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    Overview of the pharmaceutical formulation development & manufacturing of oral solid dose (OSD) dosage forms, specifically tablets & mini tablets.

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    Overview of the pharmaceutical formulation development & manufacturing of oral solid dose (OSD) dosage forms, specifically tablets & mini tablets.

    Q1. Tablet, what is it and how is it used in pharmaceuticals?

    Pharmaceutical tablets are solid, unit dosage forms prepared by compressing a drug (API) with or without diluents. Furthermore, tablets offer flexibility as oral formulations in their use and are available as film coated tablets, enteric coated tablets, buccal tablets, lozenges, extended release tablets, complex modified release tablets, etc. each having their own benefits. 

    - Complex-modified release tablets: The development of complex modified-release tablets is achieved via controlled drug delivery, involving both delayed and extended release systems of oral administration. These delivery mechanisms, employed in oral formulations like complex modified release tablets, alter the timing or rate of release of active ingredients to successfully modify the expulsion of poorly water-soluble drugs in the body.

    Typical drug delivery methods include liquids, creams, sprays, injectables, suppositories, etc. However, the preferred dosage form by a large margin, remains to be oral solid dose (OSD) dosage forms. Solid dosage manufacturing trends show that oral solid dose (OSD) dosage forms continue to play a major role in the contract manufacturing and CDMO industry, representing about 70% of the market. 

    Oral solid dosage outsourcing trends further reveal that despite the increasing types of biologics, oral solid forms such as tablets & capsules- remain dominant in the market. The ease of administration, identification, and relatively better taste assert oral solid forms as the leading mode of drug administration. Besides tablet formulations and capsules, there are other types of oral solid dose (OSD) dosage forms, namely:

    - Powders 

    - Granules

    - Sachets

     

    Amongst these pharmaceutical products, tableted oral solid forms are the preferred formulations for drug delivery. Tablets have the greatest dose precision, lowest content variability, lowest cost, and various other favorable qualities that make them a desired choice amongst pharma CMOs and CDMOs offering formulation development services (contract development services).

    Active pharmaceutical ingredients (API) and excipients such as binders, lubricants, and fillers are the diverse ingredients present in tablets. In order to create a homogenous mixture, the process of blending is employed during tablet manufacturing to mix the excipients and APIs together. Ultimately, tablets function as unit doses that deliver the desired quantity of active pharmaceutical ingredients (API) to the end consumer with unparalleled accuracy. 

    Q2. What are the steps involved in the drug product (formulation) development of tablets?

    Pharma CDMOs that offer tablet drug product development services with access to well-equipped development, pilot scale and commercial facilities can work with tablet batches from a few hundred grams to full commercial production scale.

    Tablet formulation development is a stylized process. Each Pharma CMO and CDMO uses their own pharmaceutical formulation development and manufacturing methodology. Some use the systematic Design of Experiments (DOE) approach, some test one variable at a time, and many use a combination of the two. However, all formulators need a methodology that gives them reliable and useful information to identify problems before the formulation development of tablets begin.

     

    The pharmaceutical formulation development of tablets is completed in the following steps:

    1. Preformulation Studies: Preformulation is the stage of development in the pharmaceutical industry, during which the physicochemical properties of drug substances are characterized and established. This could provide important information for formulation design or anticipate the needs for molecular modification. Every drug has intrinsic chemical and physical properties which need to be considered before the formulation development of pharmaceutical products. 

    2. Dispensing: The first step in tablet development and formulation, after preformulation studies have been conducted and appropriate oral formulations have been chosen, is called dispensing. Dispensing involves weighing all the ingredients in tablets accurately to ensure desired API & excipient amounts in the tablet formulations. 

    3. Sizing: The second step in tablet formulation development is known as sizing. During sizing the active ingredients and pharmaceutical excipients used in tablet formulations are broken down to finely divided forms, in order to augment flow properties and enable easier mixing of the ingredients in oral formulations.

    4. Powder Blending: Powder blending uses cutting edge technologies to mix powders and achieve homogeneous mixtures. This step of tablet development and formulation gives blend uniformity and distributes lubricants evenly in the resulting powdered mixture. 

    5. Granulation: Most fine pharmaceutical compounds require the formulation development process known as granulation, offered by pharmaceutical CDMOs, to improve their flow properties and processing properties prior to tableting. Granulation can be divided into two types: dry granulation and wet granulation. 

    In the pharmaceutical development industry, granulation may be defined as a pharmaceutical development service wherein small particles of drugs and excipients adhere together by forming bonds which result in the formation of large aggregates called granules. Contract development & manufacturing organizations (CDMO) and pharma CMOs offer such pharmaceutical contract manufacturing services.

    6. Drying & Dry Screening: If the wet granulation route of tablet formulation development is used in the previous step, then it is followed by drying and dry screening. This step in tablet development and formulation refers to drying wet granules after they have been screened. Dry screening in tablet development refers to passing the dried granules through a mesh screen to achieve the oral formulation ready to undergo compression.

    7. Tablet Compression: The term “direct compression” is defined as the drug product formulation development process by which tablets are compressed directly from powdered mixtures of API and suitable excipients. Direct compression (DC) is by far the simplest means of tablet formulation development and manufacturing, as it only requires the active pharmaceutical ingredient (API) to be properly blended with appropriate excipients before compression.

    8. Coating: Tablets are coated to achieve taste masking of bitter tastes and unpleasant odors of the pharmaceutical oral formulations. During the formulation development of tablets, coatings can change the release profiles of the oral solid dose (OSD) dosage forms. Complex modified release tablets can be formulated using coatings. Therefore, coating is considered as a major tablet drug product development service to modify the release profile of drug products.

    Q3. What are pharmaceutical mini tablets and what are the benefits they offer?

    Mini-tablets represent a new trend in solid dosage formulation development and manufacturing, with the main goal of overcoming some therapeutic obstacles. Pharmaceutical mini tablets are solid oral dosage forms with a diameter less than or equal to 3 mm, separated into subunits of conventional tablets. Mini-tablet formulation development is similar to standard tablets, but the only difference is the use of multiple punches. Pharma CMOs and CDMOs offer mini tablets drug product development services. 

    Numerous CDMOs offer mini tablets drug product development services for pediatric and geriatric dosage forms since they are easier to swallow than conventional tablets and capsules. In addition, they can be used to meet a full range of dissolution profiles, including delayed-release, controlled-release, and combination-release. 

    Mini tablets are multiple unit dosage forms and are better than granules and pellets as mini tablet manufacturing is easy to undertake, and they are more stable. Mini-tablets offer finished dosage form flexibility in that they can be delivered as capsules, sachets or compressed into larger tablets. 

    These mini tablet drug delivery systems are ideal for delivering fixed dose combination pharmaceutical oral solid forms. In mini tablets drug product development services, one type of pharmaceutical mini-tablet can be mixed with another or with pellets, granules or powders and then filled into finished dosage forms in order to avoid incompatibilities in combination products.

     

     Mini tablet drug product development services offer various benefits, including but not limited to:

    - Increase in productivity

    - Acceleration in time to market

    - Less risk of dose dumping 

    - Ease of minitablet manufacturing 

    - Mini tablet drug delivery systems are ideal for coating

    - Mini tablet formulation development can produce formulations with various release profiles

    - High drug loading 

    Q4. What are the technologies involved in the formulation development of mini tablets?

    In principle, mini-tablets development and formulation is similar to the larger, conventional tablet development and formulation. However, successful development of mini tablet drug delivery systems require specialist expertise as many drug product development issues are enhanced due to their small size. Mini tablet drug product development services are enabled by several tablet technologies developed for mini tablet development and formulation. Mini tablet pharmaceutical development services and the mini tablet formulation technologies that enable them, are explored below:

    1. Dispensing:

    Dispensing is performed with the help of weighing and measuring apparatuses and aims to accurately weigh out API, excipients & other ingredients that make a tablet.

    2. Sizing:

    Sizing drug product development services are carried out to reduce and obtain the desired particle sizes before later stages of development of mini tablet formulations. Sizing is carried out with the help of fluid energy mills, colloidal mills, ball mills, etc.

    3. Blending/Mixing:

    Blending or mixing is very important for the drug product development of oral solid dosage forms. Blending mini tablet drug product development services create homogenized mixtures for granulation followed by compression. Blending is carried out by using tumbling blenders, oblicone blenders, agitated powder blender and other mini tablet formulation technologies.

    4. Granulation:

    Granulation creates aggregates of adhered pharmaceutical oral solid forms that are ready for compression. This mini tablet drug product development service is achieved with the help of fluidized bed granulators, roto granulators, high shear granulation mini tablet formulation technologies, etc.

    5. Compression:

    Compression in mini tablet development and formulation is the stage at which fine powders and APIs are directly compressed for the development of mini tablet formulations. Compression mini tablet drug product development services are carried out with the help of rotary tablet press, multiple tip punch machines, etc.

    6. Coating:

    During the development of mini tablet formulations, coatings are used to mask bitter taste and unpleasant odor of mini tablet pharmaceutical oral solid form to make them more suitable for consumption. This drug product formulation development service can be performed on fluidized bed coaters, perforated coating pans, standard pans, etc.

    Evaluation of the physical and analytical properties of the mini tablets produced can help define the optimum drug formulation development route, composition, and processing window, and can be leveraged to assess manufacturing risks and risks associated with the corresponding mini tablets drug product development services. Many of the tests applied to larger-sized tablets can also be applied to mini tablets, although some modifications may be needed.

    Q5. What are the latest advances in tablet manufacturing?

    Traditional drug formulation development of tablets can be expensive, time consuming, inefficient and creates a lot of waste. Recent trends in the drug product formulation development and manufacturing of tablets reduce the need for manual input and process validation drug product support services, and further enhance product quality and process reliability. 

    Industrial pharmaceutical product development of tablets and mini tablet development and formulation has progressed to complete automation. With trends towards global marketing and regulatory requirements, the specifications for the facility, and the product too are becoming more stringent in recent times. Tablet CDMOs offering formulation development services use several tableting technology to meet the requirements of the growing market.

    Various tablet CDMO offering formulation development services with recent advancements in tableting, partake in the production of immediate release tablets such as orally dispersible mini tablets, mouth dissolving/fast dissolving tablets, conventional effervescent, uncoated and film coated tablets etc. modified release tablet formulations including layered tablets such as inlay tablets, tablet in tablet, bilayer tablet, medicated chewing gum, tablet tarts, pastilles, lollipop, tablet inserts, clinicaps, caplets and child ecstasy tablets. The latest advances in tablet and mini tablet development and formulation are listed below.

    - Advancements in raw materials:

    Ready to use co-pressed blends, which are ready for direct compression, cut out multiple steps in drug formulation development of tablets and are gaining traction amongst drug product support service providers. These oral formulations accelerate time to market for finished dosage forms.

    - Advancement in granulation technology:

    Granulation is one of the most important drug product support services in the pharmaceutical product development of tablets. Pharmaceutical contract manufacturing units are shifting towards using steam granulation, melt granulation, moisture activated dry granulation, etc. over traditional granulation as it creates superior products, decreases time to market, and cuts steps from the standard processes set in place.

    - Advancements in compression technology offered by tablet CDMO:

    Recent advances in compression are due to innovations in compression technologies. Pharmaceutical contract manufacturing units are moving towards double punch technologies, exchangeable compression modules, die-disc technologies, etc. in order to provide superior drug product support services for tablets.

    - Advances in tablet coating techniques:

    The pharmaceutical product development of tablets is augmented by novel coating techniques like fluid bed or air suspension coating, compression coating, electrostatic coating, etc. The drug product development of oral dosage forms can make drug products undesirable to consumers. Therefore advances in coating techniques and technologies can create augmented drug product support services for coating tablets.

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        FORMULATION DEVELOPMENT OF TABLETS

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        Quotient Sciences offers formulation development services for solid oral dosage forms, including immediate, sustained and modified release tablets, mini-tablets and orally disintegrating tablets (ODTs), etc.

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        Pfizer CentreOne

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        FORMULATION DEVELOPMENT FOR TABLETS

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        Pfizer CentreOne excels in the development and manufacturing of oral solid dosage forms such as tablets, capsules, granules & highly potent products for both clinical and commercial needs.

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        Formulation Development for Tablets

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        Porton Pharma Solutions

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        CDMO FOR TABLETS

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        Porton Pharma is a contract development and manufacturing organization that is involved in the formulation development of oral solid dosage forms such as immediate release, modified release, and double-layer tablets.

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        CDMO for Tablets

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        Ropack Inc

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          PROTOTYPE FORMULATION OF TABLET

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          Ropack offers formulation development of pharmaceutical products at all stages. From early prototype development, formulation selection, optimization & release profile definition to late-stage formulation troubleshooting & lifecycle management.

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          STABICON LIFE SCIENCE PVT LTD

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            ORAL SOLIDS - EARLY FORMULATION DEVELOPMENT

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            Preformulation/reformulation for oral solid forms, semi solid (only oral drug delivery) and topical formulations, preclinical formulation, prototype development (lab scale) batches and tech transfer support.

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            Axxelent Pharma Science

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              TABLET FORMULATION DEVELOPMENT

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              Axxelent offers contract development for various oral solid dosage forms, including film-coated tablets, sugar-coated tablets, bilayer tablets, ODTs (orally disintegrating tablets), chewable and sublingual tablets.

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              STABICON LIFE SCIENCE PVT LTD

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                TABLET DEVELOPMENT

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                Preformulation/reformulation for oral solid forms, semi solid (only oral drug delivery) and topical formulations, preclinical formulation, prototype development (lab scale) batches and tech transfer support.

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                Pharma Service: API & Drug Product Development

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                Unither Pharmaceuticals

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                TABLET FORMULATION DEVELOPMENT

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                Unither Pharmaceuticals is able to provide a range of flexible services in the production of tablets & capsules. They work from the early stages of R&D to create a new dry form or they can be your partner in reformulating or packaging an existing product.

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                Piramal Pharma Solutions

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                FORMULATION DEVELOPMENT OF TABLETS

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                Piramal offers pharmaceutical development services for oral solids, such as oral disintegrating tablets, sublingual tablets, press-coated tablets, bi-layered, delayed & modified-release tablets, etc.

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                Pierre Fabre

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                TABLET FORMULATION & DEVELOPMENT SERVICES

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                Pierre Fabre, a full service CDMO offers contract development services from pharmaceutical formulation to commercialization of oral solids (tablet, capsule, powder sachet), lozenges and paste forms (cream, ointment, gel), etc.

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                GRAM Laboratory Inc

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                  PHARMACEUTICAL DEVELOPMENT OF TABLETS

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                  Gram has scientific expertise encompassing the drug product development of a variety of dosage forms including, sterile liquids, powders, emulsions and suspensions, tablets, capsules, oral liquids, ophthalmics, lyophilized powders, topicals, etc.

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                  Progenerics Pharma Pvt Ltd

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                    GENERIC TABLET DEVELOPMENT

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                    Progenerics is focused on pharmaceutical product development of high quality and affordable global generic products. CDMO facilities are capable of developing all dosage forms like general solids & injectables, oncology solids & injectables, creams, etc.

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                    JGL d.d

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                    FORMULATION DEVELOPMENT OF TABLETS

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                    JGL offers traditional pharmaceutical oral dosage forms such as tablets, capsules & granules, non-sterile solutions (syrups and drops), and semi-solid forms (ointments, creams and gels).

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                    Ropack Inc

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                      PHARMACEUTICAL PRODUCT DEVELOPMENT SERVICES

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                      Ropack offers formulation development of pharmaceutical products at all stages. From early prototype development, formulation selection, optimization & release profile definition to late-stage formulation troubleshooting & lifecycle management.

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                      PENMIX LTD.

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                        TABLET DRUG PRODUCT DEVELOPMENT

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                        Penmix has its own division specialized in developing penicillin and injectable drug products. In the development division, the efficiency of the process is maximized along each step from planning, research & product development to regulatory affairs.

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                        Sushen Medicamentos Pvt. Ltd

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                          IMMEDIATE RELEASE TABLET FORMULATION

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                          SUSHEN is an end-to-end CDMO offering contract services for drug delivery research and drug product development. SUSHEN’s expertise can bring a complex formulation project in to bioequivalence & clinical development via high quality, innovative solutions.

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                          Progenerics Pharma Pvt Ltd

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                            DEVELOPMENT OF TABLETS FOR ONCOLOGY

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                            Progenerics is focused on pharmaceutical product development of high quality, affordable generic products gloablly. CDMO facilities are capable of developing all dosage forms like general solids & injectables, oncology solids & injectables, creams, etc.

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                            Societal CDMO

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                            DEVELOPMENT OF EXTENDED RELEASE TABLETS

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                            Recro provides formulation development services for a variety of pharmaceutical products. They offer the development of extended release oral solid dosage forms such as tablets, capsules & DEA controlled substances, as well as cGMP clinical supplies.

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                            Adare Pharma Solutions

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                            FORMULATION DEVELOPMENTS OF TABLETS

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                            Minitabs™ MMTS™ (Multi Mini Tablet System) provides the flexibility of multiparticulate dosage forms with functional membranes applied to 1.0 - 2.0 mm cylindrical tablets in order to control release rates.

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                            Madras Pharmaceuticals

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                            FORMULATION DEVELOPMENT OF TABLETS

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                            Madras Pharma's state-of-the-art R&D is well equipped to handle various developmental challenges & capable of developing, scaling up & commercializing various tablets (film coated, chewable, modified/extened release, dispersible, hormonal, potent).

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                            PSR Pharma Science and Research

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                              TABLET FORMULATION DEVELOPMENT

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                              PSR's team has extensive experience working with the following processes and drug delivery methods: Tablet development & formulation.

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                              Zenvision Pharma LLP

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                                TABLET DEVELOPMENT

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                                Formulation development is the core activity at Zenvision Pharma and it includes preformulation, formulation development studies, analytical method development & validation, stability studies, dossier preparation & technology Transfer.

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                                Prague Scientific

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                                FORMULATION DEVELOPMENT OF TABLETS

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                                Prague Scientific offers formulation development for solid oral tablets with immediate, modified & delayed release. It has various technologies, including direct compression, encapsulation, dry & wet granulation, Wurster coating, etc.

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                                Chanelle Medical

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                                TABLET DRUG PRODUCT FORMULATION DEVELOPMENT

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                                Chanelle Medical has thrived on the strength of its high quality science driven research and development programmes. Their drug products are developed using in-house scientific expertise and assistance from their development laboratory in Amman, Jordan.

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                                PharmaVize NV

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                                  DEVELOPMENT & MANUFACTURING OF TABLETS

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                                  Pharmavize can manufacture various dosage forms including oral solid forms like tablets.

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                                  Bioplus Life Sciences

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                                  FORMULATION DEVELOPMENT OF TABLETS

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                                  BioPlus Life Sciences offers formulation development for tablets, including conventional, chewable, dispersible, orodispersible, extended-release, enteric-coated, etc.

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                                  Zenvision Pharma LLP

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                                    BILAYER TABLET FORMULATION DEVELOPMENT

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                                    Formulation development is the core activity at Zenvision Pharma and it includes preformulation, formulation development studies, analytical method development & validation, stability studies, dossier preparation & technology Transfer.

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                                    ORIT LABS LLC

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                                    FORMULATION DEVELOPMENT OF GENERIC TABLETS

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                                    Orit Laboratories specializes in generic oral pharmaceutical product development. Specifically, their focus is in analytical development servics and formulation development of generic oral dosage forms for the US market.

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                                    Recipharm AB

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                                    MINI-TABLET FORMULATION DEVELOPMENT

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                                    Recipharm has experience in tableting, coating & pharmaceutical packaging required for successful mini-tablet formulation development. Their CDMO provides drug product development for mini-tablets & performs technical transfers & commercial manufacturing.

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                                    Aizant Drug Research Solutions Pvt. Ltd.

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                                    CDMO FOR TABLET FORMULATION DEVELOPMENT

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                                    Aizant's scientists use Quality-By-Design (QbD) tools at all stages of formulation development. Design of experiments (DOE) along with risk assessment strategies allows them to design efficient experimental plans.

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                                    Tianjin Hankang Pharmaceutical Biotechnology

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                                      FORMULATION DEVELOPMENT OF TABLETS

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                                      Hankang has the development capabilities for over 30 pharmaceutical formulations including tablets, freeze-dried tablets, capsules, soft capsules, granules, and other drug products.

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                                      Aizant Drug Research Solutions Pvt. Ltd.

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                                      CDMO FOR FILM COATED TABLETS

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                                      Aizant's scientists use Quality-By-Design (QbD) tools at all stages of formulation development. Design of experiments (DOE) along with risk assessment strategies allows us to design our experimental plan.

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                                      Sofarimex

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                                        DEVELOPMENT OF TABLET

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                                        Sofarimex is the leader manufacturing company of pharmaceutical products in Portugal. This factory has a large productive flexibility, producing several pharmaceutical forms like solids, liquids, semi-solids & sterile products.

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                                        Sai Life Sciences Limited

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                                        TABLET FORMULATION DEVELOPMENT

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                                        Sai Life Sciences have vast & rich expertise of working across multiple technologies with increasing complexity to develop variety of solid dosage forms such as conventional tablets, immediate release/modified release tablets, oral disintegrating tablets.

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                                        STABICON LIFE SCIENCE PVT LTD

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                                          UROGENITAL TABLETS DEVELOPMENT

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                                          Preformulation/reformulation for solid, semi solid (only orals) and topical formulations dosage form, pre-clinical formulation, prototype development (lab scale) batches and tech transfer support.

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                                          Catalent Pharma Solutions

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                                          FORMULATION DEVELOPMENT FOR TABLETS

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                                          Catalent is your trusted partner for your oral solid dose product needs such as tablets & capsules, from clinical development through to commercial manufacturing. They have experience in handling highly potent compounds including controlled substances.

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                                          Eurofins CDMO

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                                          FORMULATION DEVELOPMENT OF TABLETS

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                                          Eurofins CDMO offers strong experience in a wide range of different drug delivery routes, drug delivery systems and drug production technologies, including oral & solid formulations (tablets, capsules), buccal delivery, etc.

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                                          JAMP PHARMA

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                                            ORAL FORMS - TABLET

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                                            Through a diversified and growing portfolio, JAMP Pharma constantly develops innovative medications, vitamins, supplements, natural products and health & beauty products in Oral Forms, Lotions, Ophthalmics, Topicals, Injectables, Suppositories & Patches.

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                                            Vici Health Sciences

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                                              TABLET FORMULATION & DEVELOPMENT SERVICES

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                                              Vici is an integrated CDMO that offers contract development of a variety of orally administered formulations such as tablets. It provides a wide range of coated, extended-release, mini-tablets, ODT, chewable tablets, sublingual tablets, etc.

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                                              IDRS Labs

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                                                FORMULATION DEVELOPMENT OF TABLETS

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                                                IDRS Labs is involved in the formulation development of a variety of oral solids such as tablets including chewable, sublingual, bilayer, immediate, delayed, modified, multi-particulate, effervescent, and dispersible (ODT).

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                                                JSL Health Sciences

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                                                  FORMULATION DEVELOPMENT OF TABLETS

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                                                  JSL Health Sciences is a contract research and development organization specialized in providing formulation development services for tablets including immediate release, modified release, pellet-containing, bilayer, and OROS.

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                                                  PCI Pharma Services

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                                                  FILM COATED TABLETS FOR CLINICAL DEVELOPMENT

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                                                  Equipped to meet the needs of development and small batch requirements, PCI's CDMO facility is scaled to develop & manufacture up to 10kg batches of film coated tablets for clinical development.

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                                                  Om Sai Pharma Pack

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                                                    CDMO FOR TABLETS

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                                                    Om Sai Pharma Pack is a contract development and manufacturing organization (CDMO) that offers formulation development services for oral solid dosage forms such as tablets, capsules, and pellets.

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                                                    Appcure Labs

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                                                      TABLET FORMULATION DEVELOPMENT

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                                                      Appcure Labs is a pharmaceutical research and development company that develops generic formulations such as tablets. It also offers other solid dosage forms including capsules, pellets, etc.

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                                                      AVIZ Laboratories

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                                                        EFFERVESCENT TABLET DEVELOPMENT

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                                                        Aviz prides itself on being able to develop and manufacture quality effervescent tablets, at globally competitive prices.

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                                                        UPM Pharmaceuticals

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                                                        BILAYER, COATED, ENCAPSULATED MINI TABLETS

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                                                        Formulation development capabilities include blending, high shear granulation, fluid bed granulation, extrusion-spheronization, roller compaction, bi-layer compression, mini-tablets, encapsulated tablets and beads, coated tablets.

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                                                        Avaca Pharma

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                                                          DEVELOPMENT OF IMMEDIATE RELEASE TABLETS

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                                                          We perform formulation assessment, early stage proof of concept, formulation selection, design of experiments, pre formulation, release profile determination, formulation strategy, process development, optimization and technology development.

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                                                          Avivia

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                                                            DEVELOPMENT OF TABLET

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                                                            We are able to offer formulation development services for a variety of dosage forms including tablets, capsules, gels, creams, Liquids, solutions, suspensions, emulsions, suppositories, pessaries, granules for reconstitution & liquids for sterilization.

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                                                            Atral

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                                                              FORMULATION DEVELOPMENT OF TABLETS

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                                                              Over the 70 years in the Portuguese market, Laboratórios Atral offers the development and manufacturing services for oral (tablets, capsules), semi-solid, liquid and injectable solids, especially in the form of penicillins and cephalosporins.

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                                                              GALENIX INNOVATIONS

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                                                                IMMEDIATE RELEASE TABLET DEVELOPMENT

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                                                                All kinds of dosage forms are developed at Galenix, from the most simple to the most sophisticated one. Patented Drug Delivery Systems developed by Galenix may also modify the drug product’s features in order to respond to special requirements.

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                                                                Custom Pharma Services

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                                                                  FORMULATION DEVELOPMENT SERVICES OF TABLETS

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                                                                  Custom’s expert chemists, scientists and process engineers — many with 35 years of experience in the pharmaceutical industry — offer an extensive range of clinical and product development expertise, including significant preformulation and formulation exp

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                                                                  M2M Pharmaceuticals Ltd

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                                                                    TABLET FORMULATION DEVELOPMENT

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                                                                    M2M Pharmaceuticals Ltd, a Contract Research Organization (CRO) supports early stage product development for pharmaceutical, food and biotech companies with various services in Method Development and Validation, Physico-Chemical Analysis, Formulation and Quality/Regulatory support.

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                                                                    AUPA Biopharm

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                                                                      CDMO FOR TABLETS

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                                                                      Aupa BioPharm develops specific oral dosage forms such as slow-release and controlled-release tablets. It is a contract development and manufacturing organization (CDMO) that also offers orally disintegrating (ODTs) and sustained release tablets.

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                                                                      Biolink LifeSciences

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                                                                        TABLET FORMULATION DEVELOPMENT

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                                                                        Biolink Life Sciences provides immediate release solid dosage prototype development services for tablets, capsules, powders, and multi-particulate and modified release prototype development services for tablets and/or multi-particulates beads.

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                                                                        Lamda Laboratories

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                                                                          DEVELOPMENT OF MODIFIED RELEASE TABLETS

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                                                                          Our key area of expertise are Immediate/Modified Rrelease -Tablets/ Capsules/Solutions/Suspensions/ Powders; Topical Dosage Forms-Creams, Ointments, Cutaneous solutions; Sterile Dosage Forms-Injectables, Nasal preparations, Ophthalmic preparations.

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                                                                          Torrent Pharmaceuticals Limited

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                                                                          FORMULATION DEVELOPMENT FOR TABLETS

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                                                                          Torrent Pharma's state-of-the art R & D centre offers formulation development services for various types of tablets such as sustained release tablet, delayed release tablet, osmotic tablet, bi-layered, tablet in tablet, etc.

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                                                                          Novick Biosciences

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                                                                            TABLET FORMULATION DEVELOPMENT

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                                                                            All formulation services can be utilized independently or fully integrated within on-going services at Novick. These services include the development of Tablets, Capsules, Pellets, Liquid Orals, Powder/Granules, Semi Solids, Topicals, Ophthalmics.

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                                                                            Globela Pharma

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                                                                            TABLET DEVELOPMENT

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                                                                            Globela Pharma Pvt Ltd has uplifted our existing R & D facility, and installed fully functioning in house R & D center- with state of the art infrastructure, and experienced, skilled manpower.

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                                                                            Cyndea Pharma S.L

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                                                                              IMMEDIATE RELEASE TABLET DEVELOPMENT

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                                                                              Development and manufacturing of women healthcare products and niche type products for third party partners (B2B), covering world wide markets.

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                                                                              Aragen Life Sciences

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                                                                              DEVELOPMENT OF IMMEDIATE RELEASE TABLET

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                                                                              GVK BIO adopts a comprehensive, time-bound strategy in developing stable products that are efficient in all quality aspects.

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                                                                              Labiana Life Sciences S.A

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                                                                              DEVELOPMENT & IMPROVEMENT OF TABLET

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                                                                              LABIANA GROUP offers development and improvement of sterile solutions or suspensions, lyophilizates, eye drops, liquids in solution or non-sterile suspension, oral powders, capsules and tablets.

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                                                                              Softigel Procaps

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                                                                              TABLET DEVELOPMENT

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                                                                              Softigel is specialized in softgel technologies and offer access to other drug delivery systems (DDS) such as sterile liquids, injectables, prefilled syringes, creams, ointments, gels, powders, tablets and hard gel capsules.

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                                                                              Siegfried AG

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                                                                              DEVELOPMENT OF TABLET FORMULATIONS

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                                                                              Siegfried is your expert in complex oral drug delivery systems with the most advanced development, manufacturing and packaging capabilities in the CDMO industry installed in state of the art facilities located in Zofingen (Switzerland) and Hal Far (Malta).

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                                                                              Cambrex Corporation

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                                                                              INTEGRATED DEVELOPMENT & MANUFACTURING-TABLET

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                                                                              With fully integrated development and manufacturing services for solid dosage forms (Tablet, Capsule & Powder), liquids, creams and both sterile and non-sterile ointments, our experts develop and manufacture drug products with success.

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                                                                              Servier

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                                                                              CDMO CAPABILITIES FOR TABLET

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                                                                              Servier CDMO has the capabilities to deliver your project from development through to the manufacture of large commercial batch sizes of tablets, capsules or powders. Servier has 60 years of experience with a proven track record of quality and regulatory approval to ensure reliability for your

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