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    Company profile for Medichem S.A

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    Medichem Sustainability Report 2023 – Einf (Non-Financial Information)

    01 Aug 2024

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    Join Medichem At Cphi Worldwide 2024: Your Gateway To High-Quality Apis And FDFs

    26 Jul 2024

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    En Medichem Renovamos La Carta De Diversidad

    21 Jun 2024

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    Medichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

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    About

    Medichem is an indepently-owned company based in Barcelona. Founded in 1972 and with more than 45 years, Medichem has been engaged in the process development and manufacture of Active Pharmaceutical Ingredients (APIs), including Highly Potent. In 2016, Medichem merged with Combino Pharm, which is devoted to the development and manufacture (licensing) of Finished Dosage Forms. With this merger, Medichem has become a vertically integrated pharmaceutical company which can offer a complete range of products and services for the pharmaceutical industry with the highest standards of quality, operational excellence and environment respect.

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    Spain
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    Carrer de Fructuós Gelabert, 608970 Sant Joan Despí, Barcelona
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    +34 934776440
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    CPhI India 2024

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    CORPORATE CONTENT #SupplierSpotlight

    Product List 2024

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    Corporate Presentation

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    APIs Product List 2024

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    GMP Certificate 2023

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    FDF Product List 2024

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    APIs Under Development 2024

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    Dossiers Under Development 2024

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    APIs Under Consideration 2024

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    Dossiers Under Consideration 2024

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    Chlorhexidine API

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    Chlorhexidine FDF

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    Flow Chemistry

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    DATA COMPILATION #PharmaFlow

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    DMF filings hit all-time high in Q3 2024; China tops list with 58% increase in Type II submissions

    DMF filings hit all-time high in Q3 2024; China tops list with 58% increase in Type II submissions

    Drug Master Files, or DMFs, are confidential documents that play a crucial role in the pharmaceutical industry. These files, submitted to the US Food and Drug Administration (FDA), contain detailed information about ingredients, manufacturing processes, and packaging of medicines. They help the FDA oversee drug quality. Of the four types, Type II DMFs involve active pharmaceutical ingredients (APIs) for both branded and generic drugs. The third quarter (Q3) of 2024 saw Type II DMF submissions set a new record. A total of 309 Type II DMFs were submitted to the FDA during this period, a substantial 24.6 percent increase over Q3 2023 (with 248 submissions). The second quarter of 2024 too saw a remarkable increase, with 237 Type II DMFs being submitted compared to 178 in Q2 2023. View FDA DMF Filings in Q3 2024 (Power BI Dashboard, Free Excel Available) China witnesses steep rise in DMF submissions, beats India with maximum filings In Q3 2024, China filed 153 DMFs submissions, marking a substantial 57.7 percent increase from the 97 submissions filed in Q3 2023. India maintained its strong position but fell to the number two spot with 110 DMFs, representing a modest 3.8 percent increase from 106 in Q3 2023. The US, which came a distant third, saw a slight decline in DMF submissions, with 13 filed in Q3 2024, as compared to 18 in Q3 2023. For several years, India had a lead in Type II DMFs. Since 2020, which marked the start of the pandemic, we have noticed a gradual increase in DMFs filed by China. This year, China has surpassed India considerably in the first three quarters. During the first nine months of 2024, China submitted 372, while India filed 286 DMFs. If this lead is maintained in Q4, DMFs from China will surpass that of India in 2024.  Amongst European countries, Spain led with seven DMFs, followed by Italy at four, and Germany and the Netherlands at three each. Among other nations, Japan contributed six while Israel submitted four DMFs. In company-wise tally, China’s Jiangsu East-Mab Biomedical Technology topped the list with an impressive 14 DMFs. On its heels were Indian companies — MSN at 13 DMFs, and Vamsi Labs and Hetero Drugs at nine DMFs each. China’s Porton Pharma and Wuxi AppTec filed five, while Shanghai Keze Yongxin Biotechnology, and Qingdao Glycogene Pharmaceutical contributed four submissions each. India's Maithri Drugs also submitted four. Japanese company Santeja filed five. Overall, Asia accounted for nearly 90 percent, with China contributing a dominant 49.5 percent of all DMF submissions. India was at 35.6 percent, the US at 4.2 percent, while Europe contributed 6.5 percent.  View FDA DMF Filings in Q3 2024 (Power BI Dashboard, Free Excel Available) Diabetes, obesity, cancer, women’s health drugs emerge as hot molecules in Q3 2024 In terms of molecules, semaglutide (used for the treatment of type 2 diabetes and weight management) and relugolix (to treat prostate cancer and uterine fibroids) saw six DMF filings each in Q3 2024, indicating significant industry interest in these compounds. Following closely behind were semaglutide’s competitor tirzepatide and overactive bladder therapy vibegron, garnering four DMFs each. Finerenone (a non-steroidal drug for chronic kidney disease associated with type 2 diabetes) and voclosporin (an immunosuppressant for lupus nephritis) saw three DMFs each.  The last quarter also witnessed the introduction of 14 molecules with first-time DMFs. Among them were acetoxy empagliflozin, cabozantinib fumarate, tivozanib hydrochloride monohydrate, diosmetin, trilaciclib, clenbuterol hydrochloride, fenoterol hydrobromide, tapinarof and fezolinetant. Fezolinetant, with a DMF from Spain’s Moehs Iberica, is the active ingredient in Astellas’ Veozah, which is the first non-hormonal treatment for menopausal symptoms approved by the FDA. Tapinarof, filed by India’s Maithri Drugs, is used in Vtama, a novel steroid-free psoriasis cream. Other compounds that made their DMF debut include berotralstat, calcium phosphoryl choline chloride, phloroglucinol dihydrate, belumosudil mesylate and trimethylphloroglucinol. During Q2 2024, there were 19 drugs that saw DMF submissions for the first time, including molecules like triptorelin, sorafenib, pralsetinib, trilaciclib dihydrochloride, resmetirom (hepatology) and teneligliptin hydrochloride hydrate (metabolic disorders).  View FDA DMF Filings in Q3 2024 (Power BI Dashboard, Free Excel Available)    GDUFA fee for FY 2025: The FDA’s Generic Drug User Fee Amendments (GDUFA) is a law designed to speed access to safe and effective generic drugs to the public and reduce costs to the industry. The fiscal year 2025 fee rates were published on July 31, 2024. The FDA has revised fees under GDUFA III for all categories. While there is a slight increase in the DMF fee from US$ 94,682 in 2024 to US$ 95,084 in 2025, the ANDA fee has witnessed a significant jump — from US$ 252,453 in 2024 to US$ 321,920 in 2025. FY 2024 and FY 2025 User Fee Rates Generic drug fee category Fees rates for FY 2024 Fees rates for FY 2025 Applications: Abbreviated New Drug Application (ANDA) US$ 2,52,453   US$ 3,21,920   Drug Master File (DMF) US$ 94,682 US$ 95,084 Facilities: Active Pharmaceutical Ingredient (API)—Domestic US$ 40,464 US$ 41,580 API—Foreign US$ 55,464 US$ 56,580 Finished Dosage Form (FDF)—Domestic US$ 2,20,427   US$ 2,31,952 FDF—Foreign US$ 2,35,427   US$ 2,46,952 Contract Manufacturing Organization (CMO)—Domestic US$ 52,902 US$ 55,668 CMO—Foreign US$ 67,902 US$ 70,668 GDUFA Program: Large size operation generic drug applicant US$ 17,29,629   US$ 18,91,664 Medium size operation generic drug applicant US$ 6,91,852   US$ 7,56,666 Small business generic drug applicant US$ 1,72,963   US$ 1,89,166 Our view The highlight of the last few quarters has been the sharp rise in Type II DMF filings from China. The submission of a DMF is not required by law or any FDA regulation. FDA’s DMF guideline offers guidance on acceptable approaches to meeting regulatory requirements. Moreover, DMFs establish trust in APIs from lesser-known companies. With a growing emphasis on compliance and quality assurance, it appears that Chinese drug companies are eager to demonstrate their commitment to high standards and build trust in the US market. And that’s good news for the pharmaceutical industry.   
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    NEWS #PharmaBuzz

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    Medichem Sustainability Report 2023 – Einf (Non-Financial Information)
    Medichem Sustainability Report 2023 – Einf (Non-Financial Information)

    01 Aug 2024

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    https://www.medichem.es/news/medichem-sustainability-report-2023-einf-non-financial-information/

    PRESS RELEASE
    01 Aug 2024
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    Join Medichem At Cphi Worldwide 2024: Your Gateway To High-Quality Apis And FDFs
    Join Medichem At Cphi Worldwide 2024: Your Gateway To High-Quality Apis And FDFs

    26 Jul 2024

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    https://www.medichem.es/news/join-medichem-at-cphi-worldwide-2024-your-gateway-to-high-quality-apis-and-fdfs/

    PRESS RELEASE
    26 Jul 2024
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    En Medichem Renovamos La Carta De Diversidad
    En Medichem Renovamos La Carta De Diversidad

    21 Jun 2024

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    https://www.medichem.es/news/en-medichem-renovamos-la-carta-de-diversidad/

    PRESS RELEASE
    21 Jun 2024
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    Medichem En El Programa Dona’M Ciència
    Medichem En El Programa Dona’M Ciència

    17 Jun 2024

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    https://www.medichem.es/news/medichem-en-el-programa-donam-ciencia/

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    17 Jun 2024
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    Since 2021, Our API Manufacturing Site In Celrà Certified By (PMDA)
    Since 2021, Our API Manufacturing Site In Celrà Certified By (PMDA)

    31 May 2024

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    https://www.medichem.es/news/api-manufacturing-site-in-celra-certified-by-pmda/

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    31 May 2024
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    We Are Happy To Announce Sugammadex APIs Has Been Approved By Japanese
    We Are Happy To Announce Sugammadex APIs Has Been Approved By Japanese

    27 May 2024

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    https://www.medichem.es/news/sugammadex-api-approved-by-japanese-authorities/

    PRESS RELEASE
    27 May 2024
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    Virtual BoothMedichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

    Regulatory Info :

    Registration Country : Spain

    2-Phenoxyethanol; Octenidine Hydrochloride

    Medichem S.A

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    Amiodarone Hydrochloride

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    Dosage Form : Intravenous Bag

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    Dosage Strength : 1.5MG/ML

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    Virtual BoothMedichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

    Regulatory Info :

    Registration Country : Spain

    Amiodarone Hydrochloride

    Medichem S.A

    Dosage Form : Intravenous Bag

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    Dosage Strength : 1.8MG/ML

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    Virtual BoothMedichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

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    Apixaban

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    Dosage Form : Film Coated Tablet

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    Dosage Strength : 2.5MG

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    Apixaban

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    Dosage Strength : 5MG

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    Calcium Gluconate

    Medichem S.A

    Dosage Form : Intravenous Vial

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    Dosage Strength : 100MG/ML

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    Virtual BoothMedichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

    Regulatory Info :

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    Captopril

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    Dosage Form : Tablet

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    Dosage Strength : 12.5MG

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    Captopril

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    Dosage Form : Tablet

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    Dosage Strength : 25MG

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    Virtual BoothMedichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

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    Captopril

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    Dosage Form : Tablet

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    Dosage Strength : 50MG

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    Virtual BoothMedichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

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    Registration Country : Spain

    Captopril

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    Dosage Form : Tablet

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    Dosage Strength : 100MG

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    Medichem S.A is a supplier offers 73 products (APIs, Excipients or Intermediates).

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