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    [{"orgOrder":0,"company":"Aileron Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Peptide","year":"2020","type":"Not Applicable","leadProduct":"ALRN-6924","moa":"MDM2-MDMX","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Aileron Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aileron Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Aileron Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Aileron Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Peptide","year":"2020","type":"Not Applicable","leadProduct":"ALRN-6924","moa":"MDM2-MDMX","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Aileron Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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    Find Clinical Drug Pipeline Developments & Deals by Aileron Therapeutics

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                            01

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Aileron Therapeutics

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                            Lead Product(s) : Sulanemadlin

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Advancium Health

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Aileron And Advancium Sign Deal for ALRN-6924 Retinoblastoma Therapy

                            Details : Through the acquisition, Advancium will expand its oncology portfolio by acquiring ALRN-6924 (sulanemadlin), which is being evaluated for the treatment of retinoblastoma.

                            Brand Name : ALRN-6924

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 31, 2024

                            Lead Product(s) : Sulanemadlin

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Advancium Health

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            02

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
                            Not Confirmed

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aileron Completes Enrollment in Phase 1b Trial of LTI-03 in Pulmonary Fibrosis

                            Details : LTI-03 is a novel, Caveolin-1-related peptide that addresses both inhibition of pro-fibrotic signaling & survival of critical epithelial cells. It is being developed for idiopathic pulmonary fibrosis.

                            Brand Name : LTI-03

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            September 23, 2024

                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Aileron Therapeutics

                            U.S.A arrow
                            Medlab Asia & Asia Health
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                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I

                            Sponsor : Titan Partners Group

                            Deal Size : $40.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Aileron Completes $40 Million Underwritten Registered Direct Offering

                            Details : The proceeds will advance the clinical development of Aileron’s lead candidate, LTI-03, currently in early-stage trials for idiopathic pulmonary fibrosis.

                            Brand Name : LTI-03

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            May 03, 2024

                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I

                            Sponsor : Titan Partners Group

                            Deal Size : $40.0 million

                            Deal Type : Public Offering

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                            04

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
                            Not Confirmed

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I

                            Sponsor : Titan Partners Group

                            Deal Size : $4.6 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Positive Initial Data Reported from Immutep's Efti Combined with Radiotherapy in Phase II

                            Details : The net proceeds will be used to advance the development of LTI-03, a peptide representing an important region of the Caveolin 1 (Cav1) protein, for the treatment of idiopathic pulmonary fibrosis.

                            Brand Name : LTI-03

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            May 01, 2024

                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I

                            Sponsor : Titan Partners Group

                            Deal Size : $4.6 million

                            Deal Type : Public Offering

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                            05

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
                            Not Confirmed

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aileron Therapeutics Reports Positive Data from Phase 1b Trial Of LTI-03 in IPF

                            Details : LTI-03 is a novel, Caveolin-1-related peptide that addresses both inhibition of pro-fibrotic signaling and survival of critical epithelial cells. Being developed for idiopathic pulmonary fibrosis.

                            Brand Name : LTI-03

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            May 01, 2024

                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I

                            Recipient : Lung Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Aileron Therapeutics Announces Acquisition of Lung Therapeutics

                            Details : The acquisition includes multiple clinical stage, orphan pulmonary disease candidates, including LTI-03, a Caveolin-1-related peptide in development for the treatment of idiopathic pulmonary fibrosis (IPF).

                            Brand Name : LTI-03

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            October 31, 2023

                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I

                            Recipient : Lung Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            07

                            Aileron Therapeutics

                            U.S.A arrow
                            Medlab Asia & Asia Health
                            Not Confirmed

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
                            Not Confirmed
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                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase I

                            Sponsor : Clear Street LLC

                            Deal Size : $18.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Aileron Therapeutics Announces Acquisition of Lung Therapeutics

                            Details : Aileron intends to use the proceeds primarily to complete the ongoing Phase 1b clinical study of LTI-03, a Caveolin-1-related peptide in development for the treatment of idiopathic pulmonary fibrosis.

                            Brand Name : LTI-03

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            October 31, 2023

                            Lead Product(s) : LTI-03

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase I

                            Sponsor : Clear Street LLC

                            Deal Size : $18.0 million

                            Deal Type : Private Placement

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                            08

                            Aileron Therapeutics

                            U.S.A arrow
                            Medlab Asia & Asia Health
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                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : ALRN-6924

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aileron Therapeutics Announces Termination of Phase 1b Breast Cancer Chemoprotection Trial and Exploration of ...

                            Details : ALRN-6924 is an MDM2/MDMX inhibitor that leverages Aileron’s proprietary peptide drug technology. The primary endpoint of the Phase 1b open-label trial was duration and incidence of severe neutropenia in cycle 1.

                            Brand Name : ALRN-6924

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 21, 2023

                            Lead Product(s) : ALRN-6924

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Aileron Therapeutics

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                            Medlab Asia & Asia Health
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                            Lead Product(s) : ALRN-6924

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aileron Therapeutics Announces Oral Presentation of Non-Clinical Data Demonstrating ALRN-6924 Protected Human ...

                            Details : The primary endpoints are duration and incidence of severe neutropenia (Grade 4) in cycle 1. Secondary endpoints include the chemoprotective effect of ALRN-6924 on chemotherapy-induced alopecia, as well as other hematologic and non-hematologic toxicities...

                            Brand Name : ALRN-6924

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            September 30, 2022

                            Lead Product(s) : ALRN-6924

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Aileron Therapeutics

                            U.S.A arrow
                            Medlab Asia & Asia Health
                            Not Confirmed

                            Aileron Therapeutics

                            U.S.A arrow
                            Medlab Asia & Asia Health
                            Not Confirmed
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                            Lead Product(s) : ALRN-6924,Doxorubicin Hydrochloride,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Aileron Therapeutics Is Pleased to Outline Strategy to Strengthen Phase 1b Clinical Trial of ALRN-6924 in Pati...

                            Details : Enhancements to protocol, informed by recent ALRN-6924 data, are designed to improve the opportunity to demonstrate protection against chemotherapy-induced severe neutropenia, alopecia (hair loss) and potentially other toxicities in patients with p53-mut...

                            Brand Name : ALRN-6924

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 01, 2022

                            Lead Product(s) : ALRN-6924,Doxorubicin Hydrochloride,Cyclophosphamide

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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