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NV-CoV-2 (NV-387) was designed to mimic sulfated proteoglycans that a large number of virus families bind to as the first step in infecting a cell. It may possess significant antiviral activity against many other virus families in addition to COVID-19, MPox and Smallpox virus infections.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 30, 2024

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The drug NV-CoV-2 contains the Company's nanoviricide active agent, NV-387, which has shown strong broad-spectrum antiviral activity not only against multiple coronaviruses, but also against RSV and in a model for Smallpox therapeutics.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 28, 2023

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NV-CoV-2 (NV-387) was designed to mimic sulfated proteoglycans that a large number of virus families bind to as the first step in infecting a cell. It may possess significant antiviral activity against many other virus families in addition to MPox and Smallpox virus infections.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 14, 2023

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NV-CoV-2 (NV-387) was designed to mimic sulfated proteoglycans that a large number of virus families bind to as the first step in infecting a cell. It may possess significant antiviral activity against many other virus families in addition to coronaviruses.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 21, 2023

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NV-CoV-2 (NV-387) is a first-in-class chemical nanomachine that acts by a novel mechanism of action is re-Infection blocker. which is invetigated for the treatment of covid-19 infection.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 11, 2023

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NV-CoV-2 (NV-387) is a first-in-class chemical nanomachine that acts by a novel mechanism of action is re-Infection blocker. which is invetigated for the treatment of covid-19 infection.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 29, 2023

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Details:

NV-CoV-2 (NV-387) was designed to mimic sulfated proteoglycans that a large number of virus families bind to as the first step in infecting a cell. It may possess significant antiviral activity against many other virus families in addition to coronaviruses.


Lead Product(s): NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: Phase IProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 25, 2023

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Under this Agreement, Karveer has the right to commercialize the Company's COVID drugs NV-CoV-2 and NV-CoV-2-R in India. To enable commercialization, Karveer has undertaken Clinical Development and Evaluation and is sponsoring these two drugs in India for this purpose.


Lead Product(s): NV-CoV-2

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-CoV-2

Highest Development Status: Phase I/ Phase IIProduct Type: Large molecule

Partner/Sponsor/Collaborator: Karveer Meditech

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement April 04, 2023

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The Company has also demonstrated the ability of NV-387 to encapsulate and improve the pharmacokinetics and pharmacodynamics of a very difficult drug, namely remdesivir, that is formulated in a cyclodextrin-based formulation at present (Veklury® Gilead).


Lead Product(s): Tecovirimat,NV-387

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-387

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 04, 2022

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In this well-known assay, NV-CoV-2 was as effective as the neutralizing antibody in reducing the virus infection. This study demonstrates that NV-CoV-2 attacks the SARS-CoV-2 pseudovirion particles and renders them incapable of binding to the ACE2 positive cells.


Lead Product(s): NV-Cov-2,Remdesivir

Therapeutic Area: Infections and Infectious Diseases Product Name: NV-Cov-2-R

Highest Development Status: PreclinicalProduct Type: Small molecule

Partner/Sponsor/Collaborator: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 11, 2021

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