1. Aerosol Ot
2. Colace
3. Deh Na Ss
4. Deh-na-ss
5. Diethylhexyl Sodium Sulfosuccinate
6. Dioctyl Sulfosuccinate
7. Dioctyl Sulfosuccinate, Sodium
8. Dioctyl Sulfosuccinates
9. Dioctyl Sulfosuccinic Acid
10. Dioctyl Sulfosuccinic Acid, Ammonium Salt
11. Dioctyl Sulfosuccinic Acid, Barium Salt
12. Dioctyl Sulfosuccinic Acid, Calcium Salt
13. Dioctyl Sulfosuccinic Acid, Magnesium Salt
14. Dioctyl Sulfosuccinic Acid, Potassium Salt
15. Dioctyl Sulfosuccinic Acid, Sodium Salt
16. Dioctylsulfosuccinate
17. Dioctylsulphosuccinate, Sodium
18. Docusate
19. Docusate Calcium
20. Docusate Potassium
21. Doss
22. Sodium Bis(2-ethylhexyl)sulfosuccinate
23. Sodium Dioctyl Sulfosuccinate
24. Sodium Dioctylsulphosuccinate
25. Sodium Sulfosuccinate, Diethylhexyl
26. Sulfosuccinate, Diethylhexyl Sodium
27. Sulfosuccinate, Dioctyl
28. Sulfosuccinates, Dioctyl
29. Sulfosuccinic Acid Bis(2-ethylhexyl) Ester
1. 577-11-7
2. Dioctyl Sodium Sulfosuccinate
3. Dioctyl Sulfosuccinate Sodium Salt
4. Aerosol Ot
5. Dioctylal
6. Diotilan
7. Disonate
8. Molatoc
9. Regutol
10. Velmol
11. Doxol
12. Nevax
13. Dialose
14. Doxinate
15. Soliwax
16. Molcer
17. Waxsol
18. Adekacol Ec 8600
19. Docusate (sodium)
20. Constonate
21. Mervamine
22. Clestol
23. Defilin
24. Obston
25. Requtol
26. Docusate Sodium Salt
27. Diox
28. Modane Soft
29. Alcopol O
30. Sulfimel Dos
31. Manoxal Ot
32. Manoxol Ot
33. Aerosol Aot
34. Aerosol Gpg
35. Wetaid Sr
36. Aerosol Ot-a
37. Dioctyl Sulfosuccinate Sodium
38. Colace
39. Laxinate 100
40. Sanmorin Ot 70
41. Triton Gr 7
42. Triton Gr-5
43. Aerosol Ot 70pg
44. Aerosol Ot 75
45. Celanol Dos 65
46. Celanol Dos 75
47. Coloxyl
48. Comfolax
49. Coprola
50. Dioctyl
51. Docolace
52. Docuprene
53. Dulcivac
54. Eurowet
55. Humifen Wt 27g
56. Solusol-75%
57. Silace
58. Bloat Treatment
59. Docusato Sodico
60. Nikkol Otp 70
61. Aerosol A 501
62. Alkasurf Ss-o 75
63. Solusol-100%
64. Docusate Sodique
65. Nekal Wt-27
66. Berol 478
67. Docusatum Natricum
68. Empimin Op70
69. Sanmorin Ot 70n
70. Bis(2-ethylhexyl) Sulfosuccinate Sodium Salt
71. Natrii Dioctylsulfosuccinas
72. Tex-wet 1001
73. Airrol Ct-1
74. Doc Q Lace
75. Mackanate Dos-70
76. Nikkol Otp-75
77. Gemtex Pa-70
78. Rapisol A 30
79. Triton Gr-pg 70
80. Sodium Dioctyl Sulphosuccinate
81. Nissan Rapisol A 30
82. Jamylene
83. Bis(2-ethylhexyl) Sodium Sulfosuccinate
84. Sodium 2-ethylhexylsulfosuccinate
85. Sodium Bis(2-ethylhexyl) Sulfosuccinate
86. Hsdb 3065
87. Ins No.480
88. Monawet Mo 65-150
89. 2-ethylhexyl Sulfosuccinate Sodium
90. Einecs 209-406-4
91. Ins-480
92. Dioctyl Sodium Sulphosuccinat
93. Sodium 1,4-bis(2-ethylhexyl) Sulfosuccinate
94. Unii-f05q2t2ja0
95. Dioctyl Ester Of Sodium Sulfosuccinate
96. Bis(2-ethylhexyl)sodium Sulfosuccinate
97. Di-(2-ethylhexyl) Sodium Sulfosuccinate
98. Sodium Di-(2-ethylhexyl) Sulfosuccinate
99. Docusate Sodique [inn-french]
100. Docusato Sodico [inn-spanish]
101. F05q2t2ja0
102. Docusatum Natricum [inn-latin]
103. Dtxsid8022959
104. Dioctyl Ester Of Sodium Sulfosuccinic Acid
105. Ai3-00239
106. Diethylhexyl Sodium Sulfosuccinate
107. Sodium Sulfodi-(2-ethylhexyl)-sulfosuccinate
108. Chemax Doss/75e
109. Mfcd00012455
110. Nsc-760404
111. Butanedioic Acid, Sulfo-, 1,4-bis(2-ethylhexyl) Ester, Sodium Salt
112. Chebi:4674
113. Dtxcid102959
114. Bis-2-ethylhexylester Sulfojantaranu Sodneho
115. E 480
116. E-480
117. Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
118. Ec 209-406-4
119. Sol Sodowej Sulfobursztynianu Dwu-2-etyloheksylowego
120. Sodium Docusate
121. 1,4-bis(2-ethylhexyl)sulfobutanedioate, Sodium Salt
122. Nsc 760404
123. Aot
124. Docusate Sodium [usan:usp:inn:ban]
125. Sbo
126. Sodium Di(2-ethylhexyl) Sulfosuccinate
127. Diomedicone
128. Complemix
129. Dioctlyn
130. Diosuccin
131. Dulsivac
132. Laxinate
133. Molofac
134. Sobital
135. Coprol
136. Diovac
137. Konlax
138. Kosate
139. Softil
140. Revac
141. Aec Diethylhexyl Sodium Sulfosuccinate
142. Alphasol Ot
143. Docusate Sodium (ii)
144. Docusate Sodium [ii]
145. Docusate Sodique (inn-french)
146. Docusato Sodico (inn-spanish)
147. Sulfosuccinic Acid Bis(2-ethylhexyl) Ester Sodium Salt
148. Dess
149. Monawet Md 70e
150. Docusate Sodium (mart.)
151. Docusate Sodium [mart.]
152. Docusatum Natricum (inn-latin)
153. Docusate Sodium (usp-rs)
154. Docusate Sodium [usp-rs]
155. Geriplex
156. Unilax
157. Sodium 1,4-bis((2-ethylhexyl)oxy)-1,4-dioxobutane-2-sulfonate
158. Dioctyl Sodium Sulfosuccinate (jan)
159. Dialose Plus
160. Senokot S
161. Correctol Caplets
162. Correctol Tablets
163. Docusate Sodium (usp Impurity)
164. Docusate Sodium [usp Impurity]
165. Senokap Dss
166. Docusate Sodium (usan:usp:inn:ban)
167. Docusate Sodium (usp Monograph)
168. Docusate Sodium [usp Monograph]
169. D-s-s
170. Cas-577-11-7
171. Dioctyl Sodium Sulfosuccinate [jan]
172. Correctol Extra Gentle Tablets
173. Ncgc00164140-03
174. Sv 102
175. Promolaxin
176. Colistat
177. Prenexa
178. Purgasol
179. Vinacol
180. Natrii Docusas
181. Bis(2-ethylhexyl) S-sodium Sulfosuccinate
182. Docusol
183. Colace Clear
184. Docqlace
185. Docusate Sod
186. Enemeez Kids
187. Docu Liquid
188. Single-use
189. Sodium 1,4-bis(2-ethylhexyl)sulfosuccinate
190. 1,4-bis(2-ethylhexyl) Sodium Sulfosuccinate
191. Docusol Kids
192. Senexon-s
193. Docusato De Sodio
194. Docusate Sodium; Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
195. Folca[s Care Pme
196. Folcal Dha
197. Senna-s
198. Di(2-ethylhexyl)sulfosuccinic Acid, Sodium Salt
199. Betr Stool Softener
200. Bis(ethylhexyl) Ester Of Sodium Sulfosuccinic Acid
201. Cvs Stool Softener
202. Docusate Mini Enema
203. Heb Stool Softener
204. Bis-2-ethylhexylester Sulfojantaranu Sodneho [czech]
205. Colace (tn)
206. Laxa-basic 100
207. Sodium Di(2-ethylhexyl)sulfosuccinate
208. Clear Stool Softener
209. Enemeez
210. Winco Stool Softener
211. Gentle Stool Softener
212. Sulfosuccinic Acid, Bis(2-ethylhexyl)ester Sodium Salt
213. Kroger Stool Softener
214. Stool Softener Liquid
215. Bloat Release
216. Stool Softner
217. Docusate Sodium Liquid
218. Pet-enema
219. Topcare Stool Softener
220. Disposable Enema
221. Deh Na Ss
222. Deh-na-ss
223. Dulcolax Stool Softener
224. Feline Pet-ema
225. Pet-ema
226. Phillips Stool Softener
227. Stool Softener Laxative
228. H E B Stool Softener
229. Sol Sodowej Sulfobursztynianu Dwu-2-etyloheksylowego [polish]
230. Docusate Sodium (usp)
231. Docusate Sodium 100mg
232. Docusate Sodium 250mg
233. Walgreens Stool Softener
234. Basic Care Stool Softener
235. Good Sense Stool Softener
236. Pluspharmastool Softener
237. Succinic Acid, Sulfo-, 1,4-bis(2-ethylhexyl) Ester, Sodium Salt
238. Ncgc00183136-01
239. Cvs Health Stool Softener
240. Stool Softenergentle Relief
241. Betr Remedies Stool Softener
242. Schembl4113
243. Gentle Relief Stool Softner
244. Gentle Relief Stool Softnet
245. Dqzate Stool Softener
246. Healthy Mamamove It Along
247. Dulcolax Pink Stool Softener
248. Good Neighbor Stool Softener
249. Harris Teeter Stool Softener
250. Docusate Sodium [mi]
251. Dioctylsulphosuccinate, Sodium
252. Exchange Select Stool Softener
253. H E B Stool Softenerlaxative
254. Mls004773938
255. Quality Choice Stool Softener
256. Docusate Sodium [inn]
257. Stool Softenerregular Strength
258. Topcare Stool Softenerlaxative
259. Cvs Stool Softenerfruit Punch
260. Dioctyl Sulfosuccinate, Sodium
261. Stool Softener Docusate Sodium
262. Docusate Sodium [hsdb]
263. Docusate Sodium [usan]
264. Docusate Sodium 50 Mg
265. Docusate Sodium 100 Mg
266. Stool Softener Regular Strength
267. Stool Softenerextra Strength
268. Docusate Sodium [vandf]
269. Gericare Docusate Sodium Liquid
270. Preferred Stool Softenerlaxative
271. Chembl1905872
272. Cvs Health Stool Softener Clear
273. Kroger Stool Softenerfruit Punch
274. A06aa02
275. Correctol Stool Softener Laxative
276. Docusate Sodium [who-dd]
277. Non-habit Forming Stool Softener
278. Sulfosuccinic Acid, Di-(2-ethylhexyl) Ester, Sodium Salt
279. Hms3264p07
280. Hms3885b10
281. Sodium Sulfosuccinate, Diethylhexyl
282. Sulfosuccinate, Diethylhexyl Sodium
283. Bcp31325
284. Hy-b1268
285. Walgreens Stool Softenerfruit Punch
286. Extra Strength Stool Softener
287. Good Neighbor Stool Softenerlaxative
288. Phillips Stool Softenerbulk Docusate
289. Sodium Dioctyl Sulfosuccinate (inn)
290. Tox21_112087
291. Tox21_113469
292. Tox21_201342
293. Tox21_300496
294. Docusate Sodium 100mg Two-tone
295. Quality Choice Stool Softenerlaxative
296. S4588
297. Stool Softener Laxativeextra Strength
298. Dioctyl Disodium Sulfosuccinate
299. Akos015901806
300. Ccg-213234
301. Cs-4813
302. Docusate Sodium, Extra Strength
303. Docusate Sodium Salt, Bioxtra, >=99%
304. Docusate Sodium-stool Softener Laxative
305. Dioctyl Sulfosuccinate Sodium Salt, 96%
306. Dok Extra Strength Stool Softener
307. Ncgc00164140-01
308. Ncgc00254414-01
309. Ncgc00258894-01
310. As-13347
311. E480
312. Smr001595510
313. Sy010813
314. Dioctyl Sodium Sulfosuccinate [fcc]
315. Bis(2-ethylhexyl) Sulfosuccinatesodium Salt
316. Dioctyl Sulfosuccinate Sodium Salt, >=97%
317. Extra Strength Stool Softener Laxative
318. Ns00074370
319. Stool Softener Docusate Sodium 50 Mg
320. Docusate Sodium, Extra Strength250 Mg
321. D00305
322. Docusate Sodium Salt, P.a., 99.0-100.5%
323. E77584
324. Docusate Sodium Salt, Purum, >=96.0% (tlc)
325. Docusate Sodium Salt, Bioultra, >=99.0% (tlc)
326. Docusate Sodium, Meets Usp Testing Specifications
327. Q2815334
328. W-105447
329. F8880-5559
330. Sulfobutanedioic Acid Bis(2-ethylhexyl Ester) Sodium Salt
331. Docusate Sodium, British Pharmacopoeia (bp) Reference Standard
332. Docusate Sodium, European Pharmacopoeia (ep) Reference Standard
333. Sodium 1,4-bis(2-ethylhexyloxy)-1,4-dioxobutane-2-sulfonate
334. Docusate Sodium, United States Pharmacopeia (usp) Reference Standard
335. 1,4-bis(2-ethylhexyl)sodiumsulfosuccinate Pound>>dioctyl Sulfosuccinate Sodium Salt
336. Butanedioic Acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) Ester, Sodium Salt (1:1)
337. Yal
| Molecular Weight | 444.6 g/mol |
|---|---|
| Molecular Formula | C20H37NaO7S |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 18 |
| Exact Mass | g/mol |
| Monoisotopic Mass | g/mol |
| Topological Polar Surface Area | 118 |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 546 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 3 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
Cathartics; Excipients; Surface-Active Agents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
Oral bulk-forming, lubricant, and stool softener laxatives are indicated prophylactically in patients who should not strain during defecation, such as those with an episiotomy wound, painful thrombosed hemorrhoids, fissures or perianal abbesses, body wall and diaphragmatic hernias, anorectal stenosis, or postmyocardial infarction. /Laxatives; Included in US product labeling/
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1704
Oral laxatives are indicated for the short-term relief of constipation. Oral bulk-forming laxatives, stimulant laxatives, and carbon dioxide-releasing suppositories are indicated to facilitate defecation in geriatric patients with diminished colonic motor response. Oral bulk-forming laxatives and stool softener laxatives are preferred to treat constipation that may occur during pregnancy and postpartum to help re-establish normal bowel function or to avoid straining if hemorrhoids are present. In severe cases of constipation, such as with fecal impaction, mineral oil and stool softener laxatives administered orally or rectally are indicated to soften the impacted feces. To help complete the evacuation of the impacted colon, a rectal stimulant or saline laxative may follow. /Laxatives; Included in US product labeling/
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1704
Laxatives should not be given to young children (up to 6 years of age) unless prescribed by a physician. Since children are not usually able to describe their symptoms precisely, proper diagnosis should precede the use of a laxative. This will avoid the complication of an existing condition(e.g., appendicitis) or the appearance of more severe side effects. /Laxatives/
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1705
Side/Adverse Effects: Those indicating need for medical attention: Incidence rare: Allergies, undetermined (skin rash). /Laxatives/
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1707
Side/Adverse Effects: Those indicating need for medical attention only if they continue or are bothersome: Incidence less frequent: Stomach and/or intestinal cramping; throat irritation - with liquid forms. /Laxatives/
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1707
Because concurrent use of the docusate salts may increase the absorption of mineral oil, their concomitant administration is not recommended. /Docusate salts/
American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 952
For more Drug Warnings (Complete) data for BIS(2-ETHYLHEXYL) SODIUM SULFOSUCCINATE (7 total), please visit the HSDB record page.
3. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT FOR 70 KG PERSON (150 LB).
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-274
Surface-Active Agents
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)
A06AA02
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
A - Alimentary tract and metabolism
A06 - Drugs for constipation
A06A - Drugs for constipation
A06AA - Softeners, emollients
A06AA02 - Docusate sodium
...DRUG IS ABSORBED FROM GI TRACT & IS EXCRETED IN SIGNIFICANT CONCN IN BILE.
Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 922
SINCE THE DRUG IS ABSORBED FROM GI TRACT & IS EXCRETED IN SIGNIFICANT CONCN IN BILE...
Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 922
In vitro studies suggest that these salts of dioctylsulfosuccinic acid lower the surface tension of the stool to permit water and lipids to enter more readily and thus soften the feces. ... More recent evidence indicates that they may stimulate the secretion of water and electrolytes on contact with the mucosa.
American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 949
Reduce surface film tension of interfacing liquid contents of the bowel, promoting permeation of additional liquid into the stool to form a softer mass. /Laxatives/
USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1705
BUILDING BLOCK
END USE APIs
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