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Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate (Na+)

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Also known as: Sodium risedronate, 115436-72-1, Actonel, Atelvia, Risedronate (sodium), Ne 58095

Molecular Formula

C₇H₁₀NNaO₇P₂

Molecular Weight

305.09 g/mol

InChI Key

DRFDPXKCEWYIAW-UHFFFAOYSA-M

FDA UNII

OFG5EXG60L

A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.

1 2D Structure

CAS 115436-72-1

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate

2.1.2 InChI

InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1

2.1.3 InChI Key

DRFDPXKCEWYIAW-UHFFFAOYSA-M

2.1.4 Canonical SMILES

C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

OFG5EXG60L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-hydroxy-2-(3-pyridyl)ethylidene Diphosphonate

2. 2-(3-pyridinyl)-1-hydroxyethylidene-bisphosphonate

3. 2-(3-pyridinyl)-1-hydroxyethylidenebisphosphonate

4. Actonel

5. Atelvia

6. Bisphosphonate Risedronate Sodium

7. Risedronate

8. Risedronate Sodium, Bisphosphonate

9. Risedronic Acid

10. Risedronic Acid, Monosodium Salt

11. Sodium, Bisphosphonate Risedronate

2.3.2 Depositor-Supplied Synonyms

1. Sodium Risedronate

2. 115436-72-1

3. Actonel

4. Atelvia

5. Risedronate (sodium)

6. Ne 58095

7. Risedronic Acid Monosodium Salt

8. Risedronate Monosodium

9. Ofg5exg60l

10. Risedronate Sodium Anhydrous

11. Ne-58095 Anhydrous

12. Sodium Trihydrogen (1-hydroxy-2-(3-pyridyl)ethylidene)diphosphonate

13. 115436-72-1 (sodium)

14. Risedronic Acid Sodium

15. Benet

16. Nsc-722598

17. Nsc-759280

18. Actonel (tn)

19. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Monosodium Salt

20. Sodium Hydrogen (1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl)phosphonate

21. Risedronate Sodium [usan]

22. Risedronic Acid Sodium Salt

23. Mfcd00867080

24. 122458-82-6

25. Unii-ofg5exg60l

26. Optinate

27. Acrel

28. Risedronate Sodium [usan:usp]

29. Sodium Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate

30. Optinate Septimum

31. Monosodium Risedronate

32. Monosodium (1-hydroxy-2-(3-pyridinyl)ethylidene)bisphosphonate

33. Ne 58095 Sodium

34. Risedronate Sodium (usp)

35. Chembl1654

36. Schembl18377

37. Risedronate Sodium, Min 97%

38. Chebi:8868

39. Dtxsid20924178

40. Risedronate Sodium [vandf]

41. Risedronate Sodium [mart.]

42. Act03362

43. Bcp22742

44. Hy-b0119

45. Risedronate Sodium [usp-rs]

46. Risedronate Sodium [who-dd]

47. Ac-732

48. Mfcd01706268

49. S1428

50. Akos015833432

51. Ab09807

52. Ccg-213235

53. Cs-1883

54. Nsc 722598

55. Nsc 759280

56. Risedronate Sodium [orange Book]

57. Ncgc00346521-01

58. Ac-20120

59. As-13309

60. Risedronate Sodium [usp Monograph]

61. Ft-0631078

62. M2289

63. Risedronic Acid Monosodium Salt [mi]

64. D00942

65. H11438

66. Ab01274790-01

67. Q-201723

68. Q27285633

69. 2-(3-pyridinyl)-2-hydroxyethylidene-1,1-bisphosphonate

70. Monosodium 1-hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonate

71. 1-hydroxy-2-(3-pyridinyl) Ethylidene Bis-phosphonic Acid Monosodium Salt

72. Hydrogen [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonate (na+)

73. P,p'-[1-hydroxy-2-(3-pyridonyl)ethylidene]bis-phosphonic Acid Sodium Salt

74. Phosphonic Acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

75. Phosphonic Acid, (2-hydroxy-2-(3-pyridinyl)ethylidene)bis-, Disodium Salt

76. Risedronate Sodium, United States Pharmacopeia (usp) Reference Standard

77. Risedronate Sodium;risedronic Acid Sodium;ne-58095; Ne 58095; Ne58095

78. Sodium Hydrogen-1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethylphosphonate

79. Sodium;hydroxy-(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphinate

80. (1-hydroxy-2-(pyridin-3-yl)ethane-1,1-diyl)bis(phosphonic Acid) Sodium Salt

81. Risedronate Sodium 2.5-hydrate, European Pharmacopoeia (ep) Reference Standard

82. Risedronate Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

83. 934544-85-1

2.4 Create Date

2005-09-13

3 Chemical and Physical Properties

Molecular Formula	C₇H₁₀NNaO₇P₂
Molecular Weight	305.09 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	304.98301994 g/mol
Monoisotopic Mass	304.98301994 g/mol
Topological Polar Surface Area	151 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	375
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 3
Drug Name	ACTONEL
Active Ingredient	RISEDRONATE SODIUM
Company	APIL (Application Number: N020835. Patents: 5994329, 5994329PED, 6015801, 6015801PED, 6165513, 6165513PED, 6432932, 6432932PED, 6465443, 6465443PED, 7192938, 7192938PED, 7718634, 7718634*PED)

2 of 3
Drug Name	ATELVIA
Active Ingredient	RISEDRONATE SODIUM
Company	APIL (Application Number: N022560. Patents: 7645459, 7645460, 8246989)

3 of 3
Drug Name	RISEDRONATE SODIUM
Active Ingredient	RISEDRONATE SODIUM
Company	APOTEX INC (Application Number: A090877); AUROBINDO PHARMA LTD (Application Number: A200296); AUROBINDO PHARMA LTD (Application Number: A206768); MACLEODS PHARMS LTD (Application Number: A203533); MYLAN PHARMS INC (Application Number: A200477); SUN PHARMA GLOBAL (Application Number: A090886); TEVA PHARMS USA (Application Number: A077132); TEVA PHARMS USA (Application Number: A079215); TEVA PHARMS USA (Application Number: A203217)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Bisphosphonate [EPC]; Diphosphonates [CS]; Bisphosphonate [EPC]

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