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Alvotech","highestDevelopmentStatusID":"12","companyTruncated":"Quallent Pharmaceuticals \/ Alvotech"},{"orgOrder":0,"company":"Boehringer Ingelheim GmbH","sponsor":"Quallent Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"GERMANY","productType":"Large molecule","year":"2024","type":"Agreement","leadProduct":"Adalimumab","moa":"","graph1":"Immunology","graph2":"Approved","graph3":"Boehringer Ingelheim GmbH","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Boehringer Ingelheim GmbH \/ Quallent Pharmaceuticals","highestDevelopmentStatusID":"12","companyTruncated":"Boehringer Ingelheim GmbH \/ Quallent Pharmaceuticals"},{"orgOrder":0,"company":"Coherus Biosciences","sponsor":"Hong Kong King-Friend Industrial Co. Ltd","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Divestment","leadProduct":"Adalimumab","moa":"","graph1":"Immunology","graph2":"Approved","graph3":"Coherus Biosciences","amount2":0.040000000000000001,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Immunology","amount2New":0.040000000000000001,"dosageForm":"","sponsorNew":"Coherus Biosciences \/ Hong Kong King-Friend Industrial Co. Ltd","highestDevelopmentStatusID":"12","companyTruncated":"Coherus Biosciences \/ Hong Kong King-Friend Industrial Co. Ltd"}]

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                          01

                          Details : HUMIRA® is a fully human anti-TNF-α monoclonal antibody, got additional approval for a highdose regimen in adult patients with ulcerative colitis and for a new regimen in pediatric patients.

                          Brand Name : Humira

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 27, 2021

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Eisai

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          02

                          Details : HUMIRA (adalimumab) is the first and only subcutaneous biologic treatment option for pediatric patients from 5 years of age with moderately to severely active ulcerative colitis.

                          Brand Name : Humira

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 24, 2021

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          03

                          Details : Approval for adalimumab based on results from the pivotal Phase 3 ENVISION I study showing the higher dosage of HUMIRA induced clinical remission in 60 percent of patients at Week 8 and 45 percent of patients, who responded at Week 8, were in remission a...

                          Brand Name : Humira

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 24, 2021

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Abbvie Company Banner

                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Through the divestment, Coherus reinforces its strategic focus on oncology Yusimry (adalimumab) biosimilar to Humira. It is indicated for the treatment of Rheumatoid Arthritis.

                          Brand Name : Yusimry

                          Molecule Type : Large molecule

                          Upfront Cash : $40.0 million

                          June 27, 2024

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Hong Kong King-Friend Industrial Co. Ltd

                          Deal Size : $40.0 million

                          Deal Type : Divestment

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Boehringer Ingelheim will manufacture adalimumab-adbm for Quallent, continuing the commercialization of Boehringer Ingelheim-labeled Cyltezo.

                          Brand Name : Cyltezo

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          May 13, 2024

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Quallent Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Cyltezo (adalimumab-biosimilar) is a TNF blocker indicated for rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis treatment.

                          Brand Name : Cyltezo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 01, 2024

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Alvotech will manufacture its high-concentration interchangeable biosimilar, AVT02, a monoclonal antibody and that has been approved as a biosimilar to Humira (adalimumab) for Quallent.

                          Brand Name : AVT02

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 30, 2024

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Alvotech

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The agreement aims to further enhance access to Simlandi (adalimumab-ryvk) in the U.S. market, the newly U.S. FDA approved high-concentration interchangeable biosimilar to Humira.

                          Brand Name : Simlandi

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 19, 2024

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Undisclosed

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Simlandi (adalimumab) is the first interchangeable biosimilar to Humira for various arthritic conditions and Crohn’s disease.

                          Brand Name : Simlandi

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 23, 2024

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Teva Pharmaceutical Industries

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Hyrimoz (adalimumab-adaz) binds with specificity to TNF-alpha and inhibits its interaction with the p55 and p75 cell surface TNF receptors, which is approved for rheumatic diseases, Crohn's disease, ulcerative colitis, plaque psoriasis, uveitis and hidra...

                          Brand Name : Hyrimoz

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 21, 2023

                          Lead Product(s) : Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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