
32
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet
Grade : Parenteral, Oral, Topical
Application : Solubilizers
Excipient Details : Polysorbate 20 is used in parenteral products such as biologics. It is used as a solubilizer, surfactant, emulsifier & suspension stabilizer.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Polysorbate 20
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet
Grade : Parenteral, Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Polysorbate 20
Dosage Form : Cream / Lotion / Ointment, Gel, Injectable / Parenteral, Tablet
Category : Solubilizers
Brand : POLYSORBATE 20
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Parenteral, Oral, Topical
33
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Injectable / Parenteral
Grade : Oral, Parenteral
Brand Name : L-Arginine L-Aspartate
Application : Solubilizers
Excipient Details : L-Arginine L-Aspartate is used as a stabilizer and a solubilizer in various oral and injectable dosage forms.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : L-Arginine L-Aspartate Excipient
Dosage Form : Injectable / Parenteral
Grade : Oral, Parenteral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : L-Arginine L-Aspartate Excipient
Dosage Form : Injectable / Parenteral
Category : Solubilizers
Brand : L-ARGININE L-ASPARTATE
Applications : L-Arginine L-Aspartate is used as a stabilizer and a solubilizer in various oral and injectable dosage forms.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral, Parenteral
34
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Gel, Tablet
Grade : Oral, Topical
Application : Solubilizers
Excipient Details : Poloxamer 407 is used as a solubilizer & wetting agent & coating plasticizer in OSDs such as tablets & topical formulations such as creams, gels, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Poloxamer 407
Dosage Form : Cream / Lotion / Ointment, Gel, Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Poloxamer 407
Dosage Form : Cream / Lotion / Ointment, Gel, Tablet
Category : Solubilizers
Brand : POLOXAMER 407
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Oral, Topical
35
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : L-lysine hydrate is used as a binder in tablet formulations, ensuring the cohesion of the ingredients. It is also used as a solubility enhancer.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : L-Lysine Hydrate Excipient
Dosage Form : Tablet
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Brand : L-LYSINE HYDRATE
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
36
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Tablet
Grade : Oral
Brand Name : L-Lysine L-Aspartate
Application : Solubilizers
Excipient Details : L-lysine L-aspartate is used as a solubility enhancer of poorly soluble drugs and as a binder in oral dosage forms such as tablets.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : L-lysine L-asparate
Dosage Form : Tablet
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Brand : L-LYSINE L-ASPARTATE
Applications : L-lysine L-aspartate is used as a solubility enhancer of poorly soluble drugs and as a binder in oral dosage forms such as tablets.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
37
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Dosage Form : Ophthalmic Solution
Grade : Topical, Parenteral
Application : Solubilizers
Excipient Details : Syntadex 7702 is used as a solubilizer in ophthalmic drug products and in topical formulations such as creams, lotions, and ointments.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Ingredient(s) : Petroleum Jelly Excipient
Dosage Form : Ophthalmic Solution
Grade : Topical, Parenteral
DKSH is your trusted partner for companies looking to grow their business in Asia & beyond.
Brand : SYNTADEX 7702
Applications : Syntadex 7702 is used as a solubilizer in ophthalmic drug products and in topical formulations such as creams, lotions, and ointments.
Pharmacopoeia Ref : N/A
Technical Specs : N/A
Grade : Topical, Parenteral
38
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Application : Solubilizers
Excipient Details : EUDRAGIT® L 12,5 (organic solution), a delayed release polymer is used to increase solubility of poorly soluble products such as tablets and capsules.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Methacrylic Acid Methyl Methacrylate Copolymer
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : Methacrylic Acid Methyl Methacrylate Copolymer
Category : Solubilizers
Brand : EUDRAGIT® L 12,5
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
39
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Gel, Solution
Grade : Parenteral, Topical, Oral
Brand Name : Polyethylene Glycol 4000
Application : Solubilizers
Excipient Details : PEG 4000 is used as a thickener & suspending agent in suspension injections. It is also used as plasticizer, binder, lubricant & solubilizer.
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Ingredient(s) : Polyethylene Glycol 4000
Dosage Form : Cream / Lotion / Ointment, Gel, Solution
Grade : Parenteral, Topical, Oral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Polyethylene Glycol 4000
Dosage Form : Cream / Lotion / Ointment, Gel, Solution
Category : Solubilizers
Brand : POLYETHYLENE GLYCOL 4000
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Grade : Parenteral, Topical, Oral
40
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Topical, Oral
Application : Solubilizers
Excipient Details : Polysorbate 40 is used as a wetting and solubilizing agent in various topical and oral formulations.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Polysorbate 40
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Topical, Oral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Polysorbate 40
Dosage Form : Cream / Lotion / Ointment, Tablet
Category : Solubilizers
Brand : POLYSORBATE 40
Applications : Polysorbate 40 is used as a wetting and solubilizing agent in various topical and oral formulations.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Topical, Oral
41
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Application : Solubilizers
Excipient Details : EUDRAGIT® S 12,5 (Organic solution) a delayed release polymer, used to increase solubility of poorly soluble drugs such as tablets and capsules.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Methacrylic Acid Methyl Methacrylate Copolymer
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : Methacrylic Acid Methyl Methacrylate Copolymer
Category : Solubilizers
Brand : EUDRAGIT® S 12,5
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
42
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Topical, Oral
Brand Name : Sorbitan Palmitate
Application : Solubilizers
Excipient Details : Sorbitan palmitate is used as a wetting and solubilizing agent in various topical and oral formulations.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Sorbitan Palmitate Excipient
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Topical, Oral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Sorbitan Palmitate Excipient
Dosage Form : Cream / Lotion / Ointment, Tablet
Category : Solubilizers
Brand : SORBITAN PALMITATE
Applications : Sorbitan palmitate is used as a wetting and solubilizing agent in various topical and oral formulations.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Topical, Oral
43
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Oral, Topical
Brand Name : Polyoxyethylene (40) Hydrog...
Application : Solubilizers
Excipient Details : Polyoxyethylene (40) Hydrogenated Castor Oil is used as a wetting agent in OSDs. It is also used in SEDDS & as a solubilizer in topical dosage forms.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Polyoxyl 40 Hydrogenated Castor Oil
Dosage Form : Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : POLYOXYETHYLENE (40) HYDROGENATED CASTOR OIL
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Oral, Topical
44
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Capsule, Granule / Pellet, Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : EUDRAGIT® FS 100 (powder) a delayed release polymer, used to increase solubility of poorly soluble products such as tablets, capsules and granules.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Methyl Methacrylate
Dosage Form : Capsule, Granule / Pellet, Tablet
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : Methyl Methacrylate
Dosage Form : Capsule, Granule / Pellet, Tablet
Category : Solubilizers
Brand : EUDRAGIT® FS 100
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
45
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Injectable / Parenteral
Grade : Parenteral, Oral, Topical
Application : Solubilizers
Excipient Details : Oleic acid is used as a co-emulsifier in fat emulsion injections and as an emulsifier and transdermal penetration enhancer in topical formulations.
Pharmacopoeia Ref : USP/EP
Technical Specs : NA
Ingredient(s) : Oleic Acid Excipient
Dosage Form : Injectable / Parenteral
Grade : Parenteral, Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : OLEIC ACID
Pharmacopoeia Ref : USP/EP
Technical Specs : NA
Grade : Parenteral, Oral, Topical
46
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Brand Name : Polyoxyl 15 Hydroxystearate
Application : Solubilizers
Excipient Details : Polyoxyl 15 hydroxystearate is used as a solubilizer, emulsifier, and redispersant in injectable solutions and emulsions.
Pharmacopoeia Ref : USP/EP
Technical Specs : NA
Ingredient(s) : Polyoxyl 15 Hydroxystearate
Dosage Form : Injectable / Parenteral
Grade : Parenteral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Polyoxyl 15 Hydroxystearate
Dosage Form : Injectable / Parenteral
Category : Solubilizers
Brand : POLYOXYL 15 HYDROXYSTEARATE
Applications : Polyoxyl 15 hydroxystearate is used as a solubilizer, emulsifier, and redispersant in injectable solutions and emulsions.
Pharmacopoeia Ref : USP/EP
Technical Specs : NA
Grade : Parenteral
47
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Oral, Topical
Brand Name : Polyoxyl 20 Cetostearyl Eth...
Application : Solubilizers
Excipient Details : Polyoxyl 20 cetostearyl ether is used as a wetting agent in OSDs. It is also used as a solubilizer in topical formulations such as lotions and gels.
Pharmacopoeia Ref : USP/EP
Technical Specs : NA
Ingredient(s) : Polyoxyl 20 Cetostearyl Ether
Dosage Form : Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : POLYOXYL 20 CETOSTEARYL ETHER
Pharmacopoeia Ref : USP/EP
Technical Specs : NA
Grade : Oral, Topical
48
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Injectable / Parenteral, Solution, Tablet
Grade : Parenteral, Oral, Topical
Brand Name : Polyoxyethylene (35) Castor...
Application : Solubilizers
Excipient Details : Polyxyl 35 castor oil is used as surfactant & emulsifier in parenteral formulations. It acts as solubilizer & emulsifier in oral & topical products.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Polyoxyl 35 Castor Oil
Dosage Form : Injectable / Parenteral, Solution, Tablet
Grade : Parenteral, Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Polyoxyl 35 Castor Oil
Dosage Form : Injectable / Parenteral, Solution, Tablet
Category : Solubilizers
Brand : POLYOXYETHYLENE (35) CASTOR OIL
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Parenteral, Oral, Topical
49
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Oral, Topical
Brand Name : Polyoxyl 40 Stearate
Application : Solubilizers
Excipient Details : Polyoxyl (40) stearate is used as an emulsifier, solubilizer & wetting agent in oral & topical dosage forms such as creams, lotions, ointments, etc.
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Ingredient(s) : Polyoxyl 40 Stearate Excipient
Dosage Form : Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : POLYOXYL 40 STEARATE
Pharmacopoeia Ref : ChP/USP/EP/JP
Technical Specs : NA
Grade : Oral, Topical
50
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Brand Name : EUDRAGIT® FS 30 D
Application : Solubilizers
Excipient Details : EUDRAGIT® FS 30 D (aqueous dispersion), a delayed release polymer, used to increase solubility of poorly soluble OSDs such as tablets and capsules.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Methacrylic Acid Excipient, Methyl Acrylate, Methyl Methacrylate
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Ingredient(s) : Methacrylic Acid Excipient, Methyl Acrylate, Methyl Methacrylate
Category : Solubilizers
Brand : EUDRAGIT® FS 30 D
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
51
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Tablet
Grade : Oral, Topical
Brand Name : Polyoxyl 60 Hydrogenated Ca...
Application : Solubilizers
Excipient Details : Polyoxyl (60) hydrogenated castor oil is used as a wetting agent in OSDs such as tablets. It is also used as a solubilizer in topical dosage forms.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Polyoxyl 60 Hydrogenated Castor Oil
Dosage Form : Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : POLYOXYL 60 HYDROGENATED CASTOR OIL
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Oral, Topical
52
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Oral, Topical
Brand Name : Sorbitan Stearate (Span 60)
Application : Solubilizers
Excipient Details : Sorbitan stearate (Span 60) is used as an emulsifier, solubilizer, and stabilizer in creams, gels, tablets, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Sorbitan Stearate Excipient
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Oral, Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Sorbitan Stearate Excipient
Dosage Form : Cream / Lotion / Ointment, Tablet
Category : Solubilizers
Brand : SORBITAN STEARATE (SPAN 60)
Applications : Sorbitan stearate (Span 60) is used as an emulsifier, solubilizer, and stabilizer in creams, gels, tablets, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Oral, Topical
53
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Gel
Grade : Topical
Application : Solubilizers
Excipient Details : Polysorbate 60 is used as a solubilizer, wetting agent, surfactant, emulsifier & stabilizer in topical dosage forms such as creams, suspensions, etc.
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Ingredient(s) : Polysorbate 60
Dosage Form : Cream / Lotion / Ointment, Gel
Grade : Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : POLYSORBATE 60
Pharmacopoeia Ref : ChP/USP/EP
Technical Specs : NA
Grade : Topical
54
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Topical, Oral
Application : Solubilizers
Excipient Details : Sucrose laurate is used as a wetting and solubilizing agent in various oral and topical formulations.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Sucrose Laurate Excipient
Dosage Form : Cream / Lotion / Ointment, Tablet
Grade : Topical, Oral
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Ingredient(s) : Sucrose Laurate Excipient
Dosage Form : Cream / Lotion / Ointment, Tablet
Category : Solubilizers
Brand : SUCROSE LAURATE
Applications : Sucrose laurate is used as a wetting and solubilizing agent in various oral and topical formulations.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Topical, Oral
55
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Dosage Form : Cream / Lotion / Ointment
Grade : Topical
Application : Solubilizers
Excipient Details : Poloxamer 188 is used as a wetting and solubilizing agent in topical formulations.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : Poloxamer 182
Dosage Form : Cream / Lotion / Ointment
Grade : Topical
Nanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.
Brand : POLOXAMER 182
Applications : Poloxamer 188 is used as a wetting and solubilizing agent in topical formulations.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Topical
56
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Dosage Form : Tablet
Grade : Oral
Application : Solubilizers
Excipient Details : L-methionine is used as a solubility enhancer to improve the solubility of poorly soluble drugs such as tablets.
Pharmacopoeia Ref : NA
Technical Specs : NA
Ingredient(s) : L Methionine Excipient
Dosage Form : Tablet
Grade : Oral
Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!
Brand : L-METHIONINE
Applications : L-methionine is used as a solubility enhancer to improve the solubility of poorly soluble drugs such as tablets.
Pharmacopoeia Ref : NA
Technical Specs : NA
Grade : Oral
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