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The net proceeds will be used to support Crossject’s activities in bringing its Zepizure (midazolam), a short-acting hypnotic-sedative epileptic rescue therapy, to market.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zepizure

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Gemmes Venture

Deal Size: $8.2 million Upfront Cash: Undisclosed

Deal Type: Public Offering June 04, 2024

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Under the terms of the agreement, Crossject Zepizure (midazolam) will be commercialized in the European market for the treatment of epileptic seizures.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zepizure

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Undisclosed

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement May 02, 2024

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The financing aims to support the clinical development of Zepizure (midazolam), a short-acting hypnotic-sedative medication currently undergoing evaluation in patients for the treatment of epileptic seizures.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zepizure

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Heights Capital Management

Deal Size: $12.0 million Upfront Cash: Undisclosed

Deal Type: Financing February 27, 2024

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Under the agreement, Syneos Health will provide support in all pre-launch and launch activities for Zepizure (midazolam), an epileptic rescue therapy for epileptic seizures.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zepizure

Highest Development Status: ApprovedProduct Type: Small molecule

Recipient: Syneos Health

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement January 04, 2024

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The agreement aims for the commercialization of Crossject's innovative rescue therapy for epileptic seizures Zepizure (midazolam), previously known as ZENEO® Midazolam, in northern Europe covering Germany, the UK, Denmark, Sweden, Finland and Norway.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zepizure

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Undisclosed

Deal Size: $1.0 million Upfront Cash: Undisclosed

Deal Type: Agreement December 22, 2023

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Under the agreement, AFT will commercialise ZENEO® Midazolam, a combination of the single use needle-free auto injector ZENEO® and the drug product midazolam, in epileptic seizures in Australia and New Zealand.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zeneo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: AFT Pharmaceuticals

Deal Size: $0.7 million Upfront Cash: Undisclosed

Deal Type: Licensing Agreement July 20, 2023

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ZENEO and the syringe with intramucular needle showed a similar and low inter-subject variability of midazolam pharmacokinetics. This is an additional demonstration that an injection with ZENEO reached muscle in the same way as an injection with a syringe and a 30 mm needle.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zeneo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 02, 2022

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ZENEO's Midazolam is developed as a combination of the single use needle-free auto injector ZENEO and the drug product midazolam, which is an improved anti-convulsant benzodiazepine recommended for treatment of strong seizures resulting from epilepsia.


Lead Product(s): Midazolam

Therapeutic Area: Neurology Product Name: Zeneo

Highest Development Status: ApprovedProduct Type: Small molecule

Partner/Sponsor/Collaborator: BARDA

Deal Size: $60.0 million Upfront Cash: Undisclosed

Deal Type: Agreement June 18, 2022

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