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    Find Clinical Drug Pipeline Developments & Deals by Achilles Therapeutics

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                            01

                            Achilles Therapeutics

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                            Lead Product(s) : mRNA Based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Discovery Platform

                            Sponsor : Arcturus Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Achilles and Arcturus Collaborate on Second-Generation mRNA Cancer Vaccines

                            Details : The collaboration with Arcturus Therapeutics, to evaluate best-in-class, self-amplifying mRNA vaccines for the treatment of patients suffering from neoplasms.

                            Brand Name : mRNA Based Therapy

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            May 22, 2024

                            Lead Product(s) : mRNA Based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery Platform

                            Sponsor : Arcturus Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            02

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                            Lead Product(s) : ATL001,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Achilles Provides Interim Update on Neoantigen T Cells in NSCLC and Melanoma Trials

                            Details : ATL001 is a clonal neoantigen reactive T cell therapy, which is being evaluated in combination with pembrolizumab for advanced unresectable or metastatic non-small cell lung cancer.

                            Brand Name : ATL001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 04, 2024

                            Lead Product(s) : ATL001,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

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                            Lead Product(s) : ATL001,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Achilles Therapeutics to Present Early Proof of Concept of Safety and Clinical Activity of Clonal Neoantigen R...

                            Details : cNeT (ATL001) are the active component of the final, precision T cell product which target tumors through recognition of a patient’s clonal neoantigens present on all tumor cells.

                            Brand Name : cNet

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            November 30, 2022

                            Lead Product(s) : ATL001,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Autologous T Cell Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Achilles Therapeutics Announces Grant of US Patent on Immunotherapies Targeting Clonal Neoantigens Identified ...

                            Details : ACE is a proprietary method for determining clonality of patient-specific mutations that drives the PELEUS™ bioinformatics platform. Clonal neoantigens are original mutations formed early in tumor evolution that are expressed on all cancer cells and ab...

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            November 22, 2022

                            Lead Product(s) : Autologous T Cell Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

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                            Lead Product(s) : ATL001,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Achilles Therapeutics Doses First Patient with Higher-dose cNeT in Phase I/IIa CHIRON Trial in Advanced NSCLC ...

                            Details : A positive review by an Independent Data Safety Monitoring Committee, the Company has initiated enrollment in Cohort B of the THETIS clinical trial to evaluate cNeT I(ATL001) in combination with a PD-1 checkpoint inhibitor for the treatment of metastatic...

                            Brand Name : cNet

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 09, 2022

                            Lead Product(s) : ATL001,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : ATL001

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Center for Breakthrough Medicines

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Achilles Therapeutics Announces Manufacturing Expansion in the UK and Partnership for Manufacturing in the US

                            Details : The second GMP manufacturing site will initially support Achilles’ proprietary VELOS™ manufacturing process with an annual capacity of 200 cNeT (Clonal NeoantigenT-cells) doses at peak production. The Company’s first US GMP manufacturing facility t...

                            Brand Name : cNet

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            April 12, 2022

                            Lead Product(s) : ATL001

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Center for Breakthrough Medicines

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            Lead Product(s) : Antisense Oligonucleotide

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Secarna Pharma

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Secarna Pharmaceuticals and Achilles Therapeutics Sign Research, Option and License Agreement to Develop Optim...

                            Details : Secarna will employ its commercially validated discovery and development platform, LNAplus™, to generate ASO candidates against selected targets that potentially play a central role in the ex vivo optimization of personalized T cell therapies being dev...

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            November 10, 2021

                            Lead Product(s) : Antisense Oligonucleotide

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Secarna Pharma

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            Lead Product(s) : Neoantigen Reactive T cells

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Achilles Therapeutics Presents Data at the 2021 European Society for Gene and Cell Therapy (ESGCT) Congress De...

                            Details : Achilles uses DNA sequencing data from patients, together with its proprietary PELEUS bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develop precision T cell-based product candidates specifically targeting thos...

                            Brand Name : ATL001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 22, 2021

                            Lead Product(s) : Neoantigen Reactive T cells

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Achilles Therapeutics

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                            Lead Product(s) : ATL001

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Achilles Therapeutics Enrolls First US Patient in Ongoing Phase I/IIa Study in Advanced Non-small Cell Lung Ca...

                            Details : The primary objective of the trial is to assess the safety and tolerability of cNeT. Clinical efficacy will be evaluated as a secondary measure.

                            Brand Name : ATL001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 01, 2021

                            Lead Product(s) : ATL001

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Neoantigen Reactive T cells

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $175.5 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Achilles Therapeutics Announces Closing of $175.5 million Initial Public Offering

                            Details : Achilles has two ongoing Phase I/IIa trials, including a study of a clonal neoantigen T cell therapy in patients with advanced non-small cell lung cancer, which dosed its first patient in June last year.

                            Brand Name : ATL001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            April 06, 2021

                            Lead Product(s) : Neoantigen Reactive T cells

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : J.P. Morgan

                            Deal Size : $175.5 million

                            Deal Type : Public Offering

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