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    [{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"University of California, Irvine","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Collaboration","leadProduct":"Neural stem cells","moa":"","graph1":"Genetic Disease","graph2":"Undisclosed","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"","sponsorNew":"AgeX Therapeutics \/ University of California, Irvine","highestDevelopmentStatusID":"1","companyTruncated":"AgeX Therapeutics \/ University of California, Irvine"},{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"IMS001","moa":"","graph1":"Neurology","graph2":"IND Enabling","graph3":"AgeX 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Therapeutics","sponsor":"ImStem Biotechnology","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Licensing Agreement","leadProduct":"IMS001","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Undisclosed","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"AgeX Therapeutics \/ AgeX","highestDevelopmentStatusID":"1","companyTruncated":"AgeX Therapeutics \/ AgeX"},{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"Pluristyx","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Agreement","leadProduct":"ESI human embryonic stem cells","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Undisclosed","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"AgeX Therapeutics \/ AgeX Therapeutics","highestDevelopmentStatusID":"1","companyTruncated":"AgeX Therapeutics \/ AgeX Therapeutics"},{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Collaboration","leadProduct":"Hypoimmunogenic cells","moa":"","graph1":"Immunology","graph2":"Discovery Platform","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"AgeX Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"3","companyTruncated":"AgeX Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"ImStem 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Therapeutics","sponsor":"Lygenesis","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Termination","leadProduct":"AGEX-VASC1","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Preclinical","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"","sponsorNew":"AgeX Therapeutics \/ LyGenesis","highestDevelopmentStatusID":"4","companyTruncated":"AgeX Therapeutics \/ LyGenesis"},{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"Serina Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Merger","leadProduct":"POZ-apomorphine","moa":"","graph1":"Neurology","graph2":"Preclinical","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"AgeX Therapeutics \/ Serina Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"AgeX Therapeutics \/ Serina Therapeutics"},{"orgOrder":0,"company":"AgeX Therapeutics","sponsor":"Serina Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Small molecule","year":"2024","type":"Merger","leadProduct":"POZ-Apomorphine","moa":"","graph1":"Neurology","graph2":"Preclinical","graph3":"AgeX Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Injection","sponsorNew":"AgeX Therapeutics \/ Serina Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"AgeX Therapeutics \/ Serina Therapeutics"}]

    Find Clinical Drug Pipeline Developments & Deals by AgeX Therapeutics

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                            01

                            AgeX Therapeutics

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                            Lead Product(s) : POZ-Apomorphine

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Serina Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Serina Therapeutics Announces Completion of Merger with AgeX Therapeutics

                            Details : The combined company will focus on advancing pre-clinical studies of Serina’s lead drug candidate SER-252 (POZ-apomorphine) for treatment of Parkinson’s Disease, and expanding POZ Platform.

                            Brand Name : SER-252

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            March 26, 2024

                            Lead Product(s) : POZ-Apomorphine

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Serina Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            02

                            AgeX Therapeutics

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                            Lead Product(s) : POZ-apomorphine

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Serina Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Serina Therapeutics and AgeX Therapeutics Enter into Merger Agreement

                            Details : The combined company will keep Serina name and trade on the New York Stock Exchange under the ticker "SER", and focus on advancing pre-clinical studies of Serina’s lead drug candidate SER-252 (POZ-apomorphine) for treatment of Parkinson’s Disease, an...

                            Brand Name : SER-252

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 30, 2023

                            Lead Product(s) : POZ-apomorphine

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Serina Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            03

                            AgeX Therapeutics

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                            Lead Product(s) : AGEX-VASC1

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Preclinical

                            Sponsor : Lygenesis

                            Deal Size : Undisclosed

                            Deal Type : Termination

                            DEALS_DEV arrow-down

                            AgeX Therapeutics and LyGenesis Terminate Merger Negotiations

                            Details : AgeX has two preclinical cell therapy programs: AGEX-VASC1 (vascular progenitor cells) for tissue ischemia and AGEX-BAT1 (brown fat cells) for Type II diabetes.

                            Brand Name : AGEX-VASC1

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            July 23, 2021

                            Lead Product(s) : AGEX-VASC1

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Lygenesis

                            Deal Size : Undisclosed

                            Deal Type : Termination

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                            04

                            AgeX Therapeutics

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                            Lead Product(s) : AgeX-BAT1

                            Therapeutic Area : Endocrinology

                            Study Phase : Preclinical

                            Sponsor : Ohio State University

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            AgeX to Collaborate with The Ohio State University to Generate Animal Data for AgeX’s BAT Cell Therapy Candi...

                            Details : The Ohio State University will use AgeX’s brown adipocyte tissue (BAT) cell therapy candidate AgeX-BAT1 in mice to determine whether transplantation of AgeX-BAT1 cells may improve diet-induced obesity, metabolic health including glucose metabolism, and...

                            Brand Name : AgeX-BAT1

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 10, 2021

                            Lead Product(s) : AgeX-BAT1

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Preclinical

                            Sponsor : Ohio State University

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            05

                            AgeX Therapeutics

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                            Lead Product(s) : LYG-LIV0001

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase II

                            Recipient : Lygenesis

                            Deal Size : Undisclosed

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            AgeX Therapeutics and LyGenesis to Negotiate Merger Agreement

                            Details : LYG-LIV0001 is a regenerative mobile remedy comprising allogeneic hepatocytes suspended in a buffered cell preservation resolution which are transplanted into periduodenal lymph nodes.

                            Brand Name : LYG-LIV0001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 02, 2021

                            Lead Product(s) : LYG-LIV0001

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase II

                            Recipient : Lygenesis

                            Deal Size : Undisclosed

                            Deal Type : Merger

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                            06

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                            Lead Product(s) : IMS001

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : IND Enabling

                            Sponsor : ImStem Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            AgeX Therapeutics Sublicenses Stem Cell Line ESI-053 to ImStem Biotechnology for Development of Cell Therapy C...

                            Details : ImStem has obtained from AgeX a non-exclusive, royalty-bearing sublicense to use AgeX’s clinical-grade ESC line ESI-053 to derive ImStem’s investigational MSC product candidate IMS001 for development in COVID-19 as well as acute respiratory distress ...

                            Brand Name : IMS001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 28, 2020

                            Lead Product(s) : IMS001

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : IND Enabling

                            Sponsor : ImStem Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            07

                            AgeX Therapeutics

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                            Lead Product(s) : ESI human embryonic stem cells

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Undisclosed

                            Recipient : Pluristyx

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            AgeX Therapeutics and Pluristyx Announce Manufacturing, Marketing, and Distribution Agreement

                            Details : The agreement is a key step in AgeX’s licensing and collaboration strategy to facilitate industry and academic access to its hESC lines, its PureStem® cell derivation and manufacturing platform, and its UniverCyte™ immunotolerance technology.

                            Brand Name : ESI hESC

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            June 16, 2020

                            Lead Product(s) : ESI human embryonic stem cells

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Undisclosed

                            Recipient : Pluristyx

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            08

                            AgeX Therapeutics

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                            Lead Product(s) : IMS001

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Undisclosed

                            Recipient : ImStem Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            AgeX Therapeutics and ImStem Biotechnology Sign Non-Binding Letter of Intent for Investigational MSC Candidate...

                            Details : ImStem will obtain from AgeX a non-exclusive license to use AgeX’s embryonic stem cell line ESI 053 to derive ImStem’s investigational MSC product IMS001 for development in COVID-19 as well as acute respiratory distress syndrome due to other causes.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            June 02, 2020

                            Lead Product(s) : IMS001

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Undisclosed

                            Recipient : ImStem Biotechnology

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            09

                            AgeX Therapeutics

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                            Lead Product(s) : Recombinant pluripotent stem cell-derived pancreatic islet beta cells

                            Therapeutic Area : Endocrinology

                            Study Phase : Undisclosed

                            Sponsor : Sernova

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            AgeX Therapeutics and Sernova to Engineer Universal Locally Immune Protected Cell Therapies for Type I Diabete...

                            Details : Sernova to utilize AgeX’s UniverCyteTM gene technology to generate transplantable, universal immune-protected therapeutic cells for Sernova’s Cell PouchTM Platform.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            May 29, 2020

                            Lead Product(s) : Recombinant pluripotent stem cell-derived pancreatic islet beta cells

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Undisclosed

                            Sponsor : Sernova

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            AgeX Therapeutics

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                            Lead Product(s) : IMS001

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ImStem Biotechnology Announces FDA has Lifted the Hold and Cleared IND for IMS001

                            Details : ImStem plans to initiate a phase 1 clinical study in patients with relapsing-remitting, secondary, and primary progressive forms of MS in 2020 in the US.

                            Brand Name : IMS001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 20, 2020

                            Lead Product(s) : IMS001

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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