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                          01

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022 (ixoberogene soroparvovec) is a gene therapy candidate, which utilizes a vector capsid AAV.7m8. It is being evaluated for the treatment of neovascular or wet age-related macular degeneration.

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 01, 2024

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022 (ixoberogene soroparvovec) is a gene therapy in phase 2 trials for wet age-related macular degeneration, utilizing AAV.7m8 vector carrying aflibercept.

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 08, 2024

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022 (Ixoberogene soroparvovec) is utilizes a propriety vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette, which is investigated for the treatment of wet AMD.

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 26, 2023

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : Under the agreement, Adverum grants Ray Therapeutics a worldwide, non-exclusive license of AAV.7m8 together with its RTx-015 asset, for the prevention, treatment, diagnosis or amelioration of any ocular disorder utilizing Ray’s optogenetics approach.

                          Brand Name : RTx-015

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 12, 2023

                          Lead Product(s) : RTx-015,AAV.7m8

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Ray Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          05

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022, (ixoberogene soroparvovec (Ixo-vec), is clinical-stage gene therapy product candidate being developed for treatment of wet AMD, utilizes proprietary vector capsid, AAV.7m8, carrying an aflibercept coding sequence under control of proprietary ex...

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 04, 2022

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022 (Ixoberogene Soroparvovec) utilizes a proprietary vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette.

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 14, 2022

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : OPTIC trial participants had an 81%-98% reduction in annualized anti-VEGF injections and demonstrated continuous therapeutic aflibercept protein expression levels through three years following a single, in-office intravitreal injection of ADVM-022 (ixobe...

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 15, 2022

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022 (ixoberogene soroparvovec),utilizes a propriety vector capsid, AAV.7m8, carrying an aflibercept coding sequence under the control of a proprietary expression cassette for the treatment of wet AMD.

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 08, 2022

                          Lead Product(s) : Ixoberogene Soroparvovec

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : ADVM-022 (AAV.7m8-aflibercept) is a gene therapy product, is designed to reduce the current treatment burden which often results in undertreatment and vision loss in patients with wet AMD receiving anti-VEGF therapy in clinical practice.

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 06, 2022

                          Lead Product(s) : AAV.7m8-Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          CPhI India 2024
                          Not Confirmed
                          CPhI India 2024
                          Not Confirmed

                          Details : Three-year aflibercept protein expression demonstrates continuous and consistent therapeutic levels from ADVM-022 (AAV.7m8-Aflibercept) in OPTIC study subjects with wet age-related macular degeneration (wet AMD).

                          Brand Name : ADVM-022

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 09, 2022

                          Lead Product(s) : AAV.7m8-Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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