1. 2-picoline
2. 2-picolinium Bromide
1. 2-picoline
2. 109-06-8
3. O-picoline
4. Alpha-picoline
5. Pyridine, 2-methyl-
6. Picoline
7. Methylpyridine
8. A-picoline
9. Pyridine, Methyl-
10. 2-methyl-pyridine
11. O-methylpyridine
12. Picoline, Alpha
13. .alpha.-picoline
14. Rcra Waste Number U191
15. 1333-41-1
16. Nsc 3409
17. 2-mepy
18. .alpha.-methylpyridine
19. Chebi:50415
20. Nsc-3409
21. 3716q16q6a
22. Ncgc00160644-01
23. Dsstox_cid_1899
24. Dsstox_rid_76392
25. Dsstox_gsid_21899
26. Alpha-methylpyridine
27. Cas-109-06-8
28. Ccris 1721
29. Hsdb 101
30. Einecs 203-643-7
31. Rcra Waste No. U191
32. Ai3-2409
33. Alpha Picoline
34. 2-methylpridine
35. Ai3-24109
36. Unii-3716q16q6a
37. 2--picoline
38. 2-methyl Pyridine
39. Picoline (related)
40. Picoline, .alpha.
41. Mfcd00006332
42. 2-picoline, 98%
43. 2-methylpyridine, 98%
44. Ec 203-643-7
45. Nciopen2_007826
46. Nciopen2_007919
47. Wln: T6nj B1
48. Bidd:er0295
49. Chembl15732
50. .alpha.-picoline [mi]
51. 2-picoline, Analytical Standard
52. 2-methylpyridine [hsdb]
53. Dtxsid9021899
54. Nsc3409
55. 2-picoline,(s);2-methylpyridine
56. Bcp26524
57. Tox21_111951
58. Tox21_201693
59. Stl268873
60. Zinc38192546
61. Akos000119190
62. Zinc328578702
63. Am81276
64. Ncgc00160644-02
65. Ncgc00259242-01
66. Db-023694
67. O-picoline [un2313] [flammable Liquid]
68. Ft-0613358
69. P0415
70. 2-methylpyridine, Lonza Quality, >=99.0% (gc)
71. J-510091
72. Q2216745
73. Amprolium Hydrochloride Impurity A [ep Impurity]
74. F0001-0192
75. 2-methylpyridine Pound>>o-picoline Pound>>pyridine, 2-methyl-
| Molecular Weight | 93.13 g/mol |
|---|---|
| Molecular Formula | C6H7N |
| XLogP3 | 1.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 93.057849228 g/mol |
| Monoisotopic Mass | 93.057849228 g/mol |
| Topological Polar Surface Area | 12.9 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 52.1 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Alpha-picoline was rapidly absorbed by blood & penetrated into liver, heart, spleen, lungs, & muscles during 1St 10-20 min following oral admin of 0.5 g/kg to rats. It was excreted in urine during 1St 48 hr.
KUPOR VG; VOP PATOKHIMII BIOKHIM BELKOV DRUGIKH BIOL AKTIV SOEDIN: 51-2 (1972)
Addition of a methyl group onto the pyridine molecule increases the rate of absorption of the resultant picolines into the liver, kidney, & brain of rats. After ip injection of the picolines, pharmacokinetic parameters were greatly dependent upon the position of the methyl group. For example, the residence time for beta-picoline in liver, brain, & kidney was > that of alpha- or gamma-picoline. Elimination of all four pyridines was biphasic in nature, the first phase being more prolonged for pyridine & beta-picoline than for alpha- or gamma-picoline.
Zharikov GP et al; Deposited Doc (VINITI 1299-83): 11 pages (1983)
The substance is rapidly absorbed by the blood and penetrated into liver, heart, spleen, lungs, brain and muscles during the first 10 - 20 minutes after oral administration of 500 mg/kg to rats. It is excreted in urine mainly during the first 48 hrs after administration. Prevalent accumulation in the liver within 1 hr. Within 2 days however, the levels of the substance in the organs was decreased to traces.
European Commission/European Chemical Substances Information System (ESIS); IUCLID Dataset, 2-Methylpyridine (CAS 109-06-8) p. 36 (2000). Available from, as of October 20, 2014: https://esis.jrc.ec.europa.eu//
... In rabbits and dogs /2-methylpyridine/ is oxidized to alpha-picolinic acid which is excreted in the urine. alpha-Picolinuric acid is also excreted by frogs administered alpha-picoline, but only in amounts less than 1% of the dose. In hens it is excreted partly as alpha-pyridinornithuric acid.
ITC/USEPA; Information Review #425 (Draft) Methylpyridines p.34 (1984)
/It was observed that/ 96% of a 100 mg/kg oral dose of 2-methylpyridine administered to rats was excreted in the urine as picolinuric acid.
ITC/USEPA; Information Review #425 (Draft) Methylpyridines p.34 (1984)
There also is evidence that 2-methylpyridine forms an N-methylated derivative in dogs.
Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 220
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