Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Macimorelin
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Ceapro
Deal Size : Undisclosed
Deal Type : Merger
Aeterna Zentaris and Ceapro Complete Merger Transaction
Details : The combined company will focus on the development of AEZS-130 (macimorelin), a ghrelin receptor agonist and a small molecule that stimulates the secretion of growth hormone from the pituitary gland.
Brand Name : AEZS-130
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 03, 2024
Lead Product(s) : Macimorelin
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Ceapro
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : Macimorelin
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Ceapro
Deal Size : Undisclosed
Deal Type : Merger
Details : The combined company will focus on the development of AEZS-130 (macimorelin), a ghrelin receptor agonist and a small molecule that stimulates the secretion of growth hormone from the pituitary gland.
Brand Name : AEZS-130
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 14, 2023
Lead Product(s) : Macimorelin
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Ceapro
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : Macimorelin Acetate
Therapeutic Area : Endocrinology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Macimorelin (Macrilen®; GHRYVELIN™), a ghrelin agonist, is an orally active small molecule that stimulates the secretion of growth hormone from the pituitary gland.
Brand Name : Macrilen
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 05, 2023
Lead Product(s) : Macimorelin Acetate
Therapeutic Area : Endocrinology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Macimorelin
Therapeutic Area : Endocrinology
Study Phase : Approved
Sponsor : Novo Nordisk
Deal Size : Undisclosed
Deal Type : Termination
Details : Under the Commercial License, Novo Nordisk was granted an exclusive license for the development, manufacturing, registration and commercialization of Macrilen™ (macimorelin) in the U.S. and Canada.
Brand Name : Macrilen
Molecule Type : Small molecule
Upfront Cash : Undisclosed
August 29, 2022
Lead Product(s) : Macimorelin
Therapeutic Area : Endocrinology
Highest Development Status : Approved
Sponsor : Novo Nordisk
Deal Size : Undisclosed
Deal Type : Termination
Lead Product(s) : Autoimmunity Modifying Biologicals
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Aeterna Zentaris Achieves Proof-of-Concept for the Treatment of NMOSD with AIM Biologicals Program
Details : Preliminary data with mouse 2D2 models of spontaneous autoimmune encephalomyelitis (EAE) indicate that mouse-adapted AIM Biologicals may reduce optic neuritis, loss of inner nuclear layer neurons and EAE symptoms.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 13, 2022
Lead Product(s) : Autoimmunity Modifying Biologicals
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Autoimmunity Modifying Biologicals
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : AIM Biologicals
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The pre-clinical data presented showed consistent effects in various in-vitro and in-vivo models, verifying the potential of HLA-G based molecules to induce antigen-specific immune-modulation.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 12, 2022
Lead Product(s) : Autoimmunity Modifying Biologicals
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : AIM Biologicals
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AIM Biologicals utilize a novel mechanism based on peptide antigens that are presented on immunosuppressive MHC class I molecules, to selectively and efficiently induce antigen-specific tolerance.
Brand Name : Undisclosed
Molecule Type : Peptide
Upfront Cash : Not Applicable
April 25, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Undisclosed
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Aeterna Zentaris Abstract Accepted for Presentation at 13th International Congress on Autoimmunity
Details : Antigen presentation on MHC class Ib-related molecules induces Aquaporin4-specific regulatory T cells in PBMC from NMOSD patients and prevents experimental autoimmune encephalomyelitis in mice.
Brand Name : Undisclosed
Molecule Type : Peptide
Upfront Cash : Not Applicable
April 11, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Delayed Clearance Parathyroid Hormone
Therapeutic Area : Endocrinology
Study Phase : Preclinical
Sponsor : University of Sheffield
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AEZS-150 (delayed clearance parathyroid hormone fusion polypeptides DC-PTH), a proprietary fusion protein consisting of a modified GHBP linked to parathyroid hormone PTH1-34 with the goal to provide a PTH analog with delayed clearance of one or two weeks...
Brand Name : AEZS-150
Molecule Type : Peptide
Upfront Cash : Not Applicable
March 02, 2022
Lead Product(s) : Delayed Clearance Parathyroid Hormone
Therapeutic Area : Endocrinology
Highest Development Status : Preclinical
Sponsor : University of Sheffield
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Macimorelin
Therapeutic Area : Endocrinology
Study Phase : Approved
Sponsor : H.C. Wainwright & Co.
Deal Size : $12.0 million
Deal Type : Public Offering
Aeterna Zentaris Announces Pricing of $12 Million Public Offering
Details : The Company intends to use the net proceeds of this offering for general corporate purposes, which includes funding of a pediatric clinical trial in the E.U. and U.S. for Macrilen, the investigation of further therapeutic uses of macimorelin.
Brand Name : Macrilen
Molecule Type : Small molecule
Upfront Cash : Undisclosed
July 01, 2020
Lead Product(s) : Macimorelin
Therapeutic Area : Endocrinology
Highest Development Status : Approved
Sponsor : H.C. Wainwright & Co.
Deal Size : $12.0 million
Deal Type : Public Offering
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