Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Merck & Co
Deal Size : $11,500.0 million
Deal Type : Acquisition
Merck Completes Acquisition of Acceleron Pharma Inc.
Details : Through the successful completion of the acquisition of Acceleron Pharma, Merck would be growing its cardiovascular portfolio and pipeline, including Acceleron’s lead therapeutic candidate, sotatercept, has a novel mechanism of action with the potentia...
Product Name : ACE-011
Product Type : Protein
Upfront Cash : $11,500.0 million
November 19, 2021
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Merck & Co
Deal Size : $11,500.0 million
Deal Type : Acquisition
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The PULSAR Phase 2 trial evaluating sotatercept in combination with approved PAH-specific medicines in patients with PAH achieved its primary endpoint of improvement in pulmonary vascular resistance and its key secondary endpoint of improvement in 6-minu...
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
November 05, 2021
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Merck & Co
Deal Size : $11,500.0 million
Deal Type : Acquisition
Merck to Acquire Acceleron Pharma Inc
Details : Under the terms of the acquisition agreement, Merck will acquire all outstanding shares of Acceleron including its pipeline having lead therapeutic candidate, sotatercept, in Phase 3 trials as add-on to current standard of care for the treatment of PAH.
Product Name : ACE-011
Product Type : Protein
Upfront Cash : $11,500.0 million
September 30, 2021
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Merck & Co
Deal Size : $11,500.0 million
Deal Type : Acquisition
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : A total of 106 patients were randomized in a 3:3:4 ratio to receive placebo, sotatercept 0.3 mg/kg, or sotatercept 0.7 mg/kg subcutaneously every three weeks on top of standard-of-care therapies.
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
May 19, 2021
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The SPECTRA Phase 2 trial is a single arm, open-label, multi-center exploratory study to determine the eects of sotatercept plus standard of care in adults with WHO functional class III PAH.
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
May 19, 2021
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Results show patients treated with sotatercept experienced improvements in hemodynamic and functional endpoints compared with placebo.
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
January 04, 2021
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Acceleron is currently advancing a Phase 3 development plan for sotatercept, beginning with the registrational trial known as STELLAR expected to initiate by the end of this year.
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
December 14, 2020
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Echocardiography data obtained during the PULSAR trial showed that patients on stable background PAH-specific therapies treated with sotatercept experienced improvement in a measure of cardiopulmonary function known as right ventricular-pulmonary arteria...
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
November 13, 2020
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Treatment with sotatercept in first set of patients in the ongoing SPECTRA Phase 2 trial was associated with substantial improvements in hemodynamics, exercise tolerance and exercise capacity at week 24.
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
November 13, 2020
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The presentation of the PULSAR trial echocardiography data, which earned the AHA’s “Cardiopulmonary Best Abstract” award, will focus on sotatercept’s effects on cardiac right ventricular function in conjunction with pulmonary arterial pressure in...
Product Name : ACE-011
Product Type : Protein
Upfront Cash : Inapplicable
September 11, 2020
Lead Product(s) : Sotatercept
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable