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Find Clinical Drug Pipeline Developments & Deals by Achilles Therapeutics
The collaboration with Arcturus Therapeutics, to evaluate best-in-class, self-amplifying mRNA vaccines for the treatment of patients suffering from neoplasms.
Lead Product(s):
mRNA Based Therapy
Therapeutic Area:OncologyProduct Name: mRNA Based Therapy
ATL001 is a clonal neoantigen reactive T cell (cNeT) therapy, which is being evaluated in combination with pembrolizumab for the treatment of advanced unresectable or metastatic non-small cell lung cancer.
cNeT (ATL001) are the active component of the final, precision T cell product which target tumors through recognition of a patient’s clonal neoantigens present on all tumor cells.
ACE is a proprietary method for determining clonality of patient-specific mutations that drives the PELEUS™ bioinformatics platform. Clonal neoantigens are original mutations formed early in tumor evolution that are expressed on all cancer cells and absent from healthy tissue.
A positive review by an Independent Data Safety Monitoring Committee, the Company has initiated enrollment in Cohort B of the THETIS clinical trial to evaluate cNeT I(ATL001) in combination with a PD-1 checkpoint inhibitor for the treatment of metastatic malignant melanoma.
The second GMP manufacturing site will initially support Achilles’ proprietary VELOS™ manufacturing process with an annual capacity of 200 cNeT (Clonal NeoantigenT-cells) doses at peak production. The Company’s first US GMP manufacturing facility to be operated by CBM.
Secarna will employ its commercially validated discovery and development platform, LNAplus™, to generate ASO candidates against selected targets that potentially play a central role in the ex vivo optimization of personalized T cell therapies being developed by Achilles.
Achilles uses DNA sequencing data from patients, together with its proprietary PELEUS bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develop precision T cell-based product candidates specifically targeting those clonal neoantigens.
Achilles has two ongoing Phase I/IIa trials, including a study of a clonal neoantigen T cell therapy in patients with advanced non-small cell lung cancer, which dosed its first patient in June last year.