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    [{"orgOrder":0,"company":"Aadi Bioscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Sirolimus","moa":"FK506-binding protein 1A","graph1":"Oncology","graph2":"Approved","graph3":"Aadi Bioscience","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Aadi Bioscience \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Aadi Bioscience \/ Not Applicable"},{"orgOrder":0,"company":"Aadi Bioscience","sponsor":"Eoc Pharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2021","type":"Collaboration","leadProduct":"Nab-sirolimus","moa":"mTOR","graph1":"Oncology","graph2":"Approved","graph3":"Aadi 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Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Partnership","leadProduct":"Adagrasib","moa":"KRAS G12C","graph1":"Oncology","graph2":"Preclinical","graph3":"Aadi Bioscience","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Aadi Bioscience \/ Mirati Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Aadi Bioscience \/ Mirati Therapeutics"},{"orgOrder":0,"company":"Aadi Bioscience","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Adagrasib","moa":"mTOR","graph1":"Oncology","graph2":"Preclinical","graph3":"Aadi 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                            01

                            Aadi Bioscience

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                            Lead Product(s) : Nab-sirolimus,Sotorasib,Adagrasib

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Improved Anti-Tumor Activity of KRAS Inhibitors in Combination with Nab-sirolimus at...

                            Details : ABI-009 (Nab-sirolimus) is a novel albumin-bound nanoparticle form of the mTOR inhibitor sirolimus and is approved for the treatment of locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa).

                            Brand Name : ABI-009

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 27, 2022

                            Lead Product(s) : Nab-sirolimus,Sotorasib,Adagrasib

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Aadi Bioscience

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                            Lead Product(s) : Adagrasib,Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Mirati Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Mirati Therapeutics and Aadi Bioscience Partner to Evaluate the Combination of Adagrasib with Nab-sirolimus in...

                            Details : Under the terms of the collaboration agreement, Mirati will be responsible for sponsoring and operating the Phase 1/2 study of Adagrasib (MRTX849), and jointly with Aadi, will oversee and share the cost of the study.

                            Brand Name : MRTX849

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            October 12, 2022

                            Lead Product(s) : Adagrasib,Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Mirati Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            03

                            Aadi Bioscience

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Avoro Capital

                            Deal Size : $72.5 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces $72.5 Million Private Placement Equity Financing

                            Details : The company intends to use net proceeds from the financing to fund research and development of Nab-sirolimus and additional clinical opportunities with FYARRO and for working capital and general corporate purposes.

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 22, 2022

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Avoro Capital

                            Deal Size : $72.5 million

                            Deal Type : Private Placement

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                            04

                            Aadi Bioscience

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Exploratory Biomarker Data from Patients in Its AMPECT Trial and Expanded Access Pro...

                            Details : Nab-sirolimus is an albumin-bound mTOR inhibitor approved by the U.S. Food and Drug Administration (FDA) as FYARRO™ for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa.

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 26, 2022

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Aadi Bioscience

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Foundation Medicine

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Collaborations with Next Generation Sequencing Leaders

                            Details : Partners will collect and analyze clinical and molecular data to determine which patients may be eligible to participate in Aadi’s PRECISION 1 clinical trial for ABI-009. The goals are to increase patient match rate, reduce screen failure rate and incr...

                            Brand Name : ABI-009

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 09, 2022

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Foundation Medicine

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            06

                            Aadi Bioscience

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                            Lead Product(s) : Nab-Sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Data Presentation on incidence of TSC1 and TSC2 Alterations in Advanced Cancers at t...

                            Details : Based on data from the AMPECT trial with FYARRO and following discussions with the FDA about other emerging data with FYARRO, Aadi has initiated PRECISION 1, a tumor-agnostic registrational trial in mTOR inhibitor-naïve solid tumors.

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 08, 2022

                            Lead Product(s) : Nab-Sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Aadi Bioscience

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                            Lead Product(s) : Nab-Sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces First Patient Dosed in its PRECISION 1 Phase 2 Registrational Trial of nab-Sirolimus...

                            Details : FYARRO is an mTOR inhibitor indicated for the treatment of adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa).

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 31, 2022

                            Lead Product(s) : Nab-Sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Aadi Bioscience

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                            Lead Product(s) : Nab-Sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aadi Bioscience to Present New Preclinical Data on nab-Sirolimus (ABI-009) at AACR-NCI-EORTC Virtual Internati...

                            Details : nab-Sirolimus (ABI-009), an mTOR inhibitor bound to human albumin that has demonstrated significantly higher tumor accumulation, greater mTOR target suppression, and increased tumor growth inhibition over other mTOR inhibitors.

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 06, 2021

                            Lead Product(s) : Nab-Sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Aadi Bioscience

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Aerpio Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Closing of Merger with Aerpio Pharmaceuticals and $155M Private Placement

                            Details : The combined, publicly traded company will focus on the advancement, expansion and commercialization of Aadi’s clinical stage pipeline, including Aadi’s lead program for its nanoparticle albumin-bound mTOR inhibitor, FYARRO™, an mTOR inhibitor boun...

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 26, 2021

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Aerpio Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            10

                            Aadi Bioscience

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Acuta Capital Partners

                            Deal Size : $155.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Closing of Merger with Aerpio Pharmaceuticals and $155M Private Placement

                            Details : Proceeds from the PIPE financing are expected to be used for the commercialization of FYARRO in advanced malignant PEComa, a planned tumor-agnostic registrational trial in solid tumors harboring inactivating alterations in the mTOR pathway genes TSC1 and...

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 26, 2021

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Acuta Capital Partners

                            Deal Size : $155.0 million

                            Deal Type : Private Placement

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