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    Looking for Overview? Find API Manufacturing for Low Temperature / Cryogenic conditions & other pharma service details on PharmaCompass.

    Cryogenic Reactions
    HTL Biotechnology is the world leader in the responsible development and production of pharmaceutical-grade biopolymers.
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    01 Polpharma (1)

    02 Axplora (1)

    03 Minakem (1)

    04 PMC Isochem (1)

    05 Neuland Laboratories (1)

    06 Alven Laboratories (1)

    07 Anacipher (1)

    08 Bellen Chemistry (1)

    09 Bioindustria L.I.M. Spa (1)

    10 CARBOGEN AMCIS AG (1)

    11 DOTTIKON EXCLUSIVE SYNTHESIS AG (1)

    12 Evotec (1)

    13 Grace (1)

    14 Olon S.p.A (1)

    15 Recipharm AB (1)

    16 ScinoPharm Taiwan, Ltd (1)

    17 Siegfried AG (1)

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    01 China (1)

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    03 France (2)

    04 Germany (2)

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    Polpharma

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    CRYOGENIC REACTIONS

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    Polpharma API is a contract development and manufacturing organization (CDMO) that has experience in cryogenic reactions for pilot and commercial scale with operational temperatures down to -80 °C.

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    Category: Low Temperature / Cryogenic conditions

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    Cryogenic Reactions

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    Axplora

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    CRYOGENIC CHEMISTRY

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    Axplora's Chasse-sur-Rhône site in France offers CDMO services for APIs from process development, clinical supply to commercial manufacturing. It also provides low-temperature reactions, industrial chromatography, and high-pressure hydrogenation.

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    CRYOGENIC CHEMISTRY

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    Minakem

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    LOW TEMPERATURE CHEMISTRY

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    Minakem is a leader in certain technologies such as low-temperature chemistry, flow reactions, hazardous chemistry and HPAPIs (high-potency active pharmaceutical ingredients), including cytotoxic molecules.

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    PMC Isochem

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    CRYOGENIC REACTIONS

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    PMC Isochem offers cGMP cryogenic reactions. It works on both rapid evaluation and process development for scale-up of cryogenic reactions.

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    PMC Isochem Cryogenic Reactions

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    Neuland Laboratories

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    CRYOGENIC REACTIONS

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    Neuland is a contract development and manufacturing organization (CDMO) that has the capability to handle cryogenic reactions with a reactor volume of 25 kiloliters.

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    Alven Laboratories

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    PERFORMING A VARIABILITY OF REACTIONS (-50°C)

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    Alven's facility has all relevant infrastructure to perform a variability of reactions and production conditions, including Temperature range -50 °C to 200 °C.

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    DOTTIKON EXCLUSIVE SYNTHESIS AG

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    LOW-TEMPERATURE PROCESSES

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    DOTTIKON has know-how and low-temperature equipment (glass and Hastelloy) on all scales for batch-wise as well as continuous processing: Research & Development up to 0.5 l and down to –80 °C, Small-scale & Pilot up to 160 l and down to –80 °C, Production

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    Recipharm AB

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    LOW TEMPERATURE REACTIONS

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    Recipharm's multi-purpose plant can manufacture several API products at a time, including generic & hormonal APIs. The facility is equipped to handle low temperature (–80 degrees Celsius), high temperature (150 degrees Celsius) & high pressure reactions.

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    Bioindustria L.I.M. Spa

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    TEMPERATURE CAPABILITIES (-100°C TO +170°C)

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    Biondustria L.I.M has temperature capabilities from -100°C to +170°C.

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    ScinoPharm Taiwan, Ltd

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    LOW TEMPERATURE ASYMMETRIC SYNTHESIS

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    ScinoPharm's core competency will be to specialize in producing international cGMP-quality Active Pharmaceutical Ingredients through organic synthesis.

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    Anacipher

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      CRYOGENIC REACTION FACILITIES

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      Synthetic Labs are supported by expert team of scientist in handling mg to Kg scale Reactions, adequate Utility Services, hygienic Environment, cryogenic & High pressure Reaction Facilities and separate Laboratories for CRAMS and Generic Research.

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      Grace

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        LOW TEMPERATURE (-80º C) MANUFACTURING CAPABILITIES

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        Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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        Siegfried AG

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        CRYOGENIC REACTIONS

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        Special technologies and manufacturing processes including full scale cryogenics, phosgenation, hazardous reactions, isolation technology, micro-reactors, and spray drying, and having 800 liters hastelloy C22 reactor for cryogenic reactions, and temperature range -100°C to 250°C.

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        Olon S.p.A

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        LOW TEMPERATURE REACTIONS

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        In the area of fully synthetic organic chemicals, Olon S.p.A. has a wide range of advanced and sophisticated technologies such as organo-metallic chemistry, low temperature reactions, photo-chemistry, etc. that consent to obtain very complex APIs and building blocks.

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        CARBOGEN AMCIS AG

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        TEMPERATURE RANGE FROM -80°C TO +250 °C

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        Large-scale production capacities (upto 4’500 L, with a temperature range from -80°C to +250 °C) allow the efficient production of early-phase APIs and large-scale intermediates under nonGMP conditions at the CARBOGEN AMCIS Swiss’ facilities.

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        Evotec

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        CRYOGENIC CAPABILITY UPTO –80°C

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        Our key aspects of Evotec’s pilot plant offering is Cryogenic capability to –80°C and  up to +160°C

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        Bellen Chemistry

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          CRYOGENIC REACTIONS

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          Bellen Chemistry's manufacturing plant in Shandong, China, utilize cryogenic reactors with an operating range down to -78 °C & hydrogenators ranging from 100L to 2000L that operate up to 50 bar. Their current reactor volume is ~100m3.

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