1. 3 Chloro 1,2 Propanediol
2. 3 Chloropropanediol
3. 3 Monochloropropane 1,2 Diol
4. 3-chloropropanediol
5. 3-mcpd
6. 3-monochloropropane-1,2-diol
7. Alpha Chlorhydrin
8. Alpha Chlorohydrin
9. Alpha-chlorhydrin
10. Alpha-chlorohydrin
11. Alpha-monochlorohydrin, Glycerol
12. Glycerol Alpha Monochlorohydrin
13. Glycerol Alpha-monochlorohydrin
14. U 5897
15. U-5897
16. U5897
1. 96-24-2
2. 3-chloropropane-1,2-diol
3. Alpha-chlorohydrin
4. Chlorodeoxyglycerol
5. Epibloc
6. Glycerol Alpha-monochlorohydrin
7. 1,2-propanediol, 3-chloro-
8. Chloropropanediol
9. A-chlorohydrin
10. 3-chloropropanediol
11. 3-chloropropylene Glycol
12. Glycerol Chlorohydrin
13. Glyceryl Chloride
14. 1-chloro-2,3-dihydroxypropane
15. 1-chloropropane-2,3-diol
16. Alpha-chlorohydrine
17. Chlorohydrin
18. Monochlorohydrin
19. 3-mcpd
20. 1-chloro-2,3-propanediol
21. Glycerin Epichlorohydrin
22. Glycerol 3-chlorohydrin
23. 2,3-dihydroxypropyl Chloride
24. 1-chloro-1-deoxyglycerol
25. Alpha-monochlorohydrin
26. 3-chloro-1,2-dihydroxypropane
27. U 5897
28. 1,2-dihydroxy-3-chloropropane
29. 3-chloro-1,2-propylene Glycol
30. Glyceryl Alpha-chlorohydrin
31. Glyceryl-alpha-chlorohydrin
32. (rs)-3-chloro-1,2-propanediol
33. .alpha.-chlorohydrin
34. Glycerin Alpha-monochlorhydrin
35. (+/-)-3-chloro-1,2-propanediol
36. 3-monochloro-1,2-propanediol
37. 3-monochloropropane-1,2-diol
38. 1,2-propanediol, 3-dichloro-
39. (+-)-2,3-dihydroxychloropropane
40. 3-chloro-1,2-propandiol
41. A-monochlorohydrin
42. Beta,beta'-dihydroxyisopropyl Chloride
43. U-5897
44. Chloropropylene Glycol
45. A-glycerol Chlorohydrin
46. Chloro-1,2-propanediol
47. Chloro-1,2-dihydroxypropane
48. Qgs78a3t6p
49. Glycerine Alpha-monochlorohydrin
50. Glycerin .alpha.-monochlorhydrin
51. Chebi:18721
52. Chlorhydrin
53. Monochlorhydrin
54. Dsstox_cid_664
55. Dsstox_rid_75718
56. 3-chloro-propane-1,2-diol
57. Dsstox_gsid_20664
58. Caswell No. 214a
59. Ekorod A
60. (s)-( )-3-chloro-1,2-propanediol
61. Cas-96-24-2
62. Ccris 4607
63. Hsdb 2052
64. Einecs 202-492-4
65. Un2689
66. 3-mcdp
67. Unii-qgs78a3t6p
68. Epa Pesticide Chemical Code 117101
69. Brn 0635684
70. Ai3-11200
71. U5897
72. (2r)-(-)-3-chloropropane-1,2-diol
73. (2s)-(+)-3-chloropropane-1,2-diol
74. Mfcd00004712
75. Chlorohydrin-
76. .alpha.-monochlorohydrine
77. 3-chloro1,2-propanediol
78. Alpha-glycerol Chlorohydrin
79. Glycerol A-monochlorohydrin
80. (+/-)-alpha-chlorohydrin
81. Ec 202-492-4
82. 3-chloro-1,2-propan-diol
83. Glycerol Alpha -chlorohydrin
84. Glyceryl Alpha -chlorohydrin
85. 3-chloropropandiol-(1,2)
86. 3-chloro-1,2-propane Diol
87. 3-chloro-1,2-propane-diol
88. Schembl19213
89. 3-dichloro-1,2-propanediol
90. 4-01-00-02484 (beilstein Handbook Reference)
91. Glycerol .alpha.-chlorohydrin
92. Glyceryl .alpha.-chlorohydrin
93. Mls000028887
94. Glycerin Alpha -monochlorhydrin
95. .alpha.-monochlorohydrin
96. Dl-.alpha.-chlorohydrin
97. Glycerol-alpha -monochlorohydrin
98. Chembl3185949
99. Dtxsid4020664
100. 3-chloro-1,2-proandiol
101. Glycerol-.alpha.-monochlorohydrin
102. Racemic 3-chloro-1,2-propanediol
103. .alpha.-chlorohydrin [mi]
104. 3-chloro-1,2-dihydroxy-n-propane
105. Act05631
106. Amy21866
107. Bcp31835
108. Tox21_202262
109. Tox21_302959
110. Bbl011374
111. Stl146471
112. Akos000121375
113. (.+/-.)-2,3-dihydroxychloropropane
114. Sb44720
115. Un 2689
116. .alpha.-chlorohydrin, (+/-)-
117. Ncgc00249201-01
118. Ncgc00256557-01
119. Ncgc00259811-01
120. Smr000059152
121. Vs-02932
122. (+/-)-2,3-dihydroxychloropropane
123. (+/-)-3-chloro-1,2-propanediol, 98%
124. .beta.,.beta.'-dihydroxyisopropyl Chloride
125. Db-028420
126. (s)-acetylthio-3-phenylpropionicacid
127. 3-chloro-1,2-propanediol Monochlorhydrin
128. Ft-0605055
129. Ft-0605261
130. 3-chloropropane-1,2-diol;chlorodeoxyglycerol
131. C18676
132. Q223066
133. 3-chloropropylene Glycol. Epibloc (pestcon)
134. (+/-)-3-chloro-1,2-propanediol, Analytical Standard
135. 3-chloro-1,2-propanediol 100 Microg/ml In Methanol
136. 3-chloro-1,2-propanediol 100 Microg/ml In Acetonitrile
137. 3-chloro-1,2-propanediol 100 Microg/ml In Ethyl Acetate
138. (+/-)-3-chloro-1,2-propanediol, Purum, >=98.0% (gc)
139. Glycerol Alpha-monochlorohydrin [un2689] [keep Away From Food]
| Molecular Weight | 110.54 g/mol |
|---|---|
| Molecular Formula | C3H7ClO2 |
| XLogP3 | -0.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 110.0134572 g/mol |
| Monoisotopic Mass | 110.0134572 g/mol |
| Topological Polar Surface Area | 40.5 Ų |
| Heavy Atom Count | 6 |
| Formal Charge | 0 |
| Complexity | 32 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Chemosterilants
Compounds that cause reproductive sterility in organisms. They are sometimes used to control pest populations by sterilizing males within the population. (See all compounds classified as Chemosterilants.)
FOLLOWING ADMIN OF ALPHA-CHLOROHYDRIN (100 MG/KG, IP) TO MALE RATS, BETA-CHLOROLACTIC ACID & OXALIC ACID WERE ISOLATED FROM URINE.
JONES AR ET AL; XENOBIOTICA 8(9) 573 (1978)
Glycidol ... an industrial chemical, has been showed to be a reproductive toxicant in short term studies and a carcinogen in rats and mice in /carcinogenicity/ studies. The reproductive toxicity of glycidol was believed to result from its conversion to alpha-chlorohydrin by the action of hydrochloric acid in the stomach. The comparative disposition of glycidol was investigated in rats following oral or iv admin at doses of 37.5 and 75 mg/kg. ... Approx 87-92% of the dose was absorbed from the gastrointestinal tract of the rat. (14)C-Glycidol equivalents were eliminated in urine (40-48% of the dose in 72 hr), feces (5-12%), and exhaled as CO2 (26-32%). At both doses, 9-12% and 7-8% (estimated) of the dose remained in tissues at 24 or 72 hr following dosing, respectively. In general, the concn of glycidol equivalents in tissues were proportional to the dose. The highest concn of radioactivity were /noted/ in the blood cells, thyroid, liver, kidney, spleen, and the lowest in adipose tissue, skeletal muscle, and plasma. The pattern of distribution of radioactivity in tissues was similar for both the iv and oral routes. The total recovery of radioactivity ranged from 87 to 91% of the dose. Urinary radioactivity was resolved by HPLC analysis into 15 metabolites. There were one major (14-21% of the dose) and four lesser metabolites (each representing 2-8%); the others were minor, each representing 1% or less of the dose. In general, the urinary metabolic profile was similar to iv or oral admin of the two doses studied. ...
Nomeir AA et al; J Toxicol Environ Hlth 44 (2): 203-17 (1995)
The ultrastructural changes of each epididymal segment of the rat were brought about by alpha-chlorohydrin (20 mg/kg/day, for successive five times). The alteration appeared in proper order from initial segment to caudal segment, and the digression in profundity and range got less serious as the distance to the testis increased. This alteration disappeared gradually as the time went by. The recovery process also began at initial segment but its cycle was shortened gradually from initial segment to caudal segment. These results showed the factor that caused the above mentioned processes stemmed from the testis chiefly and was in epididymal plasma. It affected each epididymal segment along the epididymal lumen and to the injury of the epididymal epithelium; at the same time, the concentration of the factor became more decreased. The relationship between the antifertility effect of alpha-chlorohydrin and the ... ultrastructural changes of the epididymis and the mechanism of the double effects depending on dose of alpha-chlorohydrin were discussed.
Luo S et al; Acta Acad Med Hubei 12 (2): 120-5 (1991)
An acute phase of severe hepatic necrosis induced by dichloropropanol was examined immunohistochemically and ultrastructurally, in order to study chronological changes of sinusoidal morphology during acute hepatic injury. Male wistar rats were injected with 1,3-dichloro-2-propanol (DC2P) and sacrificed at various intervals after the injections. DC2P injected rats showed zonal necrosis of the centrilobular space with a peak from 24 to 48 hr after the injection. Destruction of sinusoidal linings appeared at 4 hr, and was gradually aggravated along the advancing hepatocytic necrosis. Monocytic influx into the necrotic areas was initiated at 6 hr. At 48 hr, collapsed centrilobular spaces showed a loss of most sinusoidal structures with active phagocytosis of macrophages, proliferation of perisinusoidal cells and accumulation of collagen fibrils. At 72 hr, there were many regenerating sinusoidal structures, which were composed of rather thick and less fenestrated endothelium and underlying multilayered processes of mesenchymal cells, along the regenerating hepatocytes. In these areas, occasional junctions between regenerating hepatocytes and mesenchymal cells were /observed/. Reconstruction of sinusoidal linings was closely related to the hepatocytic regeneration, and a hepatocytic mesenchymal interaction might participate in this morphodynamic course of the sinusoidal reconstruction.
PMID:8196516 Harataka J et al; Liver 14 (2): 90-7 (1994)
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