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    Comanche Biopharma Closes Oversubscribed $75 Million Series B Financing to Advance Mission to Develop and Make Globally Available the First Treatment Ta...

    Details:

    Comanche will initiate a clinical study of CBP-4888, a fixed-dose combination of two small interfering ribonucleic acid (siRNAs) duplex oligonucleotides targeting soluble fms-like tyrosine kinase–1 (sFLT1) mRNA isoformse, in pregnant preeclamptic patients.


    Lead Product(s): CBP-4888

    Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: CBP-4888

    Highest Development Status: Phase IProduct Type: Large molecule

    Partner/Sponsor/Collaborator: Google Ventures

    Deal Size: $75.0 million Upfront Cash: Undisclosed

    Deal Type: Series B Financing January 17, 2024

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    Comanche Biopharma Receives US FDA Fast Track Designation for CBP-4888 for the Treatment of sFlt-1 Mediated Pre-Term Preeclampsia

    Details:

    CBP-4888 is a fixed-dose combination of siRNA-2283 and siRNA-2519 targeting two soluble fms-like tyrosine kinase–1 (sFLT1) mRNA isoforms, which is investigated for the treatment of sFlt-1 mediated pre-term preeclampsia.


    Lead Product(s): siRNA-2283,siRNA-2519

    Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: CBP-4888

    Highest Development Status: Phase IProduct Type: Large molecule

    Partner/Sponsor/Collaborator: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable August 23, 2023

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    Comanche Biopharma Announces FDA Clearance of Investigational New Drug (IND) Application for CBP-4888, an siRNA Investigational Therapy for the Treatmen...

    Details:

    CBP-4888 is a fixed-dose combination of two chemically-synthesized, lipid-conjugated siRNAs duplex oligonucleotides (siRNA-2283 and siRNA-2519) targeting and decreasing the production of soluble fms-like tyrosine kinase-1 in the placenta, as a treament for preeclampsia.


    Lead Product(s): CBP-4888

    Therapeutic Area: Obstetrics/Gynecology (Women’s Health) Product Name: CBP-4888

    Highest Development Status: IND EnablingProduct Type: Large molecule

    Partner/Sponsor/Collaborator: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable March 30, 2023

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