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AK104 (cadonilimab) is a PD-1/CTLA-4 bi-specific antibody which is being investigated in phase 3 in combination with chemotherapy (Carboplatin, Pemetrexed, Paclitaxel) for PD-L1 negative non-small cell lung cancer.
Lead Product(s): Cadonilimab,Carboplatin,Pemetrexed
Therapeutic Area: Oncology Product Name: AK104
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 06, 2024
Details:
AK104 (cadonilimab) is a bispecific antibody that targets both PD-1 & CTLA-4. It is under phase 3 clinical development in combination with chemotherapy for the treatment of unresectable locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma.
Lead Product(s): Cadonilimab,Capecitabine,Oxaliplatin
Therapeutic Area: Oncology Product Name: AK104
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable December 05, 2023
Details:
AK104 (cadonilimab) is a PD-1/CTLA-4 bi-specific antibody approved and marketed for use in combination with chemotherapy as first-line therapy for advanced gastric or gastroesophageal junction cancer (GC/GEJC).
Lead Product(s): Cadonilimab
Therapeutic Area: Oncology Product Name: AK104
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 07, 2023
Details:
AK117 (ligufalimab) is a next generation of humanized lgG4 anti-CD47 antibody without hemagglutination effect, which is investigated in Combination with Azacitidine for the treatment of Myelodysplastic Syndromes.
Lead Product(s): Ligufalimab,Azacitidine
Therapeutic Area: Oncology Product Name: AK117
Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 27, 2023
Details:
SMT112 (ivonescimab) is a potential first-in-class investigational PD-1/VEGF bi-specific antibody, which is investigated for the treatment of first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer.
Lead Product(s): Ivonescimab
Therapeutic Area: Oncology Product Name: SMT112
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Summit Therapeutics
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 29, 2023
Details:
AK112/SMT112 (ivonescimab) is a potential first-in-class investigational PD-1/VEGF bi-specific antibody, which is investigated for the treatment of first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer.
Lead Product(s): Ivonescimab
Therapeutic Area: Oncology Product Name: AK112
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 25, 2023
Details:
AK101 (ebdarokimab) is a novel fully human Interleukin-12/Interleukin-23 monoclonal antibody, which is investigated for the treatment of adult patients with moderate-to-severe plaque-type psoriasis.
Lead Product(s): Ebdarokimab
Therapeutic Area: Dermatology Product Name: AK101
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 24, 2023
Details:
SMT112 (Ivonescimab) is a potential first-in-class investigational PD-1/VEGF bi-specific antibody, which is investigated for the treatment of first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer.
Lead Product(s): Ivonescimab
Therapeutic Area: Oncology Product Name: SMT112
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Summit Therapeutics
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 18, 2023
Details:
NMPA has accepted its NDA for its fully human anti-PCSK9 monoclonal antibody AK102 (ebronucimab) for 2 indications 1) primary hypercholesterolemia and mixed hyperlipidemia, and 2) heterozygous familial hypercholesterolemia.
Lead Product(s): Ebronucimab
Therapeutic Area: Cardiology/Vascular Diseases Product Name: AK102
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: AD Pharmaceuticals
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 01, 2023
Details:
AK104 (cadonilimab) is a PD-1/CTLA-4 bi-specific antibody approved and marketed for use in combination with chemotherapy as first-line therapy for advanced gastric or gastroesophageal junction cancer (GC/GEJC).
Lead Product(s): Cadonilimab
Therapeutic Area: Oncology Product Name: AK104
Highest Development Status: Phase IIIProduct Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 14, 2023