Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : AMP945,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Adagene Expands Collaboration Program for ADG126 with KEYTRUDA® Efficacy
Details : ADG126 (muzastotug) is a human anti-CTLA-4 SAFEbody, designed for specific target binding, under development for metastatic microsatellite-stable colorectal cancer.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Not Applicable
February 09, 2024
Lead Product(s) : AMP945,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AMP945,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Adagene Presents Data on ADG126 Combined with Pembrolizumab in MSS Colorectal Cancer
Details : ADG126 (muzastotug) is a masked anti-CTLA-4 SAFEbody. It is currently being evaluated in phase 1/2 clinical trials for the treatment of microsatellite-stable colorectal cancer.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 16, 2024
Lead Product(s) : AMP945,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ADG126,Toripalimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Exelixis
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The collaboration aims for the development of novel masked antibody-drug conjugate (ADC) candidates, including ADG126 leveraging Adagene’s proprietary SAFEbody precision masking technology.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : $12.1 million
May 04, 2023
Lead Product(s) : ADG126,Toripalimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Exelixis
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : TPST-1120,Bevacizumab,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Recipient : Tempest Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TPST-1120 is an oral, small molecule, selective PPAR⍺ antagonist, can kill tumor cells directly and target suppressive immune pathways in the tumor microenvironment. It is being developed for hepatocellular carcinoma.
Brand Name : TPST-1120
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 28, 2023
Lead Product(s) : TPST-1120,Bevacizumab,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Recipient : Tempest Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ADG126 is a fully human anti-CTLA-4 SAFEbody designed to mask the antibody binding site of ADG126, which would be unmasked in the TME, where activated ADG126 would block CTLA-4 and deplete regulatory T-cells by means of ADCC.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 14, 2023
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ADG126 is a fully human anti-CTLA-4 SAFEbody designed to mask the antibody binding site of ADG126, which would be unmasked in the TME, where activated ADG126 would block CTLA-4 and deplete regulatory T-cells by means of ADCC.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 09, 2023
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ADG126,Bevacizumab,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Under the collaboration, Roche will sponsor and conduct a randomized phase 1b/2 multi-national trial to evaluate the efficacy, safety and pharmacokinetics of ADG126 in combination with bevacizumab and atezolizumab, versus atezolizumab and bevacizumab alo...
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Undisclosed
December 16, 2022
Lead Product(s) : ADG126,Bevacizumab,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : ADG116,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Data from phase 1b/2 studies in heavily pre-treated patients showcase differentiated safety profile of ADG116 across dosing levels, with repeat dosing both as monotherapy and in combination with anti-PD-1 therapy.
Brand Name : ADG116
Molecule Type : Large molecule
Upfront Cash : Not Applicable
October 11, 2022
Lead Product(s) : ADG116,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ADG126 monotherapy showed an unprecedented clinical safety profile at dosing levels up to 20 mg/kg when administered to this heavily pretreated patient population once every three weeks.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 10, 2022
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ADG126, SAFEbody applies precision-masking technology to the parental anti-CTLA-4 antibody, ADG116, for conditional activation in the TME to expand the therapeutic index and further address safety concerns with existing CTLA-4 therapies.
Brand Name : ADG126
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 26, 2022
Lead Product(s) : ADG126,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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