1. Dimethylamine Hydrochloride
2. Dimethylamine Monosulfate
3. Dimethylamine Nitrate
4. Dimethylamine Perchlorate
5. Dimethylamine Phosphate (3:1)
6. Dimethylamine Sulfate
7. Dimethylamine Sulfate (1:1)
8. Dimethylamine, Conjugate Acid
9. Dimethylammonium Chloride
10. Dimethylammonium Formate
1. N-methylmethanamine
2. 124-40-3
3. N,n-dimethylamine
4. Methanamine, N-methyl-
5. Dimethyl-amine
6. Dimethylamine Anhydrous
7. Dimethylamine (anhydrous)
8. Rcra Waste Number U092
9. Dimethylamine Solution
10. (ch3)2nh
11. Dimethylamine Aq
12. Nsc 8650
13. Hnme2
14. Me2nh
15. Dimethylamine Aqueous Solution
16. Arq8157e0q
17. Chebi:17170
18. Nsc-8650
19. Dimethylamin
20. Dimethyl Amine
21. Dimethylamine, Purum, >=99.0%
22. Mfcd00008288
23. Ccris 981
24. Dimethylamine Solution, 40 Wt. % In H2o
25. Hsdb 933
26. Dimethylamine, In Aqueous Solution
27. Einecs 204-697-4
28. Ai3-15638-x
29. Un1032
30. Un1160
31. Rcra Waste No. U092
32. Dimethlamine
33. Dimethlyamine
34. Dimethyamine
35. Dimethylammonia
36. Dimethylarnine
37. Dimetylamine
38. Dirnethylamine
39. Unii-arq8157e0q
40. Di-methylamine
41. Dimetyl Amine
42. N,n-dimethylamin
43. N,n Dimethylamine
44. N,n Dimethyl Amine
45. N,n- Dimethylamine
46. N,n-dimethyl Amine
47. Dimethylamine Solution (over 55% But Not Over 65%)
48. N-methyl-methanamine
49. Dimethylamine Solution (45% Or Less)
50. N, N-dimethyl Amine
51. Nhme2
52. N-methyl-1-methanamine
53. Dimethylamine, Anhydrous
54. Dsstox_cid_4057
55. Dimethylamine [mi]
56. Dimethylamine Reagent Grade
57. Nh(me)2
58. Ec 204-697-4
59. Methylaminomethylidyneradical
60. Dimethylamine [hsdb]
61. Dimethylamine, >=99.8%
62. Dsstox_rid_77272
63. Nciopen2_007708
64. Dsstox_gsid_24057
65. Dimethylamine Anhydrous (dot)
66. Un 1160 (salt/mix)
67. Chembl120433
68. Dimethylamine Solution (over 45% But Not Over 55%)
69. Gtpl5177
70. Nh(ch3)2
71. Wln: 1m1
72. Dtxsid5024057
73. Nsc8650
74. Dimethylamine, Anhydrous, >=99%
75. Dimethylamine (~2.0 M In Thf)
76. Str00287
77. Tox21_302439
78. Bdbm50416497
79. Dimethylamine Solution 40% In Water
80. Dimethylamine, 2m In Tetrahydrofuran
81. Nsc187661
82. Stl263869
83. N-methylmethanamine (acd/name 4.0)
84. Akos008968166
85. Dimethylamine Solution 1.0 M In Thf
86. Dimethylamine Solution 2.0 M In Thf
87. Nsc-187661
88. Un 1032
89. Dimethylamine Solution, 2.0 M In Thf
90. Dimethylamine (ca. 8% In Acetonitrile)
91. Dimethylamine Solution 2.0m In Methanol
92. Dimethylamine, 40% W/w Aqueous Solution
93. Ncgc00255288-01
94. Cas-124-40-3
95. Dimethylamine Solution, 2.0 M In Methanol
96. Dimethylamine Solution, Cp, 50% In H2o
97. D0643
98. D3292
99. D3936
100. D3948
101. D4198
102. D5884
103. D5885
104. Dacarbazine Impurity D [ep Impurity]
105. C00543
106. Dimethylamine (ca. 7% In N,n-dimethylformamide)
107. Q408022
108. Molybdoceric Acid (h8 Ce Mo12 O42), Eicosahydrate
109. Dimethylamine Solution [un1160] [flammable Liquid]
110. Dimethylamine, 40% W/w Aqueous Solution, In Ampoule
111. Dimethylamine, Anhydrous [un1032] [flammable Gas]
112. Z57834054
113. Metformin Hydrochloride Impurity F [ep Impurity]
114. Dimethylamine Solution, Purum, 33% In Absolute Ethanol (~5.6 M)
| Molecular Weight | 45.08 g/mol |
|---|---|
| Molecular Formula | C2H7N |
| XLogP3 | -0.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | g/mol |
| Monoisotopic Mass | g/mol |
| Topological Polar Surface Area | 12 |
| Heavy Atom Count | 3 |
| Formal Charge | 0 |
| Complexity | 2.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
The disposition and pharmacokinetics of [(14)C]dimethylamine [(14)C] DMA) following 6-hr inhalation of either 10 or 175 ppm were determined in male Fischer 344 rats. Seventy-two hours after termination of exposure, the disposition of recovered radioactivity was similar for each airborne concentration, with more than 90% in the urine and feces, 7 to 8% in selected tissues and the carcass, and 1.5% exhaled as (14)CO2. Over 98% of the radioactivity in the urine was unmetabolized DMA. Analysis of tissue radioactivity immediately after exposure to [(14)C]DMA showed that the respiratory nasal mucosa contained the highest concentration of (14)C, followed by the olfactory nasal mucosa; concentrations of (14)C in liver, lung, kidney, brain, and testes were approximately 2 orders of magnitude less than in the nasal mucosal tissues. Radioactivity in plasma of rats exposed by inhalation to 175 ppm of [(14)C]DMA decayed in a biphasic manner. The terminal half-life for plasma radioactivity was similar to the half-lives of some plasma proteins, suggesting incorporation of (14)C into proteins subsequent to metabolism of [(14)C]DMA. The results indicate that, while most of the inhaled DMA is excreted unchanged, a small amount of oxidative metabolism of DMA occurs.
PMID:6138225 McNulty MJ, Heck HD; Drug Metab Dispos 11 (5): 417-20 (1983)
1. The fate of [(14)C]-dimethylamine was investigated following oral administration to four male volunteers. 2. The major route of excretion was urine, with 94% of the administered radioactivity being voided over 3 days (87% during the first 24 hr). Small amounts (1-3%) of radioactivity were found in the faeces and expired air. 3. Metabolism was limited with only 5% being demethylated to methylamine. The remainder of the dose was excreted unchanged. 4. Pharmacokinetic studies indicated rapid (t1/2ab = 8 min) and extensive absorption (bioavailability = 82%) from the gastrointestinal tract followed by widespread distribution and a fairly prompt excretion (t1/2el = 6-7 hr) with a plasma clearance of 190 mL/min.
PMID:8059541 Zhang AQ et al; Xenobiotica 24 (4): 379-87 (1994)
The urinary excretion of dimethylamine has been measured in 203 unrelated healthy volunteers (102 male) who maintained their normal diets. ... The average daily output was 17.43 +/- 11.80 mg (mean +/- SD) (21.21 +/- 14.78 male; 13.74 +/- 5.65 female) with values for the majority of the population lying within the 0.68-35.72 mg range. Four male outliers excreted up to 109.2 mg; these large amounts of dimethylamine were presumed to be of dietary origin. ...
PMID:7758205 Zhang AQ et al; Clin Chim Acta 233 (1-2): 81-8 (1995)
In the gastro-intestinal tract of male Wistar rats fed a commercial diet containing 23.6 ppm dimethylamine (DMA), the concentration of DMA was highest (11.2 +/- 2.1 ppm) in the stomach and declined towards the lower regions. In contrast, the highest DMA concentration (6.6 +/- 2.5 ppm) was observed in the upper small intestine in rats fed a diet containing only 1.0 ppm DMA. DMA was absorbed in the intestines, and the disappearance curves were monoexponential. The t1/2 values for DMA in the ligated stomach, upper and lower small intestine, caecum and large intestine were 198, 8.3, 11.6, 31.5 and 11.0 min, respectively. The DMA concentration in the blood had increased to 3.0 +/- 1.0 ppm (from a pre-injection level of 0.28 +/- 0.06 ppm) 5 min after the injection of 250 micrograms DMA into the ligated upper small intestine. The disappearance curve for DMA in the blood was monoexponential and the t1/2 for the initial 15 min was 12.5 min when 250 micrograms DMA was injected into a femoral vein. The peak concentrations of DMA in the intestine and bile, respectively, were 15.6 +/- 12.6 ppm (at 15 min) and 3.7 +/- 1.9 ppm (at 30 min after the iv injection of DMA). In this 30-min period, urinary DMA increased from 17.3 +/- 9.4 to 139 +/- 23 ppm. These results show that, following ingestion, DMA is absorbed from the intestine into the blood, from which it disappears rapidly, the major part being excreted in the urine while a small proportion is excreted in the bile or secreted into the intestine, where it may be reabsorbed.
PMID:6540740 Ishiwata H et al; Food Chem Toxicol 22 (8): 649-53 (1984)
For more Absorption, Distribution and Excretion (Complete) data for Dimethylamine (12 total), please visit the HSDB record page.
It is extensively absorbed (bioavailability 72%); 5% is demethylated to methylene, but 95% is secreted unchanged in the urine.
Ellenhorn, M.J., S. Schonwald, G. Ordog, J. Wasserberger. Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams and Wilkins, 1997., p. 1427
The intragastric formation of nitrosodimethylamine (NDA) by bacteria existing in the gastrointestinal tract of monkey was examined by determining the in vitro formation of nitrosodimethylamine from nitrite and dimethylamine in the brain-heart-infusion (BHI) medium, adjusted to pH 6 with gastric juice containing 5000 ppm sodium nitrate and 1000 ppm dimethylamine. Nitrosodimethylamine formation depended on the activity of the nitrate-reducing bacteria in the stomach contents of the monkey, and the concn of nitrite was clearly related to the amount of nitrosodimethylamine. NDA was formed in the brain-heart-infusion medium alone at pH 5 and 6. The addition of gastric juice to the medium increased the formation of nitrosodimethylamine.
Hayashi N et al; Eisei Shikensho Hokoku 100: 72-6 (1982)
The extent of nitrosamine formation and the metabolism of the resultant nitrosamines in vivo were investigated by using (15)N-stable isotope labeling and by the determination of the isotope ratio in the expired N. (15)N-labeled dimethylamine (1.1 mmol/kg) and various doses of nonlabeled nitrile (0.55-2.2 mmol/kg) or labeled nitrile without dimethylamine administered to male rats, which were placed in an enclosed respiratory system. The system was flushed with a mixture containing 80% He and 20% O, and N content of the recirculating atmosphere was determined. When labeled dimethylamine and nonlabeled nitrile were administered, nitrile reacted with secondary amines, followed by enzymic alpha-hydroxylation and decomposition of the ensuing alkyldiazohydroxide to molecular N and an alkyl cation as ultimate carcinogen. When (15)N nitrile was administered, N was released (nitrile reacted with primary amines to release molecular N and formation of the corresponding alcohol or olefin).
Frank H et al; Fresenius Z Anal Chem 317 (6): 660 (1984)
Dimethylamine is the immediate precursor of dimethylnitrosamine, a known potent carcinogen in a wide variety of animal species. Although small amounts of dimethylamine are ingested directly, the major dietary source is believed to be via choline and related materials. Owing to quantitative recoveries following oral administration, urinary dimethylamine levels provide good overall measures of body exposure. The oral administration of equimolar amounts (1 mmol/kg body weight) of potential amine precursors to male Wistar rats produced only small increases in urinary dimethylamine after choline (+ 11%; 0.60 +/- 0.36% dose), dimethylaminopropanol (+ 32%; 1.49 +/- 0.30% dose), dimethylaminoethyl chloride (+ 110% 5.38 +/- 1.72% dose) and trimethylamine (+ 51%; 1.6 +/- 0.80% dose) input, whereas significantly larger increases were found following trimethylamine N-oxide ingestion (+ 355%; 12.93 +/- 1.13% dose; t-test, P < 0.001). These data suggest that trimethylamine N-oxide is a major dietary source of dimethylamine, by direct conversion and not by sequential reduction (to trimethylamine) and demethylation, and that in this respect it is of greater importance, on a molar basis, than choline.
PMID:9771553 Zhang AQ et al; Food Chem Toxicol 36 (11): 923-7 (1998)
Uremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces.
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