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(+)-(S,S)-ethambutol Dihydrochloride

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Also known as: Ethambutol hydrochloride, Ethambutol dihydrochloride, (+)-(s,s)-ethambutol dihydrochloride, (+)-2,2'-(ethylenediimino)di-1-butanol dihydrochloride, (+)-n,n'-bis(1-(hydroxymethyl)propyl)ethylenediamine dihydrochloride, (2s,2'e)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol dihydrochloride

Molecular Formula

C₁₀H₂₆Cl₂N₂O₂

Molecular Weight

277.23 g/mol

InChI Key

AUAHHJJRFHRVPV-BZDVOYDHSA-N

An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)

1 2D Structure

(+)-(S,S)-ethambutol dihydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2S)-1-hydroxybutan-2-yl]-[2-[[(2S)-1-hydroxybutan-2-yl]azaniumyl]ethyl]azanium;dichloride

2.1.2 InChI

InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1

2.1.3 InChI Key

AUAHHJJRFHRVPV-BZDVOYDHSA-N

2.1.4 Canonical SMILES

CCC(CO)[NH2+]CC[NH2+]C(CC)CO.[Cl-].[Cl-]

2.1.5 Isomeric SMILES

CC[C@@H](CO)[NH2+]CC[NH2+][C@@H](CC)CO.[Cl-].[Cl-]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Dexambutol

2. Emb Fatol

3. Emb Hefa

4. Emb-fatol

5. Emb-hefa

6. Etambutol Llorente

7. Ethambutol

8. Ethambutol Hydrochloride

9. Etibi

10. Hydrochloride, Ethambutol

11. Llorente, Etambutol

12. Miambutol

13. Myambutol

2.2.2 Depositor-Supplied Synonyms

1. Ethambutol Hydrochloride

2. Ethambutol Dihydrochloride

3. (+)-(s,s)-ethambutol Dihydrochloride

4. (+)-2,2'-(ethylenediimino)di-1-butanol Dihydrochloride

5. (+)-n,n'-bis(1-(hydroxymethyl)propyl)ethylenediamine Dihydrochloride

6. (2s,2'e)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol Dihydrochloride

7. N,n'-bis[(2s)-1-hydroxybutan-2-yl]ethane-1,2-diaminium Dichloride

8. Chebi:4878

9. (+)-2,2'-(ethylenediimino)-di-1-butanol Dihydrochloride

10. 1070-11-7

11. 134566-79-3

12. [(2s)-1-hydroxybutan-2-yl](2-{[(2s)-1-hydroxybutan-2-yl]azaniumyl}ethyl)azanium Dichloride

2.3 Create Date

2010-09-20

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₂₆Cl₂N₂O₂
Molecular Weight	277.23 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	276.1371335 g/mol
Monoisotopic Mass	276.1371335 g/mol
Topological Polar Surface Area	73.7 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	109
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ethambutol hydrochloride
Drug Label	MYAMBUTOL ethambutol hydrochloride is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. The structural formula is:MYAMBUTOL 100 and 400 mg tab...
Active Ingredient	Ethambutol hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	100mg; 400mg
Market Status	Prescription
Company	Lupin; Barr

2 of 2
Drug Name	Ethambutol hydrochloride
Drug Label	MYAMBUTOL ethambutol hydrochloride is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. The structural formula is:MYAMBUTOL 100 and 400 mg tab...
Active Ingredient	Ethambutol hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	100mg; 400mg
Market Status	Prescription
Company	Lupin; Barr

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Antimycobacterial [EPC]

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(+)-(S,S)-ethambutol dihydrochloride Manufacturers

A (+)-(S,S)-ethambutol dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of (+)-(S,S)-ethambutol dihydrochloride, including repackagers and relabelers. The FDA regulates (+)-(S,S)-ethambutol dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. (+)-(S,S)-ethambutol dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

(+)-(S,S)-ethambutol dihydrochloride Suppliers

A (+)-(S,S)-ethambutol dihydrochloride supplier is an individual or a company that provides (+)-(S,S)-ethambutol dihydrochloride active pharmaceutical ingredient (API) or (+)-(S,S)-ethambutol dihydrochloride finished formulations upon request. The (+)-(S,S)-ethambutol dihydrochloride suppliers may include (+)-(S,S)-ethambutol dihydrochloride API manufacturers, exporters, distributors and traders.

(+)-(S,S)-ethambutol dihydrochloride GMP

(+)-(S,S)-ethambutol dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of (+)-(S,S)-ethambutol dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right (+)-(S,S)-ethambutol dihydrochloride GMP manufacturer or (+)-(S,S)-ethambutol dihydrochloride GMP API supplier for your needs.

(+)-(S,S)-ethambutol dihydrochloride CoA

A (+)-(S,S)-ethambutol dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to (+)-(S,S)-ethambutol dihydrochloride's compliance with (+)-(S,S)-ethambutol dihydrochloride specifications and serves as a tool for batch-level quality control.

(+)-(S,S)-ethambutol dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each (+)-(S,S)-ethambutol dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

(+)-(S,S)-ethambutol dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia ((+)-(S,S)-ethambutol dihydrochloride EP), (+)-(S,S)-ethambutol dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia ((+)-(S,S)-ethambutol dihydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.