1. 134-85-0
2. (4-chlorophenyl)(phenyl)methanone
3. P-chlorobenzophenone
4. Methanone, (4-chlorophenyl)phenyl-
5. (4-chlorophenyl)-phenylmethanone
6. P-cbp
7. Benzophenone, 4-chloro-
8. 4-chloro Benzophenone
9. 4-benzoylphenyl Chloride
10. P-chlorophenyl Phenyl Ketone
11. Wih1iz728u
12. Cetirizine Impurity (4-chlorobenzophenone)
13. Nsc-2872
14. Para-chlorobenzophenone
15. Mfcd00000622
16. Unii-wih1iz728u
17. 4-chlorophenyl Phenyl Ketone
18. (4-chlorophenyl)phenylmethanone
19. Hsdb 2740
20. Nsc 2872
21. Einecs 205-160-7
22. Ai3-00705
23. Clemastine (m2)
24. 4-cbp
25. 4-chlorobenzophenone, 99%
26. Dsstox_cid_30242
27. Dsstox_gsid_51687
28. Schembl50462
29. Phenyl-(4-chlorophenyl)-ketone
30. Chembl3560455
31. Dtxsid2051687
32. Nsc2872
33. Chebi:167846
34. Bcp27841
35. Str01449
36. Zinc2504270
37. Phenyl 4-chlorophenyl Ketone
38. Tox21_304009
39. (4-chlorophenyl)(phenyl)methanone #
40. Stl453116
41. 4-chlorobenzophenone [usp-rs]
42. Akos000119405
43. 4-chlorophenyl-phenyl Methanone
44. Cs-w004344
45. Ps-7925
46. Ncgc00357224-01
47. Ac-23664
48. Cas-134-85-0
49. Db-042255
50. Ft-0618187
51. D77656
52. 4-chlorobenzophenone(chunks Or Pellets Or Flake)
53. Ah-034/32828041
54. W-108278
55. Q27292660
56. Z425389590
57. Meclozine Dihydrochloride Impurity C [ep Impurity]
58. 4-chlorobenzophenone, United States Pharmacopeia (usp) Reference Standard
| Molecular Weight | 216.66 g/mol |
|---|---|
| Molecular Formula | C13H9ClO |
| XLogP3 | 4.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 2 |
| Exact Mass | 216.0341926 g/mol |
| Monoisotopic Mass | 216.0341926 g/mol |
| Topological Polar Surface Area | 17.1 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 213 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
The metabolism of clemastine, 2-(2-(1-(4-chlorophenyl)-1-phenylethoxylethyl])-1-methylpyrrolidine, has been studied in three adult male volunteers after a single oral dose of 20 mg as the fumarate. After enzymatic hydrolysis solvent extracts of urine were derivatized with N-methyl-N-trimethylsilyltrifluoroacetamide-ammonium iodide and analysed by gas chromatography-mass spectrometry. The structures of metabolites were determined on the basis of electron impact and chemical ionization mass spectra and the identities of some (e.g. carbinol, 4-chlorobenzophenone and 4-chlorophenylstyrene) were confirmed by use of authentic standards. The principal route of metabolism of clemastine in man involves direct oxidation, O-dealkylation (fission of the ether bond), aromatic hydroxylation, aliphatic oxidation, alcoholic dehydration, and then enzymatic hydrolysis. Of the total amount of metabolites excreted in the urine 35% was carbinol (metabolite M3, major metabolite), 15% was M1, 17% was M2, 11% was M4, 9% was M5, 8% was M6 and 5% was M7.
PMID:10197418 Ho CM et al; J Pharm Pharmacol 51(1): 53-9 (1999)
LOOKING FOR A SUPPLIER?
