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    [{"orgOrder":0,"company":"Aerpio Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Razuprotafib","moa":"VE-PTP","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Aerpio Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Aerpio Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Aerpio Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Aerpio Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Razuprotafib","moa":"VE-PTP","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Aerpio 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Bioscience","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2021","type":"Merger","leadProduct":"Nab-sirolimus","moa":"mTOR","graph1":"Oncology","graph2":"Approved","graph3":"Aerpio Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Aerpio Pharmaceuticals \/ Aerpio Pharmaceuticals","highestDevelopmentStatusID":"12","companyTruncated":"Aerpio Pharmaceuticals \/ Aerpio Pharmaceuticals"},{"orgOrder":0,"company":"Aerpio Pharmaceuticals","sponsor":"Aadi Bioscience","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2021","type":"Merger","leadProduct":"Nab-sirolimus","moa":"mTOR","graph1":"Oncology","graph2":"Approved","graph3":"Aerpio Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Aerpio Pharmaceuticals \/ Aerpio Pharmaceuticals","highestDevelopmentStatusID":"12","companyTruncated":"Aerpio Pharmaceuticals \/ Aerpio Pharmaceuticals"}]

    Find Clinical Drug Pipeline Developments & Deals by Aerpio Pharmaceuticals

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                            01

                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Aadi Bioscience

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Aadi Bioscience Announces Closing of Merger with Aerpio Pharmaceuticals and $155M Private Placement

                            Details : The combined, publicly traded company will focus on the advancement, expansion and commercialization of Aadi’s clinical stage pipeline, including Aadi’s lead program for its nanoparticle albumin-bound mTOR inhibitor, FYARRO™, an mTOR inhibitor boun...

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 26, 2021

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Aadi Bioscience

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : Aadi Bioscience

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Aerpio Pharmaceuticals and Aadi Bioscience Enter into a Definitive Merger Agreement

                            Details : Following the proposed merger, Aerpio will change its name to “Aadi Bioscience, Inc.” and the combined public company will focus on advancing Aadi’s lead product candidate, FYARROTM (sirolimus albumin-bound nanoparticles for injectable suspension; ...

                            Brand Name : Fyarro

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 17, 2021

                            Lead Product(s) : Nab-sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : Aadi Bioscience

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            03

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Quantum Leap Healthcare

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Quantum Leap Healthcare Collaborative Discontinues Testing of Aerpio Pharmaceutical's Razuprotafib in I-SPY CO...

                            Details : The I-SPY COVID Trial was halted by Quantum Leap Healthcare Collaborative because Aerpio's razuprotafib was difficult to administer in the setting of COVID-19, with 30% of patients discontinuing the agent due to disease-related hypotension.

                            Brand Name : AKB-9778

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            March 05, 2021

                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Quantum Leap Healthcare

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerpio Dosed First Patient with Razuprotafib in the Phase 2 Trial for the Prevention and Treatment of ARDS in ...

                            Details : Razuprotafib a first-in-class small molecule inhibitor of vascular endothelial protein tyrosine phosphatase, is being developed as a treatment for open angle glaucoma, and the Company intends to investigate the therapeutic potential of razuprotafib in ot...

                            Brand Name : AKB-9778

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 26, 2020

                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerpio Announces Enrollment Completed in the 28-Day Phase 2 Razuprotafib Glaucoma Trial

                            Details : The study is designed to evaluate the safety and efficacy of a topical ocular formulation of razuprotafib in approximately 195 patients followed over a 28-day period, and patients must undergo a 28-day washout prior to randomization.

                            Brand Name : AKB-9778

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 15, 2020

                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : Razuprotafib,Remdesivir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Quantum Leap Healthcare

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerpio and Quantum Leap Doses First Patients with Razuprotafib in the I-SPY COVID Trial to Treat ARDS in Criti...

                            Details : First patient with razuprotafib in the I-SPY COVID Trial, a phase 2 platform trial aimed at improving treatment of acute respiratory distress syndrome (ARDS) in severely ill COVID-19 (adult) patients.

                            Brand Name : AKB-9778

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 01, 2020

                            Lead Product(s) : Razuprotafib,Remdesivir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Quantum Leap Healthcare

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : MTEC

                            Deal Size : $5.1 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Aerpio Pharmaceuticals, Inc. Announces a Second Clinical Trial with Funding from MTEC to Evaluate Razuprotafib...

                            Details : Aerpio is developing a selective small molecule inhibitor of vascular endothelial protein tyrosine phosphatase, razuprotafib (AKB-9778), that restores Tie2 pathway activation in endothelial cells to stabilize blood vessels during vascular injury and infl...

                            Brand Name : AKB-9778

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 04, 2020

                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : MTEC

                            Deal Size : $5.1 million

                            Deal Type : Funding

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                            08

                            Aerpio Pharmaceuticals

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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerpio Announces Initiation of 28-Day Phase 2 Razuprotafib Glaucoma Trial

                            Details : Aerpio Pharmaceuticals has commenced patient enrollment in its double-blind, placebo-controlled Phase 2 trial in patients with elevated intraocular pressure (IOP) associated with open angle glaucoma (OAG) or ocular hypertension (OHT).

                            Brand Name : AKB-9778

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 24, 2020

                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Aerpio Pharmaceuticals

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                            Medlab Asia & Asia Health
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                            Aerpio Pharmaceuticals

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                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Quantum Leap Healthcare

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Aerpio Pharmaceuticals and Quantum Leap Healthcare Collaborative Announce the Selection of Razuprotafib for I-...

                            Details : The collaboration aims at evaluating razuprotafib in a new randomized, investigational treatment arm in the I-SPY COVID Trial for the treatment of acute respiratory distress syndrome (ARDS) in adult patients with moderate to severe COVID-19.

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 27, 2020

                            Lead Product(s) : Razuprotafib

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Quantum Leap Healthcare

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            10

                            Aerpio Pharmaceuticals

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                            Lead Product(s) : GB004

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase I

                            Sponsor : Gossamer Bio

                            Deal Size : $105.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Aerpio Announces Amended Licensing Deal with Gossamer Bio on its Inflammatory Bowel Disease Product Candidate ...

                            Details : The renegotiated licensing deal is intended to place Gossamer Bio in a better position to progress GB004, and in addition, is designed to facilitate the further development of each company’s respective pipelines.

                            Brand Name : Undisclosed

                            Molecule Type : Small molecule

                            Upfront Cash : $15.0 million

                            May 12, 2020

                            Lead Product(s) : GB004

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase I

                            Sponsor : Gossamer Bio

                            Deal Size : $105.0 million

                            Deal Type : Licensing Agreement

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