Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
ACELYRIN Announces Phase 2 Data and Phase 3 Program Design for Lonigutamab
Details : VB-421 (lonigutamab) is a subcutaneously delivered humanized IgG1 monoclonal antibody targeting IGF-1R. It is being evaluated for the treatment of thyroid eye disease.
Product Name : VB-421
Product Type : Antibody
Upfront Cash : Inapplicable
January 06, 2025
Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Izokibep
Therapeutic Area : Ophthalmology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Acelyrin, Inc. Announces Topline Results from Phase 2b/3 Study of Izokibep for Uveitis
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency. It is being evaluated for the treatment of non-infectious, non-anterior uveitis.
Product Name : Undisclosed
Product Type : Large molecule
Upfront Cash : Not Applicable
December 10, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ACELYRIN Reports Positive Data for Lonigutamab in Thyroid Eye Disease
Details : VB-421 (lonigutamab) is a subcutaneously delivered humanized IgG1 monoclonal antibody targeting the insulin-like growth factor-1 receptor (IGF-1R). It is being evaluated for thyroid eye disease.
Product Name : VB-421
Product Type : Large molecule
Upfront Cash : Not Applicable
March 20, 2024
Lead Product(s) : Lonigutamab
Therapeutic Area : Immunology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ACELYRIN Announces Positive Results from Phase 2b/3 of Izokibep in Psoriatic Arthritis
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated for the treatment of psoriatic arthritis.
Product Name : ABY 035
Product Type : Large molecule
Upfront Cash : Not Applicable
March 11, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
CytomX Therapeutics Announces FDA Clearance of IND Applications for CX-2051 and CX-801
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated for the treatment of hidradenitis suppurativa.
Product Name : ABY 035
Product Type : Large molecule
Upfront Cash : Not Applicable
March 11, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ACELYRIN, INC. Provides Update on Izokibep Clinical Development Program
Details : Izokibep is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated in phase 2/3 clinical trials for the treatment of psoriatic arthritis (PsA).
Product Name : ABY-035
Product Type : Small molecule
Upfront Cash : Not Applicable
November 27, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IMG-020 (izokibep) is a small therapeutic protein inhibitor of interleukin-17A (IL-17A). It is designed to overcome monoclonal antibodies limitations for hidradenitis suppurativa indication. It is being investigated for moderate-to-severe Hidradenitis.
Product Name : IMG-020
Product Type : Large molecule
Upfront Cash : Not Applicable
September 11, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Morgan Stanley
Deal Size : $621.0 million
Deal Type : Public Offering
Details : Company will use the proceeds to fund its operations, including the development of pipeline including Izokibep and commercialization activities, business development activities, and capital expenditures.
Product Name : Undisclosed
Product Type : Large molecule
Upfront Cash : Undisclosed
May 09, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Morgan Stanley
Deal Size : $621.0 million
Deal Type : Public Offering
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Study Phase : Phase II/ Phase III
Sponsor : Morgan Stanley
Deal Size : $540.0 million
Deal Type : Public Offering
ACELYRIN, INC. Announces Pricing of Upsized Initial Public Offering
Details : The net proceeds will be used to advance the clinical development of izokibep through topline data in Phase 2b/3 trials of izokibep in each of HS, PsA, and uveitis.
Product Name : Undisclosed
Product Type : Large molecule
Upfront Cash : Undisclosed
May 04, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Dermatology
Highest Development Status : Phase II/ Phase III
Sponsor : Morgan Stanley
Deal Size : $540.0 million
Deal Type : Public Offering
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IMG-020 (izokibep) is a small therapeutic protein inhibitor of interleukin-17A (IL-17A). It is designed to overcome monoclonal antibodies limitations for hidradenitis suppurativa indication. It is being investigated for psoriatic arthritis.
Product Name : IMG-020
Product Type : Large molecule
Upfront Cash : Not Applicable
April 11, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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