CAS 857890-39-2 manufacturers and suppliers on PharmaCompass

PharmaCompass

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 857890-39-2, Lenvima, Lenvatinibmesylate, Lenvatinib mesilate, Lenvatinib mesylate [usan], E7080 mesylate
Molecular Formula
C22H23ClN4O7S
Molecular Weight
523.0  g/mol
InChI Key
HWLFIUUAYLEFCT-UHFFFAOYSA-N
FDA UNII
3J78384F61

CAS	857890-39-2
Lenvatinib Mesylate is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.
1 2D Structure

CAS	857890-39-2

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic acid
2.1.2 InChI
InChI=1S/C21H19ClN4O4.CH4O3S/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11;1-5(2,3)4/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);1H3,(H,2,3,4)
2.1.3 InChI Key
HWLFIUUAYLEFCT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
3J78384F61
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-hydroxy-6-quinolinecarboxamide

2. 4-(3-chloro-4-((cyclopropylaminocarbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide

3. 4-(3-chloro-4-(n'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide

4. E 7080

5. E-7080

6. E-7080 Mesylate

7. E7080

8. E7080 Mesylate

9. Er-203492-00

10. Lenvatinib

11. Lenvatinib Mesilate

12. Lenvatinib Metabolite M2

13. Lenvatinib Methanesulfonate

14. Lenvima

15. N-(4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-n'-cyclopropylurea Monomethanesulfonate

2.3.2 Depositor-Supplied Synonyms

1. 857890-39-2

2. Lenvima

3. Lenvatinibmesylate

4. Lenvatinib Mesilate

5. Lenvatinib Mesylate [usan]

6. E7080 Mesylate

7. Lenvatinib (mesylate)

8. Unii-3j78384f61

9. E-7080 Mesylate

10. Chebi:85995

11. 857890-39-2 (mesylate)

12. 3j78384f61

13. Lenvatinib Mesilate (jan)

14. Lenvatinib Mesylate (usan)

15. N-(4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-n'-cyclopropylurea Monomethanesulfonate

16. Lenvatinib Mesilate [jan]

17. 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide Mesylate

18. 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic Acid

19. 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide Monomethanesulfonate

20. Lenvima (tn)

21. E7080mesylate

22. E7080 (mesylate)

23. Lenvatinib Methanesulfonate

24. Lenvatinib Mesylate- Bio-x

25. Schembl865174

26. Amy385

27. Chembl2105704

28. Dtxsid90235081

29. Bcp11858

30. Hy-10981a

31. Lenvatinib Mesilate [who-dd]

32. Mfcd18633219

33. Ccg-269873

34. Sb16581

35. Lenvatinib Methanesulfonate [mi]

36. Lenvatinib Mesylate [orange Book]

37. Ac-30100

38. Bl166696

39. Ds-19245

40. Cs-0030963

41. S5240

42. D09920

43. A900902

44. Q27158839

45. 4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide Methanesulfonate

46. 6-carbamoyl-4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinolin-1-ium Methanesulfonate

47. 6-quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)- 7-methoxy-, Methanesulfonate (1:1)

48. 6-quinolinecarboxamide, 4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-methoxy-, Methanesulfonate (1:1)

49. Methanesulfonic Acid--4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide (1/1)

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 523.0 g/mol
Molecular Formula C22H23ClN4O7S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass522.0975980 g/mol
Monoisotopic Mass522.0975980 g/mol
Topological Polar Surface Area178 Ų
Heavy Atom Count35
Formal Charge0
Complexity727
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Lenvima is indicated as monotherapy for the treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hrthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine (RAI).

Lenvima is indicated as monotherapy for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma (HCC) who have received no prior systemic therapy.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


5.2 ATC Code

L01XE


BUILDING BLOCK

Upload your portfolio for free, ask us
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty