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  • Chemistry
CAS 1197-18-8
Also known as: 1197-18-8, Trans-4-(aminomethyl)cyclohexanecarboxylic acid, Cyklokapron, 1197-17-7, 701-54-2, 4-(aminomethyl)cyclohexanecarboxylic acid
Molecular Formula
C8H15NO2
Molecular Weight
157.21  g/mol
InChI Key
GYDJEQRTZSCIOI-UHFFFAOYSA-N
FDA UNII
37YD696II6

Antifibrinolytic hemostatic used in severe hemorrhage.
1 2D Structure

CAS 1197-18-8

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-(aminomethyl)cyclohexane-1-carboxylic acid
2.1.2 InChI
InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
2.1.3 InChI Key
GYDJEQRTZSCIOI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC(CCC1CN)C(=O)O
2.2 Other Identifiers
2.2.1 UNII
37YD696II6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Amca

2. Amcha

3. Amchafibrin

4. Anvitoff

5. Cyklokapron

6. Exacyl

7. Kabi 2161

8. Spotof

9. T-amcha

10. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid

11. Transamin

12. Ugurol

2.3.2 Depositor-Supplied Synonyms

1. 1197-18-8

2. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid

3. Cyklokapron

4. 1197-17-7

5. 701-54-2

6. 4-(aminomethyl)cyclohexanecarboxylic Acid

7. Trans Amcha

8. Transamin

9. Tranhexamic Acid

10. Tranexamsaeure

11. Cyclocapron

12. Trans-amcha

13. Rikavarin

14. Amstat

15. Tamcha

16. Amikapron

17. Anvitoff

18. Ugurol

19. Amcha

20. Cis-tranexamic Acid

21. Frenolyse

22. Trasamlon

23. Carxamin

24. Emorhalt

25. Tranexan

26. Mastop

27. Amca

28. Cis-4-(aminomethyl)cyclohexanecarboxylic Acid

29. Rikavarin-s

30. Exacyl

31. Tranexmic Acid

32. Hexapromin

33. Transamlon

34. Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, Trans-

35. Hexatron

36. Spiramin

37. Tranex

38. Cis-amcha

39. Trans-4-aminomethylcyclohexane-1-carboxylic Acid

40. 4-(aminomethyl)cyclohexane-1-carboxylic Acid

41. Trans-tranexamic Acid

42. Acidum Tranexamicum

43. Lysteda

44. Acido Tranexamico

45. Acide Tranexamique

46. Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, Cis-

47. Cl 65336

48. Femstrual

49. Bay 3517

50. 4-(aminomethyl)-cyclohexanecarboxylic Acid

51. Cyclo-f

52. Rp 18,429

53. Cyclohexanecarboxylic Acid, 4-(aminomethyl)-

54. Cis-4-aminomethylcyclohexane-1-carboxylic Acid

55. Cyclokapron

56. Espercil

57. Haematrix

58. (1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic Acid

59. Trans-p-(aminomethyl)cyclohexanecarboxylic Acid

60. Cl-65336

61. Dv 79

62. Cis-4-(aminomethyl)cyclohexane-1-carboxylic Acid

63. Haku

64. Dv79

65. Trans-4-(aminomethyl)-1-cyclohexanecarboxylic Acid

66. Trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid

67. Lb1148

68. Mfcd00001466

69. Nsc-291305

70. Trans-1-(aminomethyl)cyclohexane-4-carboxylic Acid

71. Tranexamic Acid (transamin)

72. Dtxsid3045350

73. Retavase

74. Chebi:48669

75. 37yd696ii6

76. 6t84r30kc1

77. Mfcd19706018

78. Nsc291305

79. Tranexamic Acid(random Configuration)

80. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid Ester

81. 4-aminomethylcyclohexanecarboxylic Acid

82. Ncgc00016569-01

83. Rp-18429

84. Cas-1197-18-8

85. 4-(aminomethyl)cyclohexanecarboxylic Acid (trans-)

86. Amh

87. Tranexamic Acid Cis-form

88. Acide Tranexamique [inn-french]

89. Acido Tranexamico [inn-spanish]

90. Acidum Tranexamicum [inn-latin]

91. Dv-79

92. Cyklokapron (tn)

93. Rikavarin (tn)

94. Transamin (tn)

95. Sr-05000001794

96. Einecs 214-818-2

97. Trans-1-aminomethylcyclohexane-4-carboxylic Acid

98. Nsc 291305

99. Brn 2207452

100. Tranexamate

101. Tranexamic-acid

102. Unii-37yd696ii6

103. Unii-6t84r30kc1

104. 1ceb

105. Prestwick_476

106. Tranexamic Acid,(s)

107. Spectrum_001391

108. Tranexamic Acid [usan:usp:inn:ban:jan]

109. Prestwick0_000171

110. Prestwick1_000171

111. Prestwick2_000171

112. Prestwick3_000171

113. Spectrum2_000655

114. Spectrum3_001189

115. Spectrum4_000046

116. Spectrum5_001258

117. Chembl877

118. Trans-4-(aminomethyl)cyclohexane-carboxylic Acid

119. Oprea1_786414

120. Schembl16974

121. Bspbio_000061

122. Bspbio_002837

123. Kbiogr_000511

124. Kbioss_001871

125. Tranexamic Acid [mi]

126. 3-14-00-00868 (beilstein Handbook Reference)

127. Cis-4-(aminomethyl)cyclohexanecarboxylicacid

128. Divk1c_000655

129. Schembl186034

130. Schembl349408

131. Spectrum1502026

132. Tranexamic Acid [inn]

133. Tranexamic Acid [jan]

134. Tranexamic Acid, Cis-

135. Spbio_000689

136. Spbio_001982

137. Tranexamic Acid [inci]

138. Tranexamic Acid [usan]

139. Tranexamic Acid Ep Impurity B

140. Bpbio1_000069

141. Chembl292500

142. Gtpl6573

143. Schembl6885575

144. Schembl9885628

145. 701-54-2 (cis+trans)

146. Tranexamic Acid [vandf]

147. Tranexamic Acid [mart.]

148. Chebi:94518

149. Hms502a17

150. Kbio1_000655

151. Kbio2_001871

152. Kbio2_004439

153. Kbio2_007007

154. Kbio3_002337

155. Dtxsid50904827

156. Tranexamic Acid [usp-rs]

157. Tranexamic Acid [who-dd]

158. Wln: L6tj Avq D1z -t

159. Gydjeqrtzscioi-knvocypgsa-n

160. Gydjeqrtzscioi-uhfffaoysa-n

161. Ninds_000655

162. Dtxcid401333941

163. Hms1568d03

164. Hms1921f08

165. Hms2092p03

166. Hms2095d03

167. Hms3712d03

168. Hms3744g07

169. Pharmakon1600-01502026

170. Bcp13133

171. Bcp18146

172. Hy-b0149

173. Tranexamic Acid (jp17/usp/inn)

174. Tox21_110500

175. Bbl004469

176. Bdbm50428067

177. Ccg-39692

178. Mfcd00064951

179. Nsc758176

180. S1875

181. Stk503668

182. Tranexamic Acid [orange Book]

183. Akos005171632

184. Akos015854573

185. Akos024257901

186. Tranexamic Acid [ep Monograph]

187. Tranexamic Acid [usp Impurity]

188. Tranexamic Acid Cis-form [mi]

189. Ab86495

190. Ac-4687

191. Am84352

192. Bs-3867

193. Cl65336

194. Cs-1965

195. Db00302

196. Lb-1148

197. Nsc-758176

198. Tranexamic Acid [usp Monograph]

199. 4-(aminomethyl)cyclohexanecarboxylicacid

200. 4-aminomethyl-cyclohexanecarboxylic Acid

201. Idi1_000655

202. Ncgc00016569-02

203. Ncgc00016569-03

204. Ncgc00016569-04

205. Ncgc00016569-05

206. Ncgc00016569-06

207. Ncgc00016569-08

208. Ncgc00016569-09

209. Ncgc00094944-01

210. Ncgc00094944-02

211. P-(aminomethyl)cyclohexanecarboxylic Acid

212. As-80121

213. Bp-12345

214. Pd061983

215. Sy011438

216. Sy056656

217. Ts-02090

218. 4-(amin0methyl)-cyclohexanecarboxylic Acid

219. Sbi-0051705.p002

220. Trans 4aminomethylcyclohexanecarboxylic Acid

221. Db-074265

222. Trans-4-aminomethylcyclohexylcarboxylic Acid

223. Trans-p-aminomethylcyclohexanecarboxylic Acid

224. A0236

225. Ab00052260

226. Cs-0013687

227. Cs-0055045

228. Ns00006665

229. Trans 4-aminomethylcyclohexanecarboxylic Acid

230. Trans-4-aminomethylcyclohexanecarboxylic Acid

231. En300-91506

232. Trans-4(aminomethyl)cyclohexanecarboxylic Acid

233. Trans-4-(aminomethyl)cyclohexylcarboxylic Acid

234. Trans-4-aminomethyl Cyclohexanecarboxylic Acid

235. Trans-4-aminomethyl-cyclohexanecarboxylic Acid

236. Trans-4-aminomethylcyclohexane Carboxylic Acid

237. D01136

238. En300-121703

239. P15619

240. P20836

241. T71247

242. Trans-4-aminomethyl Cyclohexane Carboxylic Acid

243. Trans4-aminomethylcyclohexane-1-carboxylic Acid

244. Ab00052260-04

245. Ab00052260_05

246. Ab00052260_06

247. Tranexamic Acid Impurity B [ep Impurity]

248. Trans-4 -(aminomethyl)cyclohexanecarboxylic Acid

249. Trans-4-(aminomethyl)-cyclohexanecarboxylic Acid

250. Trans-4-(aminomethyl)cyclohexane Carboxylic Acid

251. Trans-4-aminomethyl-1-cyclohexanecarboxylic Acid

252. (1r,4r)-4-(aminomethyl)cyclohexanecarboxylic Acid

253. (trans)-4-(aminomethyl)cyclohexanecarboxylic Acid

254. 4-trans-(aminomethyl)cyclohexanecarboxylic Acid #

255. Q418666

256. Trans-?4-?(aminomethyl)?cyclohexanecarboxylic Acid

257. Trans-4- (aminomethyl) Cyclohexanecarboxylic Acid

258. Trans-4-(aminomethyl)- Cyclohexane Carboxylic Acid

259. Trans-4-(aminomethyl)-cyclohexane Carboxylic Acid

260. Trans-4-aminomethyl-1-cyclohexane Carboxylic Acid

261. Q-201848

262. Sr-05000001794-1

263. Sr-05000001794-2

264. Sr-05000001794-3

265. Tranexamic Acid 100 Microg/ml In Acetonitrile:water

266. Brd-k15014948-001-01-2

267. Q27256710

268. Trans-4-(aminomethyl)cyclohexanecarboxylic Acid, 97%

269. 4-(aminomethyl)cyclohexanecarboxylic Acid;tranexamic Acid

270. F8886-7867

271. Z1741970429

272. Rel-(1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylic Acid

273. Tranexamic Acid, European Pharmacopoeia (ep) Reference Standard

274. Tranexamic Acid, United States Pharmacopeia (usp) Reference Standard

275. Tranexamic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 157.21 g/mol
Molecular Formula C8H15NO2
XLogP3-2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area63.3
Heavy Atom Count11
Formal Charge0
Complexity139
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antifibrinolytic Agents

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders. (See all compounds classified as Antifibrinolytic Agents.)


4.2 ATC Code

B02AA02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


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