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    [{"orgOrder":0,"company":"Boehringer Ingelheim GmbH","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Afatinib","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"Boehringer Ingelheim GmbH","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Boehringer Ingelheim GmbH \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Boehringer Ingelheim GmbH \/ Not Applicable"},{"orgOrder":0,"company":"ECOG-ACRIN Cancer Research Group","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Afatinib","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"ECOG-ACRIN Cancer Research Group","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"ECOG-ACRIN Cancer Research Group \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"ECOG-ACRIN Cancer Research Group \/ Not Applicable"},{"orgOrder":0,"company":"Delta-Fly Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"ubenimex","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Delta-Fly Pharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Delta-Fly Pharma \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Delta-Fly Pharma \/ Not Applicable"},{"orgOrder":0,"company":"Delta-Fly Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"ubenimex","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Delta-Fly Pharma","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Delta-Fly Pharma \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"Delta-Fly Pharma \/ Not Applicable"}]

    Find Clinical Drug Pipeline Developments & Deals for Afatinib (diMaleate)

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    Afatinib (diMaleate)

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                            01

                            Delta-Fly Pharma

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                            Lead Product(s) : ubenimex,Afatinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Delta-Fly Pharma Begins Phase III Trial of DFP-14323

                            Details : DFP-14323 (Ubenimex) is a small molecule CD13 inhibitor, currently being investigated in combination with Afatinib for patients with EGFR-mutated Non-Small-Cell Lung Cancer.

                            Brand Name : DFP-14323

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 03, 2024

                            Lead Product(s) : ubenimex,Afatinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Delta-Fly Pharma

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                            Lead Product(s) : ubenimex,Afatinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Delta-Fly Pharma Initiates Phase III Trial Of DFP-14323

                            Details : Delta-Fly (ubenimex) is an aminopeptidase N inhibitor under Phase 3 trials in combination with afatinib for treating stage III/IV non-small cell lung cancer patients with EGFR mutations.

                            Brand Name : DFP-14323

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 02, 2024

                            Lead Product(s) : ubenimex,Afatinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            ECOG-ACRIN Cancer Research Group

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                            Lead Product(s) : Afatinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Genomic Study of 6000 NCI-MATCH Cancer Patients Leads to New Clinical Trial Benchmarks

                            Details : The NCI-MATCH, a precision medicine study launched by the ECOG-ACRIN Cancer Research Group and the National Cancer Institute, has found that many patients’ tumors bear genetic abnormalities that can be targeted with existing drugs—approved or experim...

                            Brand Name : Gilotrif

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 14, 2020

                            Lead Product(s) : Afatinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Boehringer Ingelheim GmbH

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                            Boehringer Ingelheim GmbH

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                            Lead Product(s) : Afatinib,Osimertinib Mesylate

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Additional Analysis of Real-World Data Confirms Sequential Gilotrif® Followed By Osimertinib Imporved Surviva...

                            Details : Sequential Gilotrif® (afatinib) and osimertinib contributed to a median overall survival (OS) of nearly four years among U.S. patients with epidermal growth factor receptor mutation-positive (EGFR M+) non-small cell lung cancer and the common resistance...

                            Brand Name : Gilotrif

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 10, 2020

                            Lead Product(s) : Afatinib,Osimertinib Mesylate

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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