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    [{"orgOrder":0,"company":"Aeterna Zentaris","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Macimorelin","moa":"","graph1":"Endocrinology","graph2":"Approved","graph3":"Aeterna Zentaris","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Aeterna Zentaris \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Aeterna Zentaris \/ Not Applicable"},{"orgOrder":0,"company":"Aeterna Zentaris","sponsor":"H.C. 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                            01

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Recipient : Ceapro

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Aeterna Zentaris and Ceapro Complete Merger Transaction

                            Details : The combined company will focus on the development of AEZS-130 (macimorelin), a ghrelin receptor agonist and a small molecule that stimulates the secretion of growth hormone from the pituitary gland.

                            Brand Name : AEZS-130

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            June 03, 2024

                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Recipient : Ceapro

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Recipient : Ceapro

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Aeterna Zentaris and Ceapro Announce Merger of Equals to Create a Diversified Biopharmaceutical Company

                            Details : The combined company will focus on the development of AEZS-130 (macimorelin), a ghrelin receptor agonist and a small molecule that stimulates the secretion of growth hormone from the pituitary gland.

                            Brand Name : AEZS-130

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            December 14, 2023

                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Recipient : Ceapro

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            03

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Macimorelin Acetate

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Provides Update on Macrilen (Macimorelin), Reiterates Advancement of Pediatric DETECT Trial

                            Details : Macimorelin (Macrilen®; GHRYVELIN™), a ghrelin agonist, is an orally active small molecule that stimulates the secretion of growth hormone from the pituitary gland.

                            Brand Name : Macrilen

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 05, 2023

                            Lead Product(s) : Macimorelin Acetate

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved

                            Sponsor : Novo Nordisk

                            Deal Size : Undisclosed

                            Deal Type : Termination

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Set to Regain Full Rights to Macrilen™ (Macimorelin) in U.S. and Canada from Novo Nordisk

                            Details : Under the Commercial License, Novo Nordisk was granted an exclusive license for the development, manufacturing, registration and commercialization of Macrilen™ (macimorelin) in the U.S. and Canada.

                            Brand Name : Macrilen

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 29, 2022

                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved

                            Sponsor : Novo Nordisk

                            Deal Size : Undisclosed

                            Deal Type : Termination

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                            05

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Autoimmunity Modifying Biologicals

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Achieves Proof-of-Concept for the Treatment of NMOSD with AIM Biologicals Program

                            Details : Preliminary data with mouse 2D2 models of spontaneous autoimmune encephalomyelitis (EAE) indicate that mouse-adapted AIM Biologicals may reduce optic neuritis, loss of inner nuclear layer neurons and EAE symptoms.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 13, 2022

                            Lead Product(s) : Autoimmunity Modifying Biologicals

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Autoimmunity Modifying Biologicals

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : AIM Biologicals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Update on Positive Pre-Clinical Results from AIM Biologicals Development Program for the Potential Treatment o...

                            Details : The pre-clinical data presented showed consistent effects in various in-vitro and in-vivo models, verifying the potential of HLA-G based molecules to induce antigen-specific immune-modulation.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 12, 2022

                            Lead Product(s) : Autoimmunity Modifying Biologicals

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : AIM Biologicals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Aeterna Zentaris

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                            Pharma, Lab & Chemical Expo
                            Not Confirmed

                            Aeterna Zentaris

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Abstract Accepted for Presentation at IMMUNOLOGY2022™, the Annual Event of the American Ass...

                            Details : AIM Biologicals utilize a novel mechanism based on peptide antigens that are presented on immunosuppressive MHC class I molecules, to selectively and efficiently induce antigen-specific tolerance.

                            Brand Name : Undisclosed

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            April 25, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Abstract Accepted for Presentation at 13th International Congress on Autoimmunity

                            Details : Antigen presentation on MHC class Ib-related molecules induces Aquaporin4-specific regulatory T cells in PBMC from NMOSD patients and prevents experimental autoimmune encephalomyelitis in mice.

                            Brand Name : Undisclosed

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            April 11, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Delayed Clearance Parathyroid Hormone

                            Therapeutic Area : Endocrinology

                            Study Phase : Preclinical

                            Sponsor : University of Sheffield

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Announces Notice of Allowance for U.S. Patent Covering AEZS-150 for the Potential Treatment o...

                            Details : AEZS-150 (delayed clearance parathyroid hormone fusion polypeptides DC-PTH), a proprietary fusion protein consisting of a modified GHBP linked to parathyroid hormone PTH1-34 with the goal to provide a PTH analog with delayed clearance of one or two weeks...

                            Brand Name : AEZS-150

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            March 02, 2022

                            Lead Product(s) : Delayed Clearance Parathyroid Hormone

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Preclinical

                            Sponsor : University of Sheffield

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Aeterna Zentaris

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                            Aeterna Zentaris

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                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved

                            Sponsor : H.C. Wainwright & Co.

                            Deal Size : $12.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Aeterna Zentaris Announces Pricing of $12 Million Public Offering

                            Details : The Company intends to use the net proceeds of this offering for general corporate purposes, which includes funding of a pediatric clinical trial in the E.U. and U.S. for Macrilen, the investigation of further therapeutic uses of macimorelin.

                            Brand Name : Macrilen

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            July 01, 2020

                            Lead Product(s) : Macimorelin

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved

                            Sponsor : H.C. Wainwright & Co.

                            Deal Size : $12.0 million

                            Deal Type : Public Offering

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