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    Overview of the formulation development of soft capsules, hard capsules & HPMC capsules & more on leading CDMOs, CROs offering capsule development.

    Renejix
    Ethypharm CDMO for Complex OSDs
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    Overview of the formulation development of soft capsules, hard capsules & HPMC capsules & more on leading CDMOs, CROs offering capsule development.

    Q1. What are pharmaceutical capsules?

    In pharmacy, capsules refers to solid dosage forms in which drug substances or APIs and inert ingredients are enclosed in a hard or soft soluble container, usually of a form of gelatin. The shell is normally made from gelatin or other suitable polymeric material and results in a simple, tasteless, odourless, elegant, easy-to-swallow dosage form without the need for a secondary coating step.

    Capsules are easy to manufacture and don't have any complex formulation requirements. Due to its ease of manufacturing and packaging, capsules are one of the most commonly used pharmaceutical dosage forms. Capsules are intended to be swallowed whole by the patient. In instances where patients (especially children) are unable to swallow capsules, the contents of the capsule can be removed and added to food prior to ingestion.

    Capsules are available in various shapes and sizes and contain a single dose of one or more active pharmaceutical ingredients (APIs). They are a safe alternative to tablets and offer numerous benefits over the tablet form. Capsules are traditionally made from gelatin, an animal protein derived from collagen. In recent years, however, plant-based alternatives such as HPMC and modified starch have come into the market to cater to vegetarians.

    Capsules may be filled with a range of formulation types including dry powders, semisolids, non aqueous liquids, and other dosage forms such as beads, mini tablets, and even mini capsules most of which are intended for oral administration as oral solid forms. 

    There are various contract development and manufacturing organizations (CDMOs) that offer CDMO services and drug delivery technologies for the formulation development and contract manufacturing and packaging of solid oral forms such as capsule drug products.

     

    Some Advantages of Capsule Dosage Forms:

    - Tasteless and odorless formulations.

    - Easy to handle and carry.

    - Unique mixes of ingredients are possible.

    - Capsules can be opened to obtain powdered ingredients.

    - Capsules are effective oxygen barriers and have excellent chemical stability.

    Q2. What are the different types of capsules?

    Capsules are dosage forms that encapsulate an active pharmaceutical ingredient (API) in a dissolvable shell. To meet the dynamic demands of the pharmaceutical industry, various types of capsules are used which include soft gelatin capsules, hard gelatin capsules, HPMC capsules, etc. These are explored in detail below. 

    Depending on the ingredients used in the capsule shell, capsules can be divided into non-veg gelatin capsules or vegetarian HPMC capsules. 

    - HPMC Capsules 

    For people with dietary restrictions, alternate dosage forms such as vegetarian HPMC capsules are available. HPMC capsules use hydroxypropyl methylcellulose as the main ingredient for the capsule body and cap. It is a safe drug for human consumption and a good alternative for gelatin capsules because of the vegetable source.

    - Gelatin Capsules 

    Gelatin is an animal protein used to make capsules, which can deliver measured amounts of products. The pharmaceutical quality gelatin used in two-piece hard-shell capsules is obtained through the processing of collagen, a protein composed of eighteen different amino acids found in the connective tissues and bones of most animals, including humans.

     

    Depending on the makeup of the gelatin capsule it can be divided into two types, hard capsules or two-piece capsules and soft capsules or one-piece capsules. The raw materials used in both types of capsules are similar. Both contain gelatin, water, colorants, preservatives, etc. In addition, soft capsules contain various plasticizers and glycerine. 

    - Soft Capsules 

    A soft capsule is a film formed into a certain shape while filling it with a liquid or paste. It can be used in many ways including a simple container (not to be ingested), to be swallowed whole, or to be used by crushing it. Compared with hard capsules, soft gelatin capsules are thicker and require additional ingredients such as glycerin to obtain their soft texture.

    Perfectly suited for liquid capsule filling or semi-solid fillings, soft capsules are widely used to deliver pharmaceutical substances and a wide range of nutraceutical supplements, such as omega-3 fish oils. Many consumers prefer soft gelatin capsules over hard capsules as they are easy to use and swallow.

    - Hard capsules

    Hard capsules are normally employed for dry solid active pharmaceutical ingredients (APIs). The capsules are manufactured in two halves – a body and cap – to assist with filling. Gelatin has been the material of choice for hard capsules because of the ability of a solution to gel and form a solid oral form just above room temperature. 

     

    Traditionally hard capsules are made from gelatin and now also from hypromellose, which serve as a vegetarian alternative. Depending on the inner fill, hard capsules can be further divided into liquid filled hard capsules created via liquid capsule filling technology and dry filled hard capsules.

    - Dry Filled Hard Capsules

    Capsules that are filled with dry ingredients such as powders, granules, beads, tablets, pellets, etc. are referred to as dry filled hard capsules (DFCs).

    - Liquid Filled Hard Capsules 

    As seen above, hard gelatin capsules are usually filled with powders, granules, or tiny pellets. However, hard capsules with liquid fillings are referred to as Liquid Filled Hard Capsules (LHFCs).

    Q3. What are the steps involved in the development and filling of capsules?

    Prior to manufacturing capsules, during the development phase, formulation development teams offer design and optimization of capsule formulations. The formulation development of capsule dosage forms includes pre-formulation studies, excipient screening, chemical compatibility and relevance studies, filling of capsules, etc. Some of these pharmaceutical development services for oral solids are explored in detail below.

    Before developing capsule formulations the suitability of active pharmaceutical ingredients (APIs) and added ingredients are characterized via preformulation studies on the basis of their physical, chemical, biochemical, and mechanical properties. This is done to develop stable, safe and effective dosage forms.

    Excipients are widely used to formulate solid drug forms such as capsules. However, the capsule forming properties of these excipients are affected by the presence of additives and active ingredients. The formulation development of capsules may therefore entail excipient screening. 

    Screening methods are used to determine the excipients which will optimize the capsule formulations. Selected diluents (fillers), disintegrants, glidants, lubricants, wetting agents, etc. are then weighed to get the required quantities for development and manufacturing. 

    Formulation for soft gelatin capsules involves liquid capsule filling, rather than powder technology. Materials are generally formulated to produce the smallest possible capsule consistent with maximum stability, therapeutic effectiveness and manufacturing efficiency. Incase of hard gelatin capsules the inner fill material could either be dry (powder filled) or liquid. 

    After development is completed, empty gelatin capsule manufacturing proceeds in the following steps in order from first to last; Dipping, spinning, drying, stripping, trimming, joining, and polishing. Hard gelatin capsules further undergo powder or liquid capsule filling via hand operated methods, semi automatic capsule devices, or automatic filling machines. 

    Every machine has its own working method. The capsule filling machine works in a step-by-step process which starts with positioning the capsules in a capsule filling tray, the caps are then removed from the bodies of the capsules and filled with the inner fill materials. The caps and bodies are then rearranged and sealed after which the capsules are expelled from the machine. 

    In capsule formulation development and during the filling of capsules, a number of quality control tests are performed to ensure that the capsules produced meet the conventional requirements established by the pharmaceutical industry over the years. 

    A contract research organization (CRO) or a contract development and manufacturing organization (CDMO) which has clinical development and pharmaceutical development capabilities as well as contract manufacturing capabilities for solid-dosage forms can offer CDMO services for capsule drug products.

    Q4. Which are the leading pharmaceutical companies offering the development of capsules?

    Leading contract research organizations (CROs) and contract development and manufacturing organizations (CDMOs) having drug delivery technologies for the formulation development of capsule drug products for clinical and commercial manufacturing are noted below.


    Quotient Sciences - Capsule Drug Product Development Services

    Quotient functions as a contract research organization (CRO) and contract development and manufacturing organization (CDMO). Quotient has solid dosage capabilities and offers clinical development and CDMO services such as formulation development for solid oral forms including immediate, sustained and modified release tablets, multiparticulates, mini-tablets, granules, and orally disintegrating tablets (ODT) along with other oral formulations. 


    Pfizer CentreOne - Capsule Drug Product Development Services

    Pfizer CentreOne has solid dosage capabilities and excels in the development and contract manufacturing and packaging of oral solid dosage forms such as capsules, tablets, granules and highly potent products for both clinical and commercial manufacturing. 

    Pfizer can optimize processes and scale up oral solid forms from clinical development to commercial manufacturing. It has integrated cGMP pilot facilities dedicated to process optimization, clinical drug manufacturing, and pharmaceutical development services for oral solids.


    Recipharm AB - Capsule Drug Product Development Services

    Recipharm offers formulation development or drug product development services for all common dosage forms including solid-dosage forms, tablets, mini tablets, capsules, hard gelatin capsules, injectables, semi-solids and liquids, etc. 

    It offers pharmaceutical formulation development contract services for all oral formulations. Recipharm has the resources to meet your project requirements whether you are looking for a small number of capsules to conduct a first-in-human study or if you need pharmaceutical development services for oral solids along with full-scale production.


    Athena Pharmaceutiques - Capsule Drug Product Development Services

    Athena S.A.S offers formulation development and manufacturing for various oral formulations such as capsules in bulk and finished packs, tablets in bulk and finished packs, pellets for filling in capsules, pellets or granules in sachets, etc.

    It offers various pharmaceutical formulation development contract services for both finished and semi-finished products like pellets to be filled in capsules and granules ready for compression.


    Eurofins CDMO - Capsule Drug Product Development Services

    Eurofins CDMO has solid-dosage capabilities and offers solid-dosage forms (capsules, tablets), parenteral formulations, ophthalmics, topicals, etc. It provides formulation development services for a wide range of different drug delivery routes and drug delivery systems for clinical and commercial manufacturing.

    Eurofins CDMO offers a full suite of pharmaceutical formulation development contract services encompassing preclinical development, formulation screening and pharmaceutical development capabilities, analytical development of oral solid forms for oral delivery, etc. 

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    Renejix

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      Renejix is a contract development and manufacturing organization (CDMO) with formulation development capabilities for soft and hard capsules. It offers controlled, immediate, modified, and extended release small molecule capsules and tablets.

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      Ethypharm

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      CDMO FOR COMPLEX OSDS

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      Ethypharm is a CDMO offering formulation development and manufacturing services for complex OSDs. It develops and produces a wide range of conventional, narcotic, and highly potent capsules by utilizing various oral solid dosage technologies.

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      Quotient Sciences

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      Quotient Sciences offers formulation development services for solid oral dosage forms, including liquid-filled capsules, immediate, sustained and modified release tablets, mini-tablets and orally disintegrating tablets (ODT), etc.

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      FORMULATION DEVELOPMENT OF CAPSULES

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      LGM Pharma is a trusted CDMO partner that offers formulation development of various oral solid dosage forms, such as capsules, tablets, beads, etc. It has a track record of regulatory approvals and successful commercial launches.

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      Athena Pharmaceutiques

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      Athena offers formulation development and manufacturing of various dosage forms, such as capsules, tablets, and pellets in capsules. It provides various types of capsules including modified and immediate release capsules.

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      FORMULATION DEVELOPMENT OF CAPSULES

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      Bora CDMO offers formulation development of capsules, single & combination fills, including powders, pellets, tablets and micro-tablets. It supports commercial formulation development & manufacturing strategies across a wide range of drug programs.

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      Fareva has more than 30 years of track record in the development and manufacturing of oral solid dosage forms such as tablets and hard capsules.

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      Aurigene Pharmaceutical Services

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      FORMULATION DEVELOPMENT OF HARD CAPSULES

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      Aurigene Pharmaceutical Services offers solid oral formulation development services for hard capsules (filled with powder/pellet), two types of mini-tablets in a single capsule and soft gelatin capsules, along with other solid dosage forms.

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      Aurigene Formulation Development of Hard Capsules

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      Douglas CDMO

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      Douglas CDMO has pilot-scale product development suites and commercial manufacturing facilities for oral drug products. It offers formulation development and production of capsules including softgels and hardgels.

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      Douglas Pharmaceuticals Formulation Development for Capsules

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      Gensenta Pharmaceuticals

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      ORAL SOLID DOSAGE FORMULATION DEVELOPMENT

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      Gensenta offers formulation development services for various oral solid dosage forms, such as hard capsules and tablets with strong R&D capability including highly potent APIs.

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      Oral Solid Dosage Formulation Development

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      JSC Olainfarm

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      CAPSULE FORMULATION DEVELOPMENT SERVICES

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      Olainfarm deals in the development of various solid dosage forms such as capsules and tablets. It develops the finished dosage forms at newly constructed and modern research laboratories with access to all state-of-the-art instruments.

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      JSC Olainfarm Capsule Formulation Development Services

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      Mikart

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      CDMO FOR CAPSULES

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      Mikart is an expert in the formulation development of solid dosage forms such as capsules. It is a CDMO that is engaged in the development of immediate, modified, delayed & extended-release capsules along with controlled substances & tablets in capsules.

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      Octavius Pharma Pvt. Ltd

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        CONTRACT DEVELOPMENT OF CAPSULES

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        Octavius Pharma is a contract development and manufacturing company that offers formulation development services for oral solids such as delayed release and sustained release capsules.

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        One Pharma

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        CDMO FOR CAPSULES

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        One Pharma is a contract development and manufacturing organization (CDMO), that offers solid dosage forms such as capsules and tablets.

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        Pfizer CentreOne

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        Pfizer CentreOne excels in the development and manufacturing of oral solid dosage forms such as capsules, tablets, granules & highly potent products for both clinical and commercial needs.

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        Porton Pharma Solutions

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        FORMULATION DEVELOPMENT FOR CAPSULES

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        Porton Pharma is engaged in the formulation development of oral solid drug products such as capsules and tablets. Its capsule range includes immediate release, modified release, and micro-pellet filled capsules.

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        Madras Pharmaceuticals

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        FORMULATION DEVELOPMENT OF CAPSULES

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        Madras Pharma is capable of developing, scaling up & commercializing various dosage forms such as capsules, soft gelatin capsules, tablets, injectables, suppositories, semi-solids & liquid orals.

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        Ropack Inc

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          PROTOTYPE FORMULATION OF CAPSULE

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          Ropack offers formulation development expertise for products at all stages. From prototype development, formulation selection, formulation optimization & release profile definition to late-stage formulation troubleshooting & lifecycle management.

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          Societal CDMO

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          DEVELOPMENT OF EXTENDED RELEASE CAPSULES

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          Recro provides formulation development services for a variety of pharmaceutical products. They offer the development of extended release oral solid dosage forms such as capsules, tablets & DEA controlled substances for clinical supply.

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          STABICON LIFE SCIENCE PVT LTD

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            CAPSULE DEVELOPMENT

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            Preformulation/reformulation for semi solid (only orals), topical & solid dosage forms, preclinical formulation, prototype development (lab scale) batches & tech transfer support.

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            Progenerics Pharma Pvt Ltd

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              CAPSULE DRUG PRODUCT DEVELOPMENT

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              Progenerics is focused on developing high quality affordable generic products for global markets. Facilities are capable of developing all dosage forms like solids, injectables, oncology solids & injectables (lyophilized product), creams & ointments, etc.

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              Pharma Service: API & Drug Product Development

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              Pierre Fabre

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              CONVENTIONAL CAPSULE DEVELOPMENT SERVICES

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              Pierre Fabre CDMO provides pharmaceutical formulation to commercial production services for conventional dry forms (capsules, tablets, sachets), lozenges and non sterile liquids (syrups and sprays), etc.

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              GRAM Laboratory Inc

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                CAPSULES

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                GRAM Laboratory's scientific staff has expertise encompassing the development of a variety of dosage forms including, sterile liquids, powders, emulsions & suspensions, tablets, capsules, oral liquids, ophthalmics, lyophilized powders, topicals, etc.

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                Ropack Inc

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                  GASTRO RESISTANT CAPSULES

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                  Ropack offers formulation development expertise for products at all stages. From prototype development, formulation selection, formulation optimization & release profile definition to late-stage formulation troubleshooting & lifecycle management.

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                  JGL d.d

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                  FORMULATION DEVELOPMENT OF CAPSULES

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                  JGL’s R&D offers the development of various oral dosage forms such as capsules, tablets and granules along with non-sterile solutions and semi-solid forms.

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                  Axxelent Pharma Science

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                    CAPSULE DEVELOPMENT SERVICES

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                    Axxelent is a contract development and manufacturing organization (CDMO), which offers development services for various oral solid dosage forms, including capsules and tablets.

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                    Ascent Innovative Medicines

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                      CAPSULE FORMULATION DEVELOPMENT

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                      Ascent offers end to end pharmaceutical formulation development services of capsules ranging from early phase development to clinical supplies for new chemical entities, generics and life cycle extension products.

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                      PharmaVize NV

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                        POWDER AND GRANULE FILLED CAPSULES

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                        Pharmavize can manufacture various dosage forms including powder and granule filled capsules.

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                        Progenerics Pharma Pvt Ltd

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                          DEVELOPING CAPSULES FOR ONCOLOGY

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                          Progenerics is focused on developing high quality affordable generic products for global markets. Facilities are capable of developing all dosage forms like solids, injectables, oncology solids & injectables (lyophilized product), creams & ointments, etc.

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                          PharmaVize NV

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                            SEMI-SOLID AND LIQUID FILLED CAPSULES

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                            Pharmavize can manufacture various dosage forms including semi-solid and liquid filled capsules.

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                            Prague Scientific

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                            FORMULATION DEVELOPMENT OF CAPSULES

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                            Prague Scientific offers formulation development for various drug delivery dosage forms, such as solid oral capsules with immediate release, modified release, delayed release, multi-unit delivery systems (pellets), etc.

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                            Sushen Medicamentos Pvt. Ltd

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                              CAPSULES FORMULATION & DEVELOPMENT

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                              SUSHEN is a global company for pharmaceutical services with a focus on drug delivery research & product development. Its expertise can bring a complex formulation project in to clinical & bioequivalence with superior quality & innovative solutions.

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                              Chanelle Medical

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                              FORMULATION DEVELOPMENT FOR CAPSULE

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                              Chanelle Medical has thrived on the strength of its high quality science driven research & development programmes. Its products are developed using in-house expert scientists & with assistance from its development laboratory in Amman, Jordan.

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                              PSR Pharma Science and Research

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                                CAPSULES

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                                PSR's team has extensive experience working with the following processes and delivery methods: Capsules.

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                                Bioplus Life Sciences

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                                CAPSULE FORMULATION DEVELOPMENT

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                                BioPlus Life Sciences is a CDMO that offers development services for various solid dosage forms, including capsules, soft gelatin capsules and vegan liquid capsules.

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                                Recipharm AB

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                                CAPSULE FORMULATION DEVELOPMENT

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                                Recipharm offers formulation development or drug product development services for all common dosage forms such as tablets, mini tablets, capsules, hard gelatin capsules, injectables, semi-solids and liquids.

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                                Zenvision Pharma LLP

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                                  HARD GELATIN CAPSULES

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                                  Formulation development is the core activity at Zenvision Pharma & it includes pre-formulation studies, formulation development, analytical method development & validation, stability studies, dossier preparation & technology transfer.

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                                  Unither Pharmaceuticals

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                                  HARD CAPSULE FORMULATION DEVELOPMENT

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                                  Unither Pharmaceuticals provides a range of flexible services for the production of capsules & tablets. They work from the early stages of R&D to create a new dry form or they can be your partner in reformulating or packaging an existing product.

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                                  PharmaVize NV

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                                    OVER ENCAPSULATED PRODUCTS

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                                    Pharmavize can manufacture various dosage forms including overencapsulated products.

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                                    ORIT LABS LLC

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                                    HARD GELATIN CAPSULES (POWDERS & PELLETS)

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                                    Orit Laboratories LLC has R&D Focused on Oral Rx Generic Pharmaceuticals including hard gelatin capsules (powders and pellets).

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                                    Tianjin Hankang Pharmaceutical Biotechnology

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                                      CDMO FOR CAPSULES

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                                      Hankang is an integrated CDMO that has formulation development capabilities for a wide range of dosage forms such as capsules including soft and hard capsules and tablets.

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                                      Aizant Drug Research Solutions Pvt. Ltd.

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                                      GRANULE & POWDER FILLED CAPSULES

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                                      Aizant's scientists use Quality-By-Design (QbD) tools at all stages of formulation development. Design of experiments (DOE) along with risk assessment strategies allows Aizant to design experimental plans efficiently.

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                                      Sofarimex

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                                        DEVELOPMENT OF CAPSULE FORMULATIONS

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                                        Sofarimex is the leader manufacturing company of pharmaceutical products in Portugal. This factory has a large productive flexibility, producing several pharmaceutical forms like solids, liquids, semi-solids & sterile products.

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                                        Sai Life Sciences Limited

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                                        FORMULATION DEVELOPMENT OF CAPSULES

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                                        Sai Life Sciences have vast & rich expertise of working across multiple technologies with increasing complexity to develop variety of dosage forms such as powder blend/granules in capsules, modified release capsules & liquid filled hard gelatin capsules.

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                                        Catalent Pharma Solutions

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                                        FORMULATION DEVELOPMENT FOR CAPSULES

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                                        Catalent is your trusted partner for your oral solid dose product needs such as capsules and tablets, from clinical development through to commercial manufacturing.

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                                        Eurofins CDMO

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                                        FORMULATION DEVELOPMENT FOR CAPSULES

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                                        Eurofins CDMO provides formulation development services for a wide range of drug delivery routes, drug delivery systems including liquid & solid oral forms (capsules, tablets), parenteral formulations, ophthalmics, topicals, etc.

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                                        Olive Healthcare

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                                          SOFT GELATIN FORMULATIONS DEVELOPMENT

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                                          Over the course of 30 years history, the development of new products at Olive has been fuelled by a fundamental desire to deliver healthcare solutions that are safe, effective, and relevant to our customer’s requirement.

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                                          Lonza Capsugel

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                                          HPMC, GELATIN & ALTERNATE POLYMER CAPSULES

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                                          With a diverse portfolio including HPMC, pullulan and gelatin capsules, Capsugel is a global leader in capsule development and capsule manufacturing.

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                                          Atral

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                                            CAPSULE FORMULATION DEVELOPMENT

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                                            Laboratórios Atral offers the development services for capsules, tablets, semi-solid, liquid and injectable solids, especially in the area of antibiotics, since they have facilities dedicated to the production of penicillins and cephalosporins.

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                                            Appcure Labs

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                                              FORMULATION DEVELOPMENT OF CAPSULES

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                                              Appcure Labs is an ideal strategic partner for outsourced pharmaceutical formulation development of solid dosage forms including capsules, tablets, and pellets.

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                                              Avivia

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                                                CAPSULES DEVELOPMENT

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                                                We are able to offer formulation development services for a variety of dosage forms including tablets, capsules, gels, creams, Liquids, solutions, suspensions, emulsions, suppositories, pessaries, granules for reconstitution & liquids for sterilization.

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                                                IDRS Labs

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                                                  CAPSULE FORMULATION DEVELOPMENT

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                                                  IDRS Labs' formulation development expertise encompasses a wide range of solid oral dosage forms such as capsules and tablets with different release profiles including mini-tablets in capsules and liquid-filled hard gelatin capsules.

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                                                  PCI Pharma Services

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                                                  CAPSULE FORMULATION DEVELOPMENT

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                                                  Equipped to meet the needs of development and clinical batch requirements, our development facility is scaled to produce up to 10kg batches of capsules.

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                                                  JAMP PHARMA

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                                                    ORAL FORMS - CAPSULE

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                                                    Through a diversified and growing portfolio, JAMP Pharma constantly develops innovative medications, vitamins, supplements, natural products and health & beauty products in Oral Forms, Lotions, Ophthalmics, Topicals, Injectables, Suppositories & Patches.

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                                                    Vici Health Sciences

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                                                      CAPSULE FORMULATION DEVELOPMENT SERVICES

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                                                      Vici has considerable experience in contract development of various orally administered formulations including capsules, coated multi-particulate beads, and powder-filled.

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                                                      Category: Formulation Development

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                                                      Torrent Pharmaceuticals Limited

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                                                      FORMULATION DEVELOPMENT FOR CAPSULES

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                                                      Torrent Pharma's state-of-the art R & D centre offers formulation development services for various types of capsules such as hard gelatin, soft gelatin, powder filled, tablet in capsules, pellets in capsules, etc.

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                                                      JSL Health Sciences

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                                                        CAPSULE FORMULATION DEVELOPMENT SERVICES

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                                                        JSL Health Sciences is a contract research and development organization that provides formulation development services for capsules such as immediate release, modified release, and pellet-containing.

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                                                        Avaca Pharma

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                                                          DEVELOPMENT OF IMMEDIATE RELEASE CAPSULES

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                                                          We perform formulation assessment, early stage proof of concept, formulation selection, design of experiments, pre formulation, release profile determination, formulation strategy, process development, optimization and technology development.

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                                                          M2M Pharmaceuticals Ltd

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                                                            CAPSULE FORMULATION DEVELOPMENT

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                                                            M2M Pharmaceuticals Ltd, a Contract Research Organization (CRO) supports early stage product development for pharmaceutical, food and biotech companies with various services in Method Development and Validation, Physico-Chemical Analysis, Formulation and Quality/Regulatory support.

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                                                            Custom Pharma Services

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                                                              FORMULATION DEVELOPMENT SERVICES OF CAPSULES

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                                                              Custom’s expert chemists, scientists and process engineers — many with 35 years of experience in the pharmaceutical industry — offer an extensive range of clinical and product development expertise, including significant preformulation and formulation exp

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                                                              AUPA Biopharm

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                                                                CDMO FOR CAPSULES

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                                                                Aupa BioPharm is a contract development and manufacturing organization (CDMO) that is engaged in the formulation development of oral solids such as capsules. It also specializes in the development of pellet-containing capsules along with general capsules.

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                                                                Biolink LifeSciences

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                                                                  CAPSULE FORMULATION DEVELOPMENT

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                                                                  Biolink Life Sciences provides immediate release solid dosage prototype development services for capsules, tablets, powders, and multi-particulate and modified release prototype development services for tablets and/or multi-particulates beads.

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                                                                  Lamda Laboratories

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                                                                    DEVELOPMENT OF MODIFIED RELEASE CAPSULES

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                                                                    Our key area of expertise are Immediate/Modified Rrelease -Tablets/ Capsules/Solutions/Suspensions/ Powders; Topical Dosage Forms-Creams, Ointments, Cutaneous solutions; Sterile Dosage Forms-Injectables, Nasal preparations, Ophthalmic preparations.

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                                                                    Category: Formulation Development

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                                                                    GALENIX INNOVATIONS

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                                                                      CAPSULES DEVELOPMENT

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                                                                      All kinds of dosage forms are developed at Galenix, from the most simple to the most sophisticated one. Patented Drug Delivery Systems developed by Galenix may also modify the drug product’s features in order to respond to special requirements.

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                                                                      Novick Biosciences

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                                                                        CAPSULE FORMULATION DEVELOPMENT

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                                                                        All formulation services can be utilized independently or fully integrated within on-going services at Novick. These services include the development of Tablets, Capsules, Pellets, Liquid Orals, Powder/Granules, Semi Solids, Topicals, Ophthalmics.

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                                                                        Globela Pharma

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                                                                        CAPSULE DEVELOPMENT

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                                                                        Globela Pharma Pvt Ltd has uplifted our existing R & D facility, and installed fully functioning in house R & D center- with state of the art infrastructure, and experienced, skilled manpower.

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                                                                        Cyndea Pharma S.L

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                                                                          SOFT GELATIN CAPSULE DEVELOPMENT

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                                                                          Development and manufacturing of women healthcare products and niche type products for third party partners (B2B), covering world wide markets.

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                                                                          Labiana Life Sciences S.A

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                                                                          DEVELOPMENT & IMPROVEMENT OF CAPSULE

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                                                                          LABIANA GROUP offers development and improvement of sterile solutions or suspensions, lyophilizates, eye drops, liquids in solution or non-sterile suspension, oral powders, capsules and tablets.

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                                                                          Avaca Pharma

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                                                                            ENCAPSULATION

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                                                                            We perform formulation assessment, early stage proof of concept, formulation selection, design of experiments, pre formulation, release profile determination, formulation strategy, process development, optimization and technology development.

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                                                                            Cyndea Pharma S.L

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                                                                              HARD GELATIN CAPSULE DEVELOPMENT

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                                                                              Development and manufacturing of women healthcare products and niche type products for third party partners (B2B), covering world wide markets.

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                                                                              Softigel Procaps

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                                                                              HARD GEL CAPSULE DEVELOPMENT

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                                                                              Softigel is specialized in softgel technologies and offer access to other delivery systems such as sterile liquids, injectables, prefilled syringes, creams, ointments, gels, powders, tablets and hard gel capsules.

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                                                                              Siegfried AG

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                                                                              DEVELOPMENT OF CAPSULE FORMULATIONS

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                                                                              Siegfried is your expert in complex oral drug delivery systems with the most advanced development, manufacturing and packaging capabilities in the CDMO industry installed in state of the art facilities located in Zofingen (Switzerland) and Hal Far (Malta).

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                                                                              Aragen Life Sciences

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                                                                              DEVELOPMENT OF CAPSULES FILLED WITH POWDER / GRANULES

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                                                                              GVK BIO adopts a comprehensive, time-bound strategy in developing stable products that are efficient in all quality aspects.

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                                                                              Aragen Life Sciences

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                                                                              DEVELOPMENT OF CAPSULES FILLED WITH IR PELLETS

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                                                                              GVK BIO adopts a comprehensive, time-bound strategy in developing stable products that are efficient in all quality aspects.

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                                                                              Cambrex Corporation

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                                                                              INTEGRATED DEVELOPMENT, MANUFACTURING-CAPSULE

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                                                                              With fully integrated development and manufacturing services for solid dosage forms (Tablet, Capsule & Powder), liquids, creams and both sterile and non-sterile ointments, our experts develop and manufacture drug products with success.

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                                                                              Servier

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                                                                              CDMO CAPABILITIES FOR CAPSULE

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                                                                              Servier CDMO has the capabilities to deliver your project from development through to the manufacture of large commercial batch sizes of tablets, capsules or powders. Servier has 60 years of experience with a proven track record of quality and regulatory approval to ensure reliability for your

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