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CAS 484-23-1

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Also known as: 484-23-1, Dihydralazin, Dihydrallazin, Dihydrallazine, Ophthazin, 1,4-dihydrazinophthalazine

Molecular Formula

C₈H₁₀N₆

Molecular Weight

190.21 g/mol

InChI Key

VQKLRVZQQYVIJW-UHFFFAOYSA-N

FDA UNII

PCU411F5L6

1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)

1 2D Structure

CAS 484-23-1

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4-hydrazinylphthalazin-1-yl)hydrazine

2.1.2 InChI

InChI=1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)

2.1.3 InChI Key

VQKLRVZQQYVIJW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C2C(=C1)C(=NN=C2NN)NN

2.2 Other Identifiers

2.2.1 UNII

PCU411F5L6

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Depressan

2. Dihydralazine Sulfate

3. Dihydrallazine

4. Dihydrazinophthalazin

5. Sulfate, Dihydralazine

2.3.2 Depositor-Supplied Synonyms

1. 484-23-1

2. Dihydralazin

3. Dihydrallazin

4. Dihydrallazine

5. Ophthazin

6. 1,4-dihydrazinophthalazine

7. Hypopresol

8. Nepresolin

9. Nepressol

10. Tonolysin

11. Dihydrazinophthalazine

12. Nepresol

13. Cassella 532

14. (4-hydrazinylphthalazin-1-yl)hydrazine

15. 1,4-dihydrazinonaphthalazine

16. C 7441

17. Nsc 526654

18. 1,4-phthalazinedione, 2,3-dihydro-, Dihydrazone

19. Phthalazine, 1,4-dihydrazino-

20. 2,3-dihydro-1,4-phthalazinedione Dihydrazone

21. Nsc-526654

22. Pcu411f5l6

23. Dihydralazine (inn)

24. Ncgc00159421-02

25. Ncgc00159421-03

26. (1z)-4-hydrazinyl-1-hydrazinylidene-1,2-dihydrophthalazine

27. Dsstox_cid_2935

28. Dihydralazine [inn]

29. Dsstox_rid_76795

30. Dsstox_gsid_22935

31. Dihidralazina

32. Dihydralazinum

33. Dihydralazine [inn:ban]

34. Dihydralazinum [inn-latin]

35. Dihidralazina [inn-spanish]

36. Cas-484-23-1

37. Ccris 7576

38. Einecs 207-605-0

39. Brn 0183442

40. 1,4-dihydrazino-phthalazine

41. Unii-pcu411f5l6

42. Dihydralazine [mi]

43. Phthalazine,4-dihydrazino-

44. 1,4-dihydrazineylphthalazine

45. 1,4-dihydrazinyl-phthalazine

46. 5-25-17-00465 (beilstein Handbook Reference)

47. Chembl35505

48. Schembl149629

49. 1,4-bis(hydrazino)phthalazine

50. Dihydralazine [who-dd]

51. Dtxsid0022935

52. Schembl14318435

53. 1, 2,3-dihydro-, Dihydrazone

54. Chebi:134841

55. (4-diazanylphthalazin-1-yl)diazane

56. Zinc4474539

57. Tox21_111653

58. Bdbm50088433

59. Nsc526654

60. Akos006276458

61. Akos025393367

62. Akos030240650

63. Tox21_111653_1

64. (4-hydrazinyl-1-phthalazinyl)hydrazine

65. Db12945

66. Gs-0013

67. Db-002370

68. Cs-0452869

69. Ft-0602022

70. 84d231

71. D07170

72. 1,4-dihydrazono-1,2,3,4-tetrahydrophthalazine

73. A827533

74. Ae-641/40262237

75. Q408370

76. Sr-01000944956

77. Sr-01000944956-1

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₈H₁₀N₆
Molecular Weight	190.21 g/mol
XLogP3	0.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	190.09669434 g/mol
Monoisotopic Mass	190.09669434 g/mol
Topological Polar Surface Area	102 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	167
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

4.2 ATC Code

C - Cardiovascular system

C02 - Antihypertensives

C02D - Arteriolar smooth muscle, agents acting on

C02DB - Hydrazinophthalazine derivatives

C02DB01 - Dihydralazine

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