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    Also known as: 1197-18-8, Trans-4-(aminomethyl)cyclohexanecarboxylic acid, Cyklokapron, 1197-17-7, 701-54-2, 4-(aminomethyl)cyclohexanecarboxylic acid
    Molecular Formula
    C8H15NO2
    Molecular Weight
    157.21  g/mol
    InChI Key
    GYDJEQRTZSCIOI-UHFFFAOYSA-N
    FDA UNII
    37YD696II6
    CAS 1197-18-8
    Antifibrinolytic hemostatic used in severe hemorrhage.
    1 2D Structure

    CAS 1197-18-8

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-(aminomethyl)cyclohexane-1-carboxylic acid
    2.1.2 InChI
    InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
    2.1.3 InChI Key
    GYDJEQRTZSCIOI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CC(CCC1CN)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    37YD696II6
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Amca

    2. Amcha

    3. Amchafibrin

    4. Anvitoff

    5. Cyklokapron

    6. Exacyl

    7. Kabi 2161

    8. Spotof

    9. T-amcha

    10. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid

    11. Transamin

    12. Ugurol

    2.3.2 Depositor-Supplied Synonyms

    1. 1197-18-8

    2. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid

    3. Cyklokapron

    4. 1197-17-7

    5. 701-54-2

    6. 4-(aminomethyl)cyclohexanecarboxylic Acid

    7. Trans Amcha

    8. Transamin

    9. Tranhexamic Acid

    10. Tranexamsaeure

    11. Cyclocapron

    12. Trans-amcha

    13. Rikavarin

    14. Amstat

    15. Tamcha

    16. Amikapron

    17. Anvitoff

    18. Ugurol

    19. Amcha

    20. Cis-tranexamic Acid

    21. Frenolyse

    22. Trasamlon

    23. Carxamin

    24. Emorhalt

    25. Tranexan

    26. Mastop

    27. Amca

    28. Cis-4-(aminomethyl)cyclohexanecarboxylic Acid

    29. Rikavarin-s

    30. Exacyl

    31. Tranexmic Acid

    32. Hexapromin

    33. Transamlon

    34. Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, Trans-

    35. Hexatron

    36. Spiramin

    37. Tranex

    38. Cis-amcha

    39. Trans-4-aminomethylcyclohexane-1-carboxylic Acid

    40. 4-(aminomethyl)cyclohexane-1-carboxylic Acid

    41. Trans-tranexamic Acid

    42. Acidum Tranexamicum

    43. Lysteda

    44. Acido Tranexamico

    45. Acide Tranexamique

    46. Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, Cis-

    47. Cl 65336

    48. Femstrual

    49. Bay 3517

    50. 4-(aminomethyl)-cyclohexanecarboxylic Acid

    51. Cyclo-f

    52. Rp 18,429

    53. Cyclohexanecarboxylic Acid, 4-(aminomethyl)-

    54. Cis-4-aminomethylcyclohexane-1-carboxylic Acid

    55. Cyclokapron

    56. Espercil

    57. Haematrix

    58. (1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic Acid

    59. Trans-p-(aminomethyl)cyclohexanecarboxylic Acid

    60. Cl-65336

    61. Dv 79

    62. Cis-4-(aminomethyl)cyclohexane-1-carboxylic Acid

    63. Haku

    64. Dv79

    65. Trans-4-(aminomethyl)-1-cyclohexanecarboxylic Acid

    66. Trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid

    67. Lb1148

    68. Mfcd00001466

    69. Nsc-291305

    70. Trans-1-(aminomethyl)cyclohexane-4-carboxylic Acid

    71. Tranexamic Acid (transamin)

    72. Dtxsid3045350

    73. Retavase

    74. Chebi:48669

    75. 37yd696ii6

    76. 6t84r30kc1

    77. Mfcd19706018

    78. Nsc291305

    79. Tranexamic Acid(random Configuration)

    80. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid Ester

    81. 4-aminomethylcyclohexanecarboxylic Acid

    82. Ncgc00016569-01

    83. Rp-18429

    84. Cas-1197-18-8

    85. 4-(aminomethyl)cyclohexanecarboxylic Acid (trans-)

    86. Amh

    87. Tranexamic Acid Cis-form

    88. Acide Tranexamique [inn-french]

    89. Acido Tranexamico [inn-spanish]

    90. Acidum Tranexamicum [inn-latin]

    91. Dv-79

    92. Cyklokapron (tn)

    93. Rikavarin (tn)

    94. Transamin (tn)

    95. Sr-05000001794

    96. Einecs 214-818-2

    97. Trans-1-aminomethylcyclohexane-4-carboxylic Acid

    98. Nsc 291305

    99. Brn 2207452

    100. Tranexamate

    101. Tranexamic-acid

    102. Unii-37yd696ii6

    103. Unii-6t84r30kc1

    104. 1ceb

    105. Prestwick_476

    106. Tranexamic Acid,(s)

    107. Spectrum_001391

    108. Tranexamic Acid [usan:usp:inn:ban:jan]

    109. Prestwick0_000171

    110. Prestwick1_000171

    111. Prestwick2_000171

    112. Prestwick3_000171

    113. Spectrum2_000655

    114. Spectrum3_001189

    115. Spectrum4_000046

    116. Spectrum5_001258

    117. Chembl877

    118. Trans-4-(aminomethyl)cyclohexane-carboxylic Acid

    119. Oprea1_786414

    120. Schembl16974

    121. Bspbio_000061

    122. Bspbio_002837

    123. Kbiogr_000511

    124. Kbioss_001871

    125. Tranexamic Acid [mi]

    126. 3-14-00-00868 (beilstein Handbook Reference)

    127. Cis-4-(aminomethyl)cyclohexanecarboxylicacid

    128. Divk1c_000655

    129. Schembl186034

    130. Schembl349408

    131. Spectrum1502026

    132. Tranexamic Acid [inn]

    133. Tranexamic Acid [jan]

    134. Tranexamic Acid, Cis-

    135. Spbio_000689

    136. Spbio_001982

    137. Tranexamic Acid [inci]

    138. Tranexamic Acid [usan]

    139. Tranexamic Acid Ep Impurity B

    140. Bpbio1_000069

    141. Chembl292500

    142. Gtpl6573

    143. Schembl6885575

    144. Schembl9885628

    145. 701-54-2 (cis+trans)

    146. Tranexamic Acid [vandf]

    147. Tranexamic Acid [mart.]

    148. Chebi:94518

    149. Hms502a17

    150. Kbio1_000655

    151. Kbio2_001871

    152. Kbio2_004439

    153. Kbio2_007007

    154. Kbio3_002337

    155. Dtxsid50904827

    156. Tranexamic Acid [usp-rs]

    157. Tranexamic Acid [who-dd]

    158. Wln: L6tj Avq D1z -t

    159. Gydjeqrtzscioi-knvocypgsa-n

    160. Gydjeqrtzscioi-uhfffaoysa-n

    161. Ninds_000655

    162. Dtxcid401333941

    163. Hms1568d03

    164. Hms1921f08

    165. Hms2092p03

    166. Hms2095d03

    167. Hms3712d03

    168. Hms3744g07

    169. Pharmakon1600-01502026

    170. Bcp13133

    171. Bcp18146

    172. Hy-b0149

    173. Tranexamic Acid (jp17/usp/inn)

    174. Tox21_110500

    175. Bbl004469

    176. Bdbm50428067

    177. Ccg-39692

    178. Mfcd00064951

    179. Nsc758176

    180. S1875

    181. Stk503668

    182. Tranexamic Acid [orange Book]

    183. Akos005171632

    184. Akos015854573

    185. Akos024257901

    186. Tranexamic Acid [ep Monograph]

    187. Tranexamic Acid [usp Impurity]

    188. Tranexamic Acid Cis-form [mi]

    189. Ab86495

    190. Ac-4687

    191. Am84352

    192. Bs-3867

    193. Cl65336

    194. Cs-1965

    195. Db00302

    196. Lb-1148

    197. Nsc-758176

    198. Tranexamic Acid [usp Monograph]

    199. 4-(aminomethyl)cyclohexanecarboxylicacid

    200. 4-aminomethyl-cyclohexanecarboxylic Acid

    201. Idi1_000655

    202. Ncgc00016569-02

    203. Ncgc00016569-03

    204. Ncgc00016569-04

    205. Ncgc00016569-05

    206. Ncgc00016569-06

    207. Ncgc00016569-08

    208. Ncgc00016569-09

    209. Ncgc00094944-01

    210. Ncgc00094944-02

    211. P-(aminomethyl)cyclohexanecarboxylic Acid

    212. As-80121

    213. Bp-12345

    214. Pd061983

    215. Sy011438

    216. Sy056656

    217. Ts-02090

    218. 4-(amin0methyl)-cyclohexanecarboxylic Acid

    219. Sbi-0051705.p002

    220. Trans 4aminomethylcyclohexanecarboxylic Acid

    221. Db-074265

    222. Trans-4-aminomethylcyclohexylcarboxylic Acid

    223. Trans-p-aminomethylcyclohexanecarboxylic Acid

    224. A0236

    225. Ab00052260

    226. Cs-0013687

    227. Cs-0055045

    228. Ns00006665

    229. Trans 4-aminomethylcyclohexanecarboxylic Acid

    230. Trans-4-aminomethylcyclohexanecarboxylic Acid

    231. En300-91506

    232. Trans-4(aminomethyl)cyclohexanecarboxylic Acid

    233. Trans-4-(aminomethyl)cyclohexylcarboxylic Acid

    234. Trans-4-aminomethyl Cyclohexanecarboxylic Acid

    235. Trans-4-aminomethyl-cyclohexanecarboxylic Acid

    236. Trans-4-aminomethylcyclohexane Carboxylic Acid

    237. D01136

    238. En300-121703

    239. P15619

    240. P20836

    241. T71247

    242. Trans-4-aminomethyl Cyclohexane Carboxylic Acid

    243. Trans4-aminomethylcyclohexane-1-carboxylic Acid

    244. Ab00052260-04

    245. Ab00052260_05

    246. Ab00052260_06

    247. Tranexamic Acid Impurity B [ep Impurity]

    248. Trans-4 -(aminomethyl)cyclohexanecarboxylic Acid

    249. Trans-4-(aminomethyl)-cyclohexanecarboxylic Acid

    250. Trans-4-(aminomethyl)cyclohexane Carboxylic Acid

    251. Trans-4-aminomethyl-1-cyclohexanecarboxylic Acid

    252. (1r,4r)-4-(aminomethyl)cyclohexanecarboxylic Acid

    253. (trans)-4-(aminomethyl)cyclohexanecarboxylic Acid

    254. 4-trans-(aminomethyl)cyclohexanecarboxylic Acid #

    255. Q418666

    256. Trans-?4-?(aminomethyl)?cyclohexanecarboxylic Acid

    257. Trans-4- (aminomethyl) Cyclohexanecarboxylic Acid

    258. Trans-4-(aminomethyl)- Cyclohexane Carboxylic Acid

    259. Trans-4-(aminomethyl)-cyclohexane Carboxylic Acid

    260. Trans-4-aminomethyl-1-cyclohexane Carboxylic Acid

    261. Q-201848

    262. Sr-05000001794-1

    263. Sr-05000001794-2

    264. Sr-05000001794-3

    265. Tranexamic Acid 100 Microg/ml In Acetonitrile:water

    266. Brd-k15014948-001-01-2

    267. Q27256710

    268. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid, 97%

    269. 4-(aminomethyl)cyclohexanecarboxylic Acid;tranexamic Acid

    270. F8886-7867

    271. Z1741970429

    272. Rel-(1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic Acid

    273. Tranexamic Acid, European Pharmacopoeia (ep) Reference Standard

    274. Tranexamic Acid, United States Pharmacopeia (usp) Reference Standard

    275. Tranexamic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 157.21 g/mol
    Molecular Formula C8H15NO2
    XLogP3-2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count2
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area63.3
    Heavy Atom Count11
    Formal Charge0
    Complexity139
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antifibrinolytic Agents

    Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders. (See all compounds classified as Antifibrinolytic Agents.)

    4.2 ATC Code

    B02AA02

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

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