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Mosaic ImmunoEngineering
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Through the acquisition, the company will utilize OT-101 (trabedersen), currently under investigation in mid-stage clinical trials with adult patients, for treating brain cancer and diffuse intrinsic pontine glioma.


Lead Product(s): Trabedersen

Therapeutic Area: Oncology Product Name: OT-101

Highest Development Status: Phase IIProduct Type: Large molecule

Recipient: Oncotelic Therapeutics

Deal Size: $15.0 million Upfront Cash: Undisclosed

Deal Type: Acquisition April 29, 2024

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MIE-101, a Cowpea mosaic virus has shown to engage multiple Toll-like receptors on host immune cells in the tumor that have evolved to detect foreign invaders enhanced antitumor effects when combined with immune checkpoint inhibitors and other standard cancer therapies.


Lead Product(s): MIE-101

Therapeutic Area: Oncology Product Name: MIE-101

Highest Development Status: IND EnablingProduct Type: Large molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 01, 2021

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Under the agreement, Mosaic has licensed rights to develop and commercialize new treatment candidates including lead product, MIE-101, is derived from the cowpea mosaic virus (CPMV), that broaden the scope and capabilities of the protein nanoparticle platform to treat cancer.


Lead Product(s): MIE-101

Therapeutic Area: Oncology Product Name: MIE-101

Highest Development Status: PreclinicalProduct Type: Large molecule

Partner/Sponsor/Collaborator: University of California San Diego

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement October 06, 2021

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