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                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : LTI-03, is a novel, synthetic peptide with a dual mechanism targeting alveolar epithelial cell survival as well as inhibition of profibrotic signaling.

                          Product Name : LTI-03

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          November 13, 2024

                          Lead Product(s) : LTI-03

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Through the acquisition, Advancium will expand its oncology portfolio by acquiring ALRN-6924 (sulanemadlin), which is being evaluated for the treatment of retinoblastoma.

                          Product Name : ALRN-6924

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          October 31, 2024

                          Lead Product(s) : Sulanemadlin

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Advancium Health

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : LTI-03 is a novel, Caveolin-1-related peptide that addresses both inhibition of pro-fibrotic signaling & survival of critical epithelial cells. It is being developed for idiopathic pulmonary fibrosis.

                          Product Name : LTI-03

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          September 23, 2024

                          Lead Product(s) : LTI-03

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The proceeds will advance the clinical development of Aileron’s lead candidate, LTI-03, currently in early-stage trials for idiopathic pulmonary fibrosis.

                          Product Name : LTI-03

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          March 05, 2024

                          Lead Product(s) : LTI-03

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Titan Partners Group LLC

                          Deal Size : $40.0 million

                          Deal Type : Public Offering

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : LTI-03 is a novel, Caveolin-1-related peptide that addresses both inhibition of pro-fibrotic signaling and survival of critical epithelial cells. Being developed for idiopathic pulmonary fibrosis.

                          Product Name : LTI-03

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          January 05, 2024

                          Lead Product(s) : LTI-03

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The net proceeds will be used to advance the development of LTI-03, a peptide representing an important region of the Caveolin 1 (Cav1) protein, for the treatment of idiopathic pulmonary fibrosis.

                          Product Name : LTI-03

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          January 05, 2024

                          Lead Product(s) : LTI-03

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Titan Partners Group LLC

                          Deal Size : $4.6 million

                          Deal Type : Public Offering

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Aileron intends to use the proceeds primarily to complete the ongoing Phase 1b clinical study of LTI-03, a Caveolin-1-related peptide in development for the treatment of idiopathic pulmonary fibrosis.

                          Product Name : LTI-03

                          Product Type : Peptide

                          Upfront Cash : Undisclosed

                          October 31, 2023

                          Lead Product(s) : LTI-03

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Clear Street LLC

                          Deal Size : $18.0 million

                          Deal Type : Private Placement

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : ALRN-6924 is an MDM2/MDMX inhibitor that leverages Aileron’s proprietary peptide drug technology. The primary endpoint of the Phase 1b open-label trial was duration and incidence of severe neutropenia in cycle 1.

                          Product Name : ALRN-6924

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          February 21, 2023

                          Lead Product(s) : Sulanemadlin

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Non-clinical data demonstrated principle that ALRN-6924 can temporarily arrest cell cycle in human scalp hair follicles and their stem cells also ALRN-6924-induced cell cycle arrest protected hair follicles from paclitaxel-induced toxicity and irreversib...

                          Product Name : ALRN-6924

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          October 05, 2022

                          Lead Product(s) : Sulanemadlin,Paclitaxel

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The primary endpoints are duration and incidence of severe neutropenia (Grade 4) in cycle 1. Secondary endpoints include the chemoprotective effect of ALRN-6924 on chemotherapy-induced alopecia, as well as other hematologic and non-hematologic toxicities...

                          Product Name : ALRN-6924

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          September 30, 2022

                          Lead Product(s) : Sulanemadlin

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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