1. 1,5-pentanediol, Disodium Salt
2. 1,5-pentanediol, Sodium Salt
3. 1,5-pentanediol, Titanium (4+) Salt (4:1)
4. Pentane-1,5-diol
1. Pentane-1,5-diol
2. 111-29-5
3. 1,5-dihydroxypentane
4. Pentamethylene Glycol
5. 1,5 Pentanediol
6. 1,5-pentylene Glycol
7. 1,5-pentamethylene Glycol
8. Alpha,omega-pentanediol
9. Nsc 5927
10. 1,5-pentandiol
11. .alpha.,.omega.-pentanediol
12. 1,5-pentane-d10-diol
13. Einecs 203-854-4
14. Unii-07uxz0scst
15. 07uxz0scst
16. Brn 1560130
17. Ai3-03318
18. Dtxsid2041256
19. Nsc-5927
20. Ec 203-854-4
21. 1219804-42-8
22. 4-01-00-02540 (beilstein Handbook Reference)
23. Pentylene Gylcol
24. 1,5-pentanodiol
25. 1.5-pentanediol
26. 9je
27. Pentan-1,5-diol
28. 1,5-pentane Diol
29. Penta-1,5-diol
30. .omega.-pentanediol
31. Mfcd00002978
32. Pentane Diol-1,5
33. 1 5-dihydroxypentane
34. Pentanediol, 1,5-
35. 1 5-pentamethylene Glycol
36. 1,5-pentanediol, 96%
37. Wln: Q5q
38. Ho(ch2)5oh
39. Schembl18788
40. Chembl448289
41. 1,5-pentanediol [mi]
42. Dtxcid0021256
43. Hsdb 6807
44. 1,5-pentanediol [inci]
45. Nsc5927
46. Chebi:185431
47. Tox21_300880
48. Akos009158215
49. Cs-w020635
50. Ncgc00248201-01
51. Ncgc00254784-01
52. Bp-30035
53. Cas-111-29-5
54. Ls-101645
55. Ft-0606982
56. P0050
57. 1,5-pentanediol, Purum, >=95.0% (gc)
58. 1,5-pentanediol, Purum, >=97.0% (gc)
59. D77911
60. En300-122591
61. H-1745
62. 1,5-pentanediol, Vetec(tm) Reagent Grade, 96%
63. A802337
64. Q161557
65. J-002554
66. F0001-0238
67. 31784-47-1
| Molecular Weight | 104.15 g/mol |
|---|---|
| Molecular Formula | C5H12O2 |
| XLogP3 | -0.1 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | g/mol |
| Monoisotopic Mass | g/mol |
| Topological Polar Surface Area | 40.5 |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 25.3 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
1,5-Pentanediol has been reported to have antimicrobial and antifungal properties in pharmaceutical applications. Additionally, 1,5-pentanediol has reported uses in products for hair loss, cold sores, nail problems, dry and scaly feet, and eczema; it can be used as a moisturizing substance and solvent.
Cosmetic Ingredient Review; Safety Assessment of Alkane Diols as Used in Cosmetics: Tentative Report for Public Comment (April 2017). Available from, as of June 12, 2017: https://www.cir-safety.org/ingredients
A controlled, double-blind comparative study was conducted to evaluate the treatment of atopic dermatitis with hydrocortisone and 1,5-pentanediol. Patients with atopic dermatitis were treated 2x/day with either 1% hydrocortisone (n=31) or 1% hydrocortisone with 25% 1,5-pentanediol (n=32) in a cream formulation for 6 weeks. Quantitative bacteria cultures were taken for Staphylococcus aureus (commonly seen in the skin of atopic dermatitis patients) from the lesional skin prior to treatment and at weeks 2, 4, and 6 of treatment. The results indicated that the hydrocortisone-only formulation was effective for 68% of the patients in that test group; the hydrocortisone plus 1,5-pentanediol formulation was effective for 69% in that group. There was a statistically significant reduction in S. aureus (baseline to week 2 and baseline to week 6) in the hydrocortisone plus 1,5-pentanediol group, which was not observed in the hydrocortisone-only group. There were 2 instances in each treatment group of "slight burning sensation" following cream application. The study authors noted that bacteria are not likely to develop resistance to 1,5-Pentanediol because of the interaction of diols on membranes.
Cosmetic Ingredient Review; Safety Assessment of Alkane Diols as Used in Cosmetics: Tentative Report for Public Comment (April 2017). Available from, as of June 12, 2017: https://www.cir-safety.org/ingredients
The therapeutic effect of 1,5-Pentanediol was investigated for the treatment of herpes simplex labialis (cold sore virus) in a placebo-controlled, randomized, double-blind clinical trial. Patients included in the trial were those with known, frequent recurrences of herpes labialis. The treatment group (n=53) received 25% 1,5-pentanediol in a gel formulation, which was applied to both lips (0.04 g total/day) during the 26-week prophylactic evaluation. The placebo group (n=52) received the same gel formulation without 1,5-Pentanediol for 26 weeks. During the occurrence of herpes labialis episodes the treatment gel or placebo was applied to both lips (0.16 g total/day) for 5 days and then the prophylactic treatment resumed until the next herpes episode. The herpes episodes reported during the trial were 109 for the treatment group and 120 for the placebo group. 1,5-Pentanediol did not demonstrate a prophylactic effect, compared to the placebo, in preventing the recurrence of herpes labialis. However, there was a statistically significant improvement in blistering, swelling, and pain for the therapeutic use of 1,5-pentanediol as compared to the placebo. There were no treatment-related adverse events attributable to 1,5-pentanediol or the placebo reported. In the treatment and placebo groups, body weight and temperature, heart rate, and clinical parameters were nearly unchanged.
Cosmetic Ingredient Review; Safety Assessment of Alkane Diols as Used in Cosmetics: Tentative Report for Public Comment (April 2017). Available from, as of June 12, 2017: https://www.cir-safety.org/ingredients
Experiments in rabbits administered single doses of alkane diols via stomach tube revealed metabolites isolated from the urine 1 to 3 days post-dosing. Propanediol glucuronic acid conjugation accounted for up to 2% of the administered dose (4 mmol/kg); 1,4-butanediol (9 g) was metabolized to succinic acid (7% of administered dose); 2,3-butanediol glucuronic acid conjugation accounted for up to 26% of the administered dose (4 mmol/kg); phenacyl glutarate (0.5% of dose) was identified after 1,5-pentanediol (8.5 g) administration; Hexanediol glucuronic acid conjugation accounted for up to 9% of the administered dose (2 mmol/kg) and adipic acid was detected.
Cosmetic Ingredient Review; Safety Assessment of Alkane Diols as Used in Cosmetics: Tentative Report for Public Comment (April 2017). Available from, as of June 12, 2017: https://www.cir-safety.org/ingredients
In human subjects dermally exposed to 25% 1,5-Pentanediol (2 applications, 12 hours apart), increasing levels of glutaric acid were detected in urine and serum (no concentrations were provided). The study authors reported that the risk of 1,5-pentanediol accumulation at the concentration tested (therapeutic dose) was low.
Cosmetic Ingredient Review; Safety Assessment of Alkane Diols as Used in Cosmetics: Tentative Report for Public Comment (April 2017). Available from, as of June 12, 2017: https://www.cir-safety.org/ingredients
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