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    [{"orgOrder":0,"company":"Aclaris Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"ATI-450","moa":"","graph1":"Immunology","graph2":"Phase I","graph3":"Aclaris Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"Aclaris Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Aclaris Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Aclaris Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"ATI-450","moa":"Mapk2","graph1":"Immunology","graph2":"Phase II","graph3":"Aclaris Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"","sponsorNew":"Aclaris Therapeutics \/ Aclaris Therapeutics","highestDevelopmentStatusID":"8","companyTruncated":"Aclaris Therapeutics \/ Aclaris Therapeutics"},{"orgOrder":0,"company":"Aclaris Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"ATI-2138","moa":"ITK\/JAK3","graph1":"Dermatology","graph2":"Phase II","graph3":"Aclaris Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Aclaris Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Aclaris Therapeutics \/ Inapplicable"}]

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                            01

                            Aclaris Therapeutics

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                            Lead Product(s) : ATI-2138

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            New Study Highlights ATI-2138 As Selective ITK, JAK3 Inhibitor

                            Details : ATI-2138 is a novel investigational covalent inhibitor of ITK and JAK3 in development for the treatment of autoimmune and inflammatory diseases, like atopic dermatitis.

                            Product Name : ATI-2138

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 12, 2025

                            Lead Product(s) : ATI-2138

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Aclaris Therapeutics

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                            Lead Product(s) : Bosakitug

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Vivo Capital

                            Deal Size : $80.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Aclaris Therapeutics Announces $80 Million Private Placement

                            Details : The company will use the proceeds to fund the research and development of its pipeline, including BSI-045B (bosakitug), a humanized monoclonal antibody targeting thymic stromal lymphopoietin.

                            Product Name : BSI-045B

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            November 18, 2024

                            Lead Product(s) : Bosakitug

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Vivo Capital

                            Deal Size : $80.0 million

                            Deal Type : Private Placement

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                            03

                            Aclaris Therapeutics

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                            Lead Product(s) : Bosakitug

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Recipient : Biosion

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Aclaris Announces Global License Agreement Adding Biologics Assets to Pipeline

                            Details : Aclaris gains worldwide rights (excluding Greater China) to BSI-045B, a novel anti-TSLP monoclonal antibody, and BSI-502, a novel bispecific antibody that is directed against both TSLP and IL4R.

                            Product Name : BSI-045B

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            November 18, 2024

                            Lead Product(s) : Bosakitug

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Recipient : Biosion

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            04

                            Aclaris Therapeutics

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                            Lead Product(s) : ATI-2138

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aclaris Doses First Patient in Phase 2a Trial of ATI-2138 for Atopic Dermatitis

                            Details : ATI-2138 is an investigational oral covalent inhibitor of ITK, and JAK3. Currently, it is being evaluated for the treatment of Moderate to Severe Atopic Dermatitis.

                            Product Name : ATI-2138

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 17, 2024

                            Lead Product(s) : ATI-2138

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Aclaris Therapeutics

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                            Aclaris Therapeutics

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                            Lead Product(s) : Baricitinib

                            Therapeutic Area : Dermatology

                            Study Phase : Approved

                            Sponsor : Eli Lilly

                            Deal Size : $31.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Aclaris Sells OLUMIANT® Royalties to OMERS for Up to $315M

                            Details : OLUMIANT (baricitinib) is the first and only JAK inhibitor FDA-approved for the treatment of COVID-19 in certain hospitalized adults requiring various degrees of oxygen support.

                            Product Name : Olumiant

                            Product Type : Small molecule

                            Upfront Cash : $26.5 million

                            July 16, 2024

                            Lead Product(s) : Baricitinib

                            Therapeutic Area : Dermatology

                            Highest Development Status : Approved

                            Sponsor : Eli Lilly

                            Deal Size : $31.5 million

                            Deal Type : Licensing Agreement

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                            06

                            Aclaris Therapeutics

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                            Lead Product(s) : ATI-1777

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aclaris Announces Top-Line Results from Phase 2b Trial of ATI-1777 for Dermatitis

                            Details : ATI-1777 is an investigational topical soft JAK 1/3 inhibitor, small molecule drug. It is under phase 2 clinical development for the treatment of mild to severe atopic dermatitis.

                            Product Name : ATI-1777

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 10, 2024

                            Lead Product(s) : ATI-1777

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Aclaris Therapeutics

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                            Aclaris Therapeutics

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                            Lead Product(s) : Deuruxolitinib phosphate

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Sponsor : Sun Pharmaceutical Industries Limited

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Aclaris Therapeutics Announces Patent License Agreement with Sun Pharma for Alopecia

                            Details : Under the license agreement, Aclaris granted Sun Pharma exclusive rights under certain patents for the use of deuruxolitinib, Sun Pharma’s JAK inhibitor, or other isotopic forms of ruxolitinib, to treat alopecia areata (AA) or androgenetic alopecia (AG...

                            Product Name : CTP-543

                            Product Type : Small molecule

                            Upfront Cash : $15.0 million

                            December 05, 2023

                            Lead Product(s) : Deuruxolitinib phosphate

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Sponsor : Sun Pharmaceutical Industries Limited

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            Aclaris Therapeutics

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                            Lead Product(s) : Zunsemetinib,Methotrexate

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aclaris Therapeutics Announces Top-line Results from 12-Week Phase 2b Trial of Oral Zunsemetinib (ATI-450) for...

                            Details : ATI-450 (zunsemetinib) is an investigational oral mitogen-activated protein kinase-activated protein kinase 2 (MK2) inhibitor for the treatment of Moderate to Severe Rheumatoid Arthritis.

                            Product Name : ATI-450

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 13, 2023

                            Lead Product(s) : Zunsemetinib,Methotrexate

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Aclaris Therapeutics

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                            Lead Product(s) : ATI-1777

                            Therapeutic Area : Dermatology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aclaris Therapeutics Completes Enrollment in Phase 2b Study of ATI-1777 for Mild to Severe Atopic Dermatitis (...

                            Details : ATI-1777 is a topical JAK inhibitor designed to minimize systemic exposure and delivered in a spray-on solution, which is investigated for the treatment of mild to severe atopic dermatitis.

                            Product Name : ATI-1777

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 03, 2023

                            Lead Product(s) : ATI-1777

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Aclaris Therapeutics

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                            Lead Product(s) : ATI-2138

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Aclaris Therapeutics Announces Positive Results from Phase 1 Multiple Ascending Dose Trial of ATI-2138, an Inv...

                            Details : ATI-2138 is an investigational oral covalent ITK/JAK3 inhibitor that is being developed as a potential therapeutic option across a variety of T cell-mediated diseases.

                            Product Name : ATI-2138

                            Product Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 18, 2023

                            Lead Product(s) : ATI-2138

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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