Company profile for Teva Pharmaceutical Industries

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About

Teva was established in 1901. Our global headquarters are based in Israel. Today we have a portfolio of more than 3,500 medicines, and produce approximately 120 billion tablets and capsules a year at 70 manufacturing facilities. We rank among the leading pharmaceutical companies in the world and are active in 60 countries. Approximately 43,000 employees around the world are dedicated to our mission. Building on our strong glob...
Teva was established in 1901. Our global headquarters are based in Israel. Today we have a portfolio of more than 3,500 medicines, and produce approximately 120 billion tablets and capsules a year at 70 manufacturing facilities. We rank among the leading pharmaceutical companies in the world and are active in 60 countries. Approximately 43,000 employees around the world are dedicated to our mission. Building on our strong global footprint, size and scale, Teva is reaffirming its commitment to place people at the center of our strategy, and enable as many as possible to live better, healthier days.

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CONTACT DETAILS

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Country
Country
Israel
Address
Address
5 Basel St., Petach Tikva Israel, 49131
Telephone
Telephone
+972-3-9267267
youtube
YouTube
Twitter
Twitter

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INTERVIEW #SpeakPharma

[Sponsored by another company]
“Translational Pharmaceutics, our flagship platform for drug development, empowers our clients with unparalleled flexibility”
This week, SpeakPharma interviews Denise Sutton, Chief Operating Officer and Site Head at Quotient Sciences’ Nottingham facility in the UK. Quotient Sciences is a drug development and manufacturing accelerator that offers the innovative Translational Pharmaceutics platform to support customers in overcoming drug development challenges. Sutton has been with the company for over 25 years. In this interview, she provides insights into the evolution of Quotient Sciences’ Nottingham facility and discusses how the organization has transformed from a small 10-bed clinic to a comprehensive drug development campus with six GMP suites. She also shares her perspective on the company’s unique approach to integrating drug development services. HIGHLIGHTS// evolution of Quotient Sciences’ Nottingham facility/ unique approach to integrating drug development services How has the Nottingham site transformed from when it was founded, to what it is today? Initially, we were a small company with fewer than 50 employees, a 10-bed clinic, and a single lab. Over 90 percent of our work focused on gamma scintigraphic imaging (a diagnostic test that creates images of the body’s internal organs and tissues using gamma rays). Due to the short half-life radionuclides we used to label dosage forms, every product we manufactured had a limited time to be dosed. At the end of 1999, we moved our headquarters to a purpose-built, two-storey facility—now known as Trent House on our now much larger Nottingham campus. We built three good manufacturing practice (GMP) suites on the top floor and three clinical wards on the bottom floor. These were very early days that marked the start of our Translational Pharmaceutics platform. We continued to expand the range of scintigraphy applications we offered in response to changing customer requirements until, in 2008, when we approached the MHRA (UK’s Medicines and Healthcare products Regulatory Agency) with a new request. We asked if it might be possible to work at the same pace as we did in our scintigraphic imaging studies, but do so for conventional drug development, without the radiolabel. We explored the application of ICH Q8 Quality by Design (QbD) guidelines to introduce a compositional design space into the CMC section of our regulatory dossier. This officially created a methodology for applying the Translational Pharmaceutics platform, and we haven't looked back since. Today, we have expanded substantially. Our Nottingham site is a campus of five buildings. We have development and analytical labs, six GMP suites, six clinical wards with a total of 85 beds (where we conduct healthy volunteer phase 1 clinical studies), and many talented colleagues covering our spectrum of CRO and CDMO services. HIGHLIGHTS// officially created a methodology for applying the Translational Pharmaceutics platform/ development and analytical labs/ six GMP suites   How is Translational Pharmaceutics applied to drug development programs? We apply Translational Pharmaceutics across three core applications: first-in-human clinical studies, drug product optimization programs through rapid formulation development and clinical testing, and as a part of human ADME (absorption, distribution, metabolism, and excretion) programs. No matter how a client chooses to work with us to apply Translational Pharmaceutics, the benefits of using a single organization and project management team to integrate services lets our clients remain in control and one step ahead of the emerging data that impacts the success of their molecule. Over all these years, our flagship Translational Pharmaceutics platform for drug development has remained unchanged in the way it empowers our customers and offers them unparalleled flexibility. HIGHLIGHTS// three core applications/ benefits of using a single organization/ clients remain in control   What would you say are the key strengths of Quotient Sciences’ Nottingham site? How do you support customer programs? Nowhere else would a single project manager oversee such a broad spectrum of activities, let alone be expected to ensure seamless, timely progression across functions that in any other company (i.e. at other CDMOs or CROs) would be delivered through multiple operating areas or through the use of a combination of third-party vendors. The project managers do face challenges. But by working with the project team, they are able to anticipate, avoid, and mitigate any impact whenever necessary. We know that time is incredibly valuable for our customers. A project Gantt chart is our project management team’s guiding light. I believe our project management team is truly world-leading – they communicate well, show great compassion, and lead with integrity. I’m super proud of our high-performing, supportive, cross-functional teams that support our customers when they trust their molecules to us, and work collaboratively to deliver the best possible service. After 25 years at Quotient, I continue to really enjoy going to work. I am indebted to various colleagues for helping me continue to feel this way. HIGHLIGHTS// project management team is truly world-leading/ high-performing, supportive, cross-functional teams/ 25 years at Quotient  

Impressions: 4916

https://www.pharmacompass.com/speak-pharma/translational-pharmaceutics-our-flagship-platform-for-drug-development-empowers-our-clients-with-unparalleled-flexibility

Radio Compass
16 Dec 2024

VLOG #PharmaReel

[Sponsored by another company]

DATA COMPILATION #PharmaFlow

[Sponsored by another company]
BMS, J&J, Bayer lead 25,000+ pharma layoffs in 2024; Amylyx, FibroGen, Kronos Bio hit by trial failures, cash crunch
Since 2022, there has been a significant surge in layoffs by pharmaceutical and biotech companies. While this trend continued into 2024, the industry showed signs of stabilization in the last four months of the year with the pace of layoffs slowing down. Nonetheless, 2024 was a challenging year. Data compiled by PharmaCompass indicates that over 25,000 layoffs were announced in 2024, driven by economic pressures, failed clinical trials, and strategic pivots. Bristol Myers Squibb and Johnson & Johnson led the layoffs with about 2,300 job cuts each. Bayer announced elimination of 1,800 positions.  View Our Interactive Dashboard on Biopharma Layoffs in 2024 (Free Excel Available) US, Europe, China bear brunt of job cuts; Big Pharma hands pink slips to 10,000 Over 190 biopharma companies announced layoffs in 2024. The year began on a grim note — 27 firms announced significant job cuts in January 2024. By the yearend, Big Pharma alone had contributed more than 10,000 layoffs to the year’s total of over 25,000. Novartis announced over 1,200 job cuts in 2024. It eliminated 330 jobs after it acquired German biotech MorphoSys through the closure of sites in Munich and Boston. Similarly, Bayer announced significant reductions at its US and Swiss facilities.  North America saw increased retrenchments, especially at biotech hubs such as Boston, San Diego, and New Jersey. Massachusetts, with Boston and Cambridge as the epicenter of US biotechnology, saw around 4,000 layoffs, with companies like Relay Therapeutics, Editas Medicine, and Takeda driving the numbers. In San Diego, workforce reductions by Takeda, and Bavarian Nordic collectively resulted in over 900 job losses, significantly impacting the local biotech ecosystem. New Jersey was subject to broader restructuring efforts with BMS and Bayer contributing nearly 1,500 layoffs. The impact in Europe was equally severe. Germany, home to some of the world’s largest pharmaceutical companies, saw over 2,500 layoffs as Bayer and Boehringer Ingelheim scaled back operations. Novartis’ decision to shut down its Munich site added hundreds more to the tally. In Switzerland, Idorsia eliminated 270 positions. Dutch biotech UniQure reduced its workforce by 65 percent (around 300 jobs). That included the sale of a Massachusetts manufacturing facility to Genezen. Denmark also felt the strain, with Leo Pharma cutting 250 roles as part of a strategic revamp. China emerged as another focal point of workforce reductions in 2024. Global pharmaceutical giants, such as Merck and Johnson & Johnson, restructured their operations in response to market complexities in the region. Local companies such as Connect Biopharma, which is transitioning to a US-focused company, also scaled back their presence in the country.  View Our Interactive Dashboard on Biopharma Layoffs in 2024 (Free Excel Available)  Amylyx, FibroGen, Lyra, Athira drastically reduce staff over setbacks in clinical trials Clinical trial failures were one of the most significant drivers of layoffs in 2024. For instance, Amylyx Pharmaceuticals faced a devastating blow when its amyotrophic lateral sclerosis (ALS) therapy, Relyvrio, failed a confirmatory trial. This led to a 70 percent reduction in its workforce, leaving only 100 employees from the 384 full-time staff reported at the end of 2023. The company’s decision to pull the therapy from the market compounded the layoffs. BioMarin Pharmaceutical had to reduce its workforce, as it streamlined its pipeline in response to trial challenges. In August, the company announced a reduction of 225 employees, citing “organizational redesign efforts”. These layoffs followed 170 redundancies announced earlier in May. FibroGen, once considered a leader in oncology drug development, was among the most heavily impacted. The high-profile failure of its anti-CTGF antibody in two late-stage cancer trials led to the discontinuation of its lead candidate, resulting in a 75 percent reduction in its US workforce. Lyra Therapeutics also implemented a 75 percent workforce reduction, affecting 87 employees, after its chronic rhinosinusitis program struggled. Similarly, Athira Pharma cut 70 percent of its team after its Alzheimer’s candidate failed a phase 2/3 trial.  View Our Interactive Dashboard on Biopharma Layoffs in 2024 (Free Excel Available)  Cash crunch, mergers compel Kronos Bio, Editas, Vincerx, Gilead to downsize In addition to clinical failures, funding constraints played a pivotal role in reshaping the biotech landscape. Kronos Bio stood out as one of the hardest-hit firms, cutting 21 percent and 83 percent of its existing workforce in March and November, respectively, as it sought to divest assets and conserve cash. Editas Medicine’s inability to secure partnerships for its sickle cell program forced the company to revert to preclinical research, resulting in a 65 percent workforce reduction. The trend of scaling back R&D pipelines was particularly evident among biotechs struggling to advance preclinical programs to clinical trials. Boundless Bio and Senti Bio exemplified this, choosing to focus on a handful of promising candidates, while reducing discovery efforts. Consolidation often results in overlapping roles, leading to inevitable workforce reductions. Apart from the MorphoSys layoffs by Novartis, Vincerx Pharma faced job losses after it got acquired by Oqory (a clinical-stage ADC company). Vincerx had to cut its workforce by 55 percent.  Amid ongoing reorganization efforts, Gilead closed its Seattle, Washington (US), office and laid off 72 employees of its subsidiary Kite Pharma. Gilead also announced that its Kite facility in Philadelphia, Pennsylvania (US), would close by mid-2025. That was followed by 104 additional layoffs at its California headquarters. In April, it had cut 58 jobs in California. Gilead also announced that its Kite facility in Philadelphia would close by mid-2025. Vir Biotechnology reduced its workforce by 25 percent (i.e. 140 layoffs) to focus on its hepatitis program, and GlycoMimetics let go of 80 percent of its workforce after the FDA demanded an additional clinical trial for its leukemia treatment. Meanwhile, Lexicon Pharmaceuticals reduced its workforce by 60 percent after it stopped commercial operations and transitioned back to being a clinical stage company.  View Our Interactive Dashboard on Biopharma Layoffs in 2024 (Free Excel Available)  Our view It takes decades to build innovation ecosystems. The concentration of layoffs in major biotech hubs has raised concerns about the potential long-term impact on these ecosystems. In 2025, the key challenge will be to maintain the momentum of innovation, as organizations operate with a leaner workforce and a more focused pipeline.  

Impressions: 4560

https://www.pharmacompass.com/radio-compass-blog/bms-j-j-bayer-lead-25-000-pharma-layoffs-in-2024-amylyx-fibrogen-kronos-bio-hit-by-trial-failures-cash-crunch

#PharmaFlow by PHARMACOMPASS
16 Jan 2025

NEWS #PharmaBuzz

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https://www.fiercepharma.com/pharma/teva-looks-peel-back-onion-cns-mental-health-conditions-it-works-latest-long-acting

FIERCE PHARMA
02 Jan 2025

https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=217642

FDA
02 Jan 2025

https://www.globenewswire.com/news-release/2024/12/23/3001498/0/en/Teva-to-Present-at-the-43rd-Annual-J-P-Morgan-Healthcare-Conference.html

GLOBENEWSWIRE
23 Dec 2024

https://www.reuters.com/legal/government/teva-loses-us-appeal-keep-inhaler-patents-fda-protected-drug-list-2024-12-20/

REUTERS
20 Dec 2024

https://www.globenewswire.com/news-release/2024/12/20/3000864/0/en/Teva-to-Host-Conference-Call-to-Discuss-Fourth-Quarter-and-Full-Year-2024-Financial-Results-and-2025-Financial-Guidance-at-8-a-m-ET-on-January-29-2025.html

GLOBENEWSWIRE
20 Dec 2024

https://www.tevapharm.com/news-and-media/latest-news/teva-and-sanofi-announce-duvakitug-anti-tl1a-positive-phase-2b-results-demonstrating-best-in-class-pote/

PRESS RELEASE
18 Dec 2024

Drugs in Development

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TEV-'749 is an investigational once-monthly subcutaneous LAI of the 2nd generation antipsychotic olanzapine being developed in in adult patients diagnosed with schizophrenia.


Lead Product(s): Olanzapine

Therapeutic Area: Psychiatry/Psychology Brand Name: TV-44749

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable November 01, 2024

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Details : TEV-'749 is an investigational once-monthly subcutaneous LAI of the 2nd generation antipsychotic olanzapine being developed in in adult patients diagnosed with schizophrenia.

Brand Name : TV-44749

Molecule Type : Small molecule

Upfront Cash : Not Applicable

November 01, 2024

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Selarsdi (ustekinumab) is a monoclonal antibody, binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses. It is approved for treating ulcerative colitis.


Lead Product(s): Ustekinumab

Therapeutic Area: Gastroenterology Brand Name: Selarsdi

Study Phase: ApprovedProduct Type: Large molecule

Recipient: Alvotech

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 22, 2024

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Details : Selarsdi (ustekinumab) is a monoclonal antibody, binds to two cytokines, IL-12 and IL-23, that are involved in inflammatory and immune responses. It is approved for treating ulcerative colitis.

Brand Name : Selarsdi

Molecule Type : Large molecule

Upfront Cash : Not Applicable

October 22, 2024

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TVB-009P(denosumab) is a biosimilar candidate to Prolia, which is being developed for the high risk for fracture, such as osteoporosis in postmenopausal women.


Lead Product(s): Denosumab

Therapeutic Area: Musculoskeletal Brand Name: TVB-009P

Study Phase: Phase IIIProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 08, 2024

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Details : TVB-009P(denosumab) is a biosimilar candidate to Prolia, which is being developed for the high risk for fracture, such as osteoporosis in postmenopausal women.

Brand Name : TVB-009P

Molecule Type : Large molecule

Upfront Cash : Not Applicable

October 08, 2024

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mAbxience will lead the development and production of an anti PD-1 biosimilar and Teva will manage regulatory approvals and oversee commercialization of this oncology treatment.


Lead Product(s): Anti PD-1-based Therapy

Therapeutic Area: Oncology Brand Name: Undisclosed

Study Phase: UndisclosedProduct Type: Large molecule

Sponsor: Mabxience

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Partnership October 03, 2024

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Details : mAbxience will lead the development and production of an anti PD-1 biosimilar and Teva will manage regulatory approvals and oversee commercialization of this oncology treatment.

Brand Name : Undisclosed

Molecule Type : Large molecule

Upfront Cash : Undisclosed

October 03, 2024

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Sandostatin-Generic (octreotide acetate) is a somatostatin analogue peptide, which is being evaluated for the treatment of acromegaly, carcinoid tumors & vasoactive intestinal peptide tumors.


Lead Product(s): Octreotide Acetate

Therapeutic Area: Endocrinology Brand Name: Sandostatin-Generic

Study Phase: ApprovedProduct Type: Peptide

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 01, 2024

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Details : Sandostatin-Generic (octreotide acetate) is a somatostatin analogue peptide, which is being evaluated for the treatment of acromegaly, carcinoid tumors & vasoactive intestinal peptide tumors.

Brand Name : Sandostatin-Generic

Molecule Type : Peptide

Upfront Cash : Not Applicable

October 01, 2024

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FDA has approved Teva's AUSTEDO XR (deutetrabenazine,vmat2 inhibitor) extended-release tablets as a once-daily treatment option for adults with tardive dyskinesia and Huntington’s disease chorea.


Lead Product(s): Deutetrabenazine

Therapeutic Area: Neurology Brand Name: Austedo

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 23, 2024

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Details : FDA has approved Teva's AUSTEDO XR (deutetrabenazine,vmat2 inhibitor) extended-release tablets as a once-daily treatment option for adults with tardive dyskinesia and Huntington’s disease chorea.

Brand Name : Austedo

Molecule Type : Small molecule

Upfront Cash : Not Applicable

September 23, 2024

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TEV-‘749 is being developed as a once-monthly subcutaneous LAI of olanzapine with the use of SteadyTeq™ technology, a copolymer technology for the treatment of adults with schizophrenia.


Lead Product(s): Olanzapine

Therapeutic Area: Psychiatry/Psychology Brand Name: TEV-‘749

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 21, 2024

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Details : TEV-‘749 is being developed as a once-monthly subcutaneous LAI of olanzapine with the use of SteadyTeq™ technology, a copolymer technology for the treatment of adults with schizophrenia.

Brand Name : TEV-‘749

Molecule Type : Small molecule

Upfront Cash : Not Applicable

September 21, 2024

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Details:

TEV-‘749 is being developed as a once-monthly subcutaneous LAI of olanzapine with the use of SteadyTeq™ technology, a copolymer technology for the treatment of adults with schizophrenia.


Lead Product(s): Olanzapine

Therapeutic Area: Psychiatry/Psychology Brand Name: TEV-‘749

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: MedinCell

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 05, 2024

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Details : TEV-‘749 is being developed as a once-monthly subcutaneous LAI of olanzapine with the use of SteadyTeq™ technology, a copolymer technology for the treatment of adults with schizophrenia.

Brand Name : TEV-‘749

Molecule Type : Small molecule

Upfront Cash : Not Applicable

September 05, 2024

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TEV-’574 (duvakitug) is a potential best-in-class human IgG1-lambda 2 mAb that targets tumor necrosis factor (TNF)-like ligand 1A, also known as TNF superfamily member 15 (TNFSF15).


Lead Product(s): Duvakitug

Therapeutic Area: Gastroenterology Brand Name: TEV-48574

Study Phase: Phase IIProduct Type: Large molecule

Sponsor: Sanofi

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 24, 2024

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Details : TEV-’574 (duvakitug) is a potential best-in-class human IgG1-lambda 2 mAb that targets tumor necrosis factor (TNF)-like ligand 1A, also known as TNF superfamily member 15 (TNFSF15).

Brand Name : TEV-48574

Molecule Type : Large molecule

Upfront Cash : Not Applicable

July 24, 2024

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Ajovy (fremanezumab) a FDA approved, humanized mAb which selectively binds the calcitonin gene-related peptide (CGRP). It is being investigated for the prevention of migraine in 6-17 years patients.


Lead Product(s): Fremanezumab

Therapeutic Area: Neurology Brand Name: Ajovy

Study Phase: Phase IIIProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 19, 2024

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Details : Ajovy (fremanezumab) a FDA approved, humanized mAb which selectively binds the calcitonin gene-related peptide (CGRP). It is being investigated for the prevention of migraine in 6-17 years patients.

Brand Name : Ajovy

Molecule Type : Large molecule

Upfront Cash : Not Applicable

July 19, 2024

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FDF Dossiers

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Brand Name : Fluracedyl 250 Mg

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Teva Pharmaceutical Industries

Dosage Form : INJ

Brand Name : Fluracedyl 250 Mg

Dosage Strength : 250mg

Packaging : 5X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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Brand Name : Fluracedyl 500 Mg

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Brand Name : Fluracedyl 500 Mg

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Dosage Form : INJ

Brand Name : Fluracedyl 500 Mg

Dosage Strength : 500mg

Packaging : 10X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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Brand Name : Fluracedyl 1000 Mg

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Dosage Form : INJ

Brand Name : Fluracedyl 1000 Mg

Dosage Strength : 1000mg

Packaging : 20X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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Brand Name : Fluracedyl 5000 Mg

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Brand Name : Fluracedyl 5000 Mg

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Dosage Form : INJ

Brand Name : Fluracedyl 5000 Mg

Dosage Strength : 5000mg

Packaging : 100X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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Brand Name : TEVA-ABACAVIR/LAMIVU...

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Teva Pharmaceutical Industries

Dosage Form : TABLET

Brand Name : TEVA-ABACAVIR/LAMIVUDINE

Dosage Strength : 600MG

Packaging : 30

Approval Date :

Application Number : 2416662

Regulatory Info :

Registration Country : Canada

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Brand Name : ABACAVIR SULFATE AND...

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Dosage Form : TABLET;ORAL

Brand Name : ABACAVIR SULFATE AND LAMI...

Dosage Strength : EQ 600MG BASE;300MG

Packaging :

Approval Date : 2016-09-29

Application Number : 79246

Regulatory Info : DISCN

Registration Country : USA

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Brand Name : Abacavir-Lamivudin-M...

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Brand Name : Abacavir-Lamivudin-M...

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Mepha Pharma

Dosage Form : Lactab

Brand Name : Abacavir-Lamivudin-Mepha

Dosage Strength : 600/300mg

Packaging :

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Registration Country : Switzerland

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Brand Name : Abiraterone-Teva

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Brand Name : Abiraterone-Teva

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Teva Pharma Australia

Dosage Form :

Brand Name : Abiraterone-Teva

Dosage Strength :

Packaging : 60

Approval Date :

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Regulatory Info :

Registration Country : Australia

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Brand Name : Abiraterone-Teva

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Brand Name : Abiraterone-Teva

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Teva Pharma Australia

Dosage Form : tablet

Brand Name : Abiraterone-Teva

Dosage Strength : 250 mg

Packaging : 120

Approval Date :

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Regulatory Info :

Registration Country : Australia

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Brand Name : ABIRATERONE ACETATE

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Brand Name : ABIRATERONE ACETATE

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Teva Pharmaceutical Industries

Dosage Form : TABLET;ORAL

Brand Name : ABIRATERONE ACETATE

Dosage Strength : 250MG

Packaging :

Approval Date : 2018-10-31

Application Number : 208432

Regulatory Info : RX

Registration Country : USA

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Teva Pharmaceutical Industries is a supplier offers 317 products (APIs, Excipients or Intermediates).

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