Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : JNJ-2056
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : $509.0 million
Deal Type : Licensing Agreement
AC Immune Receives Second Milestone Payment For Progress in ACI-35.030 Phase 2b
Details : Through the license agreement, AC Immune is investigating active immunotherapy candidate JNJ-2056 (ACI-35.030) to treat patients suffering from preclinical (pre-symptomatic) Alzheimer’s disease.
Brand Name : ACI-35.030
Molecule Type : Vaccine
Upfront Cash : Undisclosed
September 17, 2024
Lead Product(s) : JNJ-2056
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : $509.0 million
Deal Type : Licensing Agreement
Lead Product(s) : JNJ-2056
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
AC Immune’s ACI-35.030 Granted FDA Fast Track Designation for Alzheimer’s Disease
Details : ACI-35.030 (JNJ-2056) is designed to enhance the formation of broad-spectrum protective antibodies against pTau being developed for Alzheimer’s Disease.
Brand Name : ACI-35.030
Molecule Type : Vaccine
Upfront Cash : Not Applicable
July 25, 2024
Lead Product(s) : JNJ-2056
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ACI-24.060
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Takeda Pharmaceutical
Deal Size : $2,200.0 million
Deal Type : Licensing Agreement
AC Immune and Takeda Sign Agreement for Alzheimer's Immunotherapy Targeting Amyloid Beta
Details : Under the agreement, Takeda will receive exclusive option to license global rights to ACI-24.060, a potential first-in-class, anti-Abeta active immunotherapy for Alzheimer’s disease.
Brand Name : ACI-24.060
Molecule Type : Vaccine
Upfront Cash : $100.0 million
May 13, 2024
Lead Product(s) : ACI-24.060
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Takeda Pharmaceutical
Deal Size : $2,200.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Crenezumab
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Genentech
Deal Size : $418.0 million
Deal Type : Termination
AC Immune to Regain Global Rights to Crenezumab and Semorinemab
Details : AC Immune regains global rights to anti-amyloid beta antibody RO5490245 (crenezumab) and anti-Tau antibody semorinemab, both evaluated for Alzheimer’s disease.
Brand Name : RO5490245
Molecule Type : Large molecule
Upfront Cash : Undisclosed
January 22, 2024
Lead Product(s) : Crenezumab
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Genentech
Deal Size : $418.0 million
Deal Type : Termination
Lead Product(s) : ACI-35.030
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ACI-35.030 previously named as JNJ-64042056 is the first-in-class anti-pTau vaccine candidate which is being evaluated in phase 1/2 clinical trials for the treatment of Alzheimer’s Disease.
Brand Name : ACI-35.030
Molecule Type : Vaccine
Upfront Cash : Not Applicable
December 15, 2023
Lead Product(s) : ACI-35.030
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ACI-24.060
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Worldwide Clinical Trials
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ACI-24.060 is designed to enhance the formation of broad-spectrum protective antibodies having the potential to efficiently inhibit plaque formation and increase plaque clearance, which is investigated for the treatment of Alzheimer’s Disease.
Brand Name : ACI-24.060
Molecule Type : Vaccine
Upfront Cash : Not Applicable
June 27, 2023
Lead Product(s) : ACI-24.060
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Worldwide Clinical Trials
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ACI-24.060
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ACI-24.060 is designed to enhance the formation of broad-spectrum protective antibodies having the potential to efficiently inhibit plaque formation and increase plaque clearance, and thereby may reduce or prevent disease progression.
Brand Name : ACI-24.060
Molecule Type : Vaccine
Upfront Cash : Not Applicable
January 26, 2023
Lead Product(s) : ACI-24.060
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ACI-35.030
Therapeutic Area : Neurology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
AC Immune’s Alzheimer’s Disease Vaccine-candidate ACI-35.030 Selected for Further Development
Details : Early clinical testing showed that ACI-35.030, a first-in-class anti-pTau vaccine, was generally well tolerated and induced specific activity against the pathological species of Tau, including the neurotoxic pTau and ePHF species, both of which are close...
Brand Name : ACI-35.030
Molecule Type : Vaccine
Upfront Cash : Not Applicable
November 30, 2022
Lead Product(s) : ACI-35.030
Therapeutic Area : Neurology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Crenezumab
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MABT5102A (crenezumab) is a passive immunotherapy approach in which patients are treated with monoclonal antibodies that specifically recognize Aβ peptides. This humanized antibody uses an IgG4 backbone.
Brand Name : MABT5102A
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 23, 2022
Lead Product(s) : Crenezumab
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Crenezumab
Therapeutic Area : Neurology
Study Phase : Phase II
Sponsor : Genentech
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : As previously reported, numerical differences favoring MABT5102A (crenezumab) over placebo were confirmed across the co-primary, multiple secondary and exploratory endpoints, none statistically significant.
Brand Name : MABT5102A
Molecule Type : Large molecule
Upfront Cash : Not Applicable
August 02, 2022
Lead Product(s) : Crenezumab
Therapeutic Area : Neurology
Highest Development Status : Phase II
Sponsor : Genentech
Deal Size : Not Applicable
Deal Type : Not Applicable
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